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Articles 901 - 915 of 915
Full-Text Articles in Molecular and Cellular Neuroscience
Dose-Dependent Characterization Of The Rewarding And Stimulant Properties Of Cocaine Across Intraperitoneal And Intravenous Routes Of Administration, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Differential Effects Of Intra-Accumbens Sulpiride On Cocaine-Induced Locomotion And Conditioned Place Preference, Laura O'Dell
Differential Effects Of Intra-Accumbens Sulpiride On Cocaine-Induced Locomotion And Conditioned Place Preference, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Integration Of Fetal Neocortical Transplants With The Damaged Host Brain, Mette Katrine Schulz
Integration Of Fetal Neocortical Transplants With The Damaged Host Brain, Mette Katrine Schulz
Dissertations
No abstract provided.
Localization Of Dopamine Receptor Subtypes Occupied By Intra-Accumbens Administration Of Selective Antagonists That Reverse Cocaine-Induced Locomotion., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Multisite Microprobes For Electrochemical Recordings In Biological Dynamics, G. Sreenivas, S. S. Ang, R. M. Ranade, A. S. Salian, W. D. Brown
Multisite Microprobes For Electrochemical Recordings In Biological Dynamics, G. Sreenivas, S. S. Ang, R. M. Ranade, A. S. Salian, W. D. Brown
Journal of the Arkansas Academy of Science
For over 30 years, techniques have been developed that allow for the microscale (10-30 /mum) measurement of chemical signals with high temporal resolution (1-200 Hz). Such measurements, called in vivo electrochemical recordings, allow for the direct determination of neurotransmitter molecules and related compounds in biological systems. Multiple recordings, simultaneously performed at different, closely spaced, well defined locations throughout a three-dimensional tissue volume in the brain, are of interest in neuroscience. Developments in microelectronic techniques enable the fabrication of multi-electrode microprobes for recording extracellular action potentials generated by individual neurons simultaneously. A high-yield microfabrication process has been successfully developed for the …
Action Of Heptaminol Hydrochloride On Contractile Properties In Frog Isolated Twitch Muscle Fibre, Bruno Allard, Vincent Jacquemont, Fouad Lemtiri-Chlieh, Bernard Pourrias, Oger Rougier
Action Of Heptaminol Hydrochloride On Contractile Properties In Frog Isolated Twitch Muscle Fibre, Bruno Allard, Vincent Jacquemont, Fouad Lemtiri-Chlieh, Bernard Pourrias, Oger Rougier
fouad Lemtiri-Chlieh
1 Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2 Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3 The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4 The action of hepataminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5 These results could be explained by a stimulation of the Na/H antiport by heptaminol.
Presence Of A Cs-Resistant Transient Outward Current Which Distorts Ica Measurements In Guinea-Pig Single Ventricular Cells, Georges Christé, Brigitte Delachapelle, Fouad Lemtiri-Chlieh, Carlos Ojeda
Presence Of A Cs-Resistant Transient Outward Current Which Distorts Ica Measurements In Guinea-Pig Single Ventricular Cells, Georges Christé, Brigitte Delachapelle, Fouad Lemtiri-Chlieh, Carlos Ojeda
fouad Lemtiri-Chlieh
To correctlyr analyse the physical properties of ion channels and the actions of drugs upon them, it is important that the membrane conducts only the ionic species believed permeant. In guinea-pig ventricular cells it has been assumed that only ICaL flows in the potential range -50 to +60 mV in the presence of intra- and extracellular Cs (> 20 mM). We report here that this is not the case due to the presence of a Cs-insensitive, transient outward current.
Measurements Of Cytosolic Free Ca In Cultured Rat Neonate And Adult Guinea-Pig Ventricular Cardiac Myocytes, Jean-Claude Bernengo, Fouad Lemtiri-Chlieh, Carlos Ojeda, Nadine Pltonoff
Measurements Of Cytosolic Free Ca In Cultured Rat Neonate And Adult Guinea-Pig Ventricular Cardiac Myocytes, Jean-Claude Bernengo, Fouad Lemtiri-Chlieh, Carlos Ojeda, Nadine Pltonoff
fouad Lemtiri-Chlieh
Cytosolic free Ca was measured with Indo-1 (Grynkiewicz et al. 1985) as free acid (in guinea-pig cells) or as the ester (in rat neonate cells). Using image analysis we obtained concentration maps at 40 ms intervals at two wavelengths (Cannell et al. 1986). In rat neonate cells, at rest and during contraction, calcium was apparently non-uniformly distributed, in contrast to guinea-pig adult cells. Using a dual PM spectroscopic system adapted to an inverted microscope we found: (1) the conversion of Indo-AM to Indo- 1 in the cytosol is not complete (< 40% contribution to the total light); (2) rat neonate cells buffer Ca (at rest 130-170 nM) only for [Ca]. between 1 and 3 mM, whereas in adult guinea-pig cells the range extended to 10 mM; (3) during contraction [Ca]i rose from 200 nm to no more than 1 microM. Digitoxin increases basal and peak [Ca]i; (4) during spontaneous contractions, in guinea-pig cells, [Ca]i rises from 70 to 200 nm when [Ca]o = 0, and from 170 nm to about 1 microM when [Ca]o = 2 mM; (5) in voltage-clamp conditions the rise in [Ca]i does not exceed 2 microM and oscillations occur in the presence of forskolin. When loading with Indo-1, cells frequently cease to contract (Powell et al. 1988) and the variations in [Ca]i are then very small (about 200 nm at peak ICa). In both cases these values are small compared to the total charge crossing the membrane.
