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Patterns Of Fatty Acid Release From Endogenous Substrates By Human Platelet Homogenates And Membranes, A Derksen, P Cohen

Faculty, Staff and Students Publications

We describe a method for measuring the release of fatty acids from endogenous substrates of human platelet homogenates and membranes. The method depends on the availability of lipids whose fatty acids are odd-chained and therefore suitable as internal reference compounds that, at the time of lipid extraction, can be added to an incubation to permit subsequent quantification of the content of free fatty acids or fatty acids esterified to specific lipids. We found four types of lipolytic activities in human platelets. In homogenates at pH 4.0 a triglyceride lipase operated as shown by the synchrony of triglyceride degradation and release …

Lymphangiography In Staging Carcinoma Of The Prostate. A Comparison With Operative Findings, Joseph C. Cerny, Malcolm Weckstein, Riad Farah

Henry Ford Hospital Medical Journal

Pedal lymphangiography was performed In 30 patients who subsequently underwent radical retropubic prostatectomy, and radical pelvic lymphadenectomy. In 24 of 30 patients, lymphangiograms correctly predicted the presence or absence of nodal Involvement. In spite of certain limitations of the technique. It is considered an essential diagnostic study in patients considered for possible radical prostatic surgery, or in patients who may be candidates for external megavoltage radiotherapy to the prostate gland and its lymphatic drainage.

Palliative Urinary Diversion In Adenocarcinoma Of The Prostate, R. C. Youngman, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Ten patients with inoperable prostatic carcinoma, producing ureteral obstruction and azotemia, underwent palliative urinary diversion. Good quality survivals of two months to three years were obtained. These results compare favorably with the good results seer) In gynecologic neoplasm of the bladder, colon and breast. In selected cases of carcinoma of the prostate, palliative urinary diversion is indicated when the prospects exist for further benefit from chemotherapy or radiotherapy.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Radical Retropubic Prostatectomy And Pelvic Lymphadenectomy In Carcinoma Of The Prostate, Riad N. Farah, Joseph C. Cerny

Henry Ford Hospital Medical Journal

An operative technique Is described which combines regional pelvic lymphadenectomy with radical prostatectomy. The technique has been used on 30 patients with no operative mortality. Morbidity has been within acceptable limits. Thus far, only one patient has shown recurrence of the neoplasm.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Advances In The Radiation Therapy Of Carcinoma Of The Prostate, Joel Elliot White

Henry Ford Hospital Medical Journal

Basic principles of radiation biology and radiation tolerance are reviewed. The Implications for radiation therapy of newer staging techniques in carcinoma of the prostate such as exploratory laparotomy, lymphangiography, and bone marrow acid prosphatase are discussed. A technique for treating the prostate and para-aortic lymph nodes in continuity is presented. Complications and results of therapy are discussed.

Symposium On Carcinoma Of The Prostate — Introduction, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

Radionuclide Bone Imaging In The Evaluation Of Prostatic Cancer, Daniel S. Marks, William R. Eyler

Henry Ford Hospital Medical Journal

Radionuclide bone imaging is a rapid, easily performed, noninvasive method for evaluation of skeletal disease in carcinoma of the prostate, or any other malignancy. In a significant number of cases, it may provide the only evidence of metastases and frequently demonstrates more widespread Involvement than previously suspected. Thus, it may redirect the chosen course of therapy or localize sources of bone pain that are not radiographically apparent. Sixty-two percent of 42 patients studied were abnormal, of which 12% had no radiographic evidence of disease.

Bone Marrow Acid Phosphatase In The Evaluation Of Patients With Carcinoma Of The Prostate, Ronald Kabler, Riad Farah, Kenneth Greenawald, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Based on experience with 30 men having clinical stage A and B adenocarcinoma of the prostate, the authors conclude that elevation of bone marrow acid phosphatase (BMAP) is a sensitive indicator of the disease state. BMAP revealed periprostatic or nodal Involvement when osseous metastases seemed absent. BMAP is considered essential in the evaluation of all patients with prostatic carcinoma. Patients who have false negative BMAP (and are not candidates for radical prostatectomy), should undergo lymphangiography and bone scan before radiation therapy or hormonal treatment is planned.

Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo

Henry Ford Hospital Medical Journal

The role of immune mechanisms in the development and control of prostatic carcinoma appears to be complicated by the endocrine response of some tumors. The progression of endocrine-independent tumors is more directly related to host-immune response. Evaluation of the role of chemotherapeutic agents must include their effect on the host-immune response. The use of BCC in patients with metastatic prostatic carcinoma produces no alteration in cell-mediated immunity but produces local tumor necrosis. The use of nonspecific antigens to enhance host-immune response may be more effective when used as adjuvant therapy in earlier stages of prostatic adenocarcinoma.

Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee

Henry Ford Hospital Medical Journal

The management of disseminated prostatic carcinoma with hormonal and chemotherapeutic agents is discussed. Hormonal manipulation consists of ablative as well as additive modalities. A new agent, Adriamycin, has shown some effectiveness In selected cases. Significant difficulties are encountered in assessing the objective state of remission of patients undergoing therapy. Further advances through co-operative, randomized clinical trials must be sought. The development of additional chemotherapeutic agents will hopefully expand our horizons.

Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny

Henry Ford Hospital Medical Journal

From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances …

Digest Of The Philadelphia College Of Osteopathic Medicine (December 1975), Philadelphia College Of Osteopathic Medicine

Digest

The December 1975 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• PCOM Alumnae
• Listing of Alumnae
• Microfilm
• People
• News from the Hospital
• Student Council Christmas Show
• AOA Convention
• New Appointments
• PCOM's New Look
• Alumni News Briefs
• Faculty Notes
• In Memoriam

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

College Physician Agreement, 1975 October 22, Saint Francis College, Biddeford, Maine

William F. Bergen, D.O. Collection

Agreement sent to William Bergen, D.O. for the position of College Physician for the 1975-1976 Academic year.

President's Report, 1975 October 15, Osteopathic Hospital Of Maine

William F. Bergen, D.O. Collection

The Annual Report by the president of the Osteopathic Hospital of Maine includes information on support for the New England College of Osteopathic Medicine, hospital statistics, and by-law revisions.

The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews

Henry Ford Hospital Medical Journal

Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.

Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra

Henry Ford Hospital Medical Journal

This study evaluates the incidence and severity of the ocular findings and its correlation with the parotid gland changes, as demonstrated by sialography, in 82 patients with Sjogren's syndrome. It is shown that the ocular component of the syndrome manifests rather autonomously with respect to the accompanying collagen disease and that there seems to be only a tentative trend towards a positive correlation between the ocular and parotid findings. Sjogren's syndrome immunologically is closer to the collagen diseases than to the so-called organ-specific autoimmune diseases.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Supportive Care Of The Leukemic Patient, Ellis J. Van Slyck

Henry Ford Hospital Medical Journal

The outlook for the patient with leukemia or lymphoma has been improved by the exponential expansion of basic scientific knowledge in physical chemistry and microbiology, added to much new clinical information based on large cooperative group studies. Most of this progress derives, not from a specific treatment for the disease, but from better understanding and use of multiple support measures. These include the availability of blood components, such as red blood cell, platelet and granulocyte concentrates, better protective isolation measures, and greater expertise in the recognition and treatment of bacterial, fungal, and viral infections in immunosuppressed patients. In addition, the …

Spontaneous Asymptomatic Pneumoperitoneum, Fernando Canavati, Thomas A. Fox Jr.

Henry Ford Hospital Medical Journal

A 65-year-old man developed a spontaneous asymptomatic pneumoperitoneum which was managed conservatively without exploratory laparotomy. However, the authors caution that repeated and careful examinations of the abdomen, observation of vital signs, and leucocyte counts must be made. Also, complete radiological examination of the gastrointestinal and respiratory tracts is necessary to eliminate a possible unrecognized lesion that might explain the origin of the spontaneous pneumoperitoneum.

