Medicine and Health Sciences Commons^™

Left Ventricular Global And Regional Deformation In Arrhythmic Myxomatous Bileaflet Mitral Valve Prolapse Syndrome, Lakshmi Muthukumar, Arshad Jahangir, M. Faud Jan, Patrycja Galazka, Matt Umland, Mckenzie R. Schweitzer, Ana Cristina Perez Moreno, Maharaj Singh, Bijoy K. Khandheria, A. Jamil Tajik

School of Dentistry Faculty Research and Publications

No abstract provided.

Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects In Rheumatoid Arthritis, Mahdi Zavvar, Sara Assadiasl, Sina Zargaran, Maryam Akhtari, Behzad Poopak, Rassoul Dinarvand, Yousef Fatahi, Lobat Tayebi, Narjes Soleimanifar, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct …

Rare A-Type, Spiro-Type, And Highly Oligomeric Proanthocyanidins From Pinus Massoniana, Bin Zhou, Yvette Alania, Mariana C. Reis, James Mcalpine, Ana K. Bedran-Russo, Guido F. Pauli, Shao-Nong Chen

School of Dentistry Faculty Research and Publications

An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (1–3) from pine bark. Pinutwindoublin (1) is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin (2) represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B-type hexamer that consists of a peanut-derived tetramer, peanut procyanidin E, and an A-type dimer (5). Compound 3 increased the modulus of elasticity of dentin …

Tri- And Tetrameric Proanthocyanidins With Dentin Bioactivities From Pinus Massoniana, Bin Zhou, Yvette Alania, Mariana C. Reis, Rasika S. Phansalkar, Joo-Won Nam, James Mcalpine, Shao-Nong Chen, Ana K. Bedran-Russo, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Guided by dentin biomechanical bioactivity, this phytochemical study led to the elucidation of an extended set of structurally demanding proanthocyanidins (PACs). Unambiguous structure determination involved detailed spectroscopic and chemical characterization of four A-type dimers (2 and 4–6), seven trimers (10–16), and six tetramers (17–22). New outcomes confirm the feasibility of determining the absolute configuration of the catechol monomers in oligomeric PACs by one-dimensional (1D) and two-dimensional (2D) NMR. Electronic circular dichroism as well as phloroglucinolysis followed by mass spectrometry and chiral phase high-performance liquid chromatography (HPLC) analysis generated the necessary chiral reference data. In …

Synthesis And Characterization Of 3d-Printed Functionally Graded Porous Titanium Alloy, Ahmed Hindy, Farzam Farahmand, Fereydoun Pourdanesh, Maryam Torshabi, A. Hadi Al Janabi, Morteza Rasoulianboroujeni, Lobat Tayebi, Fahimeh Tabatabaei

School of Dentistry Faculty Research and Publications

This study aims to 3D print titanium alloy constructs incorporating gradient of porosities, from the fully dense core to the porous outer surface. Gradient porous specimens were prepared using selective laser melting (SLM). Fully dense specimens fabricated by SLM were used as the control group. Characterization of samples was done using X-ray tomography, uniaxial compression testing, and optical and scanning electron microscopes. The biocompatibility of fabricated samples was investigated using human periodontal ligament stem cells via assessment of cell attachment, viability, and proliferation by direct and indirect assays. The data were analyzed using ANOVA and Tukey’s post hoc test. Characterization …

Recent Advances In Designing 5-Fluorouracil Delivery Systems: A Stepping Stone In The Safe Treatment Of Colorectal Cancer, Elaheh Entezar-Almahdi, Soliman Mohammadi-Samani, Lobat Tayebi, Fatemeh Farjadian

School of Dentistry Faculty Research and Publications

5-Fluorouracil (5-FU) has become one of the most widely employed antimetabolite chemotherapeutic agents in recent decades. It is considered a first line antineoplastic agent for the treatment of colorectal cancer. Unfortunately, chemotherapy with 5-FU has several limitations, including its short half-life, high cytotoxicity and low bioavailability. In order to overcome the drawbacks of 5-FU and enhance its therapeutic efficiency, many scientific groups have focused on designing a new delivery system to successfully deliver 5-FU to tumor sites. We provide a comprehensive review on different strategies to design effective delivery systems, including nanoformulations, drug-conjugate formulations and other strategies for the delivery …

