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Full-Text Articles in Biomedical Engineering and Bioengineering
Building Process Understanding For Vaccine Manufacturing Using Data Mining, Matthew Wiener
Building Process Understanding For Vaccine Manufacturing Using Data Mining, Matthew Wiener
Vaccine Technology III
The production of vaccines is a complex biological process, with long cycle times and a high level of variation in raw materials, biological growth rates, and test methods. While long-term shifts or cycles in yield are not unusual, it is important to build understanding of the causes of shifts and cycles, for greater control and predictability. Hundreds of variables are monitored for every batch of vaccine produced; however, the relationships between product quality and the many process variables are difficult to quantify. In this article, we describe how mining historical process data using random forests and partial least squares (PLS) …
Challenges In Confronting Pandemic Influenza Using Novel Adjuvanted Vaccines, Louis F. Fries
Challenges In Confronting Pandemic Influenza Using Novel Adjuvanted Vaccines, Louis F. Fries
Vaccine Technology III
Pandemic influenza is a recurring threat throughout history. Characterized by rapid spread and high attack rate, the features of pandemic influenza are grounded in the lack of immunologic experience with pandemic virus subtypes in the majority of the human population alive during the outbreak. Immunization is regarded as a key tool in preparing for, and mitigating, pandemic influenza. Unfortunately, capacity to manufacture sufficient inactivated influenza antigen by currently-licensed processes remains challenging, and this problem is amplified by the very short timeline for production and distribution that may be available. GSK has addressed the pandemic influenza challenge by application of the …