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Articles 1 - 30 of 133
Full-Text Articles in Medicine and Health Sciences
Comparisons Between The Nod And Nor Mouse: Insight Into Diabetes Pathogenesis And Protection, Joseph Guy Daft
Comparisons Between The Nod And Nor Mouse: Insight Into Diabetes Pathogenesis And Protection, Joseph Guy Daft
All ETDs from UAB
Type 1 Diabetes (T1D) is defined as the selective immune destruction of insulin producing beta cells within the islet. A new emphasis has been put on the role of the gastrointestinal (GI) tract in T1D; however, there is much more to learn about this relationship. Distinct differences have been observed in the intestinal permeability, barrier function, commensal microbiota, and mucosal innate and adaptive immunity of patients and animals with T1D, when compared to healthy controls. The non-obese diabetic (NOD) mouse and the BioBreeding diabetes prone (BBdp) rat are commonly used to models to study T1D in humans. Most murine studies …
The Involvement Of The Ca2+-Independent Phospholipase A2ss In The Pathogenesis Of Type 1 Diabetes, Robert N. Bone
The Involvement Of The Ca2+-Independent Phospholipase A2ss In The Pathogenesis Of Type 1 Diabetes, Robert N. Bone
All ETDs from UAB
Type 1 diabetes is a metabolic disease characterized by hyperglycemia, an absolute deficiency in insulin, and the autoimmune-mediated destruction of pancreatic islet ß-cells. Since exogenous insulin does not effectively duplicate native ß-cell function and the need persists for life, strategies to prevent ß-cell death or promote ß-cell survival are expected to provide beneficial outcomes. Based on reports that Akt1 promotes ß-cell survival and proliferation, administration of viral vectors modified to effectively deliver constitutively active (CA)-Akt1 to ß-cells would be expected to be beneficial for the ß-cell. In freshly isolated islets, CA-Akt1 promoted ex vivo islet cell survival and ß-cell survival. …
Regulatory Control Of Palatogenesis And Odontogenesis By Specificity Protein 7, John Christopher Clarke
Regulatory Control Of Palatogenesis And Odontogenesis By Specificity Protein 7, John Christopher Clarke
All ETDs from UAB
Runx2 and its downstream target Specificity Protein 7 (Sp7) are essential for skeletogenesis. In humans, mutations in Sp7 gene are associated with osteogenesis imperfecta. Unlike Runx2, the role of Sp7 in palatogenesis, tooth development or differentiation of ameloblasts and odontoblasts remains unknown. The main goal of this research was to identify the functional requirement of Sp7 transcription factor during tooth development and palatogenesis. Molecular, biochemical, and histological approaches were employed to answer this question. We established Sp7-null mice that are completely void of mineralized tissue, exhibit craniofacial dysmorphogenesis and die shortly after birth. Surprisingly, Sp7 homozygous mutants exhibited normal tooth …
Osteoblast And Odontoblast Specific Regulatory Actions Of Runx2 For The Development Of Mineralized Tissues, Mitra Darice Adhami
Osteoblast And Odontoblast Specific Regulatory Actions Of Runx2 For The Development Of Mineralized Tissues, Mitra Darice Adhami
All ETDs from UAB
The Runx2 transcription factor is necessary for commitment and differentiation of mesenchymal cells into the chondroblasts, osteoblasts and odontoblasts. Runx2 induces the expression of several key genes involved in mineralization of both the bone and dentin matrices. Global Runx2-null mice are completely void of mineralized tissue and do not express osteoblast markers, indicating that Runx2 is required for commitment to the osteoblast lineage. Tooth development in Runx2-null mice is arrested in the bell stage, prior to the differentiation of odontoblasts. Thus, Runx2 is essential for development of osteoblast and odontoblast lineages. However, the functional requirements of Runx2 after commitment to …
New Niosh Headforms: Developing Novel Methods For Fabricating A More Realistic Physical Headform And Custom Facepieces And Evaluating Existing Commercially-Available Respirators, Paula Susanne Joe
All ETDs from UAB
For over 30 years, respirator sizing has been based on an anthropometric survey performed by LANL using the young and predominantly Caucasian US Air Force personnel. NIOSH, having observed the increase in diversity in the workplace, began a new survey in 2003 weighted to the US census. Finding that the LANL panel was no longer representative of the modern workforce, a new fit test panel recommending five sizing categories was created in 2007. Anthropometrically accurate headforms three-dimensional models for the average face in each size were designed in 2010. While these headforms are intended for use in respirator design, it …
Identification Of A New Schwannomatosis-Predisposing Gene And Study Of Splicing Defects Caused By Deep Intronic Nf1 Mutations Causing Neurofibromatosis Type 1, Jing Xie
