Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- University of Nebraska - Lincoln (1084)
- Old Dominion University (108)
- University of South Florida (108)
- Illinois State University (99)
- Universitas Indonesia (87)
-
- TÜBİTAK (78)
- University of South Carolina (76)
- Virginia Commonwealth University (76)
- University of Texas Rio Grande Valley (74)
- Technological University Dublin (73)
- University of Kentucky (71)
- COBRA (70)
- Montclair State University (55)
- Himmelfarb Health Sciences Library, The George Washington University (53)
- Prairie View A&M University (53)
- Utah State University (51)
- Louisiana State University (47)
- City University of New York (CUNY) (46)
- Brigham Young University (44)
- University of Nevada, Las Vegas (42)
- Portland State University (41)
- Singapore Management University (41)
- Missouri University of Science and Technology (40)
- The Texas Medical Center Library (39)
- University of Arkansas, Fayetteville (39)
- University of Texas at El Paso (38)
- Nova Southeastern University (35)
- Georgia Southern University (34)
- Wayne State University (34)
- University of Central Florida (33)
- Keyword
-
- COVID-19 (145)
- Epidemiology (86)
- Climate change (59)
- Invasive species (54)
- Sus scrofa (52)
-
- Public health (46)
- Feral swine (42)
- Humans (42)
- Machine learning (42)
- SARS-CoV-2 (37)
- Rabies (33)
- Malaria (32)
- Infectious disease (30)
- Stability (30)
- Vaccination (28)
- Disease (27)
- Transmission (27)
- HIV (26)
- Antibiotic resistance (23)
- Machine Learning (23)
- Management (22)
- SIR model (22)
- Chemistry (21)
- Tuberculosis (21)
- Wildlife damage management (21)
- Optimal control (20)
- United States (20)
- Basic reproduction number (19)
- Influenza (19)
- Mathematics (19)
- Publication Year
- Publication
-
- United States Department of Agriculture Wildlife Services: Staff Publications (696)
- Theses and Dissertations (138)
- USF Tampa Graduate Theses and Dissertations (86)
- Kesmas (80)
- Electronic Theses and Dissertations (63)
-
- Annual Symposium on Biomathematics and Ecology Education and Research (60)
- School of Natural Resources: Faculty Publications (57)
- Faculty Publications (56)
- Applications and Applied Mathematics: An International Journal (AAM) (53)
- Biology and Medicine Through Mathematics Conference (49)
- Turkish Journal of Chemistry (49)
- Epidemiology Faculty Publications (41)
- Dissertations (38)
- Open Access Theses & Dissertations (37)
- Faculty, Staff and Student Publications (36)
- Canadian Cooperative Wildlife Health Centre: Newsletters and Publications (33)
- Research Collection School Of Computing and Information Systems (33)
- SURE Journal: Science Undergraduate Research Experience Journal (32)
- Southeastern Cooperative Wildlife Disease Study: Publications (32)
- Karbala International Journal of Modern Science (31)
- School of Mathematical & Statistical Sciences Faculty Publications (30)
- Articles (29)
- Independent Study Project (ISP) Collection (29)
- Theses, Dissertations and Culminating Projects (29)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (27)
- United States Geological Survey: Staff Publications (25)
- Chemistry Faculty Publications (24)
- Harvard University Biostatistics Working Paper Series (24)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (24)
- All Works (23)
- Publication Type
- File Type
Articles 1141 - 1170 of 4289
Full-Text Articles in Entire DC Network
Genomic Tools Reveal Complex Social Organization Of An Invasive Large Mammal (Sus Scrofa), Chelsea L. Titus, Courtney F. Bowden, Timothy J. Smyser, Stephen L. Webb, James C. Beasley
Genomic Tools Reveal Complex Social Organization Of An Invasive Large Mammal (Sus Scrofa), Chelsea L. Titus, Courtney F. Bowden, Timothy J. Smyser, Stephen L. Webb, James C. Beasley
United States Department of Agriculture Wildlife Services: Staff Publications
