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Full-Text Articles in Neuroscience and Neurobiology
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Theses and Dissertations
Markers of cognitive impairment are needed to distinguish normal from pathological aging prior to the onset of clinical symptomology to improve Alzheimer’s disease (AD) treatment or prevention efforts. AD pathology is believed to develop years or even decades prior to diagnosis in medial temporal lobe subregions that provide input to the hippocampus (Braak & Braak, 1991), disrupting the ability of the hippocampus to bind individual elements of an experience to form cohesive memory representations. Eye movement behavior is a sensitive index of learning and effects of memory on eye movements have been shown to emerge rapidly (within 500-750ms of stimuli …
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Theses and Dissertations
Markers of cognitive impairment are needed to distinguish normal from pathological aging prior to the onset of clinical symptomology to improve Alzheimer’s disease (AD) treatment or prevention efforts. AD pathology is believed to develop years or even decades prior to diagnosis in medial temporal lobe subregions that provide input to the hippocampus (Braak & Braak, 1991), disrupting the ability of the hippocampus to bind individual elements of an experience to form cohesive memory representations. Eye movement behavior is a sensitive index of learning and effects of memory on eye movements have been shown to emerge rapidly (within 500-750ms of stimuli …
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Theses and Dissertations
The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …
Apoaequorin Differentially Modulates Fear Conditioning In Adult And Aged Rats, Vanessa Ehlers
Apoaequorin Differentially Modulates Fear Conditioning In Adult And Aged Rats, Vanessa Ehlers
Theses and Dissertations
Normal aging is associated with a number of changes in behavioral and cellular function, and is often linked to increased susceptibility to cognitive impairment. The hippocampus has been widely implicated in learning and memory, and many forms of learning that are hippocampus-dependent (e.g. trace fear conditioning) are impaired in aged animals. A proposed contributor to aging-related cognitive impairment is aging-related calcium (Ca2+) dysregulation. This dysregulation is thought to result from changes in specific Ca2+-regulatory mechanisms, including abnormal Ca2+ ion channel activity or expression, as well as reduced Ca2+-binding protein (CaBP) expression, which is associated with cognitive and synaptic impairment. Previous …
Investigation Of Neural Mechanisms Of Grip Relaxation, Binal Motawar
Investigation Of Neural Mechanisms Of Grip Relaxation, Binal Motawar
Theses and Dissertations
Neural mechanisms for grip relaxation are relatively unknown and understudied, as compared to mechanisms for grip initiation. Yet, termination of motor activity is as important as initiation in daily function. This knowledge gap presents incomplete understanding of neural control of hand function and its impairment with aging and neurologic disorders. The purpose of this dissertation was to identify and examine neural mechanisms of grip relaxation in healthy young adults, with aging, and in chronic stroke survivors. A series of experiments in healthy young adults showed that the relaxation from a maximum power grip was mediated by increase in the short-interval …