Dental Light-Curing Units: An American Dental Association Clinical Evaluators Panel Survey, Kevin Frazier, Ana K. Bedran-Russo, Nathaniel C. Lawson, Jacob Park, Sharukh Khajotia, Olivia Urquhart

School of Dentistry Faculty Research and Publications

Background

The ability to polymerize light-activated dental materials with dental light-curing units (DLCUs) has revolutionized dentistry. However, proper DLCU use is essential for ensuring the effectiveness and performance of these materials.

Methods

The authors developed an electronic cross-sectional survey in the American Dental Association Qualtrics Research Core platform. The survey included questions about DLCU use, unit type and selection, training, maintenance, technique, and safety measures. The authors deployed the survey to 809 American Dental Association Clinical Evaluators (ACE) panelists on October 9, 2019, and sent reminder links to nonrespondents 1 week later. They conducted exploratory and descriptive analyses using SAS …

Microfluidic Fabrication Of Microcarriers With Sequential Delivery Of Vegf And Bmp-2 For Bone Regeneration, Erfan Dashtimoghadam, Farahnaz Fahimipour, Nikita Tongas, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Wound instability and poor functional vascularization in bone tissue engineering lead to lack of tissue integration and ultimate failure of engineered grafts. In order to harness the regenerative potential of growth factors and stimulate bone healing, present study aims to design multifunctional cell therapy microcarriers with the capability of sequential delivery of essential growth factors, bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF). An on-chip double emulsion method was implemented to generate monodisperse VEGF encapsulated microcarriers. Bio-inspired poly(3,4-dihydroxyphenethylamine) (PDA) was then functionalized to the microcarriers surface for BMP-2 conjugation. The microcarriers were seeded with mesenchymal stem cells …

Electrical And Mechanical Properties Of Bzt − Xbct Lead‐Free Piezoceramics, Raziye Hayati, Mohammad Fayazi, Hadi Diargar, Mohammad Kaveh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, lead‐free (1 − x)Ba(Zr_0.2Ti_0.8)O3 − x(Ba_0.7Ca_0.3)TiO₃ compositions are synthesized via conventional solid oxide route, and the ceramics are fabricated with normal sintering in air. The effects of composition fluctuations on dielectric, piezoelectric, and mechanical properties are investigated. The phase structure and the microstructure are analyzed with X‐ray diffraction and scanning electron microscopy. The best dielectric and piezoelectric properties of ε_r = 11 207 and d₃₃ = 330 pC/N were obtained for BZT−0.35BCT and BZT−0.5BCT ceramics, respectively. The mechanical behavior—in terms of Vickers hardness and compressive and …

The Adverse Effects Of Radiotherapy On The Structure Of Dental Hard Tissues And Longevity Of Dental Restoration, Miguel Angel Munoz, Carolina Garin-Correa, Wilfredo Gonzalez-Arriagada, Ximena Quintela Davila, Patricio Haberle, Ana K. Bedran-Russo, Issis Luque-Martinez

School of Dentistry Faculty Research and Publications

Purpose:

The main goal of this study was to evaluate the impact of different ionizing radiation doses on the mineral (carbonate/phosphate ratio, crystallinity index [CI]) and organic (amide III/phosphate, amide I sub-band ratios) structures, as well as the microhardness, of enamel and dentin, along with their influence on the bonding strength stability of the etch-and-rinse (ER) and self-etch (SE) dental adhesive strategies.

