An Interdisciplinary Approach To Online Genetics Education, Pinar Ozmizrak

All Dissertations

This dissertation presents an interdisciplinary approach to online genetics education.

Chapter I provides an overview of remote education and a brief history of genetics. While the COVID-19 pandemic prompted a turn to emergency online education, exposure to this form of delivery has led to increased intentional online education.

Chapter II focuses on computer and technology use in healthcare by nursing students. This study investigated nursing students’ perspectives using a modified version of the Pretest for Attitudes Toward Computers in Healthcare (PATCH) assessment scale to explore students’ ideas about computers and technology in healthcare delivery. According to the PATCH scale, the …

Variability In Anesthesia And Its Implications For Improving Patient Safety, Joshua Michael Biro

All Dissertations

Improving patient safety in anesthesia has proven to be an arduous and challenging task. Despite the many strategies and interventions to improve patient safety that have been employed, patient harm in anesthesia remains a problem. The struggle to reduce patient harm in anesthesia is both attributable to and representative of the complexity of the anesthesia system. In navigating this complex system, anesthesia providers have different approaches to how they accomplish their work, which results in variability in anesthesia practice. This variability provides an immense challenge to designing and implementing efforts to improve patient safety, as rigid interventions are often met …

Evaluation Of Bone And Muscle Quality In Laying Hens Using Quantitative, Radiographic, Computed Tomographic, Biomechanical, And Tissue Level Measures, Cerano Harrison

All Dissertations

Bone quality is an important measure of welfare in laying hens for researchers, veterinarians, and commercial producers who bear the responsibility of providing them with care. Breeding practices that have resulted in high egg productivity of laying hen strains have resulted in an increased susceptibility to developing osteoporosis. Osteoporosis, a decrease in mineralized bone, is accompanied by increased bone fragility that can lead to potentially painful bone fractures that can inhibit some aspects of the birds natural living, respiration and flight being two examples. Current methods of examining laying hen bone quality involve the implementation of diagnostic imaging and biomechanical …

Household Environments And Functional Decline Among Middle-Aged And Older Adults In China, Dandan Zhao

All Theses

This thesis investigates the associations between household social, economic, and physical environment conditions and the trajectory of self-reported functional limitations over time among middle-aged and older adults in China. Despite the increasing interest in the impact of household environments on functional decline, most existing studies are cross-sectional or concern changes in functioning observed in two waves of surveys, and they primarily focus on the influence of one condition. This thesis explores how the trajectory of functional decline is influenced jointly by multiple household factors, including living arrangement, annual living expenditure per capita, indoor air pollution resulting from solid fuels, and …

Photodynamic Therapy To Treat Triple Negative Breast Cancer In Vitro, Hunter S. Warren

All Theses

Triple negative breast cancer (TNBC) is the most resilient form of breast cancer, being one of the leading causes of death for women and making up 7% of all cancer deaths. Photodynamic therapy (PDT) offers a minimally invasive solution to TNBC as a passive-targeting treatment that reduces the need for other well established yet harsh treatments that can be taxing on the patient. PDT involves the use of a high-energy red light on the area of a tumor injected with photosensitizers (PS) that generate reactive oxygen species (ROS) in the tumor, triggering cell death. The PS tetra(hydroxyphenyl)chlorin (m-THPC) was used …

Assessing The Snap Consumer Environment At Farmers Markets, Gabrielle C. Young, Sarah Misyak, Meredith Ledlie Johnson, Natalie E. Martin, Elena Serrano

The Journal of Extension

The SNAP at Farmers Market Environmental Assessment was developed as a tool for market managers to examine SNAP participant accessibility for redeeming SNAP benefits at farmers markets. By completing the SNAP at Farmers Market Environmental Assessment, the tool can serve as a guide for providing practical next steps for market improvement. Extension practitioners and researchers, including SNAP-Ed staff, can use the assessment tool to support policy, systems, and environment change efforts that promote access to local, high-quality foods by SNAP consumers, the redemption of SNAP benefits, and potentially increased sales at farmers markets.

