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Articles 151 - 180 of 406
Full-Text Articles in Physiology
Examining Grit Like Qualities In Nfl Qbs, John Beck, Mark Debeliso
Examining Grit Like Qualities In Nfl Qbs, John Beck, Mark Debeliso
International Journal of Exercise Science
International Journal of Exercise Science 13(5): 912-923, 2020. In order to excel in the National Football League (NFL) it would seem reasonable to assume an athlete has grit which consists of the constructs of consistency of interest and perseverance of effort. Grit-like qualities such as endurance, urgency and intensity, self-confidence, need for encouragement, and self-criticality may be of particular value for the athlete playing the Quarterback (QB) position. The purpose of the study was to assess the 5 grit-like constructs of endurance, urgency and intensity, self-confidence, need for encouragement, and self-criticality among NFL QBs. The Flippen ProfileTM assessment was …
Case Report Of A Remote Ischemic Preconditioning Intervention During Aerobic Exercise In A 44-Year-Old Amateur Triathlete Male With A History Of Acute Myocardial Infarction, Maxime Caru, François Lalonde, Hugo Gravel, Chantal Daigle, Daniel Curnier
Case Report Of A Remote Ischemic Preconditioning Intervention During Aerobic Exercise In A 44-Year-Old Amateur Triathlete Male With A History Of Acute Myocardial Infarction, Maxime Caru, François Lalonde, Hugo Gravel, Chantal Daigle, Daniel Curnier
International Journal of Exercise Science
International Journal of Exercise Science 13(3): 924-937, 2020. Over the years, exercise has become increasingly important in patients with acute myocardial infarction (AMI). However, AMI patients need to be closely monitored since they maintain cardiovascular disease risks, such as ventricular repolarization abnormalities in electrocardiograms during exercise and rest. A recent study showed the need to focus on the different potential mechanisms and the applicability of remote ischemic preconditioning (RIPC) for cardiac patients engaged in exercise rehabilitation. This is the first case report that explores the effectiveness of an RIPC intervention in a 44-year-old amateur triathlete male with a history of …
The Effects Of Walking With A Load In The Heat On Physiological Responses Among Military Reserve Female Cadets, Nurul Atikah Shuhada, Marilyn L.Y. Ong, Chee Keong Chen
The Effects Of Walking With A Load In The Heat On Physiological Responses Among Military Reserve Female Cadets, Nurul Atikah Shuhada, Marilyn L.Y. Ong, Chee Keong Chen
International Journal of Exercise Science
International Journal of Exercise Science 13(2): 900-911, 2020. This study aimed to investigate the effects of walking in a hot and humid environment while wearing a combat suit with a load on physiological responses among the Malaysian Military Reserve Officer Training Unit (ROTU) female cadets. Eight healthy female ROTU cadets (age: 21.3 ± 1.0 years old; height: 156.3 ± 4.9 cm; weight: 55.6 ± 7.5 kg) participated in this randomised, crossover trial. They walked for 1 h on a treadmill at 3 km.h-1 while carrying either 8.2 kg load (WL) or without load (WOL) in a room maintained at …
Donning A Novel Lower-Limb Restrictive Compression Garment During Training Augments Muscle Power And Strength, Jaxon T. Baum, Robert P. Carter, Eric V. Neufeld, Brett A. Dolezal
Donning A Novel Lower-Limb Restrictive Compression Garment During Training Augments Muscle Power And Strength, Jaxon T. Baum, Robert P. Carter, Eric V. Neufeld, Brett A. Dolezal
International Journal of Exercise Science
International Journal of Exercise Science 13(3): 890-899, 2020. The popularity of graduated compression garments (GCG) in sport and exercise is largely driven by the abundance of anecdotal claims suggesting their efficacy. A new line of compression apparel, restrictive compression garments (RCG), integrate novel resistance technology into lower-limb compression garments designed to provide variable resistance to movement. This study aimed to investigate the effect of donning an RCG during a 4-week training program on selected performance variables. Twelve college-aged males were recruited for four weeks of lower-body strength-power resistance training. Participants were randomized 1:1 and blinded to (i) an intervention group …
