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Articles 1 - 30 of 67
Full-Text Articles in Medicine and Health Sciences
Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani
Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani
Majalah Ilmu Kefarmasian
Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 µg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group.
Family Health Portrait, Joseph A. Woelfel
Family Health Portrait, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Green Engineering And Gate-To Gate Life Cycle Assessments For Pharmaceutical Products, Daniel Fichana
Green Engineering And Gate-To Gate Life Cycle Assessments For Pharmaceutical Products, Daniel Fichana
Theses and Dissertations
The research of this thesis focused on the environmental and processing metrics during the development of two different drugs. Previous research in life cycle assessments and green engineering have focused on other products and processes, but only a limited amount of studies have been conducted for pharmaceutical applications. This analysis concerned a gate-to-gate analysis of two distinct pharmaceutical products along with the development of a solvent selection table. The goal of this research was to determine how various processing and environmental metrics were affected by process improvements.
The first drug was the pravastatin, which was made via a fermentation route. …
Hypocaloric Nutrition In The Critically Ill Patient. Move Over South Beach, Jane Gervasio
Hypocaloric Nutrition In The Critically Ill Patient. Move Over South Beach, Jane Gervasio
Jane M. Gervasio
No abstract provided.
Hypocaloric Feeding, Permissive Underfeeding, And The Use Of Anabolic Agents In The Critically Ill Patient, Jane Gervasio
Hypocaloric Feeding, Permissive Underfeeding, And The Use Of Anabolic Agents In The Critically Ill Patient, Jane Gervasio
Jane M. Gervasio
No abstract provided.
A Stepwise Guide To Selecting A Medicare Prescription Drug Plan, Joseph A. Woelfel
A Stepwise Guide To Selecting A Medicare Prescription Drug Plan, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Medicare Part D Resources For The Health Professional, Joseph A. Woelfel
Medicare Part D Resources For The Health Professional, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
New Take-Home Screening Tests For Colon Cancer, Joseph A. Woelfel
New Take-Home Screening Tests For Colon Cancer, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Nutritional Support In The Acute Care Patient Post-Ventricular Assist Device Placement, Abby Re, Jane M. Gervasio, Robert D. Warhurst, Gary P. Zaloga
Nutritional Support In The Acute Care Patient Post-Ventricular Assist Device Placement, Abby Re, Jane M. Gervasio, Robert D. Warhurst, Gary P. Zaloga
Scholarship and Professional Work – COPHS
Abstract from American College of Clinical Pharmacy Annual Meeting, San Francisco, CA, October 23-26, 2005.
Application Of Polyelectrolyte Layer-By-Layer Nano-Assembly For Surface Modification, Encapsulation And Controlled Release, Nikhil Anil Pargaonkar
Application Of Polyelectrolyte Layer-By-Layer Nano-Assembly For Surface Modification, Encapsulation And Controlled Release, Nikhil Anil Pargaonkar
Doctoral Dissertations
In this study, we applied the traditional Electrostatic layer-by-layer (ELBL) assembly procedure to fabricate nanothin films over flat surfaces, and modify particle surfaces to influence the drug particle size, and drug release. The ELBL assembly has previously been applied to fabricate multilayer nano-scale thin films, but its ability to instantaneously influencing particle size is unique. Other unique observations such as influence on drug release as a result of polymer complexation, and thermal changes occurring during layer fabrication are recorded.
The ELBL self-assembly process was applied to produce dexamethasone particles layered with various polyelectrolyte layer combinations. These combinations were further applied …
Cis-2,6-Disubstituted Piperidines For The Treatment Of Psychostimulant Abuse And Withdrawal, Eating Disorders, And Central Nervous System Diseases And Pathologies, Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
Cis-2,6-Disubstituted Piperidines For The Treatment Of Psychostimulant Abuse And Withdrawal, Eating Disorders, And Central Nervous System Diseases And Pathologies, Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
Pharmaceutical Sciences Faculty Patents
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula...
To see the remainder of this abstract, please download this patent.
Hipaa Confusion And Fear About Protected Health Information, Joseph A. Woelfel
Hipaa Confusion And Fear About Protected Health Information, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
The Chemical Species Of Aluminum Influences Its Paracellular Flux Across And Uptake Into Caco-2 Cells, A Model Of Gastrointestinal Absorption, Yuzhao Zhou, Robert A. Yokel
The Chemical Species Of Aluminum Influences Its Paracellular Flux Across And Uptake Into Caco-2 Cells, A Model Of Gastrointestinal Absorption, Yuzhao Zhou, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Aluminum (Al) can cause neurotoxicity, a low-turnover osteomalacia, and microcytic anemia. To test the null hypothesis that the chemical form (species) of Al does not influence its mechanism or rate of absorption from the gastrointestinal tract, Al flux across and uptake into Caco-2 cells was investigated. Caco-2 cells were grown on porous membranes mounted in vertical diffusion chambers or in 35-mm-diameter plastic cell culture dishes. When 8 mM 27Al was introduced as the ion, citrate, maltolate, fluoride, or hydroxide, the apical to basolateral apparent permeability (Papp) of Al correlated highly with the Papp of lucifer yellow …
Pharmacy Newsletter : September 2005, Pharmacy Department
Pharmacy Newsletter : September 2005, Pharmacy Department
Pharmacy Newsletter
Content:
- Are Expired Drugs Dangerous?
