Physical Sciences and Mathematics Commons^™

A Comparative Approach To Question Answering Systems, Josue Balandrano Coronel

Theses and Dissertations

In this paper I will analyze three different algorithms and approaches to implement Question Answering Systems (QA-Systems). I will analyze the efficiency, strengths, and weaknesses of multiple algorithms by explaining them in detail and comparing them with each other. The overarching aim of this thesis is to explore ideas that can be used to create a truly open context QA-System. Open context QA-Systems remain an open problem.

The various algorithms and approaches presented in this work will be focused on complex questions. Complex questions are usually verbose and the context of the question is equally important to answer the query …

Development Of Arginyl-Trna Synthetase From Pseudomonas Aeruginosa As A Platform To Screen For Inhibitors Of Protein Synthesis, Daniel Cantu

Theses and Dissertations

Pseudomonas aeruginosa is a Gram- negative bacteria that is the leading cause of mortality in immunocompromised patients. Arginyl-tRNA synthetase (ArgRS) is an enzyme that catalyzes the covalent attachment of arginine to the cognate tRNAArg during protein synthesis. Scintillation proximity assays (SPA) were adapted to the aminoacylation assay and used to screen, one natural compound library (800) and one synthetic compound library (890) to identify inhibitors of the activity of ArgRS. Five compounds were identified which inhibited greater than 50% of enzymatic activity, two of these compounds (BT04F10 and BT11F03) exhibited promising MICs against Gram+ bacteria and moderate activity against Gram- …

Lie Symmetry To Nonlinear Oscillator Systems And Applications, Xiaoyan Li

Theses and Dissertations

In this paper, we apply the theory of Lie symmetry to study a generalized second-order nonlinear differential equation, which includes several physical nonlinear oscillators such as force-free Helmholtz oscillator, force-free Duffing and Duffing-van der Pol oscillators, modified Emden-type equation and its hierarchy etc, and investigate the dynamical properties of this rather general equation. We identify and classify several new integrable cases for arbitrary values of exponents, which determine the tangent vector as well as the infinitesimal generator. Using the Lie point symmetry, we find the useful infinitesimal generators and canonical coordinates, and obtain the first integrals of the second-order nonlinear …

On Hypergroups Of Order At Most 6, Jordy C. Lopez

Theses and Dissertations

This thesis surveys recent results on hypergroups as defined by Frédéric Marty in [3] and [4] and their relation to association schemes as presented in [5]. We show that every association scheme is a hypergroup. Then, we compile a few general results on hypergroups needed for our investigation of hypergroups with three, four and six elements. From [1] and [7], we give examples of hypergroups that do not come from finite schemes and from no scheme at all. Our main result occurs when considering hypergroups S with six elements that have a non-normal closed subset T of order 2 with …

Development Of A Phased Array Using Lnbs With Non-Synchronized Clocks, James I. Murray

Theses and Dissertations

A passive phased array is an array of antennas in which the phases of the signals on each element are controlled to be added to form a spatial beam. The advantage is that one can steer the beam without physically moving the constituent elements as well as create multiple beams on the sky simultaneously. This has application in the field of satellite and spacecraft communications where there is expected to be a large increase in satellite volume due to the increasing access to space. Traditional phased arrays can become costly to synchronize at satellite down-link frequencies, therefore we have built …

Identification Of Synthetic Chemical Compound Inhibitors Of Pseudomonas Aeruginosa Protein Synthesis And The Development Of Lead Series, Stephanie O. Palmer

Theses and Dissertations

Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria and a primary cause of nosocomial infections. An aminoacylation/translation (A/T) assay was developed using P. aeruginosa components to perform poly(U) mRNA directed protein synthesis. Using scintillation proximity assay (SPA) technology a high-throughput screening (HTS) platform was developed. A synthetic chemical compound library (>900) was screened, 36 hit compounds were identified and molecular targets were determined. Compounds were analyzed for enzymatic inhibition (IC50) and inhibition of bacterial cultures (MIC). Time-kill studies determined bacterial growth to be bacteriostatic or bactericidal in the presence of inhibitor. Mechanism of action, effects on eukaryotic cytosolic and mitochondrial …

Analysis And Simulation Of A Social Network, Twitter: A Case Study, Jonatan Reyes

Theses and Dissertations

The use of online social networks empowers its users to efficiently disseminate information across traditional social networks. Typically, the weight and value of messages are relative to its readers’ culture and interests. Nevertheless, in some instances, messages take the form of viral phenomenon, which circulates around the world in very short periods of time. Therefore, despite the actual content of the message spread over the network, the determination of the effectiveness of message dissemination across the social network becomes an attractive opportunity for scientific study. Since a meticulous analysis of a complete online social network would require the acquisition of …

Hydrodesulfurization Of Dibenzothiophene Using Comos2, Jacob S. Sollner

Theses and Dissertations

The hydrodesulphurization (HDS) of crude oils is an important industrial process to remove sulfur from fuels. In this study, DBT was used as a model compound to study the removal of sulfur from a decahydronaphthalene solution. The catalyst was synthesized through low pressure pathways in the absence of H2S. All the synthesized catalyst were investigated using a combination of SEM, RAMAN spectroscopy, and XRD. The materials were studied for their ability to remove DBT from solution and the reaction products were analyzed. It was observed that the major reaction pathway was the direct desulphurization pathway and zero order reaction kinetics …

Molecular Dynamic Simulation Studies Of The Androgen Receptor Complexed With 5Α-Dihydrotestosterone And An Allosteric Ligand, Everardo Villarreal Ii

Theses and Dissertations

Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can …

Global Entropy Based Greedy Algorithm For Discretization, Sai Jyothsna Jonnalagadda

