Medicine and Health Sciences Commons^™

The Public Health Exposome: A Population-Based, Exposure Science Approach To Health Disparities Research, Paul D. Juarez, Patricia Matthews-Juarez, Darryl B. Hood, Wansoo Im, Robert S. Levine, Barbara J. Kilbourne, Michael A. Langston, Mohammad Z. Al-Hamdan, William L. Crosson, Maurice G. Estes, Sue M. Estes, Vincent K. Agboto, Paul Robinson, Sacoby Wilson, Maureen Y. Lichtveld

Sociology Faculty Research

The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures “get under the skin”. The public health exposome approach has led our …

Expression Of Suppressor Of Cytokine Signaling 1 (Socs1) Impairs Viral Clearance And Exacerbates Lung Injury During Influenza Infection., Keer Sun, Sharon Salmon, Vijaya Kumar Yajjala, Christopher Bauer, Dennis W. Metzger

Journal Articles: Pathology and Microbiology

Suppressor of cytokine signaling (SOCS) proteins are inducible feedback inhibitors of cytokine signaling. SOCS1-/- mice die within three weeks postnatally due to IFN-γ-induced hyperinflammation. Since it is well established that IFN-γ is dispensable for protection against influenza infection, we generated SOCS1-/-IFN-γ-/- mice to determine whether SOCS1 regulates antiviral immunity in vivo. Here we show that SOCS1-/-IFN-γ-/- mice exhibited significantly enhanced resistance to influenza infection, as evidenced by improved viral clearance, attenuated acute lung damage, and consequently increased survival rates compared to either IFN-γ-/- or WT animals. Enhanced viral clearance in SOCS1-/-IFN-γ-/- mice coincided with a rapid onset of adaptive immune …

Examination Of Capital Murder Jurors’ Deliberations: Methods And Issues, Keith Price, Susan Coleman, Gary R. Byrd

Administrative Issues Journal

The study of capital juries remains a subject of critical interest for the public and for legislative and judicial policy makers as well as legal scholars and social scientists. Cowan, Thompson, and Ellsworth established one of the standard methodologies for examination of this topic in their 1984 seminal study by observing the subjects’ debate about conviction in a death penalty case utilizing mock juries; other scholars employed different techniques to add more information in the late 1990s. Yet, the question of death qualification and prosecutorial bias remains open to inquiry. This preliminary study found evidence to support bias toward conviction …

Ifn-Γ Causes Aplastic Anemia By Altering Hematopoietic Stem/Progenitor Cell Composition And Disrupting Lineage Differentiation, Fan Ching Lin, Megan Karwan, Bahara Saleh, Deborah L. Hodge, Tim Chan, Kimberly C. Boelte, Jonathan R. Keller, Howard A. Young

Public Health Resources

Aplastic anemia (AA) is characterized by hypocellular marrow and peripheral pancytopenia. Because interferon gamma (IFN-γ) can be detected in peripheral blood mononuclear cells of AA patients, it has been hypothesized that autoreactive T lymphocytes may be involved in destroying the hematopoietic stem cells. We have observed AA-like symptoms in our IFN-γ adenylate-uridylate-rich element (ARE)-deleted (del) mice, which constitutively express a low level of IFN-γ under normal physiologic conditions. Because no T-cell autoimmunity was observed, we hypothesized that IFN-γ may be directly involved in the pathophysiology of AA. In these mice, we did not detect infiltration of T cells in bone …

An Evidence-Based Approach To A Replacement Hospital Training Curriculum, Mark D. Beck

Doctor of Nursing Practice (DNP) Projects

Creation of a training and educational curriculum for a new or replacement facility is daunting in its own right, but without a repository of organizational knowledge cataloging the transfer of tacit to explicit knowledge from the organizations previous library of facility openings, the task becomes Herculean, with as many tasks and cast of characters as the original myths. Navigating the shoals, eddies and tides of the various aspects of this project revealed the need for a comprehensive knowledge management solution to training that is coupled with healthcare design principles and initiatives. This purpose of the DNP project is about the …

Functional Lung Avoidance For Individualized Radiotherapy (Flair): Study Protocol For A Randomized, Double-Blind Clinical Trial., Douglas A Hoover, Dante Pi Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga, Brian P Yaremko

Medical Biophysics Publications

BACKGROUND: Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some patients. Current radiotherapy planning techniques aim to minimize the radiation dose to the lungs, without accounting for regional variations in lung function. Many patients, particularly smokers, can have substantial regional differences in pulmonary ventilation patterns, and it has been hypothesized that preferential avoidance of functional lung during radiotherapy may reduce toxicity. Although several investigators have shown that functional lung can be identified using advanced imaging techniques and/or demonstrated the feasibility and …

An Examination Of Psychological Variables Influencing Perceptions Of The Self Among A Sample Of Female Exercise Initiates, Lisa Cooke

Electronic Thesis and Dissertation Repository

The general purpose of this dissertation was to explore the relationship among and within cognitive variables associated with exercise initiation and maintenance in a sample of female exercise initiates.

