Digital Commons Network^™

Baseline Health And Nutritional Parameters Of Wild Sand Tigers Carcharias Taurus Sampled In Delaware Bay, Lisa A. Hoopes, Tonya M. Clauss, Bradley M. Wetherbee, Dewayne A. Fox

Marine & Environmental Sciences Faculty Articles

Species-specific hematological reference values are essential for diagnosis and treatment of disease and maintaining overall health of animals. This information is lacking for many species of elasmobranchs maintained in zoos and aquaria, thus reducing the effectiveness of care for these animals. Descriptive statistics and reference intervals were calculated for hematocrit and complete blood cell counts, biochemistry and protein electrophoresis parameters, trace minerals, vitamins, heavy metals, reproductive hormones, and fatty acids in the blood of 153 wild Sand Tigers Carcharias taurus of both sexes and a range of sizes caught in Delaware Bay (Delaware, USA). Mean hematocrit, total white blood cell …

Editorial: Special Issue “Innovative Techniques And Approaches In The Control And Prevention Of Rabies Virus”, Amy T. Gilbert, Ryan M. Wallace, Charles E. Rupprecht

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is an ancient lethal scourge that has plagued humankind for centuries. Globally, 60,000 human deaths are estimated to occur each year from rabies virus (RABV) transmission in domestic dogs, mostly affecting children. While rabies is recognized as a neglected disease, there is cause for optimism in the context of growing global recognition, collaboration and commitment to advance a tripartite agenda to eliminate human deaths transmitted from rabid dogs by 2030, also known as “Zero By Thirty” (ZBT). Nevertheless, the ZBT goal must also confront competing challenge(s) of tracking and mitigating human morbidity and mortality during a global pandemic caused …

Spreading Rates Of Bacterial Colonies Depend On Substrate Stiffness And Permeability, Alison Patteson, Merrill Asp, Minh H. Thanh, Danielle A. Germann, Robert J. Carroll, Alana Franceski, Roy D. Welch, Arvind Gopinath

Physics - All Scholarship

The ability of bacteria to colonize and grow on different surfaces is an essential process for biofilm development. Here, we report the use of synthetic hydrogels with tunable stiffness and porosity to assess physical effects of the substrate on biofilm development. Using time-lapse microscopy to track the growth of expanding Serratia marcescens colonies, we find that biofilm colony growth can increase with increasing substrate stiffness, unlike what is found on traditional agar substrates. Using traction force microscopy-based techniques, we find that biofilms exert transient stresses correlated over length scales much larger than a single bacterium, and that the magnitude of …

Mathematical Analysis Of An Sir Disease Model With Non-Constant Transmission Rate, Emma Bollinger, Tayler Valdez, Swarup Ghosh, Sunil Giri

Student Research

• Epidemiology: A branch of medicine that studies causes, transmission, and control methods of diseases at the population level.
• Mathematical epidemiology deals with creating a model for a disease through the study of incidence and distribution of the disease throughout a population.
• Here, we have examined the behavior of a measles-like disease[2] that is characterized by a non-constant transmission rate.

Can We Use Antipredator Behavior Theory To Predict Wildlife Responses To High-Speed Vehicles?, Ryan B. Lunn, Bradley Blackwell, Travis L. Devault, Esteban Fernández-Juricic

United States Department of Agriculture Wildlife Services: Staff Publications

Animals seem to rely on antipredator behavior to avoid vehicle collisions. There is an extensive body of antipredator behavior theory that have been used to predict the distance/time animals should escape from predators. These models have also been used to guide empirical research on escape behavior from vehicles. However, little is known as to whether antipredator behavior models are appropriate to apply to an approaching high-speed vehicle scenario. We addressed this gap by (a) providing an overview of the main hypotheses and predictions of different antipredator behavior models via a literature review, (b) exploring whether these models can generate quantitative …

Modeling The Extended Low And Sudden High Periods Of Activity In Infectious Diseases, Dana Strong

Student Research Symposium

This research explores how the aggregation of individuals during disease spread may, in conjunction with noise, explain how some diseases’ trajectories spend some time at low numbers after which there is a sudden outbreak.