A comprehensive understanding of sociality in wildlife is vital to optimizing conservation and management efforts. However, sociality is complicated, especially for widely distributed species that exhibit substantive behavioral plasticity. Invasive wild pigs (Sus scrofa), often representing hybrids of European wild boar and domestic pigs, are among the most adaptable and widely distributed large mammals. The social structure of wild pigs is believed to be similar to European wild boar, consisting of matriarchal groups (sounders) and solitary males. However, wild pig social structure is understudied and largely limited to visual observations. Using a hierarchical approach, we incorporated genomic tools …
Metabolomic Analysis, Identification And Antimicrobial Assay Of Two Mangrove Endophytes, Stephen Thompson
Metabolomic Analysis, Identification And Antimicrobial Assay Of Two Mangrove Endophytes, Stephen Thompson
USF Tampa Graduate Theses and Dissertations
Natural products have played major roles in drug discovery and provided sources for many new drugs. Secondary metabolites, also called natural products, are organic compounds that are produced from fungi, bacteria, and other living organisms. Secondary metabolites produced by endophytic fungi include alkaloids, phenols, peptides, enzymes, polyketides, and terpenes. Endophytic fungi are rich sources of secondary metabolites and demonstrate bioactivity against many human pathogens including the ESKAPE pathogens. This thesis explores the diverse roles of endophytic fungi and their production of unique secondary metabolites for potential drug discovery and development. Secondary metabolites from two endophytic fungi (EG10-21E-2-HDAC & TAP14-34A-2-HDAC), collected …
Synthesis And Antibacterial Testing Of Novel Thiosulfonate Compounds, Lindsay I. Blume
Synthesis And Antibacterial Testing Of Novel Thiosulfonate Compounds, Lindsay I. Blume
USF Tampa Graduate Theses and Dissertations
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are increasing concerns in the medical community. In addition to the threat of Staphylococcus aureus, the increase in number and severity of infections caused by other antibiotic-resistant bacteria is problematic to human health, particularly among the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter). The antibiotics like the penicillins and cephalosporins used commonly to treat MRSA, VRSA, and ESKAPE pathogens have continued to decline in the effectiveness. Our laboratory has developed a number of new families of anti-MRSA and anti-VRSA antibacterial compounds. In this thesis, …
A Preliminary Study Of Proinflammatory Cytokines And Depression Following West Nile Virus Infection, Allison Lino, Timothy A. Erickson, Melissa Nolan Ph.D., Mph, Kristy O. Murray, Shannon E. Ronca
A Preliminary Study Of Proinflammatory Cytokines And Depression Following West Nile Virus Infection, Allison Lino, Timothy A. Erickson, Melissa Nolan Ph.D., Mph, Kristy O. Murray, Shannon E. Ronca
Faculty Publications
West Nile virus (WNV) is a neurotropic flavivirus that can cause acute febrile illness leading to neuroinvasive disease. Depression is a well-described outcome following infection, but the underlying pathogenic mechanisms are unknown. Proinflammatory cytokines play important roles in WNV infection, but their role in depression post-WNV remains unstudied. This research aimed to retrospectively evaluate associations between proinflammatory cytokines and new onset depression in a WNV cohort. Participants with asymptomatic WNV infection were significantly less likely to report new onset depression when compared to those with symptomatic disease. Participants with encephalitis and obesity were significantly more likely to report new onset …
Science And Curation Considerations For The Design Of A Mars Sample Return (Msr) Sample Receiving Facility (Srf), Brandi L. Carrier, David W. Beaty, Aurore Hutzler, Alvin L. Smith, Gerhard Kminek, Michael A. Meyer, Timothy Haltigin, Lindsey E. Hays, Carl B. Agee, Henner Busemann, Barabara Cavalazzi, Charles S. Cocksell, Vinciane Debaille, Daniel P. Glavin, Monica M. Grady, Ernst Hauber, Bernard Marty, Francis M., Lisa M. Pratt, Aaron B. Regberg, Caroline L. Smith, Roger E. Summons, Timothy D. Swindle, Kimberly T. Taiit, Nocholas J. Tosca, Arya Urdry, Tomohiro Usui, Michael A. Velbel, Meenakshi Wadhwa, Frances Westall, Maria-Paz Zorzano