Manuscript 1 was structured to explore the changes to exercise identity among a population of female exercise initiates (N = 78) grouped into an imagery or control condition. Previous research has found that a strong exercise identity is associated with more frequent exercise (Strachan et al., 2009) and increases over time as a person continues to exercise (Cardinal & Cardinal, 1997). Participants were assessed multiple times (weeks 0, 5, 9, …

Lack Of Medicaid Funding For Occupational Therapy Serving The Autism Spectrum Disorder Population Ages 0-5 Years, Nadia Yala

Honors Theses

The prevalence of autism in the United States is currently 1 in 68 children (Autism Alliance of Michigan, 2014). This is considered an epidemic. There are a variety of treatments available in the state of Michigan for children with autism, such as occupational therapy, speech therapy, physical therapy, and applied behavior analysis (ABA). Effective April 1^st, 2013, Michigan increased their funding cap for ABA therapy for treating children with autism. However, there is a lack of knowledge within the community and amongst professionals in regards to the critical treatment occupational therapy practitioners provide and as a result, there …

Effect Of Hydrogen Peroxide On The Biosynthesis Of Heme And Proteins: Potential Implications For The Partitioning Of Glu-TrnaGlu Between These Pathways, Carolina Farah, Gloria Levicán, Michael Ibba, Omar Orellana

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Glutamyl-tRNA (Glu-tRNA^Glu) is the common substrate for both protein translation and heme biosynthesis via the C5 pathway. Under normal conditions, an adequate supply of this aminoacyl-tRNA is available to both pathways. However, under certain circumstances, Glu-tRNA^Glu can become scarce, resulting in competition between the two pathways for this aminoacyl-tRNA. In Acidithiobacillus ferrooxidans, glutamyl-tRNA synthetase 1 (GluRS1) is the main enzyme that synthesizes Glu-tRNA^Glu. Previous studies have shown that GluRS1 is inactivated in vitro by hydrogen peroxide (H₂O₂). This raises the question as to whether H₂O₂ negatively affects …

A Critical Analysis Of Infant Mortality In Kalamazoo County, Audrey Jensen

Honors Theses

The following is a review of the state of infant and fetal health in Kalamazoo County in the 21st century. Since infant health is a marker for the effectiveness of health care, this review will analyze the leading causes of infant mortality in Kalamazoo County. Statistical indicators show that Kalamazoo County falls below both state and national IMR averages. The leading causes of infant mortality in Kalamazoo are considered preventable infant deaths. Therefore, this review will make recommendations for the reduction of IMR through the improvement of preventative prenatal healthcare practices.

Onsite Integrative Clinics: Acupuncture, Positive Patient Outcomes, And Frequency Of Provider Office Visits, Sherry Shoemaker Phd

Dissertations

Purpose and Aims. There is limited information about outcomes of care, resource utilization, and associated costs for patients who receive acupuncture in integrative health settings. The purpose of this study was to address this gap through the following aims: To examine: (1) changes in patient pain levels pre/post acupuncture treatments; (2) relationships between receiving acupuncture treatments (number of treatments, length of time, select demographic factors, (age, gender), pain level pre and post acupuncture treatments; (3) relationships between number of treatments, length of time, age, gender, pain level (pre/post acupuncture treatments) and provider visits (pre/post acupuncture treatments); and (4) relationship between …

Developmental And Cultural Perspectives On Children’S Postoperative Pain Management At Home, Brooke N. Jenkins, Michelle A. Fortier

Psychology Faculty Articles and Research

Outpatient surgery is extremely common in children, and approximately 4 million children experience significant pain after surgery in the USA each year. Management of children's postoperative pain in the home setting is suboptimal and is impacted by characteristics of children and parents, as well as the larger family and cultural context. In particular, developmental status of the child, parental beliefs regarding pain expression and analgesic use in children, cultural values and language barriers can affect management of children's postoperative pain. Targeting the myriad barriers to children's pain management by capitalizing upon the use of tailored interventions may help bridge the …