Materials and methods:

Enamel and dentin human tissue specimens were irradiated (with 0, 20, 40, and 70 Gy radiation doses, respectively) and sectioned to perform an attenuated total reflection-Fourier transform IR spectroscopy assay (ATR-FTIR) and the Vickers microhardness …

Burgeoning Polymer Nano Blends For Improved Controlled Drug Release: A Review, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Yousef Fatahi, Rassoul Dinarvand, Maryam Tavakolizadeh, Sepideh Ahmadi, Mohammad Rabiee, Mojtaba Bagherzadeh, Ali Pourjavadi, Hassan Farhadnejad, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds …

Aptamer Hybrid Nanocomplexes As Targeting Components For Antibiotic/Gene Delivery Systems And Diagnostics: A Review, Navid Rabiee, Sepideh Ahmadi, Zeynab Arab, Mojtaba Bagherzadeh, Moein Safarkhani, Behzad Nasseri, Mohammad Rabiee, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, …

Clinical Case-Based Problem-Solving Examination In Periodontics, Swati Y. Rawal, Arndt Guentsch

School of Dentistry Faculty Research and Publications

No abstract provided.

Role Of Iron On Physical And Mechanical Properties Of Brushite Cements, And Interaction With Human Dental Pulp Stem Cells, Sahar Vahabzadeh, Sarah Fleck, Joshua Marble, Fahimeh Tabatabaei, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Improving the physical, mechanical and biological properties of brushite cements (BrC) is of a great interest for using them in bone and dental tissue engineering applications. The objective of this study was to incorporate iron (Fe) at different concentrations (0.25, 0.50, and 1.00 wt%) to BrC and study the role of Fe on phase composition, setting time, compressive strength, and interaction with human dental pulp stem cells (hDPSCs). Results showed that increase in Fe concentration increases the β-tricalcium phosphate (β-TCP)/dicalcium phosphate dihydrate (DCPD) ratio and prolongs the initial and final setting time due to effective role of Fe on stabilizing …

Effect Of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium On Cerulein-Induced Acute Pancreatitis In Mice, Kamal Abdolmohammadi, Tayebeh Mahmoudi, Shahrzad Nojehdehi, Lobat Tayebi, Seyed Mahmoud Hashemi, Farshid Noorbakhsh, Alireza Abdollahi, Masoud Soleimani, Behrouz Nikbin, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

Purpose: Acute pancreatitis (AP) is an inflammatory disorder distinguished by tissue injury and inflammation of the pancreas. Using paracrine potential of mesenchymal stem cells (MSCs) provides a useful clinical approach in treating inflammatory diseases. We investigated the therapeutic effects of adipose-derived MSC conditioned medium (CM) and hypoxia preconditioned adipose-derived MSC conditioned medium (HCM) in cerulein-induced AP in mice.

Methods: AP was induced in C57BL/6 mice by intraperitoneal injection of cerulein (75 μg/ kg/h × 7 times). One hour following the last injection of cerulein, mice were treated with intraperitoneal injection of CM and HCM (500 µL/mice/30 min × 3 times). …

In Vitro And In Vivo Effects Of Concentrated Growth Factor On Cells And Tissues, Fahimeh Tabatabaei, Zahra Aghamohammadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This article reviews the biological outcome of the concentrated growth factor (CGF), a new platelet derivative used for tissue regeneration, in published articles related to the use of this product in basic and clinical studies. An electronic literature research using PubMed and SCOPUS was performed using combination of keywords: “concentrated growth factor” (OR “CGF”), AND “stem cells,” AND “cells” OR “cell proliferation” OR “cell migration” OR “cell differentiation,” AND “repair” OR “survival” OR “revitalization,” AND “tissue” OR “bone.” Forty-five articles that were published between 2012 and 2020 met the inclusion criteria. These studies have used CGF as fresh solid form, …

Three-Dimensional Bio-Printing And Bone Tissue Engineering: Technical Innovations And Potential Applications In Maxillofacial Reconstructive Surgery, Muhja Salah, Lobat Tayebi, Keyvan Moharamzadeh, Farhad B. Naini

