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Tribocorrosion And Metal Release From Austenitic Stainless Steels 304 And 201 In Simulated Cassava Food Contact, Robert Addai, Temitope E. Olowoyo, Thalia E. Standish, Jeffrey Daniel Henderson, Ubong Eduok, Yolanda Hedberg Jul 2024

Tribocorrosion And Metal Release From Austenitic Stainless Steels 304 And 201 In Simulated Cassava Food Contact, Robert Addai, Temitope E. Olowoyo, Thalia E. Standish, Jeffrey Daniel Henderson, Ubong Eduok, Yolanda Hedberg

Chemistry Publications

Cassava is the third most significant calorie source in the tropics. Its processing has changed from traditional methods to stainless steel processing machines. This study investigated the influence of cassava on metal release from two common stainless steels, ASTM 304 and 201, with and without friction, and on tribocorrosion (multianalytically) of 304. Cassava was relatively corrosive and hindered repassivation of the surface oxide of stainless steel, but it also acted as a lubricant against mechanical friction. The combined action of friction and cassava caused a significant increase in iron, chromium, nickel, and manganese release from the stainless steels (30–35- fold …


Retrieving Images From Tarnished Daguerreotypes Using X-Ray Fluorescence Imaging With An X-Ray Micro Beam With Tunable Energy, Tsun-Kong Sham, Y. Zou Finfrock, Qunfeng Xiao, Renfei Feng, Sarah Bassnet May 2024

Retrieving Images From Tarnished Daguerreotypes Using X-Ray Fluorescence Imaging With An X-Ray Micro Beam With Tunable Energy, Tsun-Kong Sham, Y. Zou Finfrock, Qunfeng Xiao, Renfei Feng, Sarah Bassnet

Visual Arts Publications

We report recent observations using a synchrotron X-ray micro-beam to retrieve images from tarnished 19th century daguerreotypes. We confirm that high quality image can always be retrieved from tarnished plates using Hg Lα XRF as long as the bulk of the image particles and their distribution remains intact. We also report results from using tunable tender X-rays (2 - 7 keV) to conduct imaging in high vacuum at energy above the Ag L-edge and the Hg M-edge, extracting images using Ag Lα and Hg Mα, respectively among others (e.g., S to track corrosion). Images obtained with the surface sensitive total …


Retrospective Pre-Post Evaluation Of A Healthy Relationships And Mental Health Promotion Program For 2s/Lgbtqia+ Youth, Nikita Kalwani Apr 2024

Retrospective Pre-Post Evaluation Of A Healthy Relationships And Mental Health Promotion Program For 2s/Lgbtqia+ Youth, Nikita Kalwani

Electronic Thesis and Dissertation Repository

Research has found that 2S/LGBTQIA+ youth experience disproportionately high mental health concerns and barriers to accessing support. Protective factors such as school-based support, peer support, and mental health interventions have been found to buffer this risk. The Healthy Relationships Program (HRP) for 2S/LGBTQIA+ Youth is a positive mental health promotion program that aims to build resiliency, bolster healthy relationship skills, and promote well-being among 2S/LGBTQIA+ youth. This study aimed to evaluate the outcomes, effectiveness, and feasibility of implementing this program within Gender and Sexuality/Gay-Straight Alliances (GSAs) in secondary schools. Data from students (N = 17) and GSA advisors who …


Anxiety In Children And Adolescents With Autism Spectrum Disorder: Behavioural Phenotypes And Environmental Factors, Caitlin E. Leachman Miss Apr 2024

Anxiety In Children And Adolescents With Autism Spectrum Disorder: Behavioural Phenotypes And Environmental Factors, Caitlin E. Leachman Miss

Electronic Thesis and Dissertation Repository

Anxiety is the most prevalent comorbidity among children and adolescents with autism spectrum disorder (ASD). The phenotypical presentation of anxiety among children and adolescents with ASD is lacking within the literature. This study sought to differentiate behavioral phenotypes associated with anxiety in children with ASD from anxiety in typically-developing children. Participants completed a series of child and parent reports measuring anxiety, depressive symptoms, ASD symptom severity, emotional problems, parental stress, and socioeconomic factors. Three distinct anxiety profiles, including moderate, high, and low, were identified. Results demonstrated that depression is the strongest predictor of high anxiety among children and adolescents with …


Luminescence And Structural Properties Of Silicon-Germanium Quantum Structures Fabricated By Ion Implantation, Matheus Coelho Adam Apr 2024