Effects Of Horizontal And Incline Bench Press On Neuromuscular Adaptations In Untrained Young Men, Suene F. N. Chaves, Valdinar A. Rocha-Júnior, Irismar G. A. Encarnação, Hugo C. Martins-Costa, Eduardo D. S. Freitas, Daniel B. Coelho, Frederico S. C. Franco, Jeremy P. Loenneke, Martim Bottaro, João B. Ferreira-Júnior
Effects Of Horizontal And Incline Bench Press On Neuromuscular Adaptations In Untrained Young Men, Suene F. N. Chaves, Valdinar A. Rocha-Júnior, Irismar G. A. Encarnação, Hugo C. Martins-Costa, Eduardo D. S. Freitas, Daniel B. Coelho, Frederico S. C. Franco, Jeremy P. Loenneke, Martim Bottaro, João B. Ferreira-Júnior
International Journal of Exercise Science
International Journal of Exercise Science 13(6): 859-872, 2020. The aim of the current study was to investigate the effects of horizontal and incline bench press as well as the combination of both exercises on neuromuscular adaptation in untrained young men. Forty-seven untrained men were randomly assigned to one of the three groups: 1) a horizontal bench press group (n= 15), 2) an incline bench press group (n= 15), and 3) a combination (horizontal + incline) group (n= 17). Training was conducted once a week for eight weeks, with equalized number of sets among groups. Muscle thickness, isometric strength and electromyography …
The Influence Of Sport-Related Concussion On Lower Extremity Injury Risk: A Review Of Current Return-To-Play Practices And Clinical Implications, Jason M. Avedesian, Tracey Covassin, Janet S. Dufek
The Influence Of Sport-Related Concussion On Lower Extremity Injury Risk: A Review Of Current Return-To-Play Practices And Clinical Implications, Jason M. Avedesian, Tracey Covassin, Janet S. Dufek
International Journal of Exercise Science
International Journal of Exercise Science 13(3): 873-889, 2020. Sport-related concussions (SRCs) are now classified as a major health concern affecting athletes across all sporting levels, with recent evidence suggesting upwards of 3.8 million SRCs occur each year. Multiple injury surveillance datasets have recently determined that athletes post-SRC, compared to non-concussed counterparts, are at greater risk for lower extremity (LE) injury beyond the resolution of traditional SRC assessment batteries. However, it is presently uncertain if common clinical practices (symptom reporting, neuropsychological (NP) examination, and static postural control analysis) can determine athletes at risk for LE injury following an SRC. A comprehensive …
Translational Regulation Of Environmental Adaptation In Bacteria, Rodney Tollerson Ii, Michael Ibba
Translational Regulation Of Environmental Adaptation In Bacteria, Rodney Tollerson Ii, Michael Ibba
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Bacteria must rapidly respond to both intracellular and environmental changes to survive. One critical mechanism to rapidly detect and adapt to changes in environmental conditions is control of gene expression at the level of protein synthesis. At each of the three major steps of translation—initiation, elongation, and termination—cells use stimuli to tune translation rate and cellular protein concentrations. For example, changes in nutrient concentrations in the cell can lead to translational responses involving mechanisms such as dynamic folding of riboswitches during translation initiation or the synthesis of alarmones, which drastically alter cell physiology. Moreover, the cell can fine-tune the levels …
The Effect Of Timing And Type Of Exercise On The Quality Of Sleep In Trained Individuals, Victoria Burgess, Jose Antonio, Helen Bland, Ronald Wagner, Jaime Tartar, Bridget Melton
The Effect Of Timing And Type Of Exercise On The Quality Of Sleep In Trained Individuals, Victoria Burgess, Jose Antonio, Helen Bland, Ronald Wagner, Jaime Tartar, Bridget Melton
International Journal of Exercise Science
