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Full-Text Articles in Life Sciences
Maternal Weight Affects Placental Dna Methylation Of Genes Involved In Metabolic Pathways In The Common Marmoset Monkey (Callithrix Jacchus), Laren Narapareddy, Derek E. Wildman, Don L. Armstrong, Amy Weckle, Aleeca F. Bell, Crystal L. Patil, Suzette D. Tardif, Corinna N. Ross, Julienne N. Rutherford
Maternal Weight Affects Placental Dna Methylation Of Genes Involved In Metabolic Pathways In The Common Marmoset Monkey (Callithrix Jacchus), Laren Narapareddy, Derek E. Wildman, Don L. Armstrong, Amy Weckle, Aleeca F. Bell, Crystal L. Patil, Suzette D. Tardif, Corinna N. Ross, Julienne N. Rutherford
Biology Faculty Publications
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation …