Engineering Commons^™

Mixing Performance Of A Novel, Continuous Confined Impinging Jets Mixer Using Competitive Reactions, Han Zheng

Theses

In this work, a novel continuous flow apparatus featuring the impingement of fluid jet streams in the presence of ultrasonic energy provided by an ultrasonic probe was tested using competitive reactions in order to determine its mixing effectiveness. The ultrasonic energy enhances micromixing of the fluid jet streams, which results in an overall mixing effectiveness improvements in different physical and chemical processes.

In the competitive reactions system used here (third Bourne reaction), one stream containing sodium hydroxide was continuously fed to the first impinging jet, while an aqueous solution of hydrochloric acid and ethyl chloroacetate was fed to the second …

Experimental Investigation Of Mixing Time In A Stirred, Torispherical-Bottomed Tank Equipped With A Retreat-Blade Impeller, Nonjaros Chomcharn

Theses

Glass-lined reactors are typically used in the pharmaceutical and specialty chemicals industries because of their material compatibility with most reactants and their cleanability. These reactors are typically equipped with a retreat-blade impeller placed close to the bottom of the tank a single baffle mounted from the top. The mixing performance of such reactors has not received significant attention in the literature, despite their ubiquitous presence in the pharmaceutical industry. In particular, mixing time, i.e., the time required by the system to achieve a predefined level of homogeneity, has not been studied to any significant degree.

In this work, the mixing …

Preparation Of Nanovehicles For Targeted Drug Delivery, Anagha Avinash Bhakay

Theses

Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work throws light on the preparation of biodegradable and non-toxic nanoparticulate systems for targeted drug delivery. The drug vehicles were made by two different processes namely electrostatic interactions and desolvation process. The drug carriers made by these processes were found to be in the size range of 150-200nm which is necessary for cellular uptake …