Science And Curation Considerations For The Design Of A Mars Sample Return (Msr) Sample Receiving Facility (Srf), Brandi L. Carrier, David W. Beaty, Aurore Hutzler, Alvin L. Smith, Gerhard Kminek, Michael A. Meyer, Timothy Haltigin, Lindsey E. Hays, Carl B. Agee, Henner Busemann, Barabara Cavalazzi, Charles S. Cocksell, Vinciane Debaille, Daniel P. Glavin, Monica M. Grady, Ernst Hauber, Bernard Marty, Francis M., Lisa M. Pratt, Aaron B. Regberg, Caroline L. Smith, Roger E. Summons, Timothy D. Swindle, Kimberly T. Taiit, Nocholas J. Tosca, Arya Urdry, Tomohiro Usui, Michael A. Velbel, Meenakshi Wadhwa, Frances Westall, Maria-Paz Zorzano
Geoscience Faculty Research
The most important single element of the “ground system” portion of a Mars Sample Return (MSR) Campaign is a facility referred to as the Sample Receiving Facility (SRF), which would need to be designed and equipped to receive the returned spacecraft, extract and open the sealed sample container, extract the samples from the sample tubes, and implement a set of evaluations and analyses of the samples. One of the main findings of the first MSR Sample Planning Group (MSPG, 2019a) states that “The scientific community, for reasons of scientific quality, cost, and timeliness, strongly prefers that as many sample-related investigations …
(R1507) Mathematical Modeling And Analysis Of Seqiahr Model: Impact Of Quarantine And Isolation On Covid-19, Manoj Kumar Singh, . Anjali
(R1507) Mathematical Modeling And Analysis Of Seqiahr Model: Impact Of Quarantine And Isolation On Covid-19, Manoj Kumar Singh, . Anjali
Applications and Applied Mathematics: An International Journal (AAM)
At the moment in time, an outbreak of COVID-19 is transmitting on from human to human. Different parts have different quality of life (e.g., India compared to Russia), which implies the impact varies in each part of the world. Although clinical vaccines are available to cure, the question is how to minimize the spread without considering the vaccine. In this paper, via a mathematical model, the transmission dynamics of novel coronavirus with quarantine and isolation facilities have been proposed. The examination of the proposed model is set in motion with the boundedness and positivity of the solution, sole disease-free equilibrium, …
Climate Change And Gender In Africa: A Review Of Impact And Gender-Responsive Solutions, Alex Awiti
Climate Change And Gender In Africa: A Review Of Impact And Gender-Responsive Solutions, Alex Awiti
Institute for Human Development, East Africa
Climate change affects livelihoods and wellbeing. Women and men may experience the impacts of climate change differently. But climate change and its associated impacts affect women negatively. A review was done on peer-reviewed literature related to the impact of climate change on gender in Africa. While there is an abundance of credible scientific evidence on the impacts of climate change, there is a dearth of reliable disaggregated data and evidence on the impact of climate change on women. The review shows that climate change affects women more negatively compared to men in five impact areas: (i) agricultural production; (ii) food …
Impact Of Covid-19 Pandemic On The Nigeria Stock Market: A Sectoral Stock Prices Analysis, Peter A. Adekunle, Yakubu A. Bello, Udochukwu G. Nwachukwu
Impact Of Covid-19 Pandemic On The Nigeria Stock Market: A Sectoral Stock Prices Analysis, Peter A. Adekunle, Yakubu A. Bello, Udochukwu G. Nwachukwu
CBN Journal of Applied Statistics (JAS)
This study examines the impact of the COVID-19 pandemic on sectoral stock prices in Nigeria stock market using daily data covering from February 28, 2020 to June 26, 2020. Applying the autoregressive distributed lag (ARDL) bounds test, the study finds that COVID-19 pandemic had adverse impact on the stock market indices in the short run. Furthermore, the study documents negative response of sectoral stock prices to the pandemic while the stock prices of the banking sub-sector are the worst hit. Compared to the consumer goods, and industrial subsector indices, the speed of adjustment to long run equilibrium is faster for …
