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Full-Text Articles in Neuroscience and Neurobiology
Deciphering The Firing Patterns Of Hippocampal Neurons During Sharp-Wave Ripples, Kourosh Maboudi Ashmankamachali
Deciphering The Firing Patterns Of Hippocampal Neurons During Sharp-Wave Ripples, Kourosh Maboudi Ashmankamachali
Theses and Dissertations
The hippocampus is essential for learning and memory. Neurons in the rat hippocampus selectively fire when the animal is at specific locations - place fields - within an environment. Place fields corresponding to such place cells tile the entire environment, forming a stable spatial map supporting navigation and planning. Remarkably, the same place cells reactivate together outside of their place fields and in coincidence with sharp-wave ripples (SWRs) - dominant electrical field oscillations (150-250 Hz) in the hippocampus. These offline SWR events frequently occur during quiet wake periods in the middle of exploration and the follow-up slow-wave sleep and are …
Probing Hippocampal Activity In Sleep, Sleep Deprivation, And Recovery Sleep, Bapun Giri
Probing Hippocampal Activity In Sleep, Sleep Deprivation, And Recovery Sleep, Bapun Giri
Theses and Dissertations
Long-term memories are established over several hours of sleep following their initial acquisition. Large-scale recordings from the hippocampus have revealed that neurons reactivate or `replay' wake-induced activity in subsequent sleep episodes, leading many to suggest replay as an underlying mechanism for sleep-mediated memory consolidation. In this dissertation, I describe experiments that examine the extent of hippocampal replay during sleep and how replay is affected in the absence of sleep. In Chapter 2, we found that the hippocampus reactivates neuronal patterns expressed during exploration of a novel environment for upto 10 hours in subsequent sleep with a half-maximum timescale of $~$6 …