Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (18652)
- Thomas Jefferson University (8401)
- Aga Khan University (7545)
- University of Kentucky (2709)
- Children's Mercy Kansas City (2695)
-
- HCA Healthcare (2501)
- Henry Ford Health (2152)
- Zucker School of Medicine at Hofstra/Northwell (2014)
- Providence (1488)
- Himmelfarb Health Sciences Library, The George Washington University (1049)
- Lehigh Valley Health Network (1032)
- Old Dominion University (940)
- Corewell Health (939)
- Rowan University (913)
- Philadelphia College of Osteopathic Medicine (860)
- University of Nebraska Medical Center (859)
- Universitas Indonesia (778)
- LSU Health New Orleans (769)
- University of Texas Rio Grande Valley (738)
- Western University (600)
- Wayne State University (579)
- Gdansk University of Physical Education and Sport (573)
- OhioHealth (572)
- University of Texas MD Anderson Cancer Center (549)
- Wright State University (526)
- Virginia Commonwealth University (516)
- General Organization of Teaching Hospitals and Institutes (GOTHI) (514)
- University of Nebraska - Lincoln (493)
- Edith Cowan University (489)
- Marshall University (464)
- Keyword
-
- Humans (15156)
- Female (6771)
- Male (5909)
- Animals (4265)
- Adult (3272)
-
- Middle Aged (3028)
- Mice (2945)
- Aged (2676)
- Child (2155)
- Adolescent (1655)
- Retrospective Studies (1627)
- COVID-19 (1560)
- United States (1496)
- Treatment Outcome (1354)
- Neoplasms (1174)
- Infant (1081)
- Tumor (1047)
- Risk Factors (1007)
- Pregnancy (984)
- Biomarkers (961)
- Young Adult (961)
- Cancer (891)
- Mutation (864)
- Child, Preschool (861)
- Prospective Studies (847)
- Thomas Jefferson University (812)
- Cell Line (796)
- Carcinoma (792)
- Immunotherapy (768)
- Obesity (739)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (10066)
- Faculty, Staff and Students Publications (6915)
- Henry Ford Hospital Medical Journal (2151)
- Journal Articles (2016)
- Manuscripts, Articles, Book Chapters and Other Papers (1314)
-
- Articles, Abstracts, and Reports (858)
- Posters (825)
- Rowan-Virtua Research Day (730)
- Department of Medicine (691)
- Pakistan Journal of Neurological Sciences (PJNS) (684)
- Pediatrics Faculty Publications (680)
- School of Medicine Faculty Publications (633)
- Conference Presentation Abstracts (602)
- Baltic Journal of Health and Physical Activity (573)
- Department of Paediatrics and Child Health (571)
- Department of Pathology and Laboratory Medicine (554)
- Journal of Medicine in Scientific Research (514)
- Research Days (488)
- Markey Cancer Center Faculty Publications (482)
- Jurnal Penyakit Dalam Indonesia (431)
- Children’s Nutrition Research Center Staff Publications (429)
- Jefferson Journal of Psychiatry (426)
- The Texas Heart Institute Journal (419)
- Department of Neurology Faculty Papers (382)
- Journal of the Saudi Heart Association (366)
- Department of Medicine Faculty Papers (361)
- Paediatrics Publications (359)
- Loma Linda University Electronic Theses, Dissertations & Projects (346)
- Obstetrics and Gynaecology, East Africa (346)
- Journal of Patient-Centered Research and Reviews (344)
- Publication Type
Articles 76891 - 76891 of 76891
Full-Text Articles in Entire DC Network
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Nebraska Center for Virology: Faculty Publications
Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …