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Articles 31 - 60 of 67
Full-Text Articles in Medicine and Health Sciences
Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Pharmaceutical Sciences Faculty Patents
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.
Generic Duragesic (Fentanyl) Patches, Joseph A. Woelfel
Generic Duragesic (Fentanyl) Patches, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Bisphosphonate-Associated Jaw Osteonecrosis, Joseph A. Woelfel
Bisphosphonate-Associated Jaw Osteonecrosis, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Bone, Muscle, And Joint Problems With Bisphosphonates, Joseph A. Woelfel
Bone, Muscle, And Joint Problems With Bisphosphonates, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
A Different Drug, A Different Country, But The Same Brand Name?, Joseph A. Woelfel
A Different Drug, A Different Country, But The Same Brand Name?, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
26Al-Containing Acidic And Basic Sodium Aluminum Phosphate Preparation And Use In Studies Of Oral Aluminum Bioavailability From Foods Utilizing 26Al As An Aluminum Tracer, Robert A. Yokel, Aaron A. Urbas, Robert A. Lodder, John P. Selegue, Rebecca L. Florence
26Al-Containing Acidic And Basic Sodium Aluminum Phosphate Preparation And Use In Studies Of Oral Aluminum Bioavailability From Foods Utilizing 26Al As An Aluminum Tracer, Robert A. Yokel, Aaron A. Urbas, Robert A. Lodder, John P. Selegue, Rebecca L. Florence
Pharmaceutical Sciences Faculty Publications
We synthesized 26Al-containing acidic and basic (alkaline) sodium aluminum phosphates (SALPs) which are FDA-approved leavening and emulsifying agents, respectively, and used them to determine the oral bioavailability of aluminum incorporated in selected foods. We selected applicable methods from published syntheses (patents) and scaled them down (∼3000- and 850-fold) to prepare ∼300–400 mg of each SALP. The 26Al was incorporated at the beginning of the syntheses to maximize 26Al and 27Al equilibration and incorporate the 26Al in the naturally-occurring Al-containing chemical species of the products. Near infrared spectroscopy (NIR) and X-ray powder diffraction (XRD) were used …
Constipation Myths, Joseph A. Woelfel
Constipation Myths, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel
Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel
Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Sudafed Pe Nasal Decongestant, Joseph A. Woelfel
Sudafed Pe Nasal Decongestant, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Palladone (Hydromorphone Extended-Release Capsules), Joseph A. Woelfel
Palladone (Hydromorphone Extended-Release Capsules), Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Blood Glucose Concentration Does Not Correlate With Organ Failure Or Outcome In Trauma Patients Receiving Enteral Nutrition, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr.
Blood Glucose Concentration Does Not Correlate With Organ Failure Or Outcome In Trauma Patients Receiving Enteral Nutrition, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr.
Scholarship and Professional Work – COPHS
Abstract from American College of Clinical Pharmacy 2005 Spring Practice and Research Forum/Updates in Therapeutics, Myrtle Beach, SC, April 10-13, 2005.
Aluminium Content Of Some Foods And Food Products In The Usa, With Aluminium Food Additives, Salim M. Saiyed, Robert A. Yokel
Aluminium Content Of Some Foods And Food Products In The Usa, With Aluminium Food Additives, Salim M. Saiyed, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
The primary objective was to determine the aluminium (Al) content of selected foods and food products in the USA which contain Al as an approved food additive. Intake of Al from the labeled serving size of each food product was calculated. The samples were acid or base digested and analysed for Al using electrothermal atomic absorption spectrometry. Quality control (QC) samples, with matrices matching the samples, were generated and used to verify the Al determinations. Food product Al content ranged from < 1–27,000 mg kg−1. Cheese in a serving of frozen pizzas had up to 14 mg of Al, from basic sodium …
Research News: 2005, No. 1, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 1, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay
Pharmaceutical Sciences Faculty Patents
The present invention relates to the use of nanoscintillation systems, or nanoparticles containing fluor molecules, that can be used to detect an electron-emitting or alpha-particle-emitting radioisotope in the absence of organic-solvents commonly used in organic-based liquid scintillation cocktails. The invention also relates to compositions and use of three oil-in-water microemulsion precursors that can be engineered rapidly, reproducibly, and cost-effectively to produce useful nanoparticles less than 100 nanometers.
C-Reactive Protein And Statin Benefits, Joseph A. Woelfel
C-Reactive Protein And Statin Benefits, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Pharmacy Care Otc Status Supported But Otc Status Of Statins Denied, Joseph A. Woelfel
Pharmacy Care Otc Status Supported But Otc Status Of Statins Denied, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Fda Warning For Aluminum-Containing Antiperspirants, Joseph A. Woelfel
Fda Warning For Aluminum-Containing Antiperspirants, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jane Gervasio
Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jane Gervasio
Jane M. Gervasio
No abstract provided.
