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Full-Text Articles in Medicine and Health Sciences
Didox Modulates Reactive Oxygen Species Production And Inflammatory Events Induced By Lipopolysaccharide (Lps) And Aryl Hydrocarbon Receptor (Ahr) Ligands In Raw 264.7 Murine Macrophages., Thabe Matsebatlela
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Aberrant activation of macrophages during inflammation results in oxidative burst release of reactive oxygen and reactive nitrogen species (ROS/RNS) which are widely accepted to participate in pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer's disease and Parkinson's disease), rheumatoid arthritis, and ageing. It is demonstrated here that Didox (3,4-Dihydroxybenzohydroxamic acid) possesses antioxidative and anti-inflammatory properties that can protect against inflammation and oxidative stress induced by lipopolysaccharide (LPS) and aryl hydrocarbon receptor (AHR) ligands (PCB126, E804, and IO) in Raw 264.7 murine macrophages. In brief, it is demonstrated here that Didox inhibits LPS-induced oxidative stress, …
Effects Of Polyunsaturated Fatty Acids On Multidrug Resistance And Dna Methylation In Human Cancer Cell Lines, Cheng-Yi Kuan
Effects Of Polyunsaturated Fatty Acids On Multidrug Resistance And Dna Methylation In Human Cancer Cell Lines, Cheng-Yi Kuan
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Accumulating evidences indicate that dietary intake of long-chain polyunsaturated fatty acids (PUFAs) can affect various cellular processes and improve response of cancer cells to chemotherapy. The mechanisms by which PUFAs affect this response are not well understood. P-glycoprotein (P-gp), encoded by the multidrug resistance gene MDR1, is a drug efflux transporter that plays an important role in the bioavailability of anti-cancer drugs. Effects of long-chain polyunsaturated fatty acids on MDR1 gene expression and functional activity in the human colon cancer cell line Caco-2 were studied in this research. Caco-2 cells were treated with different concentrations of three PUFAs: eicosapentaenoic acid …
Cooking With A Chef: A Culinary Nutrition Intervention For College Aged Students, Andrew Warmin
Cooking With A Chef: A Culinary Nutrition Intervention For College Aged Students, Andrew Warmin
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The primary objective of this study is to provide evidence that a culinary nutrition intervention is appropriate for, and of value to college students. A secondary objective is to provide evidence that the nutrition component of a culinary nutrition course can be delivered online through an interactive presentation. The study initially involved a review of literature highlighting the nutrition habits of college students, the strengths and weakness of existing cooking and nutrition classes, and other factors relating to the college student's health. Based on this literature review it was determined that a culinary nutrition course is an appropriate way to …
Women, Birth Control Pills, And Thrombophilia: An Analysis Of Risk Communication, Kerry Gomer
Women, Birth Control Pills, And Thrombophilia: An Analysis Of Risk Communication, Kerry Gomer
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The Surgeon General recently issued a call to action to reduce the incidents of blood clots, which can cause pulmonary embolism, deep vein thrombosis, and stroke. This research study was conducted to assess what risk information is available to women regarding thrombosis (blood clots) and thrombophilia (clotting disorders) in combination with birth control pills, what women know about this issue, and how to increase this awareness. A media analysis showed that very little information is available to women about thrombosis and thrombophilia with regard to birth control pills. It also demonstrated that the information that is available is often inadequate …