School of Dentistry Faculty Research and Publications

Background

Bone grafting has been considered the gold standard for hard tissue reconstructive surgery and is widely used for large mandibular defect reconstruction. However, the midface encompasses delicate structures that are surrounded by a complex bone architecture, which makes bone grafting using traditional methods very challenging. Three-dimensional (3D) bioprinting is a developing technology that is derived from the evolution of additive manufacturing. It enables precise development of a scaffold from different available biomaterials that mimic the shape, size, and dimension of a defect without relying only on the surgeon’s skills and capabilities, and subsequently, may enhance surgical outcomes and, in …

Does The Method Of Visualization Impact The Performance Of A New Surgical Task In Novice Subjects?, Mikaeel Kassam, Srikant Chakravarthi, Austin Epping, Sarah Erpenbeck, Maharaj Singh, Melanie B. Fukui, Amin Kassam, Richard Rovin

School of Dentistry Faculty Research and Publications

Introduction

Evolution of optical technology from two-dimensional to three-dimensional (3D) systems has come with an associated loss of stereoscopy and 3D depth perception. This report compares performance of surgical tasks in unbiased subjects using these systems.

Methods

Untrained subjects were randomized into two groups, robotically operated video optical telescopic-microscope (ROVOT) or surgical microscope (microscope). Subjects sutured and tied knots. Completion time, NASA-Task Load Index (TLX), and galvanic skin responses were analyzed.

Results

Intergroup analysis of suture completion time indicated that microscope use was significantly faster compared to ROVOT, whether used first or second. Regardless of which methodology was used first, …

Extra Nodal Rosai-Dorfman Disease Originating In The Nasal And Paranasal Complex And Gnathic Bones: A Systematic Analysis Of Seven Cases And Review Of Literature, Junu Ojha, Yeshwant B. Rawal, Jason L. Hornick, Kelly Magliocca, David R. Montgomery, Robert D. Foss, Kevin R. Torske, Brent Accurso

School of Dentistry Faculty Research and Publications

Rosai-Dorfman disease (RDD) is a benign, self-limiting histiocytosis of unknown etiology. The classic form of the condition includes a painless cervical lymphaenopathy [sic] accompanied by fever, weight loss and an elevated ESR. Extra nodal RDD (ENRDD) is most frequent in the head and neck. Thirty-eight cases of ENRDD have been described. Seven cases of ENRDD were identified in our pathology biopsy services. The demographic and clinical information was tabulated logically on the basis of age, gender, location and presence or absence of symptoms, treatment and follow-up. Radiographic and histopathological features were also examined. The findings in these cases were correlated …

The Incidence Of Root Canal Therapy After Full-Coverage Restorations: A 10-Year Retrospective Study, Abby Yavorek, Pradeep Bhagavatula, Kadam Patel, Aniko Szabo, Mohammed Ibrahim

School of Dentistry Faculty Research and Publications

Introduction

The process of restoring a tooth with a crown leaves many opportunities for pulpal irritation. The objective of this study was to identify and analyze the factors that contribute to the incidence of nonsurgical root canal therapy (NS-RCT) after the delivery of single-unit full-coverage restorations.

Methods

Insurance claims from 88,409 crown placements in the Delta Dental of Wisconsin insurance database were analyzed from the years 2008–2017. The Cox regression model was used to analyze the effect of the predictor variables on the survival of the tooth. Untoward events were defined as NS-RCT, tooth extraction, retreatment of root canal, or …

Manufacturing And Characterization Of Mechanical, Biological And Dielectric Properties Of Hydroxyapatite-Barium Titanate Nanocomposite Scaffolds, Mina Tavangar, Fatemeh Heidari, Raziye Hayati, Fahimeh Tabatabaei, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this research, hydroxyapatite (HA)-based ceramics were produced as suitable ceramic implants for orthopedic applications. To improve the physical, mechanical, electrical and biological properties of pure HA, we developed composite scaffolds of HA-barium titanate (BT) by cold isostatic pressing and sintering. Microstructure, crystal phases, and molecular structure were analyzed by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Bulk density values were measured using the Archimedes method. The effect of different percentages of BT on cell proliferation, viability, and ALP activity of dental pulp stem cells (DPSCs) was assessed …