International Journal of Exercise Science 13(7): 837-858, 2020. Sleep is an extremely important component for overall health and for a well-balanced training program. Recent studies have highlighted the interaction between sleep, recovery, and performance in elite and recreational athletes alike. Exercise has been known to affect the quality of sleep, nevertheless the impact is not well understood in the current research, particularly the effects of exercise timing and intensity on sleep quality. The purpose of this study was to understand if exercise timing and intensity significantly impact sleep quality among recreational exercisers. The participants involved were recreational exercisers who were …
Impact Of Hydration Status On Jump Performance In Recreationally Trained Males, Paul T. Donahue, Samuel Wilson, Charles Williams, Christopher M. Hill, Melinda Valiant, John Garner
Impact Of Hydration Status On Jump Performance In Recreationally Trained Males, Paul T. Donahue, Samuel Wilson, Charles Williams, Christopher M. Hill, Melinda Valiant, John Garner
International Journal of Exercise Science
International Journal of Exercise Science 13(4): 826-836, 2020. The vertical jump is commonly used as a means of evaluating athlete readiness. Athletes have been shown to arrive to training and competition in a hypohydrated state. Thus, this investigation sought to examine the impact of hydration status on both countermovement (CMJ) and squat jump (SJ) performance. Twenty-five recreationally trained males completed three CMJ and SJ in a euhydrated, hypohydrated and control condition. Conditions were separated by a minimum of 24 hours. Hydration status was assessed using urine specific gravity. Jump performance was evaluated using both kinematic and kinetic data obtained from …
The Effects, Perceptions, And Attitudes Of Previously Sedentary Individuals Starting An Exercise Program, Arlene Moreno, Megan Rasmussen
The Effects, Perceptions, And Attitudes Of Previously Sedentary Individuals Starting An Exercise Program, Arlene Moreno, Megan Rasmussen
Loma Linda University Research Reports
Background: Many Americans do not eat healthfully or exercise, which is associated with higher risk of disease. Nutrition and exercise awareness have increased, but people experience barriers preventing lifestyle change. Limited research has been completed on the impact of nutrition education on dietary intake.
Objective: Examine whether starting an exercise program with or without nutrition education can influence dietary choices in previously sedentary individuals, and to determine their perceptions and attitudes.
Design: Mixed methods study gathering quantitative data through a food frequency questionnaire, InBody test, and demographics/exercise activity survey. Qualitative data was gathered through focus groups. Participants …
To Play Or Not To Play: Can An Instrument Really Impact Lip And Tongue Performance?, Robert S. Thiebaud, Takashi Abe, W. Matt Denning, Jeremy P. Loenneke, Micah J. Okerlund, Joe S.J. Ryan, Whitney Boyce, Maggie Mcbride, Jared Hernandez
To Play Or Not To Play: Can An Instrument Really Impact Lip And Tongue Performance?, Robert S. Thiebaud, Takashi Abe, W. Matt Denning, Jeremy P. Loenneke, Micah J. Okerlund, Joe S.J. Ryan, Whitney Boyce, Maggie Mcbride, Jared Hernandez
Faculty and Student Publications
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. (1) Background: Increasing tongue and lip strength may help improve various speech and swallowing disorders, but it is unclear if instrumentalists who use these muscle groups for long periods of time have greater strength and endurance compared to controls. It is also unclear if instrumentalists can more accurately estimate various exercise intensities. The purpose of this study was to determine differences in lip and tongue strength and endurance between instrumentalists and non-instrumentalists (controls). A secondary purpose was to assess differences in ability to estimate various exercise intensities between the two groups. …
Cosyntropin As A Therapeutic Intervention Following Traumatic Brain Injury, Lorraine C. Siebold