Bacterial Endocarditis And Incarceration Of A Transvenous Pacemaker: Removal Under Cardiopulmonary By-Pass After Prolonged Traction Proved Ineffective, Remigio Garcia, Mehdi Hakimi-Naini

Henry Ford Hospital Medical Journal

Transvenous electrode endocardial pacing of the right ventricle is the most simple and common modality of permanent pacing at present. The incidence of endocarditis is rare. Only two patients were found in our hospital series of over 200 who had permanent transvenous pacemakers implanted. A 40-year-old housewife developed staphylococcus aureus endocarditis secondary to local wound infection in the power pack pocket, requiring removal of the infected electrode under cardiopulmonary by-pass. Prolonged traction of the retained electrode proved ineffective. The mechanism of electrode entrapment is discussed.

Congestive Cardiomyopathy As An End Stage Of Toxoplasma Myocarditis, Mohsin Alam, Wolf F. C. Duvernoy, Edward L. Quinn, Evelyn J. Fisher

Henry Ford Hospital Medical Journal

Congestive cardiomyopathy is a clinical entity which may be due to many different etiologies in addition to the primary type. The case presented defines the etiology in a 30-year-old patient as previous acute toxoplasma myocarditis. This diagnosis was corroborated by diagnostic rise of fluorescent antibody and Sabin-Feldman dye test titers and response to specific therapy. Toxoplasmosis has to be considered among the causes of congestive cardiomyopathy.

Digest Of The Philadelphia College Of Osteopathic Medicine (September 1975), Philadelphia College Of Osteopathic Medicine

Digest

The September 1975 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Alumni Weekend
• Alumni President
• Bicentennial Plans
• People
• News from the Health Care Centers
• New Appointments
• News from the College
• Class of '79
• Fall Activities
• Alumni News Briefs
• Faculty Notes
• In Memoriam

The Study Of The Pathology Of The Anterior One Third Of The Small Intestine Of The Spontaneously Diabetic Chinese Hamster, Scot Stromsta

Masters Theses

No abstract provided.

New England College Of Osteopathic Medicine Curriculum Brochure, 1975 July, New England Foundation For Osteopathic Medicine

William F. Bergen, D.O. Collection

Brochure outlines the proposed osteopathic medical curriculum for the New England College of Osteopathic Medicine.

Amikacin: Clinical And Laboratory Studies, Erwin J. Haas, T. Madhavan, Evelyn J. Fisher, Frank Cox, Keith Burch, Edward L. Quinn, Richard D. Nichols

Henry Ford Hospital Medical Journal

Amikacin was evaluated in vitro against S aureus and a variety of gram negative bacilli. In concentrations of 12.5 μg/ml or less, it suppressed the growth of all organisms except 15% of Proteus mirabilis. Peak serum levels in patients, following a 7.5 mg/kg IM dose, averaged 21 μg/ml at one hour. Most of the drug appeared in the urine during the first six hours after administration. Of six patients receiving an adequate course of treatment, all but one were cured. Treatment in that patient also failed with a subsequent course of gentamicin and carbenicillin and he was cured only by …

The Bacteriology Of The Biliary Tract: A Preliminary Report., J. A. Sapala, J. L. Ponka, T. R. Neblett

Henry Ford Hospital Medical Journal

The bacterial flora of acute biliary tract disease has not been completely elucidated. The organisms identified most often were coliforms. Anaerobic culture technics were not precise enough to provide proper identification. In a 12-month study of 250 patients operated upon for inflammatory gallbladder disease, culture specimens were collected in a most strict and rigorous fashion. It was hoped that a more exact understanding of the relationship between bacteria and inflammatory biliary tract disease might be appreciated. Important technics were developed for gathering specimens, delivery to the laboratory and culturing. More meaningful results are to be expected In the future.