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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park
Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park
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Beginning with the development of an embryo and throughout one's adult life angiogenesis plays an essential role for organ growth and repair. The balancing of pro-angiogenic factors to anti-angiogenic factors is what regulates the process of angiogenesis. When this balance is disrupted in one direction or the other, numerous disorders can occur including ocular and inflammatory diseases and, in particular, tumor growth and metastasis. Therefore, inhibition of angiogenesis has become an effective therapy for arresting the growth of tumors.
A key regulator of angiogenesis involves vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (KDR). The binding of VEGF to …
Evaluation Of Human Prolactin, Its Antagonist, And Antagonist-Based Fusion Proteins As Chemopreventative And Therapeutic Agents, Seth Tomblyn
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Cancer is a collection of diseases with many different manifestations and is the second leading cause of death in the United States. Breast cancer accounts for nearly one third of cancer diagnosis in women. Prolactin (PRL) functions as a lactogen and as a mammary gland differentiation factor. PRL acts in an autocrine/paracrine manner within the mammary gland and in breast tumors which implies PRL may be involved in breast cancer progression. This is corroborated by the PRLR over-expression in breast cancer cells lines and the majority of patient biopsies. These reasons make PRL and PRLR attractive targets for breast cancer …
Influence Of Stroke Clinical Pathway On Documentation, Shannon Sternberg
Influence Of Stroke Clinical Pathway On Documentation, Shannon Sternberg
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The purpose of this study was to determine whether the implementation of a stroke clinical pathway could improve compliance with documentation of specific quality measures for patients admitted with the diagnosis of acute ischemic stroke, hemorrhagic stroke, or transient ischemic attack. The study used the ten standardized performance measures for stroke identified by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) and integrated documentation of those measures into a stroke clinical pathway consisting of physician order sets, an interdisciplinary plan of care, and a patient/family education flow sheet. The American Stroke Association's Get with the Guidelines - Stroke (GWTG-Stroke) …
Profiling The Quality Of End Of Life Care, Catherine Murton
Profiling The Quality Of End Of Life Care, Catherine Murton
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ABSTRACT
Despite increased national debate regarding quality of life and quality of care at the end of life, patients in the United States continue to die primarily in hospitals experiencing a myriad of distressing symptoms, leaving caregivers and healthcare professionals wondering if caring for the dying will ever change in this country. There are alternatives available, but it is necessary to assess current conditions for dying patients in order to change the status quo in end of life care. Profiling how patients experience the last few months of life, as well as their terminal hospital stay, is a starting point …