Pro-Inflammatory Diet Pictured In Children With Atopic Dermatitis Or Food Allergy: Nutritional Data Of The Lina Cohort, Olivia Schütte, Larissa Bachmann, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Janine F. Felix, Stefan Röder, Ulrich Sack, Michaek Borte, Wieland Kiess, Ana C. Zenclussen, Gabriele I. Stangl

Faculty Publications

Background: Lifestyle and environmental factors are known to contribute to allergic disease development, especially very early in life. However, the link between diet composition and allergic outcomes remains unclear. Methods: In the present population-based cohort study we evaluated the dietary intake of 10-year-old children and analyses were performed with particular focus on atopic dermatitis or food allergy, allergic diseases known to be affected by dietary allergens. Dietary intake was assessed via semi-quantitative food frequency questionnaires. Based on these data, individual nutrient intake as well as children’s Dietary Inflammatory Index (C-DII™) scores were calculated. Information about atopic manifestations during the first …

Atg9a And Atg13 Cooperate To Drive Basal Autophagy, Daniel Morgan Poole

Theses and Dissertations

Autophagy, as the name suggests, is a cellular process of self-eating in which cytoplasmic debris is engulfed by a double membrane vesicle dubbed the autophagosome and is ultimately degraded and recycled by proteases in the lysosome. The process is initiated by a group of core ATG proteins, including a multi-pass transmembrane protein called ATG9A. Although ATG9A has been shown to be essential for both stress induced and basal autophagy, its mechanism and interaction network remain largely illusive. Our current study employs BioID proteomics to identify a network of interactors, including regulators of membrane fusion and vesicle trafficking, such as TRAPP, …

Economic Losses From Covid-19 Cases In The Philippines: A Dynamic Model Of Health And Economic Policy Trade-Offs, Elvira P. De Lara-Tuprio, Ma. Regina Justina E. Estuar, Joselito T. Sescon, Cymon Kayle Lubangco, Rolly Czar Joseph T. Castillo, Timothy Robin Y. Teng, Lenard Paulo V. Tamayo, Jay Michael R. Macalalag, Gerome M. Vedeja

Mathematics Faculty Publications

The COVID-19 pandemic forced governments globally to impose lockdown measures and mobility restrictions to curb the transmission of the virus. As economies slowly reopen, governments face a trade-off between implementing economic recovery and health policy measures to control the spread of the virus and to ensure it will not overwhelm the health system. We developed a mathematical model that measures the economic losses due to the spread of the disease and due to different lockdown policies. This is done by extending the subnational SEIR model to include two differential equations that capture economic losses due to COVID-19 infection and due …

Bioactivity Of Suberitenones A And B, Jared G. Waters

USF Tampa Graduate Theses and Dissertations

Throughout human history, natural products have formed the foundation of medicine. In ancient times, a myriad of herbs and fungi have been attributed properties of healing and rejuvenation. Today, that foundation still very much exists, as natural product chemists isolate bioactive compounds from plants, fungi, animals, and microorganisms alike. As more of these secondary metabolites are discovered, scientists pursue more and more sources of biodiversity that may yield new and unprecedented compounds. To this end, Antarctica has become of particular note, as its unique environmental conditions and highly isolated nature make for rare and unusual adaptations in its native wildlife. …

Microfluidic Paper Analytical Devices, Madison Page

Chemistry & Biochemistry Student Projects

Microfluidic paper analytical devices (µPADs) are small, paper-based matrices similar to Lab-on-a-Chip (LOC). They are capable of semi-quantitative analysis, with applications ranging from medical to environmental to food and beverage testing. Important to improving point-of-care devices (POCs), various techniques have been integrated into µPADs to customize analysis and fit different clinical situations.

Clostridioides Difficile Spore Production In Response To Antibiotic And Immune Stress, Adenrele Oludiran, Erin B. Purcell

College of Sciences Posters

Clostridioides (Clostridium) difficile, an anaerobic, spore-forming Gram-positive pathogenic bacterium, is a major cause of hospital-acquired infections and can persist as surface-attached biofilms for protection from antibiotic and immune stress. C. difficile can form biofilms as a single species or with other anaerobic intestinal bacteria. The environmental signals that cause individual cells to secrete toxins, form biofilms, or develop into spores that can spread the infection to new patients are unknown. In these studies, we investigate bacterial responses to different stress. Antimicrobial host-defense peptides (HDPs) produced by animal immune systems are promising candidates to develop novel therapies for bacterial infection …

