Engineering Commons^™

Automated Identification Of Tumor Microscopic Morphology Based On Macroscopically Measured Scatter Signatures, Pilar Beatriz Garcia-Allende, Venkataramanan Krishnaswamy, P Jack Hoopes, Kimberley S. Samkoe, Olga M. Conde, Brian W. Pogue

Dartmouth Scholarship

An automated algorithm and methodology is presented to identify tumor-tissue morphologies based on broadband scatter data measured by raster scan imaging of the samples. A quasi-confocal reflectance imaging system was used to directly measure the tissue scatter reflectance in situ, and the spectrum was used to identify the scattering power, amplitude, and total wavelength-integrated intensity. Pancreatic tumor and normal samples were characterized using the instrument, and subtle changes in the scatter signal were encountered within regions of each sample. Discrimination between normal versus tumor tissue was readily performed using a K-nearest neighbor classifier algorithm. A similar approach worked …

Role-Play Scenarios For Teaching Responsible Conduct Of Research: Assessment Of Outcomes, Stephanie N. Seiler, Michael C. Loui, Kerri L. Kristich, Kyoung Jin Kim, C. K. Gunsalus, Bradley J. Brummel

Ethics in Science and Engineering National Clearinghouse

No abstract provided.

Responsible Conduct Of Research Role-Plays: Conflict Of Interest, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This faculty adviser in this role-play has a major conflict of interest, which puts the student in an awkward situation. If the conflict oversight committee hasn’t contacted the student already (an unfortunately common situation), they should have. In an ideal situation, every student affected by a potential conflict of interest should have some written guidance about what to expect and how to get advice if concerns arise.

One useful step is to find out if there are any written policies or guidelines about what students can expect in situations like this: for example, is there a meeting annually or every …

Investigation Of Magnetic Resonance Imaging And Spectroscopy For The Detection Of Breast Cancer, Robert Thomas Etnire

UNLV Theses, Dissertations, Professional Papers, and Capstones

Magnetic resonance imaging (MRI) of the breast offers an alternative to screening mammography which may benefit those women at high risk for breast cancer, women under the age of 40, and those with dense breast tissue. One concern with MRI is the number of high false positives. Coupling MRI with magnetic resonance spectroscopy(MRS) may lower the number of false positives, and thus improve the diagnostic capabilities of MRI for the clinician. MRS for breast imaging focuses on the total choline containing compounds in the spectra in the suspected breast lesion to analyze areas of concern. The results of the study …

2009 - The Fourteenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Fourteenth Annual Symposium of Student Scholars, held on April 13, 2009. Includes abstracts from the presentations and posters.

Vesicles In Poiseuille Flow, Gerrit Danker, Petia M. Vlahovska, Chaouqi Misbah

Dartmouth Scholarship

Blood microcirculation critically depends on the migration of red cells towards the flow centerline. We identify theoretically the ratio of the inner over the outer fluid viscosities λ as a key parameter. At low λ, the vesicle deforms into a tank-treading ellipsoid shape far away from the flow centerline. The migration is always towards the flow centerline, unlike drops. Above a critical λ, the vesicle tumbles or breaths and migration is suppressed. A surprising coexistence of two types of shapes at the centerline, a bulletlike and a parachutelike shape, is predicted.

A Fully Automated Non-External Marker 4d-Ct Sorting Algorithm Using A Serial Cine Scanning Protocol, Greg Carnes, Stewart Gaede, Edward Yu, Jake Van Dyk, Jerry Battista, Ting-Yim Lee

Edward Yu

Current 4D-CT methods require external marker data to retrospectively sort image data and generate CT volumes. In this work we develop an automated 4D-CT sorting algorithm that performs without the aid of data collected from an external respiratory surrogate. The sorting algorithm requires an overlapping cine scan protocol. The overlapping protocol provides a spatial link between couch positions. Beginning with a starting scan position, images from the adjacent scan position (which spatial match the starting scan position) are selected by maximizing the normalized cross correlation (NCC) of the images at the overlapping slice position. The process was continued by 'daisy …

Flight Physician - April, 2009, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Nano-Formulation And Controlled Delivery Of Low Solubility Anticancer Drugs, Anshul Agarwal

