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Full-Text Articles in Medicine and Health Sciences
Fibroblast Encapsulation In Gelatin Methacryloyl (Gelma) Versus Collagen Hydrogel As Substrates For Oral Mucosa Tissue Engineering, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi
Fibroblast Encapsulation In Gelatin Methacryloyl (Gelma) Versus Collagen Hydrogel As Substrates For Oral Mucosa Tissue Engineering, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Purpose
Over the past decades, a variety of biomaterials have been investigated in terms of their suitability for oral mucosa tissue engineering. The aim of this study was to compare collagen and GelMA hydrogels as connective tissue scaffolds for fibroblasts and as substrates for seeding and culture of oral epithelial keratinocyte cells.
Methods
Human primary oral fibroblast and keratinocyte cells were isolated from gingival biopsies. The mixture of fibroblasts with GelMA or collagen gel were aliquoted within six-well tissue culture plate inserts and cross-linked using visible light or reconstitution buffer/heat, respectively. The viability of fibroblasts in the hydrogels was investigated …
Effect Of Dentin Biomodification Delivered By Experimental Acidic And Neutral Primers On Resin Adhesion, Lívia Tosi Trevelin, Yvette Alania, Mathew Mathew, Rasika S. Phansalkar, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo
Effect Of Dentin Biomodification Delivered By Experimental Acidic And Neutral Primers On Resin Adhesion, Lívia Tosi Trevelin, Yvette Alania, Mathew Mathew, Rasika S. Phansalkar, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo
School of Dentistry Faculty Research and Publications
Objectives
Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin–resin biointerfaces of two highly bioactive PAC-rich extracts, Vitis vinifera (Vv) and Camellia sinensis (Cs), delivered using neutral (NP) or acidic (AP) rinse-out primer approaches.
Methods
The depth of dentin demineralization (optical profilometry), dentin biomodification (apparent modulus of elasticity, collagen auto-fluorescence) and properties of dentin–resin interfaces (microtensile bond strength - μTBS, and micro-permeability) were investigated. NP consisted of either 15% Vv or Cs applied for …