Regulating Personal Data Usage In Covid-19 Control Conditions, Mark Findlay, Nydia Remolina
Regulating Personal Data Usage In Covid-19 Control Conditions, Mark Findlay, Nydia Remolina
Research Collection Yong Pung How School Of Law
Concern has been widely expressed about the potential for COVID-19 control technologies and resultant data sharing negatively impacting on civil rights, invading personal privacy, undermining citizen dignity through expansive data matching and ultimately providing opportunities for data use well beyond the brief of virus mitigation. This chapter offers suggestions regarding effective and inclusive regulatory responses when faced with extended surveillance, tracking/tracing, public/private provider data sharing and any breakdown in personal data firewalls, or otherwise conventional aggregated data deviations and distortion. In doing so, the chapter explores personal data usage in the context of COVID-19 as a regulatory enterprise. It addresses …
Tissue-Specific Variations In Transcription Factors Elucidate Complex Immune System Regulation, Hengwei Lu, Yi-Ching Tang, Assaf Gottlieb
Tissue-Specific Variations In Transcription Factors Elucidate Complex Immune System Regulation, Hengwei Lu, Yi-Ching Tang, Assaf Gottlieb
Faculty, Staff and Student Publications
Gene expression plays a key role in health and disease. Estimating the genetic components underlying gene expression can thus help understand disease etiology. Polygenic models termed "transcriptome imputation" are used to estimate the genetic component of gene expression, but these models typically consider only the cis regions of the gene. However, these cis-based models miss large variability in expression for multiple genes. Transcription factors (TFs) that regulate gene expression are natural candidates for looking for additional sources of the missing variability. We developed a hypothesis-driven approach to identify second-tier regulation by variability in TFs. Our approach tested two models …
Transmission Dynamics Of Covid-19 In Ghana And The Impact Of Public Health Interventions, Sylvia Ofori, Jessica S. Schwind, Kelly L. Sullivan, Benjamin J. Cowling, Gerardo Chowell, Isaac Fung
Transmission Dynamics Of Covid-19 In Ghana And The Impact Of Public Health Interventions, Sylvia Ofori, Jessica S. Schwind, Kelly L. Sullivan, Benjamin J. Cowling, Gerardo Chowell, Isaac Fung
Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
This study characterized COVID-19 transmission in Ghana in 2020 and 2021 by estimating the time-varying reproduction number (Rt) and exploring its association with various public health interventions at the national and regional levels. Ghana experienced four pandemic waves, with epidemic peaks in July 2020 and January, August, and December 2021. The epidemic peak was the highest nationwide in December 2021 with Rt ≥ 2. Throughout 2020 and 2021, per-capita cumulative case count by region increased with population size. Mobility data suggested a negative correlation between Rt and staying home during the first 90 days of the pandemic. The …
Meningococcal Meningitis In Sub-Saharan Africa: A Review, Amit U. Raysoni
Meningococcal Meningitis In Sub-Saharan Africa: A Review, Amit U. Raysoni
School of Earth, Environmental, & Marine Sciences Faculty Publications
The scourge of Meningococcal Meningitis in the Sub-Saharan African nations is well known. This review paper focuses on this very important topic and describes the symptoms, diagnoses, and available vaccines for the same. The review then focuses on the Meningitis Belt of Africa and elucidates on the introduction of MenAfriVac™ vaccine. The review ends with the success of this vaccine and the future of Meningococcal Meningitis in the context of overall global climate change.