- ADR Reportage—Year wise Presentation
- NEWS ALERT! Use of Promethazine (Phenargan) in Children
- Important Drug Warning - Herceptin (Trastuzumab)
Rna Therapeutic, Pendekatan Baru Dalam Terapi Gen, Amarila Malik
Rna Therapeutic, Pendekatan Baru Dalam Terapi Gen, Amarila Malik
Majalah Ilmu Kefarmasian
Some diseases, such as cancer, hereditary and genetic diseases, as well as viral infectious diseases, have been treated unsatisfied by the conventional therapy so far, and even more, by the gene therapy. Together with the pharmaceutical industries, researchers put their best effort to hunt some molecules that can be more favorable for such kind of therapy. After a pivotal study reported in May, 2001, it is certain that Ribonucleic acid (RNA) could effectively silence gene expression in mammalian cell line, so it was then proposed in 2004 the term RNA therapeutics. Antisense RNA therapy which came into the stage earlier …
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six small …
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Maria Cekanova MS, RNDr, PhD
BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six small …
Antitrypanosomal, Antileishmanial, And Antimalarial Activities Of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, A New Class Of Trypanothione Reductase Inhibitor, And Of N-Acyl Derivatives Of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, Kenneth T. Douglas
Antitrypanosomal, Antileishmanial, And Antimalarial Activities Of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, A New Class Of Trypanothione Reductase Inhibitor, And Of N-Acyl Derivatives Of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, Kenneth T. Douglas
Pharmaceutical Science and Research
Quaternization of the nitrogen atom of 2-amino-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition ∼40-fold (3′,4′-dichlorobenzyl-[5-chloro-2-phenylsulfan- ylphenylamino)-propyl]-dimethylammonium chloride inhibited trypanothione reductase from Trypanosoma cruzi with a linear competitive Ki value of 1.7 ( 0.2 µM). Molecular modelling explained docking orientations and energies by: (i) involvement of the Z-site hydrophobic pocket (roughly bounded by F396′, P398′, and L399′), (ii) ionic interactions for the cationic nitrogen with Glu-466′ or -467′. A series of N-acyl-2-amino-4-chlorophenyl sulfides showed mixed inhibition (Ki, Ki′ ) 11.3-42.8 µM). The quaternized analogues of the 2-chlorophenyl phenylsulfides had strong antitrypanosomal and antileishmanial activity in vitro against T. bruceirhodesiense STIB900, …
Toll-Like Receptor-4 Regulation Of Hepatic Cyp3a11 Metabolism In A Mouse Model Of Lps-Induced Cns Inflammation, Kerry B. Goralski, Dalya Abdulla, Christopher J. Sinal, Andre Arsenault, Kenneth W. Renton
Toll-Like Receptor-4 Regulation Of Hepatic Cyp3a11 Metabolism In A Mouse Model Of Lps-Induced Cns Inflammation, Kerry B. Goralski, Dalya Abdulla, Christopher J. Sinal, Andre Arsenault, Kenneth W. Renton
Faculty Publications and Scholarship
Central nervous system (CNS) infection and inflammation severely reduce the capacity of cytochrome P-450 metabolism in the liver. We developed a mouse model to examine the effects of CNS inflammation on hepatic cytochrome P-450 metabolism. FVB, C57BL/6, and C3H/HeouJ mice were given Escherichia coli LPS (2.5 μg) by intracerebroventricular (ICV) injection. The CNS inflammatory response was confirmed by the elevation of TNF-α and/or IL-1β proteins in the brain. In all mouse strains, LPS produced a 60–70% loss in hepatic Cyp3a11 expression and activity compared with saline-injected controls. Adrenalectomy did not prevent the loss in Cyp3a11 expression or activity, thereby precluding …
New Medicare Part D Prescription Drug Information: Preparing For The Change, Joseph A. Woelfel
New Medicare Part D Prescription Drug Information: Preparing For The Change, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
2005 Apothecary, Southwestern Oklahoma State University
2005 Apothecary, Southwestern Oklahoma State University
Apothecary
Congratulations to the graduating seniors of December 2004 and May 2005, to whom the 2005 Apothecary is dedicated. It is our hope that the memories captured in this edition may remind you of the years you have devoted to preparing for a successful career in pharmacy. We wish you the very best in all your endeavors.
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Pharmaceutical Sciences Faculty Publications
Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.
Oral Administration Of Capsules For Inhalation, Joseph A. Woelfel
Oral Administration Of Capsules For Inhalation, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
As-Needed Inhaled Corticosteroids For Mild Persistent Asthma, Joseph A. Woelfel
As-Needed Inhaled Corticosteroids For Mild Persistent Asthma, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed 54Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain 54Mn uptake correlated inversely with calcium (Ca) concentration, but 45Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …
The Effects Of Price Regulation On Pharmaceutical R&D And Innovation, Heather M. O'Neill, Lena Clarissa Crain
The Effects Of Price Regulation On Pharmaceutical R&D And Innovation, Heather M. O'Neill, Lena Clarissa Crain
Business and Economics Faculty Publications
As rising health care expenditures focus government attention on slowing the growth, the pharmaceutical industry comes under increasing pressure to curb prices of ethical drugs. Pharmaceutical price regulations have been implemented in many countries to control pharmaceutical expenditures. Yet, creating innovative drugs requires enormous R&D costs, which in turn require adequate expected economic returns. Since price controls reduce profits and expected returns, as countries invoke stricter price regulations, firms will either move their R&D process into less regulated markets or move out of innovative R&D. This paper assesses the impact of drug price regulations in Japan compared to market-priced drugs …
Clinical Trials, Jane Gervasio
Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
Pharmaceutical Sciences Faculty Patents
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.