All ETDs from UAB
Schwannomatosis is the third major form of the neurofibromatoses. Constitutional mutations in the SMARCB1 gene have been found only in ~50% of familial and <10% of sporadic schwannomatosis patients, suggesting additional predisposing genes exist. In the present study, we sequenced 3.72 Mb of evolutionary conserved sequences along 22q in 8 schwannomatosis patients without a SMARCB1 mutation in blood or schwannomas, and had a molecular signature consisting of somatic partial loss of 22q and a different NF2 mutation in every schwannoma. We identified LZTR1 germline mutations in 7/8 patients. Targeted sequencing of LZTR1 in 12 further patients with the same molecular signature identified 9 additional germline mutations. Loss of heterozygosity with retention of the LZTR1 mutation was present in all 25 schwannomas studied. Mutations segregated with disease in all available affected first-degree relatives. Our findings identify LZTR1 as a gene predisposing to an autosomal dominant inherited disorder of multiple schwannomas in ~80% SMARCB1-negative 22q-related schwannomatosis patients. Neurofibromatosis type 1, another major form of neurofibromatoses, is caused by loss-of-function mutations in the NF1 gene. Approximately 2% of identified NF1 mutations are deep intronic splice mutations causing the inclusion of an intronic cryptic exon in the mature mRNA. In the present study, we identified 12 different deep intronic splice mutations in 15 unrelated probands, resulting in exonization of different fragments from intron 30(23.2) or 31(23a). This study describes the largest collection of deep intronic mutations in NF1 reported so far, and pinpoints specifically the intronic sequences flanking the alternatively spliced exon 31(23a) as a hotspot for NF1 intronic splice defects. Further investigation by fragment and cloning analysis uncovered that the deep intronic mutations residing either 5' or 3' of exon 31(23a) predominantly or preferentially affect the type II isoform including exon 31(23a), suggesting that alternative splicing of exon 31(23a) depends and is regulated by multiple flanking intronic sequences.
Elucidating The Role Of Gsk3 In Synaptic And Cognitive Deficits In Fragile X Syndrome, Aimee Vinson Franklin
Elucidating The Role Of Gsk3 In Synaptic And Cognitive Deficits In Fragile X Syndrome, Aimee Vinson Franklin
All ETDs from UAB
Fragile X Syndrome (FX) is the most common inherited form of mental retarda-tion. Prominent characteristics of FX are mimicked in a mouse model with deleted fmr1 including hyperactivity, anxiety, developmental delay and social deficits. Additionally, FX mice display deficits in n-methyl-d-aspartate receptor (NMDAR) dependent long-term potentiation (LTP) at medial perforant path synapses onto dentate granule cells (MPP-DGC synapses). Because LTP is a cellular correlate of learning and memory, defi-cits in LTP at this synapse are thought to underlie impairments in pattern separation, a form of learning and memory dependent on proper DG function. Identifying the patho-logical mechanisms that cause impaired …
The Effect Of Medicaid Dental Coverage On Dental Care Utilization Among Older Americans, Ahyuda Oh
The Effect Of Medicaid Dental Coverage On Dental Care Utilization Among Older Americans, Ahyuda Oh
All ETDs from UAB
This dissertation examines the impact of Medicaid dental coverage on dental care utilization and oral health outcome of low-income elderly and non-elderly adults, using a fixed-effects model with longitudinal data of all states and multiple years from the Behavioral Risk Factors Surveillance System (BRFSS). By exploiting within-state variation over time in adult Medicaid dental coverage, the study estimates the effects of Medicaid dental coverage on dental care utilization (i.e., dental visits and dental cleanings) and oral health outcome (i.e., tooth loss). The study evaluates the effects of Medicaid dental benefits with preventive dental services on each of the three dental …
Syndecan Knockdown In The Insulin Producing Cells Of Drosophila Melanogaster Affects Energy Metabolism And Life Span, Jonathan Lund Warren
Syndecan Knockdown In The Insulin Producing Cells Of Drosophila Melanogaster Affects Energy Metabolism And Life Span, Jonathan Lund Warren
All ETDs from UAB
Drosophila melanogaster is a powerful model organism for studying human metabolic disease due to the conservation of various signaling processes and pathways. The insulin producing cells (IPCs) in the brain of adult flies sense circulating nutrients and respond by producing three insulin-like peptides (dILP2, dILP3, and dILP5). Several studies have shown that dILPs play a major role in Drosophila reproduction, metabolism, growth, and longevity. Previous data showed that flies homozygous for a hypomorphic mutation in the Drosophila syndecan (dSdc) gene had defects in energy metabolism and lower expression of brain dilp2-3 and dilp5 genes. Syndecan is a transmembrane proteoglycan that …
