Life Sciences Commons^™

Understanding Stem Instructors’ Experiences With And Perceptions Of Deaf And Hard Of Hearing Students: The First Step Towards Increasing Access And Inclusivity, Makayla Long

Honors Theses

Through an anonymous survey we analyzed Western Michigan University (WMU) STEM instructors’ experience with and understanding of teaching and interacting with Deaf and Hard of Hearing (HoH) students. The goal of this study was to capture the experiences of WMU STEM instructors and the resources available to them given their direct impact on Deaf/HoH students’ ability to succeed and receive a post-secondary education. The findings of this study support the claim that instructors are not well supported or aware of the needs of Deaf/HoH students, and do not have access to adequate resources to resolve the issue.

The first steps …

Gender And Socioeconomic Disparities In Iatrogenic In-Hospital Torsades De Points, Bradley Reinoehl

Honors Theses

It has been well established for decades that women are at increased risk for torsades de pointes (TdP). Additionally, it has been well documented that patients of lower socioeconomic status (SES) tend to have inferior health outcomes compared to other patient populations. In this study we investigate the incidence of iatrogenic in-hospital TdP among these two demographic groups. Iatrogenic in-hospital TdP is a complex combination of medical issues and including danger from QT prolonging medications. In theory, a combination of identifiable, demographic risk factors coupled with specific clinical settings could be used to identify patients at high risk for iatrogenic …

Evaluation Of Autoreactivity In Vh4-34-Containing Antibodies From Human B-1 Vs B-2 Cells, Michelle E. Ray

Masters Theses

B-1 cells are a unique population of lymphocytes, with distinct phenotypic and functional characteristics in comparison to conventional B-2 cells. B-1 cells are thought to be more closely related to the innate immune system than the adaptive, and B-1 cells constitutively secrete antibody that is recognized as broadly reactive with low levels of autoreactivity. The antibody heavy chain segment, VH4-34, is overutilized by the human B-1 cell population. VH4-34 antibodies are associated with autoreactivity, although not all VH4-34 antibodies are autoreactive. The primary objective of this study was to determine whether autoreactive forms of VH4-34 antibodies are localized only to …

Cellulose Based Separator For High-Performance Lithium-Ion Batteries, Akshit Vaidya

Masters Theses

During the past two decades, lithium-ion batteries (LIBs) have gained great success in the field of portable devices, and currently, are penetrating to the market of vehicles. Compared to the fast development of LIBs, little efforts have been dedicated to the separator, which is one of the most important components of LIBs. Primarily, the lithium-ion battery separator has two functions, one is to prevent direct contact between the positive and negative electrodes, and the other is to provide a path for effective ionic transportation. Currently, the separator market of LIBs is dominated by polyolefin materials such as polypropylene, polyethylene, and …

Exploring Song As A Reproductive Isolation Mechanism In A Hybridizing Population Of Winged Warblers, Amy E. Janik

Masters Theses

Reproductive isolation mechanisms such as song are used by birds to promote assortative mating by species and prevent gene flow when closely related species come into secondary contact. Based on the strength of a reproductive barrier, signals in hybrid zones can diverge and become more dissimilar to maintain species or converge to become more similar and make species discrimination more difficult. When two closely related species overlap in territories and have similar songs, song convergence is likely and has the capacity to disrupt species recognition. We test the hypothesis that song acts as a reproductive isolation mechanism by examining song …

Agritourism Development In Southwest Michigan: Motivations Of Agritourists And Operators, Esther Akoto Amoako

Masters Theses

National agricultural statistics show that the number of agritourism farms and the proportion of agritourism related revenues in the United States has steadily increased during the last ten years, especially among small family farms. The recent growth in agritourism is both demand - and supply-driven. However, there are limited studies that explore agritourism motivations from both the visitors' and operators’ perspectives. This study examines what the agritourists' and operators’ motivations are and the challenges facing the industry to provide information for those currently involved and those wanting to include agritourism in their operations. Online and in-person surveys and unstructured interviews …