Live Well, Eat Well, Be Active With Diabetes Curriculum Improves Type 2 Diabetes Management, Lauren Amaya, Dana Baldwin, Kathy Enyart, Arleen James, Tommie M. James, Penny R. King, Jan Maples, Lindy Peterman, Sara Randolph, Dea Rash, Kelsey Ratcliff, Joy Rhodes, Jessica Riggin, Janis Risley, Danette Russell, Janice Hermann

The Journal of Extension

Type 2 diabetes is a complex disease with several modifiable lifestyle factors. The Extension ‘Live well, Eat well, be Active with Diabetes’ curriculum provides four 90-minute lessons teaching individuals to live well, eat well, and be active with diabetes. Fourteen Extension educators implemented and evaluated the curriculum with 107 participants. Participants reported the program helped them feel better able to take care of their health. We observed significant differences in participants’ retrospective pre and post ‘Live well,’ ‘Eat well’ and ‘be Active’ total scores. Extension has a unique opportunity to educate individuals so they may better manage their diabetes.

Circumventing Ableism: A Grounded Theory Study Exploring Caregiver Strategies To Promote A Positive Identity, June Furr

All Dissertations

This qualitative research study explores how caregivers and persons with disabilities navigate the rhetoric of disability and caregiving through the interviews of fifteen caregivers and fifteen persons with disabilities using the lens of grounded theory and Burke’s (1952) dramatistic pentad. Significant findings describe how focused disability description can circumvent ableism when rhetorical resources that assist caregivers and persons with disabilities to navigate the rhetoric in disability descriptions are provided. Disability description theory includes the three stages that define, collaborate and revise, and practice and apply a disability description. This qualitative research offers an introduction into the phenomenon of …

Modeling Antihypertensive Therapeutic Inertia And Intensification To Support Clinical Action Toward Hypertension Control, Benjamin Martin

All Dissertations

Background

Hypertension is the leading modifiable risk factor for cardiovascular disease and consequent mortality worldwide. In the U.S., more than half of hypertension cases remain uncontrolled, despite availability of effective pharmaceutical treatment options. Evidence suggests that therapeutic inertia, defined as clinician failure to initiate or increase therapy when treatment goals are unmet, is the most influential barrier to improving hypertension control. Substantial rates of therapeutic inertia have been reported in ambulatory primary care settings where hypertension is typically treated and managed. Understanding and overcoming the forces driving therapeutic inertia in hypertension management is a critical strategy to reach population health …

Development Of A Novel Predictive Model And Prosthetic System To Assess Dynamic Leg Length Based Gait Biomechanics In Lower Limb Prosthesis Users, Therese Parr

All Dissertations

Individuals with transfemoral amputation often rely on a prosthesis as a replacement for their missing extremity’s structure and function. Lower-limb prosthetic devices are developed with the goal of restoring biomechanical abilities and mitigating secondary health risks for users. However, biomechanical deficits for unilateral transfemoral prosthesis users are very common and are induced by both leg length discrepancy (LLD) and current prosthetic design shortcomings. Lack of push off power as well as difficulty shortening the leg for toe clearance can result in gait compensations that lead to asymmetric limb loading, increased muscle activity, and an increased incidence of falling due to …

Comparison Of Covid-19 Diagnostic Testing Methodologies In The U.S., Joseph Blommel

All Dissertations

The onset of the COVID-19 pandemic brought about a world in which diagnostic testing for the virus that is responsible for COVID-19, SARS-CoV-2, became commonplace. Diagnostic testing was required for myriad reasons beyond simple diagnosis. We set out to compare SARS-CoV-2 testing methods, see if differences sensitivity correlated to increased positivity, and to evaluate self-collection methods.

In examining the Limit of Detection (LoD) of tests receiving FDA Emergency Use Authorization (EUA), our findings indicated that there were considerable differences in LoD. However, these differences in observed sensitivity were not correlated with the methodologic differences as reported in EUA documentation.

We …

Influences On Pregnancy: An Exploration Of Maternal Discrimination, An Alternative Model Of Prenatal Care And Health Information Online, Emily Doherty

All Dissertations

In the United States metrics of perinatal health lag far behind peer countries and is characterized by stark disparities. The studies that make up this dissertation seek to elucidate factors influencing perinatal health.

The first and second chapters provide an introduction and extensive review of the literature of factors contributing to perinatal health with specific focus on discrimination and perinatal health; group prenatal care and digital pregnancy health information. The third chapter introduces the methodology to be used by each of the following studies. Subsequent chapters are formatted as individual manuscripts, each presenting background, methodology, results, and discussion.