Sialic Acid: A Signal For Pneumococcal Egress From The Nasal Mucosa Into The Central Nervous System, Brandon L. Hatcher
Sialic Acid: A Signal For Pneumococcal Egress From The Nasal Mucosa Into The Central Nervous System, Brandon L. Hatcher
All ETDs from UAB
Streptococcus pneumoniae (pneumococcus) is one of the leading causes of bacterial meningitis world-wide. The classic paradigm in the establishment of bacterial meningitis is that in the absence of physical trauma, infection in the peripheral blood is needed to cause invasion of the central nervous system (CNS). Our previous studies have shown that pneumococci, a frequent colonizer of the nasopharynx, can cause bacterial meningitis through a nonhematogenous route by which bacteria appear to travel along the olfactory nerves, through the cribriform plate to the olfactory bulbs and into the rest of the CNS. However, with the frequency of nasopharyngeal colonization and …
The Role Of Primary Cilia In Mammary Gland And Skeletal Development, Elizabeth Mitchell
The Role Of Primary Cilia In Mammary Gland And Skeletal Development, Elizabeth Mitchell
All ETDs from UAB
Primary cilia (PC) extend from the cell body into the microenvironment detecting chemical and mechanical signals, and are required for proper development. To evaluate loss of primary cilia in mammary gland development, we developed mouse models with deletion of PC in mammary epithelial compartments. No discernable alterations to mammary development were observed in MMTV-Cre- or K14-Cre; Ift88Del lines. PC were expressed at high levels on cells in mammosphere culture; however, PC were not required for mammosphere renewal. The inability to find a significant mammary developmental phenotype in our mouse models suggested primary cilia don't have a significant function in differentiated …
3-Dimensional Comparison Of Hard And Soft Tissue Asymmetry In, Philip H. Pan
3-Dimensional Comparison Of Hard And Soft Tissue Asymmetry In, Philip H. Pan
All ETDs from UAB
Class III malocclusions are particularly prevalent in the Asian population. Threedimensional imaging has improved the ability to portray the three-dimensional characteristics of soft tissue face and underlying skeletal hard tissue. While soft tissue reflects the underlying hard tissue structures, soft tissue may either provide a compensation for hard tissue asymmetry or potentially exacerbate the asymmetry. The current study is novel in that the hard tissue and soft tissue asymmetries are both analyzed relative to the same reference point, and using 3D imaging, we have attempted to elucidate a compensation tendency between the hard and soft tissues. The sample was comprised …
Osteomimmunology Of Bone Fracture Healing And Cell And Gene Therapy Approaches For Nonunion Bone Defects, Seth G. Levy
Osteomimmunology Of Bone Fracture Healing And Cell And Gene Therapy Approaches For Nonunion Bone Defects, Seth G. Levy
All ETDs from UAB
Despite the body's ability to repair bone fractures under normal circumstances, up to 10% of the 7.9 million fractures suffered in the United States each year do not achieve bony union. Bone fractures heal with overlapping phases of inflammation, cell proliferation, and bone remodeling. Osteogenesis and angiogenesis are known to work in concert to control many stages of this process, but when one is impaired it leads to failure of bone healing, referred to as a nonunion. Such nonunion fractures often result from critical-size defects that will not completely heal over the natural lifetime of the animal. Based on this …
Patient And System Level Factors As Predictors Of Adherence To Antiretroviral Therapy Appointment Schedules In Cambodia, Gary T. Daigle
Patient And System Level Factors As Predictors Of Adherence To Antiretroviral Therapy Appointment Schedules In Cambodia, Gary T. Daigle
All ETDs from UAB
PATIENT AND SYSTEM LEVEL FACTORS AS PREDICTORS OF ADHERENCE TO ANTIRETROVIRAL THERAPY APPOINTMENT SCHEDULES IN CAMBODIA GARY T. DAIGLE EPIDEMIOLOGY / INTERNATIONAL HEALTH ABSTRACT On-time attendance at clinical appointments by patients on antiretroviral therapy (ART) is essential to the prevention of medication interruptions, viral rebound, drug resistance, and long term mortality. An observational study conducted in 2010, Enablers and Adherence to Antiretroviral Therapy in Cambodia, sought to identify factors that predict on-time clinical appointment attendance by patients on ART. These factors were classified as either ART patient level factors (e.g. demographic, clinical) or patient care and support system level factors …
Characterization Of Glycosylation-Associated Protein, Gap2, Required For The Biogenesis Of Streptococcus Parasanguinis Fimbriae-Associated Protein, Fap1, Haley Echlin