Strategies To Restore Hearing, Sydney N. Sheltz-Kempf

The Hilltop Review

We discuss strategies within the field to restore hearing in the context of a flat epithelia model. This could assist in avoiding the limitations of current treatment options along with the obstacles associated with cellular restoration attempts. A review of the important genes required for the development, differentiation, and long-term maintenance of the organ of Corti (OC) demonstrates that any future direction to regenerate hair cells necessitates a better understanding of the gene expression in addition to the cells present during the phalangeal scarring process and the flat epithelia environment. This understanding could be achieved through the development of a …

The Macroevolution Of Diadromous And Non-Diadromous Clupeiformes., Lindsey Dehaan

Honors Theses

Migration is a common life history strategy across the animal tree of life. This behavior is energetically demanding and may trigger strong selection for the evolution of an optimal ecomorphology to lessen energetic costs, yet the ecomorphology of migratory aquatic species remains poorly understood. Previous studies have demonstrated that migratory fishes exhibit predictable phenotypic patterns in body size evolution in response to evolving migration: migratory fishes are larger than non-migratory fishes. Migratory fishes may also have functional traits (e.g. fin shape) associated with locomotion that have experienced similar selective forces and exhibit predictable evolutionary patterns, resulting in migratory lineages sharing …

Supporting Black Mothers At The Transition: A Collaborative Design Prenatal Coparenting Program, Jordan Ebanaya

Masters Theses

Despite having the highest infant mortality rate of similarly developed nations, infant mortality rates have trended downward in the United States, however, the infant mortality disparity between Black and White infants persists. The causes of the disparity have been traced to social considerations of the mother especially while pregnant. These social situations include racism and discrimination, marital status of the mother, social support and pregnancy intentions, pointing to one commonality: stress. Using Boss and colleagues 2017 Conceptual Model of Family Stress, this study proposes a solution to address some of the social support, or resources, available to the expectant mother; …

Pcr Analysis On The Effects Of Alpha Synuclein Treatment On C6 Rat Glioma Cells, Michael John Helmus

Masters Theses

Multiple System Atrophy (MSA) is a rare neurological disease that mainly implicates the neuronal protein, alpha synuclein, as being centrally involved in MSA pathology. Despite synucleinopathy dogma, little is known about alpha synucleins role in MSA pathogenesis. The Ide laboratory previously conducted an Affymetrix gene expression study utilizing the post-mortem pons tissue from eight individuals with MSA and five individuals without any known neurological disorders. One conclusion from that study was that downregulation of numerous mitochondrial homeostasis related genes had occurred. It is hypothesized that alpha synuclein can perturb mitochondrial homeostasis through direct interaction with mitochondria. This study utilized Reverse …

Functional Analysis In The Home Setting Of An Older Adult With Neurocognitive Disorder, Emily Norton

Masters Theses

Currently within the behavioral gerontology literature there are no published studies that include a functional assessment in the home setting. The primary goal of the present study was to address this gap by conducting a functional analysis on a challenging behavior of an older adult with neurocognitive disorder in the home. This study occurred in two phases. During phase one, researchers conducted an antecedent functional analysis on the bizarre speech of an 81-year-old female with suspected dementia across four conditions (television on, no interactions initiated; television on, interactions initiated; television off, no interactions initiated; television off, interactions initiated). Results from …

Postactivation Potentiation Effects From Maximal Isometric Contractions Performed At Different Hip Joint Angles, Kyle Derosia

Masters Theses

The purpose of this study was to investigate the differences in vertical ground reaction force (VGRF) production and myoelectric activity after performing maximal isometric contractions at different hip joint angles. 10 healthy, experienced participants reported to the lab on two separate occasions where they performed 3 power cleans at baseline, then 4 maximal isometric deadlifts at either ~50° hip flexion angle (Max) or ~90° hip flexion angle (Min). Following the isometric deadlifts, another 3 power clean trials at 70% 1 repetition maximum were performed and used as a post-test. The isometric deadlifts served as the conditioning contraction (CC) to induce …

