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Articles 91 - 92 of 92
Full-Text Articles in Neuroscience and Neurobiology
Immediate Early Gene Expression In Medial Prefrontal Cortex And Hippocampus As A Function Of Aging, Megha Sehgal
Immediate Early Gene Expression In Medial Prefrontal Cortex And Hippocampus As A Function Of Aging, Megha Sehgal
Theses and Dissertations
Normal aging is accompanied by cognitive decline that differs from other aging-related pathological states like Alzheimer's disease. With an increasing proportion of the world population falling in an age group of 65 years and above, a preventive gerontological approach would improve the quality of life in the elderly. Especially important in this regard is the early detection of cognitive decline, so that appropriate measures can be taken to prevent development of cognitive deficits. Impairment in cognitive flexibility, the ability to modify a previously learnt behavior, is one such measure of impairment across species in aged animals. Previous work from our …
The Role Of Nmda Receptors In Extinction Of Cocaine Self-Administration, Madalyn Hafenbreidel
The Role Of Nmda Receptors In Extinction Of Cocaine Self-Administration, Madalyn Hafenbreidel
Theses and Dissertations
Relapse is highly prevalent among recovering addicts, and can be triggered by associations made between the rewarding effects of the drug and cues, such as drug paraphernalia or contexts. Inhibiting these associations, through new extinction learning, could help reduce relapse rates. Extinction is formed in phases, like other types of memory. The memory first is acquired in short-term memory, then is consolidated into long-term storage from which it can be retrieved at a later time (Quirk & Mueller, 2008). NMDA receptors are necessary for extinction in other paradigms (Santini, Muller, & Quirk, 2001), and we previously found that blocking NMDA …