Doctoral Dissertations

Optimal drug delivery and reduction of systemic adverse effects have been age old problems in chemotherapeutics in all types of human cancer. During chemotherapy, using water insoluble drugs like paclitaxel and tamoxifen, it has been realized that better formulations are needed for more specific and controlled drug delivery of these agents. In a novel approach to form high content stable nanocolloids of these drugs with controllable release rate, a sonicated layer-by-layer (LbL) polyelectrolyte coating technology is suggested. The desired features of pharmaceutical carriers for intravenous administration include their small size and biodegradability, good loading capacity for a given drug, high …

In Vitro Ovarian Tumor Growth And Treatment Response Dynamics Visualized With Time-Lapse Oct Imaging, Conor L. Evans, Imran Rizvi, Tayyaba Hasan, Johannes F. De Boer

Dartmouth Scholarship

In vitro three-dimensional models for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology.Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dynamics not previously observed. The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer.

Carbon Nanotube Membranes For Use In The Transdermal Treatment Of Nicotine Addiction And Opioid Withdrawal Symptoms, Caroline L. Strasinger, Nicole N. Scheff, Ji Wu, Bruce J. Hinds, Audra L. Stinchcomb

Pharmaceutical Sciences Faculty Publications

Transdermal systems are attractive methods of drug administration specifically when treating patients for drug addiction. Current systems however are deficient in therapies that allow variable flux values of drug, such as nicotine for smoking cessation or complex dosing regimens using clonidine when treating opioid withdrawal symptoms. Through the use of functionalized carbon nanotube (CNT) membranes, drug delivery to the skin can be controlled by applying a small electrical bias to create a programmable drug delivery system. Clearly, a transdermal patch system that can be tailored to an individual's needs will increase patient compliance as well as provide much more efficient …

Motivation In Spinoza And Rosenzweig Or Transgressing The Boundaries Of A Rationally Constructed Self, Jules Simon

Jules Simon

No abstract provided.

Federal Register: National Science Foundation, Responsible Conduct Of Research, National Science Foundation

Ethics in Science and Engineering National Clearinghouse

The National Science Foundation (NSF) is soliciting public comment on the agency’s proposed implementation of Section 7009 of the America Creating Opportunities to Meaningfully Promote Excellence in Technology, Education, and Science (COMPETES) Act (42 U.S.C. 1862o–1). This section of the Act requires that ‘‘each institution that applies for financial assistance from the Foundation for science and engineering research or education describe in its grant proposal a plan to provide appropriate training and oversight in the responsible and ethical conduct of research to undergraduate students, graduate students, and postdoctoral researchers participating in the proposed research project.’’

[Abstract by author]

Ethical Issues In Peer Review Of Research, Michael C. Loui

Ethics in Science and Engineering National Clearinghouse

No abstract provided.

Reconstruction Of A Large-Scale Reconnection Exhaust Structure In The Solar Wind, W.-L. Teh, B. U. Ö Sonnerup, Q. Hu, C. J. Farrugia

Dartmouth Scholarship

We recover two-dimensional (2-D) magnetic field and flow field configurations from three spacecraft encounters with a single large-scale reconnection exhaust structure in the solar wind, using a new reconstruction method (Sonnerup and Teh, 2008) based on the ideal single-fluid MHD equations in a steady-state, 2-D geometry. The reconstruction is performed in the rest frame of the X-line, where the flow into, and the plasma jetting within, the exhaust region are clearly visible. The event was first identified by Phan et al. (2006) in the ACE, Cluster, and Wind data sets; they argued that quasi-steady reconnection persisted for over 2 h …

Responsible Conduct Of Research Role-Plays: Whistleblowing Data Management, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play involves data mismanagement in a research lab. The graduate students suspects that the post-doc fabricated experimental results, which is a form of research misconduct. The realization or suspicion that someone has engaged in research misconduct is one of the most difficult situations researchers face. However, someone who has witnessed misconduct has an obligation to act and report this behavior. Reporting the misconduct, which also known as whistle-blowing, should be done in a cautious and responsible way. Ideally, whistle-blowers should never be afraid to come forward with questions of misconduct, as they should be supported by their institutions and …