The Relationship Of Plantar Sensation With Standing Balance And Gait Post-Stroke, Stephen Parsons

Electronic Thesis and Dissertation Repository

Gait and balance dysfunction after stroke limit independence and quality of life. Numerous contributing factors have been investigated but the role of sensation deficits has received little attention. This thesis investigated the relationship between plantar cutaneous sensation and 1) standing balance, 2) gait, and 3) use of vision to compensate for sensory loss with a secondary analysis of data from individuals with subacute stroke. Associations between standing balance, gait and sensation were investigated with Spearman correlations. Individuals classified as impaired or intact sensation were compared on gait and standing balance measures. This thesis found plantar sensation is related to standing …

Mission Nursing, Jane Dannhausen, Connie Herron

Jane E. Dannhausen

No abstract provided.

Sim-Man: Not Your Grandma's Nursing Education, Jamie Peppler, Jane Dannhausen, Katherine Willock

Jane E. Dannhausen

No abstract provided.

Millinnals Educated And Empowered With Technology, Sarah Beckman, Cheryl Sorge, Tabitha Bane

Cheryl L Bruick-Sorge

How do faculty meet the “net generation” learning needs? The challenge of engaging students was accomplished in this senior leadership course using a variety of strategies. Course requirements included a classroom presentation, multimedia applications, and a quality improvement project completed in a 90 hour practicum. Student-developed websites will be featured and evaluated for design, flow, evidence-based information, credibility, currency, and relevancy to practice. Learning outcomes will be assessed using undergraduate curriculum foundations. Participants will be invited to share strategies that were successful for them in engaging the net generation in meaningful coursework.

Ismart: Intergenerational Students Motivated To Apply Research And Technology, Sarah Beckman, Cheryl Sorge, T Bane

Cheryl L Bruick-Sorge

No abstract provided.

Student Created Websites: Demonstration Of Information Literacy Skills, Sarah Beckman, Cheryl Sorge, Tabitha Bane

Cheryl L Bruick-Sorge

Senior students are held accountable for learning outcomes in a junior level informatics course. Design skills were applied in the creation of websites used for classroom presentations on select leadership topics. These websites were used as educational tools in the practice setting. Two websites will be featured.

Five Strategies That Heighten Nurses' Awareness Of Spirituality To Impact Patient Care, Sarah Beckman, Becky Salmon, Cheryl Bruick-Sorge, S. Boxley-Harges

Cheryl L Bruick-Sorge

No abstract provided.

Meeting The Challenge Of Teaching The Millennial Nursing Student In A Neuman-Based Program, Cheryl Bruick Sorge, Becky A. Salmon

Cheryl L Bruick-Sorge

No abstract provided.

The Evolution Of Student Nurses' Concepts Of Spirituality, Sarah Beckman, Becky Salmon, Cheryl Bruick-Sorge, Sanna Boxley-Harges

Cheryl L Bruick-Sorge

Spirituality has different meanings to individuals from diverse backgrounds with minimal definitions documented in academe. This qualitative research study was to determine the evolution of student nurses' concepts of spirituality by comparing their definitions on admission and at completion of their nursing education. Student responses are discussed.

Five Strategies That Heighten Nurses' Awareness Of Spirituality To Impact Client Care, Sarah Beckman, Sanna Boxley-Harges, Cheryl Bruick-Sorge, Becky Salmon

Cheryl L Bruick-Sorge

Professional practice standards mandate that spiritual nursing care is a responsibility, not an option. This article explores 5 experiential learning activities that seek to heighten a person's awareness of his or her own spirituality and that also increases one's sensitivity to the spiritual needs of others.

Secrets Of Successful Short Grant Applications, Patricia Groves, Susan Rawl, Mary Wurzbach, Nancy Fahrenwald, Marlene Cohen, Donna Mccarthy, Julie Zerwic, Barbara Given, Donna Algase, Gregory Alexander, Vicki Conn

Gregory S Alexander

Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of …

Risk Of Second Cancers In Merkel Cell Carcinoma: A Meta-Analysis Of Population Based Cohort Studies, Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Hafiz M.R. Khan