Biomedical Applications Of Tio2 Nanostructures: Recent Advances, Sevda Jafari, Baharak Mahyad, Hadi Hashemzadeh, Sajjad Janfaza, Tooba Gholikhani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Titanium dioxide (TiO₂) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO₂ nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO₂ nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies—like poor surface interaction with surrounding tissues—by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs—like osteoporosis drugs, anticancer and antibiotics—and …

Bismuth-Based Nanomaterials: Recent Advances In Tumor Targeting And Synergistic Cancer Therapy Techniques, Samireh Badrigilan, Jalal Choupani, Hashem Khanbabaei, Mojtaba Hoseini-Ghahfarokhi, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Despite all of the efforts in the field of cancer therapy, the heterogeneous properties of tumor cells induce an insufficient therapeutic outcome when treated with conventional monotherapies, necessitating a shift in cancer treatment from monotherapy to combination therapy for complete cancer treatment. Multifunctional bismuth (Bi)-based nanomaterials (NMs) with therapeutic functions hold great promise for the fields of cancer diagnosis and therapy based on their low toxicity, X-ray sensitive capabilities, high atomic number, near-infrared driven semiconductor properties, and low cost. Herein, a comprehensive review of recent advances in various medicinal aspects of Bi-based NMs is presented including: evaluation of in-tumor site …

Turkish Paediatric Dentists’ Knowledge, Experiences And Attitudes Regarding Child Physical Abuse, Nermin Özgür, Elif Ballikaya, H. Cem Güngör, Atilla S. Ataç

School of Dentistry Faculty Research and Publications

Objectives

Numerous studies have shown that the education of health professionals is essential to effectively respond to child abuse. The present study aimed to evaluate Turkish paediatric dentists' knowledge, experiences and attitudes regarding child physical abuse.

Materials and methods

An electronic questionnaire was e‐mailed to 518 paediatric dentists. Participants’ knowledge of diagnostic indicators of child physical abuse, and their past experiences, attitudes and self‐assessment of educational needs were evaluated.

Results

The response rate was 40.9% (n = 212). Participants who completed their undergraduate education before 1997 received significantly less education on child physical abuse than participants who completed their …

Vibrational And Sonochemical Characterization Of Ultrasonic Endodontic Activating Devices For Translation To Clinical Efficacy, Erfan Dashtimoghadam, Alexander Johnson, Farahnaz Fahimipour, Mohamadali Malakoutian, Jessica Vargas, Jose Gonzalez, Mohamed Ibrahim, John Baeten, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Passive activation of endodontic irrigants provides improved canal disinfection, smear layer removal, and better subsequent sealing. Although evidence suggests that passive activating endodontic devices increase the effectiveness of irrigation, no study exists to quantitatively compare and validate vibrational characteristics and cavitation produced by different ultrasonic endodontic devices. The current study aims to compare the efficiency of various commercially available ultrasonic endodontic activating devices (i.e., EndoUltra™, EndoChuck, Irrisafe™, and PiezoFlow®). The passive endodontic activating devices were characterized in terms of tip displacement and cavitation performance using scanning laser vibrometry (SLV) and sonochemical analysis, respectively. The obtained results showed that …

Critical-Sized Bone Defects Regeneration Using A Bone-Inspired 3d Bilayer Collagen Membrane In Combination With Leukocyte And Platelet-Rich Fibrin Membrane (L-Prf): An In Vivo Study, Farahnaz Fahimipour, Farshid Bastami, Ahad Khoshzaban, Shahrbanoo Jahangir, Mohamadreza Baghaban Eslaminejad, Fahimeh Kahyyatan, Hannaneh Safiaghdam, Yeganeh Sadooghi, Majid Safa, Tahereh S. Jafarzadeh Kashi, Erfan Dashtimoghadam, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objectives

We aim to develop a 3D-bilayer collagen (COL) membrane reinforced with nano beta-tricalcium-phosphate (nβ-TCP) particles and to evaluate its bone regeneration in combination with leukocyte-platelet-rich fibrin (L-PRF) in vivo.

