Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 3 of 3
Full-Text Articles in Physiology
The Dynamics Of Life And Death: Mitochondrial Fragmentation, Mitophagy, And Swelling During Neuronal Ischemia/Reperfusion Injury, Anthony Roy Anzell
The Dynamics Of Life And Death: Mitochondrial Fragmentation, Mitophagy, And Swelling During Neuronal Ischemia/Reperfusion Injury, Anthony Roy Anzell
Wayne State University Dissertations
Ischemic brain injury caused by cardiac arrest or stroke continue to be leading caused of death and disability in the U.S. While restoration of blood flow is necessary to salvage ischemic tissue, reperfusion paradoxically exacerbates injury via the production of reactive oxygen species, which, damage mitochondria and induce cell death. Therefore, it is critical to have stringent quality control mechanisms to ensure a healthy mitochondrial network. Mitochondrial fragmentation has been well characterized in the progression of ischemia/reperfusion and its association with cell death. Conversely, the role of mitophagy has been controversial regarding whether upregulation of mitophagy serves as a restorative …
Causes And Potential Treatment For Altered Muscle Metaboreflex Control Of Ventricular Vascular Interactions In Heart Failure, Joseph Thomas Mannozzi
Causes And Potential Treatment For Altered Muscle Metaboreflex Control Of Ventricular Vascular Interactions In Heart Failure, Joseph Thomas Mannozzi
Wayne State University Dissertations
Muscle Metaboreflex Activation occurs as a result of metabolic accumulation within active skeletal muscle that stimulates type III and IV afferents. This reflex in healthy subjects causes increased ventricular contraction, tachycardia, enhanced central blood volume mobilization, and 2 mediated vasodilation as a means to increase mean arterial pressure and thereby improve perfusion pressure of active skeletal muscle. However, to date no study has evaluated the interaction between the observed changes in ventricular and vascular dynamics or how the reflex impacts contraction relaxation dynamics before and after induction of heart failure Furthermore, no study has evaluated the impact of chronic selective …
Testosterone And Interpersonal Attraction: A Placebo-Controlled Design, Stefan M. Goetz
Testosterone And Interpersonal Attraction: A Placebo-Controlled Design, Stefan M. Goetz
Wayne State University Dissertations
Testosterone has long been implicated as a neuroendocrinological mechanism in the expression of reproductive strategies. Humans the world over form and maintain pair-bonds suggesting that pair-bonds may serve to enhance reproductive fitness. However, infidelity is a perennial threat to these bonds. The data in humans suggests that testosterone is associated with mate-seeking but may be detrimental to relationship maintenance. However, past work has relied on correlational studies and additional findings from nonhuman animal models suggest that acute changes rather than baseline concentrations in testosterone may in fact protect extant pair-bonds. The present research sought to test the causal role of …