Transdisciplinary Environmental Work: An Evaluation Of Transdisciplinarity In The Field Of Environmental Science And Its Relevance To South Carolina Conservation Efforts In Lake Wateree And The Catawba Indian Reservation, Olivia Mn Shugart

Senior Theses

Transdisciplinarity describes the integration of knowledge and exchange of ideas across diverse academic disciplines, public stakeholders, and decision-makers. In this paper, I discuss the relevance of transdisciplinarity to the environmental field and offer ways in which its principles could be employed to enhance current South Carolina conservation efforts. I advocate for transdisciplinary work through analyzing existing discourse on the value of transdisciplinary research to the environmental field, and I present some of the challenges associated with this mass integration of knowledge. Finally, I describe three models of transdisciplinary research that have been proposed by scholars to address some of these …

2022 Research Day Program, Lincoln Memorial University

Research Day

This program contains abstracts and presentation summaries from LMU's 2022 Annual Research Day conference.

Economic Consequences Of The Wolf Comeback In The Western United States, Dana Hoag, Stewart W. Breck, Kevin Crooks, Becky Niemiec

United States Department of Agriculture Wildlife Services: Staff Publications

Gray wolves were eradicated from most of the United States in the 1940’s but have made a comeback in parts of their historic range over the last two decades. First reintroduced into the Greater Yellowstone Ecosystem and central Idaho in the mid-1990’s, wolves have subsequently dispersed into at least 7 western states. Coloradoans became the latest state to take interest in bolstering wolf populations, as residents passed a ballot initiative in November 2020 to reintroduce a self-sustaining population of gray wolves by the end of 2023. Conflicts between people in rural areas that might incur costs (such as livestock loss) …

Understanding Continent-Wide Variation In Vulture Ranging Behavior To Assess Feasibility Of Vulture Safe Zones In Africa: Challenges And Possibilities, Adam Kane, Ara Monadjem, H. K.Ortwin Aschenborn, Keith Bildstein, André Botha, Claire Bracebridge, Evan R. Buechley, Ralph Buij, John P. Davies, Maria Diekmann, Colleen T. Downs, Nina Farwig, Toby Galligan, Gregory Kaltenecker, Chris Kelly, Ryno Kemp, Holger Kolberg, Monique L. Mackenzie, John Mendelsohn, Msafiri Mgumba, Ran Nathan, Aaron Nicholas, Darcy Ogada, Morgan Pfeiffer, W. Louis Phipps, Matteuns D. Pretorius, Sascha Rösner, Dana G. Schabo, Gabriel Lita Shatumbu, Orr Spiegel, Lindy J. Thompson, Jan A. Venter, Munir Virani, Kerri Wolter, Corinne J. Kendall

United States Department of Agriculture Wildlife Services: Staff Publications

Protected areas are intended as tools in reducing threats to wildlife and preserving habitat for their long-term population persistence. Studies on ranging behavior provide insight into the utility of protected areas. Vultures are one of the fastest declining groups of birds globally and are popular subjects for telemetry studies, but continent-wide studies are lacking. To address how vultures use space and identify the areas and location of possible vulture safe zones, we assess home range size and their overlap with protected areas by species, age, breeding status, season, and region using a large continent-wide telemetry datasets that includes 163 individuals …

European Starling Use Of Nest Boxes Relative To Human Disturbance, Bradley Blackwell, Bruce N. Buckingham, Morgan B. Pfeiffer

United States Department of Agriculture Wildlife Services: Staff Publications

gars and to engine and flight surfaces of moored aircraft. We questioned whether consistent removal of nest material would negatively affect use of a nest site, measured by a reduction in material accumulation. We conducted our study on a 2,200-ha site in Erie County, Ohio, USA (41° 22’ N, 82° 41’ W), from April 15 through June 2, 2020. We used 120 wooden nest boxes on utility poles, protected by an aluminum predator guard below the box. Our treatments included (1) twice weekly, repeated nest material removal (RMR; n = 40 nest boxes); (2) complete nest removal, but only after …

Pre-Training Graph Neural Networks For Link Prediction In Biomedical Networks, Yahui Long, Min Wu, Yong Liu, Yuan Fang, Chee Kong Kwoh, Jiawei Luo, Xiaoli Li