Luminescence And Structural Properties Of Silicon-Germanium Quantum Structures Fabricated By Ion Implantation, Matheus Coelho Adam

Electronic Thesis and Dissertation Repository

The advancement of semiconductor materials has played a crucial role in driving positive technological breakthroughs that impact humanity in numerous ways. The presence of defects significantly alters the physical properties of semiconductors, making their analysis essential in the fabrication of semiconductor devices. I presented a new method to quantify surface and near-surface defects in single crystal semiconductors. Epitaxially-grown silicon was measured by low energy electron diffraction (LEED) to obtain the surface Debye temperature (θD). The results showed the surface θD of bulk Si (001), 1.0 μm, and 0.6 μm Si on sapphire of 333 K, 299 K, …


Performing Masculinity: Calgary Men In The Great War, Andrew J. Hawkes Apr 2024

Performing Masculinity: Calgary Men In The Great War, Andrew J. Hawkes

Electronic Thesis and Dissertation Repository

This thesis explores the masculinity of soldiers from Calgary during the Great War using a theoretical framework of hegemonic masculinity. The first chapter establishes a normative masculine standard in Calgary using local newspaper coverage of battalion departure parades. These events were rituals that celebrated militarized masculinity and reinforced the hegemonic ideal that existed across the British Empire in the early 20th century. The second chapter assesses how masculinity was performed in letters during the war. Although men strove to embody the masculine ideal, their letters were not uniform endorsements of martial masculinity. The third chapter analyzes how hegemonic masculinity …


Feedback And Focus: Exploring Post-Secondary Students’ Perceptions Of Feedback, Mindfulness, And Stress, Cecilia S, Dong, Erin Isings, Samantha M. Jones, Hugh Samson, Lisa Mccorquodale, Thomas G. W. Telfer, Tracey Ropp, Christine E. Bell Apr 2024

Feedback And Focus: Exploring Post-Secondary Students’ Perceptions Of Feedback, Mindfulness, And Stress, Cecilia S, Dong, Erin Isings, Samantha M. Jones, Hugh Samson, Lisa Mccorquodale, Thomas G. W. Telfer, Tracey Ropp, Christine E. Bell

FIMS Publications

Addressing feedback-associated stress as a barrier to learning is increasingly relevant to student success and well-being. Mindfulness practices support stress management for students during the academic feedback process. Even if students receive high-quality feedback, the receiving end of feedback can be stressful, perhaps raising feelings of anxiety, confusion, or inadequacy. Feedback literacy and mindfulness practices complement one another. Mindfulness can potentially support feedback literacy by focusing one’s attention on the tasks needed to address feedback, instead of being distracted by emotions triggered by feedback. This study, comprised of an online survey (n = 237) and focus groups (n …


Harm Reduction In Psychotherapy, Jillian Cramer Apr 2024

Harm Reduction In Psychotherapy, Jillian Cramer

Electronic Thesis and Dissertation Repository

With approximately 22 people dying due to opiate-related harms everyday in Canada (Government of Canada, 2023), there is a great need to offer low-barrier, evidence-based services for people who use substances across various disciplines, including healthcare, social services, and psychotherapy. This qualitative study examined the experiences of Canadian social justice-informed counsellors who work with clients who use substances from harm reduction frameworks of care. Seven counsellors were interviewed on their personal experiences implementing harm reduction in psychotherapy. Through a reflexive thematic analysis, five themes surfaced: axiology of harm reduction work, development of therapist surrounding harm reduction, main focuses of harm …


Voice: Exploring The Experiences Of University Students Who Have Experienced Gender-Based Violence, Rabani Nagra Mar 2024

Voice: Exploring The Experiences Of University Students Who Have Experienced Gender-Based Violence, Rabani Nagra

Electronic Thesis and Dissertation Repository

Introduction: The occurrence and severity of gender-based violence (GBV) on Canadian higher education campuses has been a concern for decades. In September 2021, there were multiple reports of GBV at several Canadian universities with Western University being an exceptional case. The goal of this study was to explore: (1) the experiences of students who have experienced GBV during their enrollment at Western University; (2) the impact of GBV on students’ academics; and (3) student knowledge and experience with GBV resources.