All ETDs from UAB
Streptococcal species possess a multitude of adhesins that facilitate adherence to a wide range of substrates; this is the first step necessary for the development of disease. Streptococcus parasanguinis is a primary colonizer of the oral cavity and adheres to the tooth surface using long fimbriae, which are composed of Fap1, a serine-rich repeat glycoprotein (SRRP). SRRPs are conserved in many Gram-positive bacteria and play a role in bacterial adhesion, fimbrial formation, biofilm formation, and bacterial pathogenesis. Although SRRPs play such an important role, the exact mechanism of their biogenesis remains a mystery. For Fap1, an eleven gene cluster is …
Formaldehyde Exposure In Pregnant Women And Its Relationship To Fetal Growth, Azita Amiri
Formaldehyde Exposure In Pregnant Women And Its Relationship To Fetal Growth, Azita Amiri
All ETDs from UAB
Formaldehyde exposure during pregnancy has been linked to adverse pregnancy outcomes such as poor fetal growth, although few studies have examined formaldehyde exposure during pregnancy and its relationship to fetal growth. The purpose of this study was to determine the level of formaldehyde exposure during pregnancy and examine the relationship between formaldehyde exposure and fetal growth. Formaldehyde exposure was examined, using vapor monitor badge and urine formic acid, in 140 women in their second trimester of pregnancy. One time urine samples were collected during a routine prenatal visit, and women wore the vapor badges for 24 hours. Fetal growth was …
Gene Expression Signatures In Tree Shrew Sclera In Different Visual Conditions, Lin Guo
Gene Expression Signatures In Tree Shrew Sclera In Different Visual Conditions, Lin Guo
All ETDs from UAB
The sclera is a target tissue that receives signals that are initiated in the retina, cascade through retinal pigment epithelium (RPE) and choroid, and cause scleral extra cellular matrix remodeling. Biomechanical alterations of the sclera are produced by these biochemical changes, and in turn control the axial length of the eye. This dissertation project examined scleral gene expression changes in mRNA level of juvenile tree shrews. Three specific aims were investigated: specific aim one tested the hypothesis that three different GO visual conditions that all produce axial elongation and myopia: minus-lens wear, form deprivation, and continuous darkness, will produce similar …
Protein O-Glcnac Modification In Diabetic Vascular Calcification, Jack Heath
Protein O-Glcnac Modification In Diabetic Vascular Calcification, Jack Heath
All ETDs from UAB
Vascular calcification is prevalent in patients of diabetes mellitus, which represents an independent risk factor that positively correlated with morbidity and mortality in these patients. Vascular calcification is now recognized as a cell-regulated process of osteogenic differentiation of vascular smooth muscle cells (VSMC) in response to stress, such as hyperglycemia and oxidative stress. Both hyperglycemia and oxidative stress have been shown to induce protein modification by O-linked ß-N-acetylglucosamine modification (O-GlcNAcylation), which is also elevated in diabetes. The present studies aimed to determine the effects of protein O-GlcNAcylation on vascular calcification in diabetes, and uncover the underlying molecular mechanisms. With the …
A Longitudinal Study Relating Patient Care Outcomes To Nurse Magnet Designation In United States Academic Medical Centers, Thomas R. Hunt
A Longitudinal Study Relating Patient Care Outcomes To Nurse Magnet Designation In United States Academic Medical Centers, Thomas R. Hunt
All ETDs from UAB
The purpose of this investigation is to determine whether the addition of the structural and process elements necessary for an academic medical center to garner its initial Magnet designation is associated with improved patient care. Donabedian's linear structure-process-outcome theory serves as the framework to empirically assess the relationship between Magnet status and patient care outcomes. The influence of such organizational factors as hospital size, clinical activity, and complexity of care is investigated. Secondary data from the American Nurse Credentialing Center (ANCC) and the University HealthSystem Consortium (UHC) is used as the basis of this empirical study. This investigation identified two …
Engineering Fibroblast-Remodeled Electrospun Matrices For Full-Thickness Skin Regeneration, Paul Bonvallet
Engineering Fibroblast-Remodeled Electrospun Matrices For Full-Thickness Skin Regeneration, Paul Bonvallet
All ETDs from UAB