Cosyntropin As A Therapeutic Intervention Following Traumatic Brain Injury, Lorraine C. Siebold
Loma Linda University Electronic Theses, Dissertations & Projects
Traumatic brain injury (TBI) is a major health concern in the United States. With over two million occurrences and approximately 50,000 deaths annually, TBI is a leading cause of death in young adults and is associated with cognitive deficits influenced by acute and persistent neuroinflammation. Melanocortins, such as adrenocorticotropic hormone (ACTH), are agonists for melanocortin receptors located in the adrenal glands and peripheral immune cells as well as throughout the central nervous system. Melanocortins ameliorate inflammation and provide a novel therapeutic approach for TBI. The focus of this dissertation was to describe and quantify effects of cosyntropin, a synthetic ACTH …
An Investigation Of Stress-Related Factors And Injury Occurrence In Division Iii Ice Hockey Athletes 2020., Christian Kiesel
An Investigation Of Stress-Related Factors And Injury Occurrence In Division Iii Ice Hockey Athletes 2020., Christian Kiesel
Master's Theses
Many variables can factor into a student athlete sustaining an injury, but one of the most interesting is stress. The Stress and Injury Model is excellent in explaining how exactly history of stressors, personality, and coping mechanisms play a pivotal role in the stress response. If these three factors cause a negative stress response, then that will lead to an athlete becoming more likely to become injured. This study used 40 ice hockey players from a Division III NCAA institution. Each participant completed the Inventory of College Students’ Recent Life Experiences (ICSRLE) and Pittsburgh Sleep Quality Index (PSQI) every month …
Evaluation Of Repetitive Jumping Intensity On The Digi-Jump Machine, T. Scott Lyons, James W. Navalta, Whitley J. Stone, Scott W. Arnett, Mark A. Schafer, Laura Igaune
Evaluation Of Repetitive Jumping Intensity On The Digi-Jump Machine, T. Scott Lyons, James W. Navalta, Whitley J. Stone, Scott W. Arnett, Mark A. Schafer, Laura Igaune
International Journal of Exercise Science
Cardiorespiratory endurance is an important element of aerobic fitness, particularly in weight management and reducing risk for cardiovascular disease. While there are numerous options for aerobic exercise, rope jumping is often overlooked. In addition to regular exercise and a healthy diet, the American Heart Association strongly recommends rope jumping. The first purpose of this study was to determine the steady state metabolic cost of repetitive jumping on the Digi-Jump machine to evaluate whether exercise on this device is more or less strenuous than similar exercise with a jump rope, as demonstrated in previous literature. A second purpose was to determine …
Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna Leduc, Rachel Shumate, John Coons, Ryan T. Conners
Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna Leduc, Rachel Shumate, John Coons, Ryan T. Conners
International Journal of Aquatic Research and Education
This study examined heart rate (HR) and stride frequency (SF) values of 30 college-aged males and females during dry-land (DL) and aquatic walking (AW). Aquatic walking trials were completed in an underwater treadmill with the water depth at waist level; the water temperature (31℃ ± 0.1℃) and room temperature (26.6℃ ± 0.1℃) were maintained at thermoneutral levels throughout the study. During each walking condition, HR and SF were recorded at treadmill speeds of 1 mph, 2 mph, and 3 mph. Participants were instructed to walk with their hands at their sides swinging as they would when walking on dry-land unless …
Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark Mckean, Brendan Burkett
Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark Mckean, Brendan Burkett
International Journal of Aquatic Research and Education