Methods: This cross-sectional, qualitative study used an interpretive description framework and dialogue maps, underpinned by intersectionality. Seventeen undergraduate students were …


Five Interconnections Of Race And Class, Michael Billeaux-Martinez, David Calnitsky Mar 2024

Five Interconnections Of Race And Class, Michael Billeaux-Martinez, David Calnitsky

Sociology Publications

This paper proposes a five-part empirical typology of interconnections of race and class. We describe the mechanisms whereby (1) race is a form of class relation; (2) race relations and class relations reciprocally affect each other; (3) race acts as a sorting mechanism into class locations; (4) race acts as a mediating linkage to class locations; and (5) race interacts with class in determining other outcomes. Rather than insisting on one or another mechanism as the overarching framework for conceptualising the interconnections between race and class, we propose a theoretical integration of all five within a functionalist model. The model …


Examining How Users Perceive And Respond To Dark Patterns, Vicky Chung, Dominique Kelly, Jacquelyn Burkell Mar 2024

Examining How Users Perceive And Respond To Dark Patterns, Vicky Chung, Dominique Kelly, Jacquelyn Burkell

FIMS Publications

Dark patterns are user interface (UI) design elements that influence users to take actions that benefit an online service and that are generally not in the user’s best interest. Studies show that users demonstrate some awareness of and ability to identify dark patterns. Users also report experiencing negative emotions such as annoyance when encountering these tactics online. Yet, while users may abstractly understand that dark patterns exist, there is a disconnect between this understanding and their behavioural responses to manipulative design. Research has experimentally determined that dark patterns are effective at influencing users’ behaviour across different online activities, including consenting …


Syntheses And Electrospinning Of Poly(Amino Acid Ester) Phosphazene Biomaterials For Tissue Engineering Applications, Meng Wang Mar 2024

Syntheses And Electrospinning Of Poly(Amino Acid Ester) Phosphazene Biomaterials For Tissue Engineering Applications, Meng Wang

Electronic Thesis and Dissertation Repository

Despite advances made in the past decades to design biomaterials for tissue engineering, challenges remain. This thesis investigated the potential of electrospun poly(α-amino acid ester) phosphazenes (PαAPz) as novel biomaterials for vascular tissue engineering applications. As a class of biodegradable biomaterials, PαAPz provides biocompatibility and tunable properties and has gained attention as promising candidates for scaffolds in regenerative medicine, but their synthesis procedure is cumbersome due to the strict anhydrous environment and specialized equipment required for the thermal ring-opening reaction to produce the intermediate poly(dichlorophosphazene) (PDCP) product.

The research begins with the successful synthesis of PDCP using relatively simpler techniques …


Concerto For Piano Duet, Edgar R. Suski Mar 2024

Concerto For Piano Duet, Edgar R. Suski

Electronic Thesis and Dissertation Repository

My Concerto for Piano Duet (ca. 23 minute duration) was born out of my passion for the concerto medium and my love of piano performance. It is composed in eleven miniature movements, joined thematically by use of the 0-3-4 motive. In addition to the solo piano duettists, a number of movements include obligato soloists from various sections of the orchestra. My musical aesthetic in this composition features expressive melodies and horizontal/linear writing with a predilection for harmonic outcomes resulting from independent lines in counterpoint with each other. I chose the piano duet instead of piano solo due to lack of …


The Ecology Of American Noir, Katrina Younes Mar 2024

The Ecology Of American Noir, Katrina Younes

Electronic Thesis and Dissertation Repository

In The Ecology of American Noir, I investigate the relationship between the conventions of noir fiction and film and its sub-types in relation to environmental crises. Specifically, I address questions that not only allow us to (re)read early hardboiled literature and neo-noir films, but that also help us identify a new sub-genre of noir and develop an ecocritical methodology: I call this contemporary sub-genre and methodology “eco-noir.” I trace the development of strategies of mapping urban blight and environmental deterioration in classic hardboiled fiction of the 1940s, neo-noir films of the 1970s, and eco-noir texts of the post millennial …


The Study Of Titan's Surface Using Impact Craters And Analogues, Jahnavi Shah Mar 2024

The Study Of Titan's Surface Using Impact Craters And Analogues, Jahnavi Shah

Electronic Thesis and Dissertation Repository

Titan, Saturn’s largest moon, is an icy world harbouring a subsurface water ocean, a substantial atmosphere, and a flowing liquid on its surface. These distinctive characteristics give rise to complex chemical reactions on Titan, and also render it akin to Earth in terms of its landforms and processes. This positions Titan as a key target for studying prebiotic chemistry. NASA's fourth New Frontiers mission, Dragonfly, is poised to explore Titan’s surface in the 2030s. Dragonfly’s primary study site will be Selk crater, a relatively fresh impact crater located in Titan’s equatorial sand seas. Impact craters serve as valuable markers for …


A Comprehensive Study Of Neural Entrainment In Developmental Language Disorder And Reading Disability, Christine Moreau Mar 2024

A Comprehensive Study Of Neural Entrainment In Developmental Language Disorder And Reading Disability, Christine Moreau

Electronic Thesis and Dissertation Repository

Prior research has suggested that reading disability (RD, dyslexia) and developmental language disorder (DLD) stem from deficits in rhythmic auditory processing, specifically in synchronizing neural oscillations (Cumming et al., 2015; Goswami, 2011). Speech relies on rhythmic patterns for signaling linguistic information at multiple timescales (e.g., phonemes, syllables; Giraud & Poeppel, 2012). The disruption of regular neural entrainment is hypothesized to lead to difficulties in processing fast acoustic changes in speech, negatively affecting phonological processing, and speech segmentation. In this dissertation, I studied neural entrainment to uncover possible areas of impairment related to speech tracking, which could help inform interventions. In …


Precision Of Metabolite-Selective Mrs Measurements Of Glutamate, Gaba And Glutathione: A Review Of Human Brain Studies., Kesavi Kanagasabai, Lena Palaniyappan, Jean Theberge Mar 2024

Precision Of Metabolite-Selective Mrs Measurements Of Glutamate, Gaba And Glutathione: A Review Of Human Brain Studies., Kesavi Kanagasabai, Lena Palaniyappan, Jean Theberge

Department of Medicine Publications

Single-voxel proton magnetic resonance spectroscopy (SV 1 H-MRS) is an in vivo noninvasive imaging technique used to detect neurotransmitters and metabolites. It enables repeated measurements in living participants to build explanatory neurochemical models of psychiatric symptoms and testing of therapeutic approaches. Given the tight link among glutamate, gamma-amino butyric acid (GABA), glutathione and glutamine within the cellular machinery, MRS investigations of neurocognitive and psychiatric disorders must quantify a network of metabolites simultaneously to capture the pathophysiological states of interest. Metabolite-selective sequences typically provide improved metabolite isolation and spectral modelling simplification for a single metabolite at a time. Non-metabolite-selective sequences provide …


Exploring And Attending To The Wellness Needs Of Teachers In A Trauma And Violence-Informed Care Framework, Guannan Song Feb 2024

Exploring And Attending To The Wellness Needs Of Teachers In A Trauma And Violence-Informed Care Framework, Guannan Song

Undergraduate Student Research Internships Conference

The work of teachers is increasingly complex. This research project explores the effects of this work, current knowledge and attitudes, and the possibilities for professional development and support in teacher wellness, inclusion, and working with students who have difficult experiences.

An online survey was sent to Associate Teachers and Teacher Candidates in the B.Ed. program at Western University. The questions in this survey asked participants about their wellness, beliefs about learning and teaching, and the effects of trauma. Participants were also invited to share what types of professional development and resources related to teacher wellness (such as specific topics and …


Trevor Paglen's Border Abstractions In The Age Of Machine Vision, Sarah Bassnet Feb 2024

Trevor Paglen's Border Abstractions In The Age Of Machine Vision, Sarah Bassnet

Visual Arts Publications

Over the past two decades, machine vision and artificial intelligence (AI) have become integrated into many aspects of daily life, and with machines generating images for other machines, humans are no longer at the centre of the image world. To explore the implications of the age of machine vision, this article focuses on a selection of work by American artist Trevor Paglen made between 2008 and 2018. It examines the significance of the US-Mexico border region as a site of his investigations and the role of abstraction in repositioning machine vision within the human-centred visual language of art. The article …


Attribution Robustness Of Neural Networks, Sunanda Gamage Feb 2024

Attribution Robustness Of Neural Networks, Sunanda Gamage

Electronic Thesis and Dissertation Repository

While deep neural networks have demonstrated excellent learning capabilities, explainability of model predictions remains a challenge due to their black box nature. Attributions or feature significance methods are tools for explaining model predictions, facilitating model debugging, human-machine collaborative decision making, and establishing trust and compliance in critical applications. Recent work has shown that attributions of neural networks can be distorted by imperceptible adversarial input perturbations, which makes attributions unreliable as an explainability method. This thesis addresses the research problem of attribution robustness of neural networks and introduces novel techniques that enable robust training at scale.