Background data

L-PRF has exhibited promising results as a cell carrier in bone regeneration in a number of clinical studies, however there are some studies that did not confirm the positive results of L-PRF application.

Methods

Mechanical & physiochemical characteristics of the COL/nβ-TCP membrane (1/2 & 1/4) were tested. Proliferation and osteogenic differentiation of seeded cells on bilayer collagen/nβ-TCP thick membrane was examined. Then, critical-sized calvarial defects in 8 …

Incorporation Of Functionalized Reduced Graphene Oxide/Magnesium Nanohybrid To Enhance The Osteoinductivity Capability Of 3d Printed Calcium Phosphate-Based Scaffolds, Meisam Omidi, Hossein Golzar, Dorsa Mohammadrezaei, Amir Yadegari, Morteza Rasoulianboroujeni, Mohadeseh Hashemi, Fatemeh Yazdian, Mohammad Shalbaf, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Improving bone regeneration is one of the most pressing problems facing bone tissue engineering (BTE) which can be tackled by incorporating different biomaterials into the fabrication of the scaffolds. The present study aims to apply the 3D-printing and freeze-drying methods to design an ideal scaffold for improving the osteogenic capacity of Dental pulp stem cells (DPSCs). To achieve this purpose, hybrid constructs consisted of 3D-printed Beta-tricalcium phosphate (β-TCP)-based scaffolds filled with freeze-dried gelatin/reduced graphene oxide-Magnesium-Arginine (GRMA) matrix were fabricated through a novel green method. The effect of different concentrations of Reduced graphene oxide-Magnesium-Arginine (RMA) (0, 0.25% and 0.75%wt) on the …

Structure, Wettability, Corrosion And Biocompatibility Of Nitinol Treated By Alkaline Hydrothermal And Hydrophobic Functionalization For Cardiovascular Applications, S. Rahimipour, E. Salahinejad, E. Sharifi, H. Nosrati, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The main objective of this study is to hydrophobize nitinol (Ni-Ti alloy) for cardiovascular applications. For this purpose, medical nitinol samples were subjected to sodium hydroxide hydrothermal treatments at various temperatures, followed by hexadecyltrimethoxysilane (HDTMS) functionalization. Then, the structure, wettability, corrosion, cytocompatibility and cell adhesion of the prepared samples were evaluated. According to the results, porous blade-shaped layers of sodium titanate were formed on the substrate surface as a result of the alkaline treatment. These nano-rough features offered considerable hydrophobicity after HDTMS processing, where a maximum water contact angle of about 140° was obtained for the sample treated at 120 …

Mmp-7 And Mmp-9 Are Overexpressed In The Synovial Tissue From Severe Temporomandibular Joint Dysfunction, Carla Loreto, Veronica Filetti, Luis Eduardo Almeida, Giusy Rita Maria La Rosa, Rosalia Leonardi, Cristina Grippaudo, Antonino Lo Giudice

School of Dentistry Faculty Research and Publications

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

Mechanistic Assessment Of Functionalized Mesoporous Silica-Mediated Insulin Fibrillation, Mohsen Akbarian, Lobat Tayebi, Soliman Mohammadi-Samani, Fatemeh Farjadian

School of Dentistry Faculty Research and Publications

Insulin, which is a small protein hormone consisting of 51 amino acids, rapidly fibrillates under stressogenic conditions. This biotechnological/ medical problematic reaction quickly accelerates in the presence of some particles, while there are several other particles that slow down the kinetic process. To address the unexplored demand of the particles that modulate protein fibrillation, we have synthesized two amino-based particles and a chitosan-coated mesoporous silica particle (MS-NH₂, MS-3NH₂, and MS-chitosan) to investigate insulin fibrillation. While these particles were fairly similar in size, they are differ in their net positive charge and surface hydrophobicity. To monitor the …