How Environmental Change Will Impact Mosquito-Borne Diseases, Arsal Khan
How Environmental Change Will Impact Mosquito-Borne Diseases, Arsal Khan
Master's Projects and Capstones
Mosquitos, the most lethal species throughout human history, are the most prevalent source of vector-borne diseases and therefore a major global health burden. Mosquito-borne disease incidence is expected to shift with environmental change. These changes can be predicted using species distribution models. With the wide variety of methods used for models, consensus for improving accuracy and comparability is needed. A comparative analysis of three recent modeling approaches revealed that integrating modeling techniques compensates for trade-offs associated with a singular approach. An area that represents a critical gap in our ability to predict mosquito behavior in response to changing climate factors, …
Promoting Infrastructure Construction In Advance To Support Sci-Tech Self-Reliance And Self-Strengthening At Higher Level, Yang Wang, Yuanchun Zhou, Yanguang Wang, Jianhui Li, Fazhi Qi, Honglin He, Fangyu Liao
Promoting Infrastructure Construction In Advance To Support Sci-Tech Self-Reliance And Self-Strengthening At Higher Level, Yang Wang, Yuanchun Zhou, Yanguang Wang, Jianhui Li, Fazhi Qi, Honglin He, Fangyu Liao
Bulletin of Chinese Academy of Sciences (Chinese Version)
The research infrastructure is the basic and strategic platform of scientific and technological innovation. In the last decade, China's research infrastructure has achieved leapfrog development in the level of observation, manufacturing, management, data acquisition, data sharing and utilization, which supports China's scientific and technological innovation activities at a higher level. Looking into the future, the scientific research paradigm is transforming. The network, data, and computing platform will not only support the development of major science and technology infrastructure and field stations in larger, more accurate, and more advanced approach, but also contribute to the transformation of scientific research paradigm. It …
Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette
Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette
Biology and Medicine Through Mathematics Conference
No abstract provided.
Understanding Biofilm-Phage Interactions In Mathematical Framework, Blessing Emerenini
Understanding Biofilm-Phage Interactions In Mathematical Framework, Blessing Emerenini
Biology and Medicine Through Mathematics Conference
No abstract provided.
Optimal Intervention Strategies To Minimize Spread Of Infectious Diseases And Economic Impact On A Dynamic Small-World Network, Malindi Whyte, Danielle Dasilva
Optimal Intervention Strategies To Minimize Spread Of Infectious Diseases And Economic Impact On A Dynamic Small-World Network, Malindi Whyte, Danielle Dasilva
Biology and Medicine Through Mathematics Conference
No abstract provided.
Multi-Strain Epidemic Model With Infected Vaccinated And Re-Infected Recovered Population: Application To Covid-19 Pandemic, Olusegun Michael Otunuga
Multi-Strain Epidemic Model With Infected Vaccinated And Re-Infected Recovered Population: Application To Covid-19 Pandemic, Olusegun Michael Otunuga
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Model Of Immune-Inflammatory Response In Covid-19 Patients, Quiyana M. Murphy
Mathematical Model Of Immune-Inflammatory Response In Covid-19 Patients, Quiyana M. Murphy
Biology and Medicine Through Mathematics Conference
No abstract provided.
Evaluating The Practical Identifiability Of A Malaria Model To Assess Conversion To Transmissible Stages, Anthony Raymond Krueger, Damie Pak, Megan Greischar, Lauren Childs
Evaluating The Practical Identifiability Of A Malaria Model To Assess Conversion To Transmissible Stages, Anthony Raymond Krueger, Damie Pak, Megan Greischar, Lauren Childs
Biology and Medicine Through Mathematics Conference
No abstract provided.
On The Trajectory Of Gonorrhea In The Us: An Application Of Generalized Compartmental Models, Scott Greenhalgh, Anna Dumas
On The Trajectory Of Gonorrhea In The Us: An Application Of Generalized Compartmental Models, Scott Greenhalgh, Anna Dumas
Biology and Medicine Through Mathematics Conference
No abstract provided.