Ten participants were assessed while walking in water and on land with wearable inertial measurement units (IMUs) attached to the right thigh. Longitudinal acceleration, anterior-posterior acceleration, and frontal axis angular velocity were measured at 100 Hz, matched with video analysis sampled at 25 Hz during the walking trials. The longitudinal acceleration showed almost 1 g from initial heel contact to 70% of one cycle, and the anterior-posterior acceleration showed a sinusoidal pattern, synchronizing the approximate posture of the thigh in water. The frontal axis angular velocity fluctuated less while walking in water compared with on land, because thigh motion speed …
Determining The Genetic Control Of Neural Tube Malformation Through Genetic Interactions With Idgf3, Elli N. Fox
Determining The Genetic Control Of Neural Tube Malformation Through Genetic Interactions With Idgf3, Elli N. Fox
Honors Projects
Genetic mutations disrupting human neural tube formation can lead to birth defects such as spina bifida and anencephaly. Defects can result in lack of neural tube closure in either the caudal (spina bifida) or cranial (anencephaly) regions. Little is known about the genes that cause these malformations. Researchers have been using the model organism Drosophila melanogaster in an attempt to determine genes responsible for neural tube malformations. Recently, an ortholog of human chitin-like protein, imaginal disc growth factor 3 (Idgf3), has been identified as important in the proper formation of Drosophila egg dorsal appendages. However, the molecular mechanism responsible for …
Physiological And Behavioral Correlates Of Hif-1 Alpha Protein Levels In The Gulf Killifish, Fundulus Grandis, Jasmine Harris
Physiological And Behavioral Correlates Of Hif-1 Alpha Protein Levels In The Gulf Killifish, Fundulus Grandis, Jasmine Harris
University of New Orleans Theses and Dissertations
Although the hypoxia-inducible transcription factor (HIF) orchestrates molecular responses to low oxygen, the amount of HIF-1α protein expressed during hypoxia varies among species, individuals, and tissues. This study measured HIF-1α protein levels along with several physiological and behavioral variables in the estuarine fish Fundulus grandis under normoxia (> 7 mg l-1 dissolved oxygen) and hypoxia (1 mg l-1 dissolved oxygen). Fish under hypoxic conditions had higher tissue levels of HIF-1α, hematocrit, blood glucose, blood lactate, frequency of aquatic surface respiration (ASR), and lower activity than normoxic controls. Under hypoxia, HIF-1α abundance in gill was positively correlated with body …
The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle
The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle
Biological Sciences Student Scholarship
Changing light conditions due to human activities represents an important emerging environmental concern. Although changes to natural light conditions can be independently detrimental, in nature, organisms commonly face multiple stressors. To understand the consequences of altered light conditions, we exposed a model amphibian (wood frog; Lithobates sylvaticus) to a control and two anthropogenic light conditions: intensified daytime illuminance and artificial light at night - ALAN (intensified daytime illuminance + extended photoperiod). We measured (1) metrics of fitness (hatching success as well as survival to, size at, and time to metamorphosis) (2) susceptibility (time to death) to a commonly cooccurring anthropogenic …
Kids Don’T Float…And Their Parents Don’T Either: Using A Family-Centered Approach In Alaska’S Kids Don’T Float Program, Michelle E. E. Bauer, Audrey R. Giles, Justina Marianayagam, Kelli M. Toth
Kids Don’T Float…And Their Parents Don’T Either: Using A Family-Centered Approach In Alaska’S Kids Don’T Float Program, Michelle E. E. Bauer, Audrey R. Giles, Justina Marianayagam, Kelli M. Toth
International Journal of Aquatic Research and Education
The goal of this experiential report is to outline the adoption of a family-centered Kids Don’t Float approach. We conducted a critical synthesis of information to reflect the expansion of the Kids Don’t Float program into a more family-centered approach. The critical synthesis provided insights into why we should adopt this approach, how it was implemented, and how it influenced drowning incidents compared to the previously used child-centered approach. The adoption of a family-centered approach may contribute to reducing drowning incidents by targeting parents, providing safety information to families, and promoting parental modelling of life jackets. Program evaluators and water …