Research Collection School Of Computing and Information Systems

Motivation: Graphs or networks are widely utilized to model the interactions between different entities (e.g., proteins, drugs, etc) for biomedical applications. Predicting potential links in biomedical networks is important for understanding the pathological mechanisms of various complex human diseases, as well as screening compound targets for drug discovery. Graph neural networks (GNNs) have been designed for link prediction in various biomedical networks, which rely on the node features extracted from different data sources, e.g., sequence, structure and network data. However, it is challenging to effectively integrate these data sources and automatically extract features for different link prediction tasks. Results: In …

Sacred Scavengers: Vulture Conservation In Nepal, Hans Nedde

Independent Study Project (ISP) Collection

In the 1990s, a veterinary drug used to treat pain and disease in cattle nearly brought the nine vulture species of Nepal to extinction. In a span of 15 years, over 97% of vultures in Nepal perished. For the past 20 years, governments, organizations, and communities have been working together to save these vital scavengers from vanishing. From the lowlands to the Himalayas, vultures have been interacting with the environment and humans for millennia. This study explores the role that vultures play both ecologically and culturally in Nepal. It investigates vultures as a crucial ecological influence and how human action …

Comparing Amphibian Species Diversity And Abundance In Natural Forest And Cacao Agroforest At Finca La Magnita, Changuinola, Bocas Del Toro, Panamá, Lake Barrett

Independent Study Project (ISP) Collection

Amphibians are currently undergoing rapid and drastic biodiversity loss worldwide, largely due to the disease Chytridiomycosis. Because of this, efforts to conserve amphibian biodiversity are urgent and have been given increasing importance. However, studies investigating the effectiveness of agroforestry systems, a commonly used agricultural method in which trees and other elements of forests are retained on land used for agriculture, for amphibian conservation are uncommon. As a result, the capacity of agroforests to serve as a tool for amphibian conservation is unclear. To determine if agroforests can serve as a habitat for amphibians and a tool for their conservation, this …

Mathematical Modelling Of Syphilis Transmission Dynamics: Impacts Of Mass Media Report, Risky Sexual Behavior And Treatment, Gasper G. Mwanga

Tanzania Journal of Science

Syphilis is one of the deadly sexually-transmitted diseases. This paper studied the impacts of sexual behavior, mass media report and treatment of infected individuals on the dynamics of syphilis transmission. The analytical and numerical analyses of the model are presented. The disease free equilibrium of the model is both locally and globally asymptotic stable when the associated reproduction number is less than unity.  Analysis of the Reproduction number shows that it is not possible to control syphilis disease transmission if the rate of individuals practicing risky sexual behavior is high. Furthermore, the treatment of late (latent and tertiary) syphilis infection …

Covid-19 Variant, Vaccine And Booster, Manas Mandal

Annual Research Symposium

No abstract provided.

A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus, Elizabeth Wagstaff, Chandrelyn Kraczek, Jack Brandon Lopez

Annual Research Symposium

A poster presentation and abstract for the Roseman Symposium. The project focuses on testing 3 essential oil blends and two disinfectants containing an essential oil blend against SARS CoV-2 in response to the COVID-19 pandemic. The project procedure involves plaque assays, disinfection, and neutralization techniques.

Analysis Of Sir Epidemic Models With Sociological Phenomenon, Robert F. Allen, Katherine C. Heller, Matthew A. Pons

Spora: A Journal of Biomathematics

We propose two SIR models which incorporate sociological behavior of groups of individuals. It is these differences in behaviors which impose different infection rates on the individual susceptible populations, rather than biological differences. We compute the basic reproduction number for each model, as well as analyze the sensitivity of R₀ to changes in sociological parameter values.

Interpretable Deep Learning For The Prediction Of Icu Admission Likelihood And Mortality Of Covid-19 Patients, Amril Nazir, Hyacinth Kwadwo Ampadu

All Works

The global healthcare system is being overburdened by an increasing number of COVID-19 patients. Physicians are having difficulty allocating resources and focusing their attention on high-risk patients, partly due to the difficulty in identifying high-risk patients early. COVID-19 hospitalizations require specialized treatment capabilities and can cause a burden on healthcare resources. Estimating future hospitalization of COVID-19 patients is, therefore, crucial to saving lives. In this paper, an interpretable deep learning model is developed to predict intensive care unit (ICU) admission and mortality of COVID-19 patients. The study comprised of patients from the Stony Brook University Hospital, with patient information such …