The Relationship Between Perceived Stress And Disordered Eating In Undergraduate Students During The Covid-19 Pandemic, Caroline G. Martin
The Relationship Between Perceived Stress And Disordered Eating In Undergraduate Students During The Covid-19 Pandemic, Caroline G. Martin
Gettysburg College Headquarters
The COVID-19 pandemic has affected and imposed challenges on nearly everyone, including college students. Despite their already stressful situations, previous research has demonstrated increased stress levels among college students during the COVID-19 pandemic. Additionally, research has also shown an increase in disordered eating for college students during the pandemic. However, few studies have investigated the relationship between both perceived stress and disordered eating during the COVID-19 pandemic. Therefore, the present study used a correlational design to investigate a potential association between perceived stress and disordered eating among undergraduate college students during the COVID-19 pandemic. By administering the EAT-26, the CSSEC, …
Contributions Of Vibrational Spectroscopy To Virology: A Review, Iqra Chaudhary, Naomi Jackson, Denise Denning, Luke O'Neill, Hugh Byrne
Contributions Of Vibrational Spectroscopy To Virology: A Review, Iqra Chaudhary, Naomi Jackson, Denise Denning, Luke O'Neill, Hugh Byrne
Articles
Vibrational spectroscopic techniques, both infrared absorption and Raman scattering, are high precision, label free analytical techniques which have found applications in fields as diverse as analytical chemistry, pharmacology, forensics and archeometrics and, in recent times, have attracted increasing attention for biomedical applications. As analytical techniques, they have been applied to the characterisation of viruses as early as the 1970s, and, in the context of the coronavirus disease 2019 (COVID-19) pandemic, have been explored in response to the World Health Organisation as novel methodologies to aid in the global efforts to implement and improve rapid screening of viral infection. This review …
Murphy Scale: A Locational Equivalent Intensity Scale For Hazard Events, Yi Victor Wang, Antonia Sebastian
Murphy Scale: A Locational Equivalent Intensity Scale For Hazard Events, Yi Victor Wang, Antonia Sebastian
Institute for ECHO Articles and Research
Empirical cross-hazard analysis and prediction of disaster vulnerability, resilience, and risk requires a common metric of hazard strengths across hazard types. In this paper, the authors propose an equivalent intensity scale for cross-hazard evaluation of hazard strengths of events for entire durations at locations. The proposed scale is called the Murphy Scale, after Professor Colleen Murphy. A systematic review and typology of hazard strength metrics is presented to facilitate the delineation of the defining dimensions of the proposed scale. An empirical methodology is introduced to derive equivalent intensities of hazard events on a Murphy Scale. Using historical data on …
Engineering Of A Multi-Epitope Subunit Vaccine Against Sasrs-Cov-2 Through The Viroinformatic Approach, Aamir Shehzada, Christijogo Sumartono, Jusak Nugraha, Helen Susilowatid, Andi Yasmin Wijayab, Hafiz Ishfaq Ahmad, Wiwiek Tyasningsih, Fedik Abdul Rantam
Engineering Of A Multi-Epitope Subunit Vaccine Against Sasrs-Cov-2 Through The Viroinformatic Approach, Aamir Shehzada, Christijogo Sumartono, Jusak Nugraha, Helen Susilowatid, Andi Yasmin Wijayab, Hafiz Ishfaq Ahmad, Wiwiek Tyasningsih, Fedik Abdul Rantam
Karbala International Journal of Modern Science
The COVID-19 outbreak has infected millions of people worldwide, but no vaccine has been discovered to combat it efficiently. This research aims to design a multi-epitope vaccine using highly efficient B- and T-cell epitopes from the SARS-CoV-2 Surabaya isolate through a viroinformatic approach. First, the putative epitopes were linked together to develop tertiary structures and then docked with toll-like receptor 4 (TLR-4) that demonstrated a robust interaction with a low eigenvalue of 4.816138 e-06. Furthermore, the structure's high immunogenic response was observed and successfully cloned into the expression vector pET28a (+). This implies that the designed vaccine can prove effective …
