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Articles 1 - 30 of 258
Full-Text Articles in Chemistry
Characterization Of Ceriporiopsis Subvermispora Bicupin Oxalate Oxidase Expressed In Pichia Pastoris, Patricia Moussatche, Eric Hoffer, Ellen W. Moomaw, Et Al.
Characterization Of Ceriporiopsis Subvermispora Bicupin Oxalate Oxidase Expressed In Pichia Pastoris, Patricia Moussatche, Eric Hoffer, Ellen W. Moomaw, Et Al.
Ellen Moomaw
Oxalate oxidase (E.C. 1.2.3.4) catalyzes the oxygen-dependent oxidation of oxalate to carbon dioxide in a reaction that is coupled with the formation of hydrogen peroxide. Although there is currently no structural information available for oxalate oxidase from Ceriporiopsis subvermispora (CsOxOx), sequence data and homology modeling indicate that it is the first manganese-containing bicupin enzyme identified that catalyzes this reaction. Interestingly, CsOxOx shares greatest sequence homology with bicupin microbial oxalate decarboxylases (OxDC). We show that CsOxOx activity directly correlates with Mn content and other metals do not appear to be able to support catalysis. EPR spectra indicate that the Mn is …
Fungal Oxalate Decarboxylase Activity Contributes To Sclerotinia Sclerotiorum Early Infection By Affecting Both Compound Appressoria Development And Function, Xiaofei Liang, Ellen W. Moomaw, Jeffrey A. Rollins
Fungal Oxalate Decarboxylase Activity Contributes To Sclerotinia Sclerotiorum Early Infection By Affecting Both Compound Appressoria Development And Function, Xiaofei Liang, Ellen W. Moomaw, Jeffrey A. Rollins
Ellen Moomaw
Sclerotinia sclerotiorum pathogenesis requires the accumulation of high levels of oxalic acid (OA). To better understand the factors affecting OA accumulation, two putative oxalate decarboxylase (OxDC) genes (Ss-odc1 and Ss-odc2) were characterized. Ss-odc1 transcripts exhibited significant accumulation in vegetative hyphae, apothecia, early stages of compound appressorium development and during plant colonization. Ss-odc2 transcripts, in contrast, accumulated significantly only during mid to late stages of compound appressorium development. Neither gene was induced by low pH or exogenous OA in vegetative hyphae. A loss-of-function mutant for Ss-odc1 (Δss-odc1) showed wild-type growth, morphogenesis and virulence, and was not characterized further. Δss-odc2 mutants hyperaccumulated …
Characterization Of Ceriporiopsis Subvermispora Bicupin Oxalate Oxidase Expressed In Pichia Pastoris, Patricia Moussatche, Eric Hoffer, Ellen W. Moomaw, Et Al.
Characterization Of Ceriporiopsis Subvermispora Bicupin Oxalate Oxidase Expressed In Pichia Pastoris, Patricia Moussatche, Eric Hoffer, Ellen W. Moomaw, Et Al.
Ellen Moomaw
Oxalate oxidase (E.C. 1.2.3.4) catalyzes the oxygen-dependent oxidation of oxalate to carbon dioxide in a reaction that is coupled with the formation of hydrogen peroxide. Although there is currently no structural information available for oxalate oxidase from Ceriporiopsis subvermispora (CsOxOx), sequence data and homology modeling indicate that it is the first manganese-containing bicupin enzyme identified that catalyzes this reaction. Interestingly, CsOxOx shares greatest sequence homology with bicupin microbial oxalate decarboxylases (OxDC). We show that CsOxOx activity directly correlates with Mn content and other metals do not appear to be able to support catalysis. EPR spectra indicate that the Mn is …
Fungal Oxalate Decarboxylase Activity Contributes To Sclerotinia Sclerotiorum Early Infection By Affecting Both Compound Appressoria Development And Function, Xiaofei Liang, Ellen W. Moomaw, Jeffrey A. Rollins
Fungal Oxalate Decarboxylase Activity Contributes To Sclerotinia Sclerotiorum Early Infection By Affecting Both Compound Appressoria Development And Function, Xiaofei Liang, Ellen W. Moomaw, Jeffrey A. Rollins
Ellen Moomaw
Sclerotinia sclerotiorum pathogenesis requires the accumulation of high levels of oxalic acid (OA). To better understand the factors affecting OA accumulation, two putative oxalate decarboxylase (OxDC) genes (Ss-odc1 and Ss-odc2) were characterized. Ss-odc1 transcripts exhibited significant accumulation in vegetative hyphae, apothecia, early stages of compound appressorium development and during plant colonization. Ss-odc2 transcripts, in contrast, accumulated significantly only during mid to late stages of compound appressorium development. Neither gene was induced by low pH or exogenous OA in vegetative hyphae. A loss-of-function mutant for Ss-odc1 (Δss-odc1) showed wild-type growth, morphogenesis and virulence, and was not characterized further. Δss-odc2 mutants hyperaccumulated …
A Sodium Salt Of The Dimer Of Boronoterephthalic Acid Anhydride, Scott Simmons, Albert Fratini, Vladimir Benin
A Sodium Salt Of The Dimer Of Boronoterephthalic Acid Anhydride, Scott Simmons, Albert Fratini, Vladimir Benin
Albert Fratini
The title compound, sodium bis(6-carboxy-1-hydroxy-3-oxo-1,3-dihydro-2,1-benzoxaborol-1-yl)oxidanium, Na+·C16H15B2O13-, was prepared in two steps from 2-bromo-p-xylene. Its crystal structure was determined at 140 K and has triclinic (P) symmetry. The compound presents a unique structural motif, including two units of the cyclic anhydride of boronoterephthalic acid, joined by a protonated, and thereby trivalent, oxonium center. Association in the crystal is realized by complementary hydrogen bonding of the carboxyl groups, as well as by coordination of the sodium cations to the oxygen centers on the five-membered rings.