Repurposing Lansoprazole And Posaconazole To Treat Leishmaniasis: Integration Of In Vitro Testing, Pharmacological Corroboration, And Mechanisms Of Action, Yash Gupta, Steven Goicoechea, Jesus G. Romero, Raman Mathur, Thomas R. Caulfield, Daniel P. Becker, Ravi Durvasula, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

Leishmaniasis remains a serious public health problem in many tropical regions of the world. Among neglected tropical diseases, the mortality rate of leishmaniasis is second only to malaria. All currently approved therapeutics have toxic side effects and face rapidly increasing resistance. To identify existing drugs with antileishmanial activity and predict the mechanism of action, we designed a drug-discovery pipeline utilizing both in-silico and in-vitro methods. First, we screened compounds from the Selleckchem Bio-Active Compound Library containing ~1622 FDA-approved drugs and narrowed these down to 96 candidates based on data mining for possible anti-parasitic properties. Next, we completed preliminary in-vitro testing …

Determinants Of Covid-19 Vaccinations Among A State-Wide Year-Long Surveillance Initiative In A Conservative Southern State, Lídia Gual-Gonzalez, Maggie S.J. Mccarter, Kyndall Dye-Braumuller, Stella Self, Connor H. Ross, Chloe Rodriguez-Ramos, Virginie G. Daguise, Melissa Nolan Ph.D., Mph

Faculty Publications

By the end of 2021, the COVID-19 pandemic resulted in over 54 million cases and more than 800,000 deaths in the United States, and over 350 million cases and more than 5 million deaths worldwide. The uniqueness and gravity of this pandemic have been reflected in the public health guidelines poorly received by a growing subset of the United States population. These poorly received guidelines, including vaccine receipt, are a highly complex psychosocial issue, and have impacted the successful prevention of disease spread. Given the intricate nature of this important barrier, any single statistical analysis methodologically fails to address all …

Cetacean Strandings In The Us Pacific Northwest 2000–2019 Reveal Potential Linkages To Oceanographic Variability, Amanda J. Warlick, Jessica L. Huggins, Dyanna M. Lambourn, Deborah A. Duffield, Dalin Nichole D'Alessandro, James M. Rice, John Calambokidis, M. Bradley Hanson, Joseph K. Gaydos, Multiple Additional Authors

Biology Faculty Publications and Presentations

Studying patterns in marine mammal stranding cases can provide insight into changes in population health, abundance, and distribution. Cetaceans along the United States West coast strand for a wide variety of reasons, including disease, injury, and poor nutritional status, all of which may be caused by both natural and anthropogenic factors. Examining the potential drivers of these stranding cases can reveal how populations respond to changes in their habitat, notably oceanographic variability and anthropogenic activities. In this study, we aim to synthesize recent patterns in 1,819 cetacean strandings across 26 species in the Pacific Northwest from 2000 to 2019 to …

Developing A Fake News Identification Model With Advanced Deep Languagetransformers For Turkish Covid-19 Misinformation Data, Mehmet Bozuyla, Akin Özçi̇ft

Turkish Journal of Electrical Engineering and Computer Sciences

The massive use of social media causes rapid information dissemination that amplifies harmful messages such as fake news. Fake-news is misleading information presented as factual news that is generally used to manipulate public opinion. In particular, fake news related to COVID-19 is defined as 'infodemic' by World Health Organization. An infodemic is a misleading information that causes confusion which may harm health. There is a high volume of misinformation about COVID-19 that causes panic and high stress. Therefore, the importance of development of COVID-19 related fake news identification model is clear and it is particularly important for Turkish language from …

Riding The Wave: Reactive Vector-Borne Disease Policy Renders The United States Vulnerable To Outbreaks And Insecticide Resistance, Kyndall C. Dye-Braumuller, Jennifer R. Gordon, Kaci Mccoy, Danielle Johnson, Rhoel Dinglasan, Melissa Nolan Ph.D., Mph

Faculty Publications

Funding for vector-borne disease surveillance, management, and research is cyclical and reactive in the United States. The subsequent effects have yielded gross inequities nationally that unintentionally support recurrent outbreaks. This policy forum is comprised of four primary subsections that collectively identify specific areas for improvement and offer innovative solutions to address national inadequacies in vector borne disease policy and infrastructure.