Responsible Conduct Of Research Role-Plays: Hazardous Substances, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play focuses on the dilemmas in balancing regulatory requirements, personal relationships and a natural reluctance to “cause trouble.” These dilemmas arise in many settings, and can be particularly acute in laboratories that handle hazardous substances because of the serious safety implications of violations. In addition, violations can carry fines and penalties for laboratories and universities where they occur. The worries of the graduate student in the role-play about potential laboratory shut-downs and corresponding research delays are all too real. Specifics of regulations vary according to the materials being handled. The underlying principles regarding human and environmental safety stay the …

Responsible Conduct Of Research Role-Plays: Human Subjects, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play addresses issues involved with human subject research and working with an Institutional Review Board (IRB).

The Belmont Report (1979) identifies three basic ethical principles that underlie all human subject research. These principles are Respect for persons, Beneficence, and Justice. Respect for persons requires us to treat individuals as autonomous human beings and not to use people as a means to an end. We must allow people to choose for themselves and provide extra protection to those with limited ability to choose, such as children. Rules derived from the principle of respect for persons include the requirements to obtain …

Responsible Conduct Of Research Role-Plays: Peer Review, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This scenario is based on “What is Responsible Peer Review?” http://ccnmtl.columbia.edu/projects/rcr/rcr_authorship/case/index.html#2, which is based on the “Confidentiality vs. Mentor Responsibilities: A Conflict of Obligations” scenario, http://onlineethics.org/reseth/appe/vol3/conflictobligations.html, which is based on a real incident.

This scenario highlights several issues in the peer review of manuscripts submitted for publication:

• Conflict of interest in the role of the reviewer

• Confidentiality of information in the manuscript

• Role of the adviser in the professional development of a graduate student

Although this scenario is not based on a single actual incident, each of the scenario’s elements occurs frequently in research in science and …

Responsible Conduct Of Research Role-Plays: Whistle-Blowing And Professional Relationships, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play focuses on a whistle-blowing scenario involving data management issues in a research lab, complicated by uncomfortable personal relationships. Whistle-blowing involves raising concerns or allegations of wrongdoing or misconduct. There is an obligation for whistle-blowers to do so in good faith, which means based on reasonable belief or facts. Suspecting that someone has engaged in research misconduct is one of the most difficult situations researchers face. This is especially true when relationships are strained for other reasons.

If you have the suspicion of research misconduct, the possible consequences for all involved can be serious. To handle the situation responsibly …

Responsible Conduct Of Research Role-Plays: Authorship, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play deals with issues concerning authorship credit. Concerns about authorship raise the ethical principle of fairness because people should receive credit for their contributions. Authors of a scientific work must have made substantial or significant contributions to the project because they are taking public responsibility for its content. Authors must also be willing and able to respond to questions about the work. The hard part of authorship is deciding what kind of intellectual contribution counts as substantial or significant and therefore warrants authorship. Despite the availability of guidelines, there are differences of opinions within and between scientific disciplines. Broad …

Responsible Conduct Of Research Role-Plays: Mentoring, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This scenario highlights the mismatch of expectations that can arise in a mentoring relationship between a graduate student and a research adviser. The adviser wants a solely professional relationship, but the student seeks a more personal relationship. Their inconsistent desires lead to inconsistent expectations about how long they should meet and what they should discuss, and subsequently to misunderstandings about the preliminary results.

Some of the problems in this scenario could have been avoided had the adviser and student negotiated mutual expectations and responsibilities when they first began working together. In general, a professor and student should agree on expectations, …

Preparation Of Nanovehicles For Targeted Drug Delivery, Anagha Avinash Bhakay

Theses

Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work throws light on the preparation of biodegradable and non-toxic nanoparticulate systems for targeted drug delivery. The drug vehicles were made by two different processes namely electrostatic interactions and desolvation process. The drug carriers made by these processes were found to be in the size range of 150-200nm which is necessary for cellular uptake …

The Use Of Ct Density Changes At Internal Tissue Interfaces To Correlate Internal Organ Motion With An External Surrogate, Stewart Gaede, Gregory Carnes, Edward Yu, Jake Van Dyk, Jerry Battista, Ting-Yim Lee