The fourth …

Opioid Prescribing Practice & Policy – A Study Of Medicaid Pediatric Population In South Carolina, Laksika Sivaraj

All Dissertations

Opioids are widely used as analgesics in different clinical settings, but they are also highly criticized for their downsides. Among the adult population, the addictive nature of opioids continues to be the main concern, while among young children, there are other adverse health outcomes that opioids can cause. These concerns have led the US Food and Drug Administration (FDA) and other professional bodies to discourage opioid prescribing for children. Nevertheless, opioids continue to be prescribed for children for contraindicated health conditions. The goal of this research is to assess opioid prescribing practices for the pediatric population in South Carolina (SC). …

A Systematic Review Of Research On Treatment & Prevention Of The Neglected Tropical Disease Leishmaniasis, Aryn Akerberg

All Theses

Leishmaniasis is a life-threatening neglected tropical disease that is caused by the protozoa parasite, Leishmania. Over one million new human leishmaniasis cases occur each all over the world, affecting most the deeply impoverished regions of the world. The disease presents in three different forms: cutaneous leishmaniasis, mucocutaneous (mucosal) leishmaniasis, and visceral leishmaniasis. Symptoms can range from self-limiting lesion to more life-threatening conditions such as fever, kidney disease, and anemia. The Leishmania parasite is transmitted via the bite of the female phlebotomine sandfly and can infect many other mammals such as canines, rodents, bats, etc. The canine leishmaniasis epidemic is also …

An In Vivo Biocompatibility Analysis Of A Novel Tissue Regeneration Matrix Using A Pig Model, Shamar Thomas

All Theses

The goal of this project is to develop an injectable bead scaffold to promote tissue regeneration in the void created by lumpectomy and to alleviate post lumpectomy problems by preventing local recurrence and minimizing surgical-related infections. Microbeads were synthesized from collagen type I and crosslinked with tannic acid to form the basis for this injectable therapeutic. Tannic acid acts as a therapeutic anticancer agent. The action mechanisms of tannins in breast cancer cells have been studied with studies showing tannins to be cytotoxic to cancer cells in a dose-dependent manner. Tannic acid induces apoptosis in breast cancer cells via caspase …

Trauma, Found Family, And Their Influence On The Creation Of A Pitch Bible, David Scheele

All Theses

Trauma is a very common theme in works of fiction, as it is something that all of us
experience in our lives and as a result is emphasized in art. Whether it is injuries, abuse, the loss of loved ones, and much more, trauma is ubiquitous within the human experience. Sometimes trauma can have lasting impacts on an individual’s mental health, often taking the form of Post-Traumatic Stress Disorder, or PTSD as it is more commonly known. We see this form of mental illness portrayed quite often in the media that we consume. Examples across various artistic mediums include Sarah …

Diagnosis Of Urinary Tract Infections And Rapid Molecular Characterization Of Antibiotic Resistance, Mohammed Harris

All Dissertations

Urinary tract infections (UTIs) are one of the most common infectious clinical entities in both community and hospital settings. They have a broad range of clinical severity yet inflict large epidemiological burden of morbidity and mortality on patients and the healthcare system with billions of dollars in cost of treatment. Understanding what methods are optimal for diagnosing UTIs are critical to mitigate the marked impact and cost of these infections.

Chapter 1 and 2 in this work surveys the broad array of diagnostic modalities for UTIs and highlights their advantages and limitations in the context of the current standard of …

Rated T For Therapy: How Video Games Portray Mental Illness And Their Effects On Social Stigmas, Christine Wendell

All Theses

Mental illness has always been a tricky subject for us to tackle as a society due to the social stigmas surrounding it. Historically, people with mental illness were seen as violent and unstable and would often need to be committed for public safety; however, a large majority of people with mental illness do not fit that bracket and often don’t reach out for help due to that fear of being “othered” by society. As time went on, these tropes faded to purely entertainment mediums but the stigmas still remain. Many video games specifically hold onto these tropes for shock value …