Skin is often severely damaged, resulting in the need for surgical intervention. There are many limitations to current therapies, therefore a synthetic skin graft would be invaluable for skin regeneration. The focus of the current study is on developing engineered scaffolds with embedded dermal fibroblasts that can be remodeled into native skin tissue upon implantation. To achieve this goal we created electrospun scaffolds composed of collagen I and polycaprolactone (PCL), and then introduced pores to allow fibroblast infiltration. In initial experiments performed to optimize pore size and collagen to PCL concentration, we determined that a 160 µm pore diameter, and …
Actions Of Grape Seed Extract In Rodent Brain And Differences In Metabolism Of Its Polyphenols In A Rodent Model Of Menopause, John Kenneth Cutts
Actions Of Grape Seed Extract In Rodent Brain And Differences In Metabolism Of Its Polyphenols In A Rodent Model Of Menopause, John Kenneth Cutts
All ETDs from UAB
Grape seed extract (GSE), a dietary supplement, has potential in the treatment and prevention of human chronic age-related diseases including cancers, cardiovascular diseases, and neurodegenerative diseases. GSE and adult hippocampal neurogenesis, independently, have enhanced learning and memory in rodents. We hypothesized that GSE enhances learning and memory, at least partially, by enhancing hippocampal neurogenesis. However, adult mice given GSE did not exhibit increased number of progenitor cells or new neurons, established markers of neurogenesis, in the dentate gyrus (DG). Also, 26-day-old pups whose mother was given GSE only while nursing had fewer new neurons in the DG compared to control …
Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley
Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley
All ETDs from UAB
Current paradigms of carcinogenic risk suggest that genetic, hormonal, and environmental factors combine to influence an individual's predilection for breast cancer and related metastatic tumor formation. The genetic component, in particular, has become the focus of many emergent studies. A renewed focus on cancer metabolism and the Warburg effect has similarly cast a spotlight on the role, if any, of the mitochondrion in directing disease progression. Analysis of the direct contribution of mitochondrial DNA on tumorigenicity is made possible through the use of mitochondrial-nuclear exchange (MNX) mice in which nuclei from normal FVB mice (the background strain of the tg: …
Relationships Among Heart Failure-Related Physical Symptoms, Social Support, Social Problem-Solving, Depressive Symptomatology, And Self-Care Behaviors In Individuals Living With Heart Failure, Lucinda Joy Graven
All ETDs from UAB
Introduction: Heart failure (HF) is a chronic condition that progressively worsens over time. The condition is more common in individuals over the age of 65 and commonly causes dyspnea, fatigue, orthopnea, nocturnal dyspnea, edema, and activity intolerance. Prior studies suggest a relationship between HF-related physical symptoms and depressive symptomatology in individuals living with HF. Depressive symptomatology in individuals with HF are linked with a higher mortality rate, decreased quality of life, decreased functional status, and disturbed sleep. Additionally, HF-related physical symptoms impact self-care in individuals living with HF. Previous studies have found that symptom severity and the associated decrease in …
Assessing The Active Kinome Of Influenza Virus Infected A549 Cells, Colm Atkins
Assessing The Active Kinome Of Influenza Virus Infected A549 Cells, Colm Atkins
All ETDs from UAB
Influenza A Virus is a respiratory pathogen of the family Orthomyxoviridae and causes significant worldwide morbidity and mortality during seasonal epidemics and periodic pandemics. As with all viruses, influenza's limited coding capacity requires the use of host proteins and processes in its replication and release cycle. Phosphorylation, mediated by cellular kinases and phosphatases, represents a significant mechanism of post-translational modification of cellular products, and is responsible for regulating the activi-ty, lifespan and localization of many lipids and proteins in host-cells. Several cellular kinases have been associated with various steps of the Influenza lifecycle, including PKC-ßII (viral entry), PKR (host defense), …
Nutrition And Health Related Outcomes In Patients On Hemodialysis, Shawona Cannon Daniel
Nutrition And Health Related Outcomes In Patients On Hemodialysis, Shawona Cannon Daniel
All ETDs from UAB
Millions of Americans are affected by kidney disease and a large proportion of these individuals require hemodialysis to sustain life. This is a life changing event. The nutritional lifestyle changes associated with hemodialysis may be a key factor to health related outcomes such as depression and health-related quality of life (HRQOL). This study examined the relationship between selected demographic characteristics, nutritional status, measured by serum albumin, normalized protein catabolic rate (nPCR), body mass index (BMI), percent body fat, and self-report dietary protein intake, and HRQOL and depression in patients undergoing chronic hemodialysis. This study also examines the magnitude of correlation …