Motor Behavior Literature Fails To Translate: A Preliminary Investigation Into Coaching And Focus Of Attention In Recreational Distance Runners., Masahiro Yamada, Jed Diekfuss, Louisa Raisbeck
Motor Behavior Literature Fails To Translate: A Preliminary Investigation Into Coaching And Focus Of Attention In Recreational Distance Runners., Masahiro Yamada, Jed Diekfuss, Louisa Raisbeck
International Journal of Exercise Science
International Journal of Exercise Science 13(5): 789-801, 2020. The benefits of using an external focus relative to an internal focus for endurance activities are well documented. However, literature has revealed that internally focused instructions are predominantly adopted in the field, and existing data are limited to highly-skilled level populations. Moreover, athletes’ focus of attention during fatigue invoking activities is unknown. The purpose of the current study was to examine what type of feedback and instructions experienced recreational individuals receive and their self-adopted focus of attention when fatigued. Distance runners answered a questionnaire related to instruction and feedback from coaches and …
Internal Training Load Measures During A Competitive Season In Collegiate Women Lacrosse Athletes, Jennifer Fields, Michael Esco, Justin Merrigan, Jason White, Margaret T. Jones
Internal Training Load Measures During A Competitive Season In Collegiate Women Lacrosse Athletes, Jennifer Fields, Michael Esco, Justin Merrigan, Jason White, Margaret T. Jones
International Journal of Exercise Science
International Journal of Exercise Science 13(4): 778-788, 2020. Monitoring internal load provides useful and non-invasive markers of training stress and adaptation. However, the relationship between internal load measures across a competitive window remains inconclusive and limited. The purpose of this study was to report various internal load measures, as well as their relationship, across a season in Division I women lacrosse athletes (n = 20). Ultra-short natural logarithm of the root mean square of successive differences (lnRMSSD), salivary testosterone, cortisol, the testosterone:cortisol ratio, and self-reported measures of fatigue and recovery were collected weekly for 13 weeks. Means ± SD …
Acute Physiologic Effects Of Performing Yoga In The Heat On Energy Expenditure, Range Of Motion, And Inflammatory Biomarkers, Bradley Lambert, Katherine Miller, Domenica Delgado, Kalyan Chaliki, Joshua Lee, Guillermo Bauza, Francesca Taraballi, David Dong, Ennio Tasciotti, Joshua Harris, Patrick Mcculloch
Acute Physiologic Effects Of Performing Yoga In The Heat On Energy Expenditure, Range Of Motion, And Inflammatory Biomarkers, Bradley Lambert, Katherine Miller, Domenica Delgado, Kalyan Chaliki, Joshua Lee, Guillermo Bauza, Francesca Taraballi, David Dong, Ennio Tasciotti, Joshua Harris, Patrick Mcculloch
International Journal of Exercise Science
International Journal of Exercise Science 13(3): 802-817, 2020. Performing yoga in a heated environment (HY) is a popular exercise mode purported to improve range of motion (ROM), body composition, and aerobic fitness. The purpose of this investigation was to compare a session of HY to room temperature yoga (RTY) with regards to ROM, oxygen consumption, caloric expenditure, and biomarkers of acute stress and inflammation. Sixteen experienced yoga practitioners (F14, M2; 40 ± 11yr; 22.6 ± 1.8 kg/m2) completed a 1-hour standardized Bikram sequence in HY (105⁰F, 40⁰C) and RTY (74⁰F, 23.3⁰C) conditions (order of conditions randomized, humidity standardized …
Switching Off The Pancreatic Islet: Complex Network Analysis Of Multicellular Clusters, Janita Patwardhan
Switching Off The Pancreatic Islet: Complex Network Analysis Of Multicellular Clusters, Janita Patwardhan
Biology and Medicine Through Mathematics Conference
No abstract provided.