Neuromuscular Junction Development In The Cutaneous Pectoris Muscle Of Rana Catesbeiana, Diana Linden, Susan Jerian, Michael Letinsky
Neuromuscular Junction Development In The Cutaneous Pectoris Muscle Of Rana Catesbeiana, Diana Linden, Susan Jerian, Michael Letinsky
Diana Linden
Synaptic specializations were studied in the developing cutaneous pectoris muscle of Rana catesbeiana tadpoles and froglets to correlate nerve terminal morphology (by light and electron microscopy), accumulation of acetylcholine receptors, and the ability of the muscle to contract following nerve stimulation. This correlated approach was used to determine the developmental timing and possible causal relationship of events in nerve and muscle maturation at the neuromuscular junction. Initially, the cutaneous pectoris nerve trunk was present in the undifferentiated presumptive cutaneous pectoris mesenchyme, prior to muscle maturation. At stage XII when the muscle was first able to contract weakly in response to …
Correlated Muscle And Nerve Development In The Bullfrog Cutaneous Pectoris, Diana Linden, Michael Letinsky
Correlated Muscle And Nerve Development In The Bullfrog Cutaneous Pectoris, Diana Linden, Michael Letinsky
Diana Linden
The development of the cutaneous pectoris muscle was studied and compared with the differentiation of its peripheral nerve in bullfrog (Rana catesbeiana) tadpoles and frogs by light and electron microscopic techniques. This muscle preparation was chosen for this study because it possesses a number of advantages for (and has become a model system for) the study of correlated nerve-muscle development. At the earliest stage examined (stage XI) the presumptive muscle did not contain any contractile or morphologically distinguishable myotubes, but was contacted by the well-defined cutaneous pectoris nerve trunk. Myotubes were present at stage XII, the same time that nerve-associated …
Sensory Modulation Of Juvenile Play In Rats, Stephen M. Siviy, Jaak Panksepp
Sensory Modulation Of Juvenile Play In Rats, Stephen M. Siviy, Jaak Panksepp
Psychology Faculty Publications
A series of experiments was conducted to determine the extent to which somatosensory stimulation is necessary for the elaboration of juvenile play in rats. Anesthetization of the dorsal body surface of juvenile rats with xylocaine reduced the frequency of pinning, an indicator variable for play, by 35% to 70%, while motivation to play, measured by dorsal contacts, an index of play solicitation, remained largely intact. These data suggest that dorsal body surface anesthetization impairs the ability of juvenile rats to perceive and/or respond to playful gestures. When untreated animals were paired with xylocaine-treated animals, the xylocaine-treated animals consistently pinned the …
Rapid Decline In Acetylcholine Release And Content Of Rat Extensor Digitorum Longus Muscle After Denervation, Diana Linden, Michael Newton, Alan Grinnell, Donald Jenden
Rapid Decline In Acetylcholine Release And Content Of Rat Extensor Digitorum Longus Muscle After Denervation, Diana Linden, Michael Newton, Alan Grinnell, Donald Jenden
Diana Linden
The amount of acetylcholine (ACh) and choline (Ch) in normal and denervated rat extensor digitorum longus (EDL) muscles, as well as that released spontaneously from these muscles, was determined by an extremely sensitive gas chromatographicmass spectrometric assay method. We found decreases in ACh content and spontaneous, resting ACh release as early as 8 h after denervation. The ACh content decreased to a plateau of 30% of control by 11 h; ACh release attained a plateau of 50% of control several hours later. These results showed that in denervated EDL muscles ACh content and spontaneous release (measured biochemically) decreased before nerve-evoked …
The Ferret - A Useful Model For Studying Visual Pathway Development, Diana Linden
The Ferret - A Useful Model For Studying Visual Pathway Development, Diana Linden
Diana Linden
No abstract provided.
Biosynthesis And Degradation Of Acetylcholine Receptors In Rat Skeletal Muscles. Effects Of Electrical Stimulation, Diana Linden, D.M. Fambrough
Biosynthesis And Degradation Of Acetylcholine Receptors In Rat Skeletal Muscles. Effects Of Electrical Stimulation, Diana Linden, D.M. Fambrough
Diana Linden
Synthesis and degradation of acetylcholine receptors in rat skeletal muscles were measured in organ culture. The rate of de novo biosynthesis and incorporation of acetylcholine receptors into extrajunctional membranes of denervated muscles was measured by determining the rate of appearance of [1] [2H, 13C, 15N]-acetylcholine receptors when muscles were cultured in medium containing [1] [2H, 13C, 15N]-amino acids. Denervated extensor digitorum longus and soleus muscles were found to synthesize new receptors for several days in organ culture at an average rate of 1.4%/h. The degradation rates for extrajunctional and junctional acetylcholine receptors were estimated by irreversibly labeling acétylcholine receptors on …
Critical Flicker Frequency In A Harp Seal, Pagophilus Groenlandicus (Erxleben, 1777), Charles D. Bernholz
Critical Flicker Frequency In A Harp Seal, Pagophilus Groenlandicus (Erxleben, 1777), Charles D. Bernholz
UNL Libraries: Faculty Publications
Critical flicker frequency (CFF) in a free-swimming harp seal (Pagophilus groenlandicus) was investigated using behavioral techniques. The resulting CFF versus intensity contour indicates a definite rod-cone break, confirming a duplex photoreceptor population whose presence had not been observed in previous morphological reports.