The Role Of Leisure Engagement In Fostering Cognition In Aging, Karen Wenzel

All Dissertations

Leisure activities are a major component of healthy aging, associated with reduced risk of cognitive decline and enhanced cognitive function. However, there is wide variation in the conceptualization and measurement of leisure. Specific leisure activities or domains have been studied in association with cognition in aging. More recently, researchers have noted that attributes of the activity, rather than the activity itself, may be significant. This study explored the current state of knowledge regarding attributes of leisure activities that foster cognition in aging. A literature review using PRISMA Scoping Review guidelines identified objectively and subjectively measured attributes of leisure engagement in …

Diabetes Self-Management Education And Support: Understanding Knowledge And The Impact, Christina Dietz

All Dissertations

Diabetes has reached epidemic proportions in the United States. To address this, many organizations employ diabetes self-management education and support (DSMES) programs to aid in managing the impact of increasing prevalence. The purpose of this dissertation is to examine the impact of two Upstate South Carolina DSMES programs on several process and outcome measures for adults with diabetes, while also identifying current primary care provider DSMES knowledge and perceptions in an Upstate South Carolina health system.

This dissertation found inconclusive results on the impact of DSMES on PCP utilization, retinal exam screening, nephropathy attention, HDL, LDL, TC, and TG. DSME …

X-Ray Interrogated Implantable Chemical And Strain Sensors For Monitoring Implant Associated Infections And Fracture Healing, Apeksha Rajamanthrilage

All Dissertations

Bone fracture healing includes complex and sequence of dynamic events to restore the integrity and biomechanical properties of the bone. While most of the fractures heal without any problem, healing is sometimes compromised. Two significant fracture healing complications are orthopedic implant-associated infections and non-unions/delayed union. These can be interrelated causes as well. Implant-associated infection can cause implant loosening, and as a result, it can delay the fracture healing process. Herein, we describe two different types of sensors that can be used in monitoring biochemical and biomechanical processes of fracture healing using X-rays.

We developed a XELCI (X-ray Excited Luminescence Chemical …

The Impact Of Covid-19 On Recreational Therapists Working In Inpatient Mental Health Settings, Summer Matics

All Dissertations

Since 2020, the novel coronavirus (COVID-19) has impacted the lives of the general public, but healthcare workers including those that work in inpatient mental health settings have seen long-lasting impacts in their workplace. Recreational therapists (CTRSs) are among the mental healthcare workers that have been impacted by the pandemic but there is no existing research that specifically studies their lived experiences. This study used the theoretical foundations and methods of hermeneutic phenomenology in order to describe how COVID-19 has impacted CTRSs’ workplace from a safety perspective, their stress and coping, and also their supervisory duties. Seventeen participants were recruited and …

Data-Driven Biomarker Panel Discovery In Ovarian Cancer Using Heterogenous Data Fusion On Exosomal And Non-Exosomal Microrna Expression Data, Paritra Mandal

All Dissertations

Ovarian cancer (OC) is an aggressive gynecological cancer and is currently the 5th leading cause of deaths due to cancer in women. High mortality rates are attributable to the vague pathogenesis and asymptomatic nature of the early stages. The development of a liquid biopsy for routine OC screening could help identify the disease at an earlier stage, making treatments more likely to be effective thereby increasing survival rates. Exosomes, small (~100nm) extracellular vesicles present in body fluids, have been shown to contain cancer-progression, onset, and related factors, making them good candidates for use in liquid biopsies. However, to date, only …

Highly Adherent Antimicrobial Coatings For Orthopedic Implants, Mikhail Bredikhin

All Dissertations

Fracture-related infections (FRIs) are the most devasting sort of complications associated with fracture fixation devices, as they lead to patients’ morbidity, prolonged hospitalization, amputations, and even death.External fixators additionally suffer from pin site infections (PSIs), which initiate at the skin entry points of the skin-metallic pin interface present in the external fixation of the damaged bones, often causing deep tissue infection and osteomyelitis. Small percutaneous pins, commonly known as Kirschner wires (K-wires), are used to treat complex fractures and deformities.They are drilled inside the diseased bone for the healing period and are left protruding outside the skin for fixation adjustments …

