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Articles 31 - 34 of 34
Full-Text Articles in Life Sciences
Effect Of Thyroid Hormone Concentration On The Transcriptional Response Underlying Induced Metamorphosis In The Mexican Axolotl (Ambystoma), Robert B. Page, S. R. Voss, A. K. Samuels, J. J. Smith, S. Putta, C. K. Beachy
Effect Of Thyroid Hormone Concentration On The Transcriptional Response Underlying Induced Metamorphosis In The Mexican Axolotl (Ambystoma), Robert B. Page, S. R. Voss, A. K. Samuels, J. J. Smith, S. Putta, C. K. Beachy
Biology Faculty Publications
Background: Thyroid hormones (TH) induce gene expression programs that orchestrate amphibian metamorphosis. In contrast to anurans, many salamanders do not undergo metamorphosis in nature. However, they can be induced to undergo metamorphosis via exposure to thyroxine (T4). We induced metamorphosis in juvenile Mexican axolotls (Ambystoma mexicanum) using 5 and 50 nM T4, collected epidermal tissue from the head at four time points (Days 0, 2, 12, 28), and used microarray analysis to quantify mRNA abundances. Results: Individuals reared in the higher T4 concentration initiated morphological and transcriptional changes earlier and completed metamorphosis by Day 28. In contrast, initiation of metamorphosis …
Rapid Dissemination Of Francisella Tularensis And The Effect Of Route Of Infection, S. S. Ojeda, Z. J. Wang, Chris A. Mares, T. A. Chang, Q. Li, E. G. Morris, P. A. Jerabek, J. M. Teale
Rapid Dissemination Of Francisella Tularensis And The Effect Of Route Of Infection, S. S. Ojeda, Z. J. Wang, Chris A. Mares, T. A. Chang, Q. Li, E. G. Morris, P. A. Jerabek, J. M. Teale
Biology Faculty Publications
Background. Francisella tularensis subsp. tularensis is classified as a Category A bioweapon that is capable of establishing a lethal infection in humans upon inhalation of very few organisms. However, the virulence mechanisms of this organism are not well characterized. Francisella tularensis subsp. novicida, which is an equally virulent subspecies in mice, was used in concert with a microPET scanner to better understand its temporal dissemination in vivo upon intranasal infection and how such dissemination compares with other routes of infection. Adult mice were inoculated intranasally with F. tularensis subsp. novicida radiolabeled with 64Cu and imaged by microPET at 0.25, 2 …
Germ-Line Chimerism And Paternal Care In Marmosets (Callithrix Kuhlii), Corinna N. Ross, J. A. French, G. Ortí
Germ-Line Chimerism And Paternal Care In Marmosets (Callithrix Kuhlii), Corinna N. Ross, J. A. French, G. Ortí
Biology Faculty Publications
The formation of viable genetic chimeras in mammals through the transfer of cells between siblings in utero is rare. Using microsatellite DNA markers, we show here that chimerism in marmoset (Callithrix kuhlii) twins is not limited to blood-derived hematopoietic tissues as was previously described. All somatic tissue types sampled were found to be chimeric. Notably, chimerism was demonstrated to be present in germ-line tissues, an event never before documented as naturally occurring in a primate. In fact, we found that chimeric marmosets often transmit sibling alleles acquired in utero to their own offspring. Thus, an individual that contributes gametes to …
Assessment Of Student Skills For Critiquing Published Primary Scientific Literature: Using A Primary Trait Analysis Scale, Manuel F. Varela, Marvin M.F. Lutnesky, Marcy P. Osgood
Assessment Of Student Skills For Critiquing Published Primary Scientific Literature: Using A Primary Trait Analysis Scale, Manuel F. Varela, Marvin M.F. Lutnesky, Marcy P. Osgood
Biology Faculty Publications
Instructor evaluation of progressive student skills in the analysis of primary literature is critical for the development of these skills in young scientists. Students in a senior or graduate-level one-semester course in Immunology at a Masters-level comprehensive university were assessed for abilities (primary traits) to recognize and evaluate the following elements of a scientific paper: Hypothesis and Rationale, Significance, Methods, Results, Critical Thinking and Analysis, and Conclusions. We tested the hypotheses that average recognition scores vary among elements and that scores change with time differently by trait. Recognition scores (scaled 1 to 5), and differences in scores were analyzed using …