Chemistry And Chemists At Florence: From The Last Of The Medici To The European Magnetic Resonance Center, Mary Virginia Orna
Chemistry And Chemists At Florence: From The Last Of The Medici To The European Magnetic Resonance Center, Mary Virginia Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Preface To Archaeological Chemistry, Mary Orna
Preface To Archaeological Chemistry, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Teacher Assessment Using Sourceview On Dvd, Mary Virginia Orna
Teacher Assessment Using Sourceview On Dvd, Mary Virginia Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Teacher Assessment Using Sourceview On Dvd, Mary Orna
Teacher Assessment Using Sourceview On Dvd, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Thirty Thousand Years Of Chemistry: Pigments, Pottery, Perfumes, Potions, Mary Orna
Thirty Thousand Years Of Chemistry: Pigments, Pottery, Perfumes, Potions, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Expression Of Acyl Carrier Proteins In Spinach, Katherine Schmid, J. Ohlrogge
Expression Of Acyl Carrier Proteins In Spinach, Katherine Schmid, J. Ohlrogge
Katherine Schmid
Dr. Schmid and Dr. Ohlrogge's contribution to the Proceedings of the 9th International Symposium on Plant Lipids; Wye, England; July 8-13, 1990.
Cyclopropane Fatty Acid Expression In Plants, Katherine Schmid
Cyclopropane Fatty Acid Expression In Plants, Katherine Schmid
Katherine Schmid
Pants [sic] are transformed with a bacterial cyclopropane fatty acid synthase gene to produce lipids containing cyclopropane fatty acids. Using this technology dihydrosterculate is produced in oilseed crops such as rape.
Artists' Pigments In Illuminated Medieval Manuscripts: Tracing Artistic Influences And Connections - A Review, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Paris: A Scientific Theme Park, Mary Orna
Paris: A Scientific Theme Park, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
New Directions In Archaeological Chemistry, Mary Orna
New Directions In Archaeological Chemistry, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Copper-Based Synthetic Medieval Blue Pigments, Mary Orna
Copper-Based Synthetic Medieval Blue Pigments, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Historic Mineral Pigments: Colorful Benchmarks Of Ancient Civilizations, Mary Orna
Historic Mineral Pigments: Colorful Benchmarks Of Ancient Civilizations, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Science History On The Road: An Overview, Mary Orna
Science History On The Road: An Overview, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
Organometallic Chemistry Can Simplify The Synthesis Of Important Biologically Active Natural Products, Daniel Becker, P Carter, J. Elliott, R. Lewis
Organometallic Chemistry Can Simplify The Synthesis Of Important Biologically Active Natural Products, Daniel Becker, P Carter, J. Elliott, R. Lewis
Daniel P. Becker
The stereoselectivity of the Pauson--Khand reaction used for the construction of a 6a-carboprostaglandin is described, and a mechanistic hypothesis is proposed to explain the experimentally observed results. A further illustration of the stereoselectivity of the dicobaltoctacarbonyl-mediated cyclization of 1,6-enynes to bicyclo[3.3.0]-octenones is provided by a sequence of transformations that depicts the route to the precursors of pentalenolactone G. Further examples of the synthetic potential of the acetylene-Co$_{2}$(CO)$_{6}$ bimetalloclusters are shown by the synthesis of a vincristine model compound, and a sequence of transformations that provide strong evidence of the intermediacy of a 1,4-diyl (p-benzyne) in the collapse of a Z-diynene …