Relationship Between One Repetition Maximum Parallel Squat And Jump Squat Peak Power, Corey Klitzke

Masters Theses

Jump squats are a simple exercise that can be used to train lower body power. Unlike many other methods of power training, jump squats do not require any specialized equipment (platforms, bumper plates, etc.). Jump squats can be used when other forms of power training are not available or are not allowed. In order to most efficiently train power, the intensity must balance force and velocity. The purpose of this study was to find the intensity that yields the peak power output of a jump squat. 12 participants (9 males, 3 female) participated in the study. Each participant completed a …

Effect Of Caffeine Supplementation On Vertical Jump Performance, Heart Rate Variability, And Electromyography, Collin T. Garner

Masters Theses

Research into caffeine’s ability to improve anaerobic performance is inconclusive. Eleven anaerobically trained individuals (mean age: 23.45 ± 1.51 years) participated in this study. Assessments of resting heart rate variability (HRV), exercise heart rate variability, surface electromyography (sEMG), static vertical jump (SJ), and countermovement vertical jump (CMJ) were conducted before and after administration of placebo and caffeinated treatments. Three trials of each vertical jump technique were performed before and after treatment administration. A 60-minute absorption period was utilized for absorption of the treatment following its ingestion. All participants performed testing on two separate occasions, once under the placebo condition and …

Antibiotic Resistant Bacteria Isolated From Michigan Birds - A High School Learning Experience, Cody Benfant

Honors Theses

Bacteria, extremely small prokaryotic cells, are everywhere throughout the world. One striking thing about bacteria is their size: comparing a 2-micrometer bacterial cell to a 6-foot-tall human is similar in scale to comparing a 6-foot-tall human to the distance between Chicago, IL and Denver, CO! Despite their small size, bacteria are found in almost every ecosystem and environment imaginable. From deep sea hydrothermal vents to the clouds miles in the sky, there are trillions of bacteria flourishing in all of Earth’s ecosystems, performing many important functions in global nutrient cycles. While the majority of bacteria are beneficial to humans, …

Astrogliosis In The Adult Zebrafish Olfactory Bulb During Repetitive Peripheral Damage, Jackson Scheib

Masters Theses

Traumatic brain injuries (TBIs), particularly if repetitive, cause massive disruptions of brain homeostasis, significant loss of neurons, and may result in death. Astrocytes are a type of cell that maintain brain homeostasis and neuronal health. Astrogliosis is a continuum of morphological and functional changes of astrocytes in response to damage. This can be neuroprotective or neurotoxic depending on the severity and type of injury. Global astrocyte scarring is typical of neurotoxic astrogliosis and is the source of secondary injury after TBIs. The adult zebrafish olfactory system is known for its capacity to recover from trauma, however, astrocytes in this system …

The Meaning Of Song Type: Exploring Behavioral Responses Of Field Sparrows To Three Simple Song Types, Eliza Foli

Honors Theses

The frequency, rate, and overall quality of a male’s song may indicate the singer’s physical quality, either as a threat or as a potential mate, and are used for species recognition. However, the degree to which a song must differ acoustically to communicate different information about the singer remains unclear. Analysis of male field sparrow simple song recorded in southwest Michigan revealed three structurally distinct clusters of simple song that differ in frequency characteristics. We hypothesize that songs in each cluster convey information about the singer and that receivers respond more strongly to songs more similar to their own song. …

The Correlation Between The Microbiome And Neurodegenerative Disorders Such As Alzheimer Disease, Aurora Mokris

Honors Theses

Recent studies suggest that there are 1.3 times as many microbial cells as human cells in the body (Abbot, 2016). Another study claims that the combined genomes of this microbiota is 150 times that of the human genome (Zhuang & Shen, 2018). If you have ever had the feeling that you are not alone in an empty room you are most certainly correct. Your body is teeming with millions of organisms living in mutualistic symbiosis with you and surrounding microbes, but at times, this seemingly harmonious relationship can be disturbed, resulting in serious physical and psychological changes to the human …