The Relationship Between Patient Complaints And Surgical Complications, Joseph Francis John
The Relationship Between Patient Complaints And Surgical Complications, Joseph Francis John
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THE RELATIONSHIP BETWEEN PATIENT COMPLAINTS AND SURGICAL COMPLICATIONS JOSEPH F. JOHN ADMINISTRATION - HEALTH SERVICES ABSTRACT Background: Patient complaints are viewed as indications of dissatisfaction with the service received or experience at a health care institution. The prediction of patient complaints is not clearly understood, and to date, very little quantitative research has evaluated the relationship between patient complaints and health care quality. Objective: The objective of this study was to examine whether (1) surgeons that operate on patients with higher perioperative surgical risk are associated with higher levels of patient complaints and (2) surgeons with higher levels of patient …
Statistical Methods For Set-Based Association Tests In Genetic Studies, Qi Yan
Statistical Methods For Set-Based Association Tests In Genetic Studies, Qi Yan
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This dissertation research focuses on developing statistical methods for set-based association tests at both pathway and gene levels in genetic studies. Set based analysis considers the biological hierarchical structure, while traditional genome-wide association studies usually focus on single-marker analysis which only access marginal effect. Therefore, pathway analysis may potentially complement single-marker analysis and provide additional insights for the genetic architecture of complex diseases. In the first study, we propose a novel way for pathway analysis that assesses the effects of genes using the sequence kernel association test (SKAT) and the effects of pathways via an extended adaptive-rank-truncated product statistic. For …
Gut Microbiome And Its Role In Obesity And Aging In C57bl/6j Mice, Yongbin Yang
Gut Microbiome And Its Role In Obesity And Aging In C57bl/6j Mice, Yongbin Yang
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The gut microbiome has been found to be associated with obesity, type 2 diabetes and many other diseases. Many studies have shown microbial composition changes with obese status or switching of diets. However, few of them have investigated the long-term microbial changes in subjects under the same environmental factors. This study examined gut microbiome changes in multiple aspects with well-controlled diet-induced obese mice models and demonstrated the following: there were great variations in gut microbiome composition and diversity in the same strain of inbred mice under the same environment and diet; certain lineages of bacteria were associated with digestive efficiency; …
Calreticulin Regulates Tgf-Ss Stimulated Extracellular Matrix Production, Kurt Zimmerman
Calreticulin Regulates Tgf-Ss Stimulated Extracellular Matrix Production, Kurt Zimmerman
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Calreticulin (CRT) is an ER chaperone and regulator of Ca2+ signaling which is increased following ER stress and in fibrotic and vascular fibroproliferative disorders. Previously, we demonstrated that ER CRT regulates type I collagen transcript, trafficking, secretion, and processing into the extracellular matrix (ECM). These studies investigated the role of CRT in regulating ECM production through control TGF-ß dependent signaling pathways. Our studies show that CRT -/- mouse embryonic fibroblasts (MEFs), rat lung fibroblasts, and human IPF lung fibroblasts with siRNA knockdown of CRT had impaired production of type I collagen and fibronectin when stimulated with TGF-ß. Similarly, knockdown of …
Effect Of Abutment Position On Retention After Cyclic Loading Of Cantilevered Y-Tzp Fpds, Aikaterini Kostagianni
Effect Of Abutment Position On Retention After Cyclic Loading Of Cantilevered Y-Tzp Fpds, Aikaterini Kostagianni
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Purpose: The influence of the vertical abutment positions on the retention of a three-unit implant supported cantilevered FPD restoration was measured and compared. Methods: The study included four groups (n=10) of cantilevered FPDs restorations, fabricated of monolithic zirconia. Prefabricated titanium implant abutments were used and connected to their analogs. The analogs were fixated on a split mold and their vertical position was adjusted on a 2 mm bases depending on the group, resulting also to an alteration of the occlusal thickness of the restorative material. The prosthesis were cemented to the abutments with Rely X Luting Plus resin modified glass …