Firstly, a novel generic framework …


The Spatial Risk Of Assault On Police Officers In Toronto, Ontario, Stephanie C. Pongracz Feb 2024

The Spatial Risk Of Assault On Police Officers In Toronto, Ontario, Stephanie C. Pongracz

MA Research Paper

Since September 12th, 2022, nine police officers in Canada have been fatally assaulted in the line of duty. These officer deaths raise important questions concerning the nature of risks police face on duty, as well as the ways we can better understand those risks. Utilizing a Risk Terrain Modelling (RTM) approach, this study examined the risk of assault to police officers in Toronto, Ontario using Assault to Peace Officer data from January 1st, 2022, to December 31st, 2022. This study revealed that the risk of assault to police varies by the physical features present …


Pain Among Immigrants To Canada: Testing The Healthy Immigrant Effect, Marouna Gomes Feb 2024

Pain Among Immigrants To Canada: Testing The Healthy Immigrant Effect, Marouna Gomes

MA Research Paper

In Canada, immigrants compose roughly one quarter of the population. The health of immigrants and their descendants is key to understanding the future health profile of all Canadians. Current literature on the health of immigrants often uses self-rated health and has produced mixed results regarding the healthy immigrant effect (HIE). Using data from the 2022 NEST survey, my study tests the HIE using chronic pain as a measure of population health to investigate the differences in pain experience among immigrants compared to the Canadian-born population. My results support the HIE: immigrants are 28% less likely to experience pain than Canadian-born …


Hands-On History: Applying A Strong Like Two People Approach To Archaeology Education, Kaylee Woldum Feb 2024

Hands-On History: Applying A Strong Like Two People Approach To Archaeology Education, Kaylee Woldum

Electronic Thesis and Dissertation Repository

This thesis explores Indigenization in the context of archaeology and Western education at the Tundra Science and Culture Camp (TSCC), a government-run summer camp in the Northwest Territories, Canada. By collaborating with Indigenous knowledge holders, it begins the process of re-designing the Human History session—a program within the TSCC that focuses on archaeology and the cultural sites around the camp—to incorporate more Indigenous pedagogies and knowledge. Drawing on semi-structured interviews and participant observation, this thesis outlines an attempt to Indigenize the Human History session at the 2022 TSCC, its successes and challenges, and diverse conceptions of what it would mean …


The Signs And Symptoms Of Discogenic Low Back Pain, Joe J. Putos Feb 2024

The Signs And Symptoms Of Discogenic Low Back Pain, Joe J. Putos

Electronic Thesis and Dissertation Repository

The signs and symptoms of low back pain (LBP) associated with disc herniation (DLBP) and its underlying mechanism(s) are not well supported. One theory proposes that some low back pain (LBP) is the result of a disc herniation compressing adjacent tissues innervated with nociceptors. The theory proposes that spinal manipulation (SM) and/or mobilizations (SMOB) can reduce the size and position of the herniation, and relieve pain and improve range of motion. There is no research to support or negate the theory even though clinical evidence supports its plausibility.

In this three-part study we examined clinical practices that have an anecdotal …


Physiotherapists Description Of Patient-Centered Care, And Barriers And Facilitators Experienced To Implementation, Maclean Jordan Feb 2024

Physiotherapists Description Of Patient-Centered Care, And Barriers And Facilitators Experienced To Implementation, Maclean Jordan

Electronic Thesis and Dissertation Repository

Patient-centered care (PCC) is a growing standard for healthcare delivery due to the benefits to patient autonomy. Lacking a cohesive definition in the physiotherapy literature, it is also lacking in implementation. Employing interpretive description with semi-structured interviews, the goal was to understand how physiotherapists drawn from private for-profit clinics in Canada describe PCC, and barriers and facilitators to providing it. Results included requiring person-centered communication in PCC, seeing Health holistically, centering the patient in care, and being a skill that becomes clearer with practice experience. Barriers included: lack of practitioner reflexivity, patient not desiring self-directed care, and limited access to …


Beyond The Portable Classroom: Investigating Portable Classrooms From Secondary Sources And Reframing Spatial Needs In Canadian Schools, Marzieh Forozantabar Feb 2024

Beyond The Portable Classroom: Investigating Portable Classrooms From Secondary Sources And Reframing Spatial Needs In Canadian Schools, Marzieh Forozantabar