Isolation And Characterization Of A Novel Terpenoid From The Needles Of Eastern White Pine (Pinus Strobus), And Its Potential Relation To Climate Change, Samantha Hack

Honors Theses

Climate changes is one of the most serious threats facing the future of our planet, and with is we will see drastic changes to water levels global temperatures, and atmospheric conditions. Modeling future atmospheric conditions is crucial if we are to plan for and mitigate the consequences of climate change – while important, these models will not be useful to future scientists unless various parameters, such as BVOC emission to the atmosphere, are accounted for and included in computer models. Eastern white pine (Pinus strobus) are predicted to be a major component of future climax forests as their abundance increases …

The Presence Of Photoreceptor Sensilla In The Posterior Sucker Of Medicinal Leeches Inferred Through Functional Visual Response., Claire Spivey

Honors Theses

Medicinal leeches gather visual input from both its eyecups and photoreceptors across its body surface; each of its 21 midbody segments possesses 14 photoreceptive sensilla. It has been previously established that the posterior sucker is composed of seven body segments that are fused during embryogenesis. Similarly, four body segments fuse to create the anterior brain. There are five bilateral pairs of eyes located on the dorsal surface of the leech’s head and seven bilateral pairs of sensilla distributed over the surface of each midbody segment (Kretz et al., 1975). If no sensilla were lost during the fusion of the seven …

Effects Of Age And Exercise On Density Of Sympathetic Innervation And Localization With Nerve Growth Factor And Glial Cell Line-Derived Neurotrophic Factor In Vascular Tissue, Kori Mecklenburg

Honors Theses

Hypertension is a condition that affects nearly 75 million people in the United States (Merai et al, 2017). To better understand this mostly idiopathic condition, the role of survival factors on arterial innervation must be understood. Nerve growth factor (NGF) and glial cell-line derived neurotrophic factor (GDNF) have been shown to support development and maintenance of the sympathetic nervous system. The aim of this study was to reveal how density of sympathetic innervation changes in mesenteric arteries over time and with six-months of exercise. Additionally, this study aimed to reveal the localization of GDNF and NGF alongside these changes in …

The Effects Of Climate Change And Forest Disturbances On Terpene Production Of White Pine (Pinus Strobus) And Red Pine (Pinus Resinosa) In Northern Michigan, Troy Dehagen

Honors Theses

The secondary impacts that climate change may have on the interactions between forests and the atmosphere through forest disturbances is of increasing interest as the climate continues to change. Anthropogenic climate change, which is a direct result of coal and fossil fuel emissions, is likely to impact forest ecology through increased temperatures and extreme precipitation events, thus increasing the frequency and severity of climate-induced forest disturbances. Forest disturbances may have a secondary impact on the production and emission of biogenic volatile organic compounds (BVOC) within forests. In the presence of oxides of nitrogen (NO_x) produced from fossil fuel …

Psychological Effects And Treatment Of An Injury On An Athlete: Suggested Treatment Plan For Athletic Trainers And Physical Therapist, Odell Miller

Honors Theses

Injuries that force athletes to lose participation in their sport and or training have a tremendous impact on their mental health. Mental health issues can be detrimental, but often times go unnoticed. For example in 2010, Kenny McKinley, a wide receiver for the Denver Broncos, was found dead after killing himself with a gun. After suffering a knee injury, he had become progressively depressed. Investigators reported that there are statements saying that McKinley didn’t know what he would do without football. According to NCAA’s Sports Science Institute (2017), the psychological response to injury can trigger mental health issues such as: …

The Effects Of Feliway On The Stress Of Cats During Veterinary Examination, Colleen Doonan

Honors Theses

The purpose of this study was to examine the effects of Feliway® during veterinary examination. Feliway® contains a synthetic version of the F3 pheromone, secreted from the cheeks of Felis sylvestris catus when rubbing against objects in the environment. It is presumed to allow cats to establish a home range to feel secure. A double-blind study was conducted to address the limitations of another study that concluded Feliway® is useful for reducing stress experienced by cats during veterinary examination. The current study found that Feliway® is not useful by itself for adequate stress reduction during feline examinations. It was concluded …