Theses and Dissertations

Discretization algorithm is a crucial step to not only achieve summarization of continuous attributes but also better performance in classification that requires discrete values as input. In this thesis, I propose a supervised discretization method, Global Entropy Based Greedy algorithm, which is based on the Information Entropy Minimization. Experimental results show that the proposed method outperforms state of the art methods with well-known benchmarking datasets. To further improve the proposed method, a new approach for stop criterion that is based on the change rate of entropy was also explored. From the experimental analysis, it is noticed that the threshold based …

Opinion Formation About Childhood Immunization And Disease Spread On Networks, Shan Shan Zhao

Theses and Dissertations

People are physically and socially connected with each other. Those connections between people represent two, probably overlapping, networks: biological networks, through which physical contacts occur, or social network, through which information diffuse. In my thesis research, I am trying to answer that question in the context of pediatric disease spread on the biological network between households as well as within them and its relationship with information sharing on the social network of households (parents in that case) via "Information Cascades." I mainly focus on the Erdos-Renyi network model. In particular, I use two different but overlapping Erdos-Renyi networks for the …

Computational Analysis Of The Sir Mathematical Model For The Dengue Fever, Joseph Phillip Diaz

Theses and Dissertations

Dengue fever is a disease affecting people in more than 100 countries. Here we consider a host and vector model for the transmission of dengue fever. This SIR model consists of three compartments of susceptible, infective and removed for host (human) and two compartments of susceptible and infective for vector (dengue mosquitos). These five compartments yield five coupled nonlinear ordinary differential equations (ODEs). After non-dimensionalization, we have a system of three nonlinear ODEs. Reproductive number and two equilibrium points are calculated for various cases. Simulation is carried out for susceptible, infective and removed and the results are presented in graphical …

Decomposition And Nitrogen Dynamics Of Turtle Grass (Thalassia Testudinum) In A Subtropical Estuarine System, Monica Delgado

Theses and Dissertations

Seagrass beds are pivotal in the functioning of coastal ecosystems in terms of productivity, organic matter turnover and nutrient cycling. Aiming to document decay and nitrogen (N) dynamics of turtle grass (Thalassia testudinum) in a subtropical estuarine system, decomposition patterns of leaves and rhizomes were characterized and compared. Nitrogen usage during decomposition of tissues, and of live tissues and epiphytes growing on live leaves, was also quantified and compared. Stable isotope ratios allowed tracing N within the seagrass bed, following N incorporation into seagrass tissues from the surrounding media (water, sediment). Leaves had a higher N content and decomposed at …

First Astrophysical Observations With The Low Frequency All Sky Monitor, Emma Youmans Handzo

Theses and Dissertations

The Low Frequency All Sky Monitor (LoFASM) is a radio telescope that consists of dipole antennas. It is sensitive to the frequencies of 10-88MHz. The primary science goals of LoFASM are to detect and study low frequency radio transient events and to develop and test low frequency interference (RFI) mitigation techniques.

Once a telescope starts collecting data, it is necessary to calibrate the telescope to convert the data into standard units. This will allow for scientific deductions to be made from the data. Once the calibration of a telescope is complete it is necessary to determine what astrophysical sources are …

3d Reconstruction Of Close Range Objects Using Free And Open Source Software And Raspberry Pi Technologies, Juan Lorenzo Monrreal

Theses and Dissertations

Existing 3D rendering open source software along with Raspberry Pi technology can be used to create an affordable method and workflow for time efficient, accurate and quality scans for 3D printing. The emergence of technology spurs a technological community working to progress in a collaborative effort. This brings a potential to the possibility of efficient and economical solutions to emerging problems, in this case, the ability to render three dimensional scans using free and open source software as well as Raspberry Pi technology. The focus of this paper will be divided into three different aspects including the background needed to …

Facile Sol-Gel Molten Salt Synthesis Of Double Perovskite La 2nimno6 As An Electrocatalyst For Oxygen Evolution Reactions, Padmini Kukkapalli

Theses and Dissertations

Double perovskites have attracted a great attention recently for its high intrinsic activity in oxygen evolution reaction (OER) in electrochemical energy storage and conversion systems in alkaline media. In this study, we are the first to report the new approach of La2NiMnO6 double perovskite which was synthesized via Sol-gel molten-Salt synthesis method. However their stability and specific activity remain challenging that need to be addressed to meet the reqiurement for OER activities. Here in this study we synthesized three different samples with varying concentrations by taking molten salts NaNO 3 and KNO3 in (1:1) ratio such as 30:30, 60:60, 90:90. …

The Bourbaki-Jacobson Correspondence, Jose R. Vera

Theses and Dissertations

A general ring theoretic correspondence between subrings of the endomorphism ring of the additive group of a commutative field will be established. This correspondence (called Bourbaki-Jacobson Correspondence) provides the ordinary Galois correspondence when applied to specific group rings. Throughout this thesis, we will work with finite dimensional field extensions.

Molecular Modeling And Mutational Mapping Of The Gpr119 Binding Site, Shane M. Askar

Theses and Dissertations

GPR119 receptor’s biological role in regulating glucose homeostasis has been studied extensively. Results in the scientific literature indicate that, when activated, GPR119 releases insulin in a glucose dependent manner. Currently the 3D structure of GPR119 has not been resolved.

The goal of this research is to use a combination of homology modeling and ligand docking studies to predict the binding mode of GPR119 ligands. Amino acids implicated to have direct interactions with docked ligands will further be assessed experimentally for their roll in binding and activation of GPR119. Our results indicate that residues W2656.48 and R813.28 are likely to be …