Serious Leisure, Job Task Load, & Satisfaction, Carson Matsick

All Theses

The study examined the relationship between degree of leisure seriousness and leisure, job, and life satisfaction, as moderated by perceived job mental workload. Serious leisure has largely been studied in reference to general life satisfaction and health outcomes, and less research exists to examine whether serious leisure participation may influence work. This study tested the following hypothesis: the relationship between serious leisure participation and employee well-being is moderated by mental workload on the job, such that a) as mental workload increases, then serious leisure participation and satisfaction will be less strongly positively correlated, and b) as mental workload decreases, then …

Barriers And Facilitators In Implementing Multiplatform Remote Patient Monitoring Of Heart Failure Patients In Clinical Settings, Zachary Andrew Reilly

All Theses

Remote patient monitoring (RPM), which provides continuous monitoring of vital signs, has become increasingly utilized in patients with heart failure (HF). As this condition impacts more than 26 million Americans each year, it is important to determine the barriers and facilitators of RPM to both improve patient care and help medical professionals make more informed medical decisions. To determine these barriers and facilitators, our research team partnered with Prisma Health-Upstate to interview healthcare professionals working at Carolina Cardiology Consultants--Greenville, which uses multiple RPM systems to monitor heart failure patients.

The twelve interviews conducted support that healthcare professionals would benefit from …

Scuba Diving Social Identity, Type Of Experience, Sociopsychobio Health, Health-Related Quality Of Life, Self-Efficacy, Disability Level, And Personality Among People With Physical Impairments: A Mixed Methods Study, Tania Santiago Perez

All Dissertations

The most common type of disability in the US is mobility or physical impairment, occurring in one in seven adults. Globally, musculoskeletal and neurological conditions account for nearly two-thirds (65.6%) of total physical rehabilitation needs. Approaches that promote healthy community living, rehabilitation, and reduce relapse and rehospitalization among people with physical impairments are critical. Participation in recreational activities and identification with social recreational groups may promote the health, quality of life, and functional abilities of people with physical impairments, contributing to reducing their hospitalization and healthcare needs. This explanatory sequential mixed methods research study had two aims. Using the experience-type …

Protecting Cattle Feedyard Workers In The Central States Region: Exploring State, Regional, And National Data On Fatal And Nonfatal Injuries In Agriculture And The Beef Production Sector, Athena K. Ramos, Suraj Adhikari, Risto Rautiainen, Aaron Yoder

The Journal of Extension

Working in agriculture can be dangerous. Despite ongoing efforts of Extension, animal production worker safety has not been adequately addressed. We present state, regional, and national counts and rates on fatal and nonfatal injuries in agriculture and animal production using publicly available data from the Bureau of Labor Statistics. We found that animal production had a high number of fatal injuries and a higher rate of nonfatal injuries than the average within agriculture. More needs to be done to protect livestock workers from injury. Extension professionals can play a key role in increasing safety knowledge and changing behaviors.

Covid-19 Prevention Behaviors In A Cooperative Extension Audience: Findings From A Nutrition Education Study, Matthew Greene, Catherine Ruth Losavio, Denise Holston

The Journal of Extension

The COVID-19 pandemic has dramatically impacted the delivery of nutrition education through Cooperative Extension. This study aimed to identify a Cooperative Extension audience’s attitudes towards virus prevention behaviors, preferred sources of information regarding COVID-19, and nutrition education preferences during the pandemic. We distributed an online survey to 477 potential nutrition education participants including questions about behaviors like mask wearing, preferences for virtual nutrition lesson delivery, and attitudes towards sources of information about COVID-19. Attitudes towards mask wearing and preferred sources of information differed significantly by race, income, and age. These differences have serious implications for future outreach and program delivery.

Minnesota Cottage Food Industry: Insights From Extension Food Safety Education, Morrine Omolo, Regina Mcgoff, Suzanne Driessen, Katherine Brandt, Joanne Slavin, Michael Schmitt

The Journal of Extension

The cottage food industry has become a significant part of the food supply in Minnesota, most likely as a result of the growing consumer demand for locally produced, minimally processed and value-added foods. Using post-training evaluations, we characterized the cottage food producers in Minnesota and assessed the impact of our food safety course. The results showed that the producers are mostly white women (71%), producing and selling a variety of products. The learners gained knowledge to safely produce and handle homemade food products for direct sale to consumers. Majority (80%) of the learners were satisfied with the course.