Mirror Therapy, A Pain Management Therapy, Gabriella Andrews

Honors Theses

This project was undertaken to explore the use of mirror therapy (MT) as a palliative for stroke patients and amputees experiencing phantom limb pain. MT is a relatively new treatment and while it has limited research, it is starting to be used more within the rehabilitation setting. Research suggests MT has beneficial effects occur with phantom limb pain as well as post-stroke patients. This study will explain the history, uses, and research behind MT not only as a form of therapy but also a non-medicinal pain reliever.

Included are interviews from physical therapists (PT) and occupational therapists (OT) along with …

Development And Validation Of Hybrid Continuum/Structural Finite Element Model For Evaluating Foot And Ankle Biomechanics, Saif Alrafeek

Dissertations

Bone is composed of two structures: compact bone and spongy bone. Spongy bone porosity highly affects the strength and the physical endurance of bone to carry loads. Most studies use continuum finite element (FE) approaches to model spongy bone and neglect porosity. Neglecting porosity may not efficiently assist orthopaedic surgeons to treat patients who experience bone physical disability. The purpose of this study is to demonstrate an inexpensive approach that simulates spongy bone with more accurate capturing of porosity and less requirements of bone information. The approach is developed through investigating the mechanical characteristics of spongy bone; that is, by …

Soy- Based Flexographic Ink For Linerboard Printing, Rahul Ramchandra Pingale

Masters Theses

Many printing inks use volatile solvents in the formulation, which are hazardous to the environment from emission of VOC’s and at the same time, synthetic resins in these inks are not biodegradable. These problems with the fluctuating and rising price of petroleum are main reasons to look for new resources for making more environmentally friendly printing inks. The majority of the commercially available water based inks are formulated based on using acrylic resins, synthetic colorants, solvents/water and additives, which are the common main components for formulating printing inks. In this research, soy proteins were tested for their suitability to partially …

Printed Dot Quality In Response To Doctor Blade Angle In Gravure Printing, Bilge N. Altay, Alexandra Pekarovicova, Paul D. Fleming

The Hilltop Review

Doctor blade is one of the critical machine part of the gravure printing press that controls the amount of ink transfer on the substrate. The angle of the blade can be varied; however, an improper angle may cause major problems. In this study, the doctor blade angle was positioned at three different level to address its effect on the printed dot quality. Print trials were made on a web-fed gravure press at the speed of 650 ft./min. A high-resolution overhead camera was used to analyze the key dot attributes. The results showed that measuring only the density of printed dot …

Tanapox: A Potential Oncolytic Virus For The Treatment Of Cancer, Joel Marty

Honors Theses

The National Cancer Institute defines cancer as a group of related diseases characterized by unimpeded cell division with metastatic abilities. Cells frequently mutate and potentially become cancerous, but generally these cells are cleared by the immune system. The disease state of cancer arises when the mutated cells evade the immune clearance, which indicates medical intervention is required. Current therapies most commonly utilize chemotherapy, radiation, or a combination of the two, however, alternative therapies are being developed such as immunotherapies and oncolytic viruses (OVs). OVs cause a viral infection, clearing cancerous cells through viral replication mechanisms, such as viral cytolysis, while …

Effects Of Instability On Core Muscle Activation In A Side Bridge, Erin E. Kishman

Masters Theses

Training the musculature of the core continues to be perceived as an essential component of conditioning and rehabilitation settings (11). A popular way to train the core is with the use of instability devices, such as Swiss ball or suspension trainer. However, there is limited research on the effects of these devices on core muscle activity. The purpose of this study was to examine core muscle activity during side bridge variations with and without instability devices (Floor, Swiss Ball, and TRX) through electromyography (EMG) of the rectus abdominis, external oblique, erector spinae, and latissimus dorsi. 39 participants performed three variations …