Stereospecific Dicobalt Octacarbonyl Mediated Enyne Cyclization For The Enantiospecific Synthesis Of A 6a-Carbocycline Analogue, Philip Magnus, Daniel Becker
Stereospecific Dicobalt Octacarbonyl Mediated Enyne Cyclization For The Enantiospecific Synthesis Of A 6a-Carbocycline Analogue, Philip Magnus, Daniel Becker
Daniel P. Becker
D-(+)-Ribonolactone 5 was converted into the butenolide 7 by pyrolysis of the derived ortho ester. Treatment of 7 with trisyl bromide gave the corresponding trisylate 9, which was converted into 10 by using Li,(CH,=CH),CuCN. Exposure of 10 to potassium carbonate in methanol gave epoxide 12, which underwent ring opening when treated with lithium (tri- methylsi1yl)acetylide-BF,.OEt, to give lactone 13. Reduction of lactone 13 with LiAlH, gave diol 18, which was converted into its derived acetonide 19. When 19 was treated with CO,(CO)~/CO/P~,PO, bicyclo[3.3.0]octenone 21 was formed in a highly stereoselective process. Conversion of 21 into the carbocycline analogue 28 was …
New (Nor)Aza-Adamantanes Are Agonists At The Newly Identified Serotonin 5ht4 Receptor And Antagonists At The 5ht3 Receptor, Daniel Flynn, Daniel Becker, Dale Spangler, Roger Nosal
New (Nor)Aza-Adamantanes Are Agonists At The Newly Identified Serotonin 5ht4 Receptor And Antagonists At The 5ht3 Receptor, Daniel Flynn, Daniel Becker, Dale Spangler, Roger Nosal
Daniel P. Becker
New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.
Use Of Atom-Transfer Radical Cyclizations As An Efficient Entry Into A New Serotonergic Norazaadamantane, Daniel Flynn, Daniel Becker, Roger Nosal, Daniel Zabrowksi
Use Of Atom-Transfer Radical Cyclizations As An Efficient Entry Into A New Serotonergic Norazaadamantane, Daniel Flynn, Daniel Becker, Roger Nosal, Daniel Zabrowksi
Daniel P. Becker
A route to azanoradamantanes is described which makes use of an atom-transfer radical cyclization to afford 3-azabicyclo[3.3.0]octanes 3A and 3B. Subsequent elaboration of exo-allylamine functionality, followed by cyclization of the endo-hydroxymethyl intermediate 9, affords the new azanoradamantanes 11 and 4. This new azatricyclic system is useful for producing serotonin 5-HT3 antagonists and 5-HT4 agonists.
1,3,4-Trisubstituted Pyrrolidinones As Scaffolds For Construction Of Peptidomimetic Cholecystokinin Antagonists , Daniel Flynn, Clara Villamil, Daniel Becker, Gary Gullikson
1,3,4-Trisubstituted Pyrrolidinones As Scaffolds For Construction Of Peptidomimetic Cholecystokinin Antagonists , Daniel Flynn, Clara Villamil, Daniel Becker, Gary Gullikson
Daniel P. Becker
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar IC50 values in a CCK-A receptor binding assay. Compound 1E behaves as a competitive antagonist in vitro and is orally active.
Sc-53116: The First Selective Agonist At The Newly Identified Serotonin 5-Ht4 Receptor Subtype, Daniel Flynn, Daniel Zabrowski, Daniel Becker, Roger Nosal
Sc-53116: The First Selective Agonist At The Newly Identified Serotonin 5-Ht4 Receptor Subtype, Daniel Flynn, Daniel Zabrowski, Daniel Becker, Roger Nosal
Daniel P. Becker
No abstract provided.
Preface To Electrochemistry, Past And Present, Mary Orna
Preface To Electrochemistry, Past And Present, Mary Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
The Chemical History Of Color, Mary Virginia Orna
The Chemical History Of Color, Mary Virginia Orna
Sr. Mary Virgina Orna O.S.U.
No abstract provided.