Department of Health Promotion and Disease Prevention

The risk of second cancers in Merkel cell carcinoma (MCC) remains uncertain since risk estimates vary worldwide. The global MCC population is growing and there is a demand for better knowledge of prognosis of this disease. The Cochrane Database of Systematic Reviews, MEDLINE, and EMBASE search engines were searched for the relevant literature between January 1999 and September 2014 by use of explicit search criteria. The main outcome was second malignancies associated with MCC patients measured by standardized incidence ratios (SIRs) or other estimates of risks. Five papers fulfilled the inclusion criteria and reported SIRs of second cancer inMCC which …

Improving Functional Mobility Following A Basal Ganglia Stroke, John Covilli

Case Report Posters

Background: The basal ganglia are located in the and are involved in voluntary motor control, emotional reactions, and cognition. The putamen is housed in the basal ganglia, and is involved in learning and motor skills. Stroke is the 4th leading cause of death in the U.S. and leads to 1 out of every 19 deaths. Stroke is the largest cause of disability in older adults, and the largest consumer of rehabilitation services in the U.S. Hypertension is a major risk factor for causing a stroke, and over 90% of patients that have had a basal ganglia stroke have also had …

The Role Of An International Cross Cultural Interprofessional Healthcare Immersion Program In Doctor Of Physical Therapy Education: An Educational Case Report, Jayme Keith

Case Report Posters

Purpose: The purpose of this educational case report is to describe an interprofessional international cross-cultural immersion healthcare program and to discuss the role of this program in the development of Doctor of Physical Therapy (DPT) students’ cultural competence, interprofessionalism, and social responsibility. Description: The Ghana Cross Cultural Health Immersion (GCCHI) program provides annual primary health care services and education in Sekondi, Takeradi and outlying communities in Ghana. Student and faculty participants from the University of New England (UNE) work in conjunction with the Ghana Health Services, Cape Coast University medical students and community health workers in order to meet the …

Postoperative Management And Core Stabilization Interventions For A Semi-Pro Football Athlete Following Lumbar Discectomy: A Case Report, Isaiah Iaea

Case Report Posters

Background: Many cases of low back pain (LBP) are idiopathic in nature, however, LBP in result of a herniated intervertebral disc exerting pressure on the nerve root may require lumbar discectomy to relieve sciatica and radiating pain. Although there is evidence to support successful return to work in the general population and return to sports in professional athletes, less is known regarding the interventions that played a role in their return. Purpose: The purpose of this case report is to describe the physical therapy management and core stabilization interventions for a semi-pro football athlete following lumbar discectomy who sustained a …

The Role Of An International Cross Cultural Interprofessional Healthcare Immersion Program In Doctor Of Physical Therapy Education: An Educational Case Report, Jayme Keith

Case Report Papers

Background and Purpose: Today’s healthcare team requires providers to be culturally sensitive and competent interprofessional collaborators. Interprofessional Education (IPE) helps to provide a collaborative foundation for healthcare providers. Cross-cultural immersion (CCI) educational programs foster cultural awareness. Service-learning (SL) programs create opportunities for students to have interprofessional and cross cultural experiences. The purpose of this educational case report is to describe an interprofessional international cross-cultural immersion healthcare program and to discuss the role of this program in the development of (DPT) students’ cultural competence, interprofessionalism, and social responsibility. Case Description: The Ghana Cross Cultural Healthcare Immersion (GCCHI) is a University based …

Improving Independent Functional Mobility Following A Left Basal Ganglia Hemorrhagic Stroke: A Case Report, John Covilli

Case Report Papers

Background and Purpose: The purpose of this case report is to compile and summarize the physical therapy management for improving independent functional mobility following a left basal ganglia hemorrhagic stroke in the outpatient setting. Additionally, this report will provide a brief overview of the presentation and medical management of a left basal ganglia hemorrhagic stroke. Case Description: The patient, JD, had a stroke on 2012 and was left with multiple impairments ranging from his cognition to his strength and active range of motion. This case covers his physical therapy management over a 12 week period with hour long appointments twice …

Postoperative Management And Core Stabilization Interventions For A Semi-Pro Football Athlete Following Lumbar Discectomy: A Case Report, Isaiah Iaea

Case Report Papers

Although there is evidence to support a high success rate to return to work in the general population and to sports play in athletes following discectomy, less is known regarding the interventions that played a role in their return. The following case describes the interventions and management of a recreational football player following discectomy. Case description: The patient was a self-described highly active 24-year-old male post discectomy. The patient had pain, poor body mechanics, gait abnormalities, range of motion deficits, and strength deficits of his low back and lower extremities. Physical therapy interventions included soft tissue mobilization, stretching, exercise, and …