Electronic Thesis and Dissertation Repository

Despite the prevalence of portable classrooms in Canadian schools, research on their characteristics, utilization, and effects is limited. This study investigates portable classrooms in Canada through a two-stage research approach. First, it explored news articles to identify common concerns about portable classrooms in Canada. The dataset comprises 243 news articles. The analysis revealed three overarching concerns about these structures: 1) The factors that lead school districts to use portable classrooms; 2) Safety and comfort in portable classrooms; 3) Strategies to alleviate accommodation issues. Then, Nair’s (2014) principles of contemporary school design were used to critically interrogate the utilization of portable …


Transportation And Land Use Planning For Healthy Cities, Naser Ahmed Feb 2024

Transportation And Land Use Planning For Healthy Cities, Naser Ahmed

Electronic Thesis and Dissertation Repository

Healthy cities provide physical and mental health benefits to citizens. To promote scientific transportation and land use planning for healthy cities, robust geospatial methods are required. This thesis introduces two new geospatial methods to facilitate healthy transportation and land use planning. First, to help healthy land use planning, a new analytical framework for identifying green space deserts based on various walking distance thresholds is introduced. This method is particularly useful in low-middle-income countries in the Global South where guidelines for proper walking distance thresholds to green spaces are missing. Second, to aid healthy transportation planning, a new measure of transit-based …


Analyses For Assessing The Centreline Translation, Asymmetrical Wind-Field, And Velocity Fluctuations Of Tornado Vortices, Niall C. Bannigan Feb 2024

Analyses For Assessing The Centreline Translation, Asymmetrical Wind-Field, And Velocity Fluctuations Of Tornado Vortices, Niall C. Bannigan

Electronic Thesis and Dissertation Repository

Tornadoes present an ever-increasing threat to communities worldwide, especially those with geographic conditions that place them in the path of several tornadoes annually. These conditions are likely to be exacerbated by ongoing trends in the climate. As such, it is necessary to move towards experimental and numerical tornado-like vortex studies that allow for more advanced simulation methods. Novel techniques for tracking and analysing tornado vortices simulated at high spatial and temporal resolution are presented herein. Significant wandering of the tornado's position and large peaks in the velocity field can be captured, demonstrating tangential gusting at more than 1.5 times the …


Incidence Of First-Episode Status Epilepticus And Risk Factors In Ontario, Canada, Rebecca Grace Couper, Tresah Antaya, Piotr Wilk, Teneille Gofton, Derek B. Debicki, Jorge Burneo Feb 2024

Incidence Of First-Episode Status Epilepticus And Risk Factors In Ontario, Canada, Rebecca Grace Couper, Tresah Antaya, Piotr Wilk, Teneille Gofton, Derek B. Debicki, Jorge Burneo

Neuroepidemiology Research Unit Publications

Background: Status epilepticus (SE) is a neurological emergency characterized by prolonged seizures. However, the incidence of first-episode SE is unclear, as estimates vary greatly among studies. Additionally, SE risk factors have been insufficiently explored. Therefore, the objectives of this study were to estimate the incidence of first-episode SE in Ontario, Canada, and estimate the associations between potential sociodemographic and health-related risk factors and first-episode SE.

Methods: We conducted a population-based retrospective cohort study using linked health administrative datasets. We included individuals who completed Canada's 2006 Census long-form questionnaire, lived in Ontario, were between 18 and 105, and had no history …


Share Cannabidiol Exposure During Gestation Leads To Adverse Cardiac Outcomes Early In Postnatal Life In Male Rat Offspring., Daniel B. Hardy, Steven R. Laviolette, Kendrick Lee, David Rc Natale Feb 2024

Share Cannabidiol Exposure During Gestation Leads To Adverse Cardiac Outcomes Early In Postnatal Life In Male Rat Offspring., Daniel B. Hardy, Steven R. Laviolette, Kendrick Lee, David Rc Natale

Physiology and Pharmacology Publications

Introduction: Studies indicate that *7% of pregnant individuals in North America consume cannabis in pregnancy. Pre-clinical studies have established that maternal exposure to D9-tetrahydrocannabinol (THC; major psychoactive component in cannabis) leads to fetal growth restriction and impaired cardiac function in offspring. However, the effects of maternal exposure to cannabidiol (CBD; major non-euphoric constituent) on cardiac outcomes in offspring remain unknown. Therefore, our objective is to investigate the functional and underlying molecular impacts in the hearts of offspring exposed to CBD in pregnancy. Methods: Pregnant Wistar rats were exposed to either 3 or 30mg/kg CBD or vehicle control i.p. daily from …