Fully Automated Synthesis Of (Phospho)Peptide Arrays In Microtiter Plate Wells Provides Efficient Access To Protein Tyrosine Kinase Characterization., Carl Saxinger, Thomas P. Conrads, David J. Goldstein, Timothy D. Veenstra
Fully Automated Synthesis Of (Phospho)Peptide Arrays In Microtiter Plate Wells Provides Efficient Access To Protein Tyrosine Kinase Characterization., Carl Saxinger, Thomas P. Conrads, David J. Goldstein, Timothy D. Veenstra
Pharmaceutical Sciences Faculty Publications
BACKGROUND: Synthetic peptides have played a useful role in studies of protein kinase substrates and interaction domains. Synthetic peptide arrays and libraries, in particular, have accelerated the process. Several factors have hindered or limited the applicability of various techniques, such as the need for deconvolution of combinatorial libraries, the inability or impracticality of achieving full automation using two-dimensional or pin solid phases, the lack of convenient interfacing with standard analytical platforms, or the difficulty of compartmentalization of a planar surface when contact between assay components needs to be avoided. This paper describes a process for synthesis of peptides and phosphopeptides …
Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel, N. B. O'Mara
Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel, N. B. O'Mara
School of Pharmacy Faculty Articles
No abstract provided.
Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel
Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Isosorbide Dinitrate Plus Hydralazine In Blacks With Heart Failure, Joseph A. Woelfel
Isosorbide Dinitrate Plus Hydralazine In Blacks With Heart Failure, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Seasonal Affective Disorder (Sad) Light Therapy, Joseph A. Woelfel
Seasonal Affective Disorder (Sad) Light Therapy, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr.
Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr.
Scholarship and Professional Work – COPHS
Abstract from Clinical Nutrition Week, Orlando, FL, January 29-February 2, 2005.
Chronic Outpatient Sildenafil Therapy For Pulmonary Hypertension In A Child After Cardiac Surgery, Chad A. Knoderer, E. S. Ebenroth, J. W. Brown
Chronic Outpatient Sildenafil Therapy For Pulmonary Hypertension In A Child After Cardiac Surgery, Chad A. Knoderer, E. S. Ebenroth, J. W. Brown
Scholarship and Professional Work – COPHS
We report the case of a 14-month-old male with d-transposition of the great arteries, ventricular septal defect, and pulmonary hypertension successfully treated with long-term sildenafil following cardiac surgery. To our knowledge, this is the first published report of long-term sildenafil treatment in a child after corrective cardiac surgery.
Assessment Of Autoimmune Responses Associated With Asbestos Exposure In Libby, Montana, Usa, Jean C. Pfau, J. J. Sentissi, G. Weller, Elizabeth Putnam
Assessment Of Autoimmune Responses Associated With Asbestos Exposure In Libby, Montana, Usa, Jean C. Pfau, J. J. Sentissi, G. Weller, Elizabeth Putnam
Biomedical and Pharmaceutical Sciences Faculty Publications
Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear antibody (ANA) tests have been reported in small cohorts exposed to asbestos, but many questions remain regarding the prevalence, pattern, and significance of autoantibodies associated with asbestos exposures. The population in Libby, Montana, provides a unique opportunity for such a study because of both occupational and environmental exposures that have occurred as a result of the mining of asbestos-contaminated vermiculite near the community. As part of a multifaceted assessment of the impact of asbestos exposures on this population, this study explored the possibility …
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Laboratory Experiments Collection
There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and …
Computational Studies Of Melatonin Analogues, Jessica Lynne Baima
Computational Studies Of Melatonin Analogues, Jessica Lynne Baima
Honors Theses
Melatonin (MLT, N-Acetyl-5-methoxytryptamine), a naturally occurring hormone produced by the pineal gland, plays a crucial role in the regulation of circadian rhythms. Melatonin supplements are utilized in treating various sleep disorders, but detrimental side effects currently discourages its use in space. Computer generated molecular models of MLT analogues were studied with the purpose of resolving the deficiencies within existing therapeutic agents by constructing an enhanced MLT analogue. The MT receptor binding data for each analogue was obtained from the literature and Sybyl 6.9 was used to perform 3-D quantitative structure-activity relationship (QSAR) studies on eight data sets, using the comparative …
Mouse Cytomegalovirus M33 Is Necessary And Sufficient In Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, Daniel N. Streblow
Mouse Cytomegalovirus M33 Is Necessary And Sufficient In Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, Daniel N. Streblow
Pharmacy Faculty Articles and Research
Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors are necessary for the in vivo pathogenesis of MCMV, the function of these proteins is unknown. Since vascular smooth muscle cell (SMC) migration is of critical importance for the development of atherosclerosis and other vascular diseases, the ability of M33 to promote SMC motility was assessed. Similar to human CMV, MCMV induced the migration of mouse aortic SMCs but not mouse fibroblasts. To demonstrate whether M33 was required for MCMV-induced SMC migration, we employed interfering-RNA technology to specifically …