Edward Yu

The purpose of this paper is to describe a non-invasive method to monitor the motion of internal organs affected by respiration without using external markers or spirometry, to test the correlation with external markers, and to calculate any time shift between the datasets. Ten lung cancer patients were CT scanned with a GE LightSpeed Plus 4-Slice CT scanner operating in a ciné mode. We retrospectively reconstructed the raw CT data to obtain consecutive 0.5 s reconstructions at 0.1 s intervals to increase image sampling. We defined regions of interest containing tissue interfaces, including tumour/lung interfaces that move due to breathing …

Environmental Healthy Requirements In Residential Buildings: Amman As A Case Study, Philadelphia University

Philadelphia University, Jordan

No abstract provided.

Archetype Alignment: A Two-Level Driven Semantic Matching Approach To Interoperability In The Clinical Domain, Damon Berry, Jesus Bisbal

Conference Papers

Semantic interoperability between electronic health record systems and other information systems in the health domain implies agreement about the structure and the meaning of the information that is communicated. There are still a number of similar but different EHR system approaches. Some of the newer approaches adopt the two-layer model approach where a generic reference model is constrained by archetypes into valid clinical concepts which can be exchanged. The meaning of the concepts that are represented by an archetype can be conveyed by embedding codes from a commonly recognised terminology at appropriate points in the archetype. However, as the number …

Retrofitting Tractors With Rollover Protective Structures: Perspective Of Equipment Dealers, Shalome M. Tonelli, Kelley J. Donham, Kerry Leedom-Larson, Wayne Sanderson, Mark A. Purschwitz

Biosystems and Agricultural Engineering Faculty Publications

This study was one of a cluster of studies that originated via requests for proposals from the NIOSH National Agricultural Tractor Safety Initiative. The present study design consisted of several steps: (1) formation of an advisory group, (2) development and testing of a standard paper self-responding survey instrument, (3) sample selection of farm equipment dealers, (4) administration of the survey, (5) assessment and analysis of the survey, and (6) in-person response panel of dealers (n = 80) to review results of the questionnaire for further definition and sharpening of the recommendations from the survey. A key finding is that most …

Lentes De Contacto Rígidos Gas Permeables Esclerales, Una Opción Terapéutica En El Tratamiento De Enfermedades De La Superficie Ocular, Fermín Eduardo Arias Gómez

Ciencia y Tecnología para la Salud Visual y Ocular

Los lentes de contacto esclerales han mantenido un pequeño pero valioso lugar entre los lentes de contacto en la práctica clínica. Es evidente que, debido a la poca instrucción del lente escleral, no se le ha dado una alta prioridad en el ámbito profesional, lo que conlleva a que muchos profesionales no tengan una comprensión de sus ventajas intrínsecas y, en consecuencia, rara vez se prescribe o recomienda su uso. Este tipo de lentes rígidos gas permeables desempeñan un papel importante y no se valoran suficientemente en el tratamiento de enfermedades corneales, así como su beneficio para la rehabilitación visual …

Biocompatibility Of Poly-Ε-Caprolactone-Hydroxyapatite Composite On Mouse Bone Marrow-Derived Osteoblasts And Endothelial Cells, Haiying Yu, Paul H. Wooley, Shang-You Yang

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Tissue-engineered bone may be developed by seeding the cells capable of both osteogenesis and vascularization on biocompatible composite scaffolds. The current study investigated the performance of mice bone marrow-derived osteogenic cells and endothelial cells as seeded on hydroxyapatite (HA) and poly-ε-caprolactone (PCL) composite scaffolds.

Methods

Mononuclear cells were induced to osteoblasts and endothelial cells respectively, which were defined by the expression of osteocalcin, alkaline phosphatase (ALP), and deposits of calcium-containing crystal for osteoblasts, or by the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) and von Willebrand factor (vWF), and the formation of a capillary network in Matrigel™ …

The Journal Of Undergraduate Research: Volume 07

The Journal of Undergraduate Research

This is the complete issue of the South Dakota State University Journal of Undergraduate Research, Volume 7.