The Ssdna Mutator Apobec3a Is Regulated By Cooperative Dimerization, Markus-Frederik Bohn, Shivender Shandilya, Tania Silvas, Ellen Nalivaika, Takahide Kouno, Brian Kelch, Sean Ryder, Nese Yilmaz, Mohan Somasundaran, Celia Schiffer
The Ssdna Mutator Apobec3a Is Regulated By Cooperative Dimerization, Markus-Frederik Bohn, Shivender Shandilya, Tania Silvas, Ellen Nalivaika, Takahide Kouno, Brian Kelch, Sean Ryder, Nese Yilmaz, Mohan Somasundaran, Celia Schiffer
Celia A. Schiffer
Deaminase activity mediated by the human APOBEC3 family of proteins contributes to genomic instability and cancer. APOBEC3A is by far the most active in this family and can cause rapid cell death when overexpressed, but in general how the activity of APOBEC3s is regulated on a molecular level is unclear. In this study, the biochemical and structural basis of APOBEC3A substrate binding and specificity is elucidated. We find that specific binding of single-stranded DNA is regulated by the cooperative dimerization of APOBEC3A. The crystal structure elucidates this homodimer as a symmetric domain swap of the N-terminal residues. This dimer interface …
Structure Of The Vif-Binding Domain Of The Antiviral Enzyme Apobec3g, Takahide Kouno, Elizabeth Luengas, Megumi Shigematsu, Shivender Shandilya, Jingying Zhang, Luan Chen, Mayuko Hara, Celia Schiffer, Reuben Harris, Hiroshi Matsuo
Structure Of The Vif-Binding Domain Of The Antiviral Enzyme Apobec3g, Takahide Kouno, Elizabeth Luengas, Megumi Shigematsu, Shivender Shandilya, Jingying Zhang, Luan Chen, Mayuko Hara, Celia Schiffer, Reuben Harris, Hiroshi Matsuo
Celia A. Schiffer
The human APOBEC3G (A3G) DNA cytosine deaminase restricts and hypermutates DNA-based parasites including HIV-1. The viral infectivity factor (Vif) prevents restriction by triggering A3G degradation. Although the structure of the A3G catalytic domain is known, the structure of the N-terminal Vif-binding domain has proven more elusive. Here, we used evolution- and structure-guided mutagenesis to solubilize the Vif-binding domain of A3G, thus permitting structural determination by NMR spectroscopy. A smaller zinc-coordinating pocket and altered helical packing distinguish the structure from previous catalytic-domain structures and help to explain the reported inactivity of this domain. This soluble A3G N-terminal domain is bound by …
Simultaneously Targeting The Ns3 Protease And Helicase Activities For More Effective Hepatitis C Virus Therapy, Jean Ndjomou, M Corby, Noreena Sweeney, Alicia Hanson, Cihan Aydin, Akbar Ali, Celia Schiffer, Kelin Li, Kevin Frankowski, Frank Schoenen, David Frick
Simultaneously Targeting The Ns3 Protease And Helicase Activities For More Effective Hepatitis C Virus Therapy, Jean Ndjomou, M Corby, Noreena Sweeney, Alicia Hanson, Cihan Aydin, Akbar Ali, Celia Schiffer, Kelin Li, Kevin Frankowski, Frank Schoenen, David Frick
Celia A. Schiffer
This study examines the specificity and mechanism of action of a recently reported hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase-protease inhibitor (HPI), and the interaction of HPI with the NS3 protease inhibitors telaprevir, boceprevir, danoprevir, and grazoprevir. HPI most effectively reduced cellular levels of subgenomic genotype 4a replicons, followed by genotypes 3a and 1b replicons. HPI had no effect on HCV genotype 2a or dengue virus replicon levels. Resistance evolved more slowly to HPI than telaprevir, and HPI inhibited telaprevir-resistant replicons. Molecular modeling and analysis of the ability of HPI to inhibit peptide hydrolysis catalyzed by a variety …
Structural Basis For Mutation-Induced Destabilization Of Profilin 1 In Als, Sivakumar Boopathy, Tania Silvas, Maeve Tischbein, Silvia Jansen, Shivender Shandilya, Jill Zitzewitz, John Landers, Bruce Goode, Celia Schiffer, Daryl Bosco
Structural Basis For Mutation-Induced Destabilization Of Profilin 1 In Als, Sivakumar Boopathy, Tania Silvas, Maeve Tischbein, Silvia Jansen, Shivender Shandilya, Jill Zitzewitz, John Landers, Bruce Goode, Celia Schiffer, Daryl Bosco
Celia A. Schiffer
Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this fatal disease is unknown. We demonstrate that ALS-linked mutations severely destabilize the native conformation of PFN1 in vitro and cause accelerated turnover of the PFN1 protein in cells. This mutation-induced destabilization can account for the high propensity of ALS-linked variants to aggregate and also provides rationale for their reported loss-of-function phenotypes in cell-based assays. The source of this destabilization is illuminated by the X-ray crystal structures of several PFN1 proteins, revealing an expanded cavity near the protein core of the …