Swimming Pool Environment And Respiratory Health Issues Experienced By Masters Swimmers: Results From A Literature Review And Survey Of United States Masters Swimming Clubs, Jody C. Gan, Julia Snegg, William Harder
Swimming Pool Environment And Respiratory Health Issues Experienced By Masters Swimmers: Results From A Literature Review And Survey Of United States Masters Swimming Clubs, Jody C. Gan, Julia Snegg, William Harder
International Journal of Aquatic Research and Education
After three members of a Masters adult swim club died of lung cancer, both a literature review and survey were conducted with representatives from 746 United States Masters Swimming clubs to explore a possible relationship between swimming and cancers of the respiratory tract. Six other clubs reported known cancers of the respiratory tract among club members, but none of the other 740 clubs reported a similar cluster of lung cancer. More clubs reported cases of chronic respiratory infections and widespread complaints about air quality. While no studies exploring a relationship between swimming and lung cancer could be found in the …
Comparative Study Of Spectral Sensitivity, Irradiance Sensitivity, Spatial Resolution And Temporal Resolution In The Visual Systems Of Aratus Pisonii And Ocypode Quadrata, Ruchao Qian
All HCAS Student Capstones, Theses, and Dissertations
Autrum’s studies (1950, 1958) on terrestrial arthropods first revealed that the visual systems of arthropods reflected their lifestyles and habitats, demonstrating that rapidly moving predatory diurnal species tend to have better temporal resolution than slower moving nocturnal species. In order to test Autrum’s hypothesis that visual adaptions are driven by predator/prey interactions, the visual physiology of a nocturnal fast-moving predatory crab, the Atlantic ghost crab (Ocypode quadrata), and a diurnal herbivorous crab, the mangrove tree crab (Aratus pisonii), was examined and compared. Spectral sensitivity, irradiance sensitivity, and temporal resolution of the crabs were quantified using the …
The Role Of Central Ace2 And Nrf2 In Sympatho-Excitation: Responses To Central Angiotensin Ii, Anyun Ma
The Role Of Central Ace2 And Nrf2 In Sympatho-Excitation: Responses To Central Angiotensin Ii, Anyun Ma
Theses & Dissertations
Sympatho-excitation is a key characteristic in cardiovascular diseases such as chronic heart failure (CHF) and primary Hypertension (HTN). Evidence suggests that increased sympathetic tone is closely related to activation of the Renin-Angiotensin-Aldosterone system (RAAS) in the central nervous system. An underlying mechanism for sympatho-excitation is thought to be oxidative stress resulting from Angiotensin II (AngII) type 1 receptor (AT1R) activation. Over the past several decades, pharmacological targeting of components of the RAAS have been used as standard therapy in CHF and HTN. However, additional therapeutic strategies are necessary to control these diseases. Oxidative stress is regulated, in part, by the …
Glucose Metabolism Of Breast Cancer Sub-Clones That Preferentially Metastasize To The Lungs And Bone, Anna G. Skubiz
Glucose Metabolism Of Breast Cancer Sub-Clones That Preferentially Metastasize To The Lungs And Bone, Anna G. Skubiz
Honors Theses
Malignant breast cancers exhibit preferential metastasis to bone and lung (1). While changes in gene expression in lung-specific (LM) and bone-specific metastasis (BoM) lines derived from the MDA-MB-231 breast cancer line have been identified, few metabolic genes are differentially expressed; thus it is unknown if tissue-specific metabolic reprogramming occurs. Two hallmarks of cancer cells are an altered metabolic phenotype characterized by enhanced conversion of glucose to lactate in spite of adequate oxygen availability for complete mitochondrial oxidation of this substrate (referred to as aerobic glycolysis or the Warburg effect) and a greater dependence on glutamine. These changes in primary tumor …
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh
Honors Theses
Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …
Investigatin Actin-Myosin Mechanics To Model Heart Disease Using Fluorescence Microscopy And Optical Trapping, Justin Edward Reynolds
Investigatin Actin-Myosin Mechanics To Model Heart Disease Using Fluorescence Microscopy And Optical Trapping, Justin Edward Reynolds
Honors Theses
Hypertrophic cardiomyopathy (HCM) is a hereditary disease in which the myocardium becomes hypertrophied, making it more difficult for the heart to pump blood. HCM is commonly caused by a mutation in the β-cardiac myosin II heavy chain. Myosin is a motor protein that facilitates muscle contraction by converting chemical energy from ATP hydrolysis into mechanical work and concomitantly moving along actin filaments. Optical tweezers have been used previously to analyze single myosin biophysical properties; however, myosin does not work as a single unit within the heart. Multiple myosin interacts to displace actin filaments and do not have the same properties …