Needs Assessment Of Southeastern United States Vector Control Agencies: Capacity Improvement Is Greatly Needed To Prevent The Next Vector-Borne Disease Outbreak, Kyndall C. Dye-Braumuller, Jennifer R. Gordon, Danielle John, Josie Morrissey, Kaci Mccoy, Rhoel R. Dinglasan, Melissa Nolan Ph.D., Mph
Needs Assessment Of Southeastern United States Vector Control Agencies: Capacity Improvement Is Greatly Needed To Prevent The Next Vector-Borne Disease Outbreak, Kyndall C. Dye-Braumuller, Jennifer R. Gordon, Danielle John, Josie Morrissey, Kaci Mccoy, Rhoel R. Dinglasan, Melissa Nolan Ph.D., Mph
Faculty Publications
A national 2017 vector control capacity survey was conducted to assess the United States’ (U.S.’s) ability to prevent emerging vector-borne disease. Since that survey, the southeastern U.S. has experienced continued autochthonous exotic vector-borne disease transmission and establishment of invasive vector species. To understand the current gaps in control programs and establish a baseline to evaluate future vector control efforts for this vulnerable region, a focused needs assessment survey was conducted in early 2020. The southeastern U.S. region was targeted, as this region has a high probability of novel vector-borne disease introduction. Paper copies delivered in handwritten envelopes and electronic copies …
Insights Into Molecular Recognition And Reactivity From Molecular Simulations Of Protein-Ligand Interactions Using Md And Qm/Mm, Jerrano L. Bowleg
Insights Into Molecular Recognition And Reactivity From Molecular Simulations Of Protein-Ligand Interactions Using Md And Qm/Mm, Jerrano L. Bowleg
Theses and Dissertations
In this thesis, we have employed two computational methods, molecular dynamics (MD) and hybrid quantum mechanics/molecular mechanics (QM/MM) MD simulations with umbrella sampling (US), to gain insights into the molecular mechanism governing the molecular recognition and reactivity in several protein-ligand complexes. Three systems involving protein-ligand interactions are examined in this dissertation utilizing well-established computational methodologies and mathematical modeling. The three proteins studied here are acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1). These enzymes are known to interact with a variety of ligands. AChE dysfunction caused by organophosphorus (OP) chemicals is a severe hazard since AChE is …
Large Scale Disease Modeling, Walker Mattox
Large Scale Disease Modeling, Walker Mattox
Master's Theses
In this we study large scale disease modeling. After understanding the mechanics behind the SIR disease model in an ODE sense, we will apply this knowledge to model disease spread in more and more increasing advanced cellular automata. Eventually, some of our cellular automata will include long distance travel. From this discrete data, we can then build an SIR model in the PDE sense to display large scale disease spread.
Hepatitis B And D: A Forecast On Actions Needed To Reduce Incidence And Achieve Elimination, Scott Greenhalgh, Andrew Klug
Hepatitis B And D: A Forecast On Actions Needed To Reduce Incidence And Achieve Elimination, Scott Greenhalgh, Andrew Klug
Spora: A Journal of Biomathematics
Viral hepatitis negatively affects the health of millions, with the worst health outcomes associated with the hepatitis D virus (HDV). Fortunately, HDV is rare and requires prior infection with the hepatitis B virus (HBV) before it can establish infection and transmit. Here, we develop a mathematical model of HBV and HDV transmission in Sub-Saharan Africa to investigate the effects of hepatitis B vaccination on both HBV and HDV. Our findings illustrate a hepatitis B vaccination rate above 0.006 year-1 reduces hepatitis D by over 90%, and a vaccination rate above 0.0221 year-1 reduces hepatitis B by over 90%, …