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Articles 31 - 35 of 35
Full-Text Articles in Biomedical Engineering and Bioengineering
The Global Manufacture Of Polio Vaccine In The Endgame Of Eradication, Philip Minor
The Global Manufacture Of Polio Vaccine In The Endgame Of Eradication, Philip Minor
Vaccine Technology III
The manufacture of medicines is increasingly globalised but biological products such as vaccines are more complex and their production raises significantly different issues to that of chemical entities. New producers in any region of the world may have difficulty in recognising all the concerns involved and can benefit from technology transfer exercises and a strong and scientifically competent regulatory authority. The issues will be discussed in the context of the Global Polio Eradication Initiative in its terminal phases and future needs for the manufacture of polio vaccine.
Clinical Development Of Formulated Therapeutic And Prophylactic Dna-Based Vaccines, Alain Rolland
Clinical Development Of Formulated Therapeutic And Prophylactic Dna-Based Vaccines, Alain Rolland
Vaccine Technology III
Over the recent years, plasmid DNA vaccines have reached licensure against infectious hematopoietic necrosis virus in farmed salmon (Canada), West Nile virus in horses and metastatic melanoma in dogs (United States). A number of approaches are currently evaluated in clinical trials to enhance the potency of DNA vaccines in humans, including formulation of DNA with delivery systems and adjuvants as well as administration of DNA with devices. This presentation will report on the development of TransVaxTM, a poloxamer-formulated therapeutic DNA vaccine against human cytomegalovirus (CMV) in transplant patients. A vaccine that increases CMV-specific T-cell responses could reduce CMV reactivation after …
Challenges In Confronting Pandemic Influenza Using Novel Adjuvanted Vaccines, Louis F. Fries
Challenges In Confronting Pandemic Influenza Using Novel Adjuvanted Vaccines, Louis F. Fries
Vaccine Technology III
Pandemic influenza is a recurring threat throughout history. Characterized by rapid spread and high attack rate, the features of pandemic influenza are grounded in the lack of immunologic experience with pandemic virus subtypes in the majority of the human population alive during the outbreak. Immunization is regarded as a key tool in preparing for, and mitigating, pandemic influenza. Unfortunately, capacity to manufacture sufficient inactivated influenza antigen by currently-licensed processes remains challenging, and this problem is amplified by the very short timeline for production and distribution that may be available. GSK has addressed the pandemic influenza challenge by application of the …
Poly-Methyl Vinyl Ether-Co-Maleic Anhydride Nanoparticles As Antigen Delivery And Activating Systems, Carlos Gamazo, Ibai Tamayo, Ana I. Camacho
Poly-Methyl Vinyl Ether-Co-Maleic Anhydride Nanoparticles As Antigen Delivery And Activating Systems, Carlos Gamazo, Ibai Tamayo, Ana I. Camacho
Vaccine Technology III
The incorporation of antigens into poly-methyl vinyl ether-co-maleic anhydride nanoparticles (NP) has demonstrated to enhance the immune responses in terms of a potent Th1-adjuvant capacity. This fact may be explained by the implemented possibilities that NP render to the antigen: controlled release from the vehicle and chemotaxis for APC recruitment. Besides, after oral administration, it was reported that the bioadhesive nature of the polymer enhanced the interaction of the particulate-adjuvant to the gut mucosa. Moreover, these NP allow the adhesion of antigens and ligands to its outer shell, creating high antigen density surfaces that increase the possibilities of antigen recognition …
Human Cells For Prostate Cancer Vaccine Therapy - The Impact Of Centrifugation Upon Key Product Quality Attributes, Michael Delahaye, Katherine Lawrence, Carol Chu Mike Hoare, Stephen Ward
Human Cells For Prostate Cancer Vaccine Therapy - The Impact Of Centrifugation Upon Key Product Quality Attributes, Michael Delahaye, Katherine Lawrence, Carol Chu Mike Hoare, Stephen Ward
Vaccine Technology III
Centrifugation is a unit operation used within a wide range of bioprocesses, including the production of a whole cell cancer vaccine to treat Hormone Refractory Prostate Cancer (HRPC) which has been tested in Phase II clinical trials. To quantify the effect of centrifugation-related stresses upon a whole cell vaccine population, a design of experiments (DOE) based investigation at micro-scale was implemented. Qualification of the cells may be by membrane integrity and by surface marker density as well as cytokines released and retained during bioprocessing. These and possibly other factors combine to affect the biopotency of the cells and their clinical …