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Borders And Boundaries In The Lives Of Migrant Agricultural Workers, C. Susana Caxaj, Amy Cohen, Bonar Buffam, Abe Oudshoorn Dec 2020

Borders And Boundaries In The Lives Of Migrant Agricultural Workers, C. Susana Caxaj, Amy Cohen, Bonar Buffam, Abe Oudshoorn

Global Health Equity Publications

In 2018, roughly 72%of the 69,775 temporary migrant agricultural labourers arriving in Canada participated in the Seasonal Agricultural Workers Program (SAWP). Despite having legal status in Canada, these individuals are often systematically excluded from community life and face barriers when accessing health and social services. SAWP workers’ exclusion from many public spaces and their incomplete access to the benefits of Canadian citizenship or residency provide us a unique opportunity to examine social and political mechanisms that construct(in)eligibility for health and protection in society.As individuals seeking to care for the sick and most marginalized, it is important for nurses to understand …


Protecting Health Data In A Pandemic: A Systematic Adversarial Threat Analysis Of Contact Tracing Apps, Leah Krehling Dec 2020

Protecting Health Data In A Pandemic: A Systematic Adversarial Threat Analysis Of Contact Tracing Apps, Leah Krehling

Electronic Thesis and Dissertation Repository

In this thesis centralized, decentralized, Bluetooth, and GPS based applications of digital contact tracing were reviewed and assessed. Using privacy principles created by a contingent of security and privacy experts from across Canada, a metric of assessing an application’s privacy was created. An attack tree was built to assess the security of the contact tracing applications. Eighteen attacks were theorized against contact tracing applications currently in use. An application’s vulnerability to the attacks was measured using a scoring system developed for this purpose. The results of the security scores were used to create a metric for assessing the security of …


A Truly Magical Summer: My Experiential Learning Credit With The Walt Disney World Cultural Exchange Program, Sierra Joseph Dec 2020

A Truly Magical Summer: My Experiential Learning Credit With The Walt Disney World Cultural Exchange Program, Sierra Joseph

SASAH 4th Year Capstone and Other Projects: Publications

For my SASAH experiential learning credit, I participated in the Culture Exchange Program (CEP) at Walt Disney World in Orlando, Florida. This program invites international post-secondary education students to work at Disney during their summer break. I worked as a Slide Operator at the Typhoon Lagoon Waterpark. Working in the “Most Magical Place on Earth” necessitates lots of training, structure, and specific procedures to follow in this safety-critical role. While working at the waterpark was a wonderful experience, my experiential learning also existed outside working hours such as connecting with other international students and being integrated into American culture. This …


Immigrant’S Personal Network In The Integration Process: A Case Study Of Ghanaian Immigrants’ In The Toronto Census Metropolitan Area, Emmanuel Kojo Kyeremeh Dec 2020

Immigrant’S Personal Network In The Integration Process: A Case Study Of Ghanaian Immigrants’ In The Toronto Census Metropolitan Area, Emmanuel Kojo Kyeremeh

Electronic Thesis and Dissertation Repository

This dissertation focuses on the integration of recent immigrants in receiving societies by analyzing their personal networks' contribution to this process. Although migration studies have stressed the importance of relationships or im/migrant networks in different spatial contexts, gaps exist in understanding this phenomenon. Specifically, studies on immigrants' networks' structure and composition that indicate their integration level in the host society is missing within the literature. This research, therefore, contributes to our understanding of personal networks. It considers the structure of immigrants’ network by examining the role of their migration project and context of reception towards developing ties in the host …


Perspectives Of Canadian University Coaches On Integrating Sport Psychology And Mental Performance Consultants In Varsity Programs, Federico Cisneros Sánchez Dec 2020

Perspectives Of Canadian University Coaches On Integrating Sport Psychology And Mental Performance Consultants In Varsity Programs, Federico Cisneros Sánchez

Electronic Thesis and Dissertation Repository

Recently, sport psychology has become a more popular resource for athletes and coaches when looking to increase performance. It is unknown how many Canadian universities utilize sport psychology services in their athletic programs. Semi-structured interviews were conducted with coaches of Canadian university varsity teams to learn about their opinions on sport psychology and mental performance consultants (MPCs). The research was approached from a pragmatic perspective. Results showed that MPCs are important to enhance performance and provide mental health resources. MPCs provide athletes with personal and leadership development, mental skills training, and mental health support. MPCs can also be a resource …


The Role Of Haptic Expectations In Reaching To Grasp: From Pantomime To Natural Grasps And Back Again, Robert L. Whitwell, Nathan J. Katz, Melvyn A. Goodale, James T. Enns Dec 2020

The Role Of Haptic Expectations In Reaching To Grasp: From Pantomime To Natural Grasps And Back Again, Robert L. Whitwell, Nathan J. Katz, Melvyn A. Goodale, James T. Enns

Brain and Mind Institute Researchers' Publications

© Copyright © 2020 Whitwell, Katz, Goodale and Enns. When we reach to pick up an object, our actions are effortlessly informed by the object’s spatial information, the position of our limbs, stored knowledge of the object’s material properties, and what we want to do with the object. A substantial body of evidence suggests that grasps are under the control of “automatic, unconscious” sensorimotor modules housed in the “dorsal stream” of the posterior parietal cortex. Visual online feedback has a strong effect on the hand’s in-flight grasp aperture. Previous work of ours exploited this effect to show that grasps are …


Biodegradability Of Cellulose And Its Impact On Oxygen Transfer Efficiency And Biological Nutrients Removal, Ahmed Shawki Ahmed Dec 2020

Biodegradability Of Cellulose And Its Impact On Oxygen Transfer Efficiency And Biological Nutrients Removal, Ahmed Shawki Ahmed

Electronic Thesis and Dissertation Repository

Cellulose from toilet paper is a significant fraction of particulate organics, which is recoverable. For the first time, comprehensive mapping and tracking the fate of cellulose across various unit processes at full-scale in two water resource recovery facilities located in North America and Europe was undertaken. The influent cellulose content accounted for approximately one-third of the total suspended solids (TSS). More than 80% of the raw wastewater cellulose was captured in primary treatment. The high cellulose content of the primary sludge accounting for 17%-35% of the TSS facilitates cellulose recovery. Cellulose biodegradation efficiency varied between 70%-90% of the primary effluent, …


(End)Zones And (Out)Fields Of Production: Contemporary Conditions Of Labor And Artistic Critique, Stephanie G. Anderson Dec 2020

(End)Zones And (Out)Fields Of Production: Contemporary Conditions Of Labor And Artistic Critique, Stephanie G. Anderson

Electronic Thesis and Dissertation Repository

In a 2013 exhibition publication titled It’s the Political Economy, Stupid!, John Roberts made the observation that “Over the last ten years we have become witness to an extraordinary assimilation of art theory and practice into the categories of labor and production.” Whereas once art claimed for itself a critical capacity in relation to the larger system of capitalist domination by its status as a putatively ‘autonomous’ sphere of production from which it leveraged its difference and critique, today it is largely acknowledged that there is no longer any such ‘outside’ to be aspired to. If, in the recent …


Risk Stratification For Treatment Decisions In People At Ultra-High Risk For Psychosis: A Cost-Effectiveness Analysis, Olajumoke Marissa Ologundudu Dec 2020

Risk Stratification For Treatment Decisions In People At Ultra-High Risk For Psychosis: A Cost-Effectiveness Analysis, Olajumoke Marissa Ologundudu

Electronic Thesis and Dissertation Repository

People with psychotic disorders have long-term negative health outcomes and contribute large health system costs. Intervening among those at ultra-high risk (UHR) for psychosis may prevent or mitigate risk for psychotic disorder; however, it is unclear if we should treat all UHR individuals or only those above a certain risk threshold. The objectives were to systematically review the literature on the cost-effectiveness of UHR programs, and to conduct an economic evaluation of a risk stratification strategy, where treatment decisions are based on the probability of transitioning to psychotic disorder. Our systematic review found that UHR programs are potentially cost-effective. The …


Assessment Of Landing Biomechanics And Rehabilitation After Anterior Cruciate Ligament Reconstruction, Sheila S. Gagnon Dec 2020

Assessment Of Landing Biomechanics And Rehabilitation After Anterior Cruciate Ligament Reconstruction, Sheila S. Gagnon

Electronic Thesis and Dissertation Repository

Aberrant landing biomechanics increase the risk of anterior cruciate ligament (ACL) injury and are a focus of rehabilitation after ACL reconstruction. The purpose of the present thesis was to develop and evaluate methods of assessing landing mechanics and investigate the effects of different rehabilitation strategies after ACL reconstruction. Three studies were conducted. The first study used a Delphi process to develop the content of a Clinician-Rated Drop Vertical Jump Scale to evaluate jump landing mechanics during rehabilitation after ACL reconstruction. Twenty experts participated in four rounds of questioning, resulting in 92% agreement for knee valgus collapse, lateral trunk lean, insufficient …


Case – 18F-Dcfpyl-Positron Emission Tomography/Computed Tomography (Pet/Ct) Time Of Imaging, Golmehr Sistani, Ur Metser, Glenn S. Bauman, David T. Laidley, Stephen E. Pautler, Katherine A. Zukotynski Dec 2020

Case – 18F-Dcfpyl-Positron Emission Tomography/Computed Tomography (Pet/Ct) Time Of Imaging, Golmehr Sistani, Ur Metser, Glenn S. Bauman, David T. Laidley, Stephen E. Pautler, Katherine A. Zukotynski

Medical Biophysics Publications

No abstract provided.


Reliability-Based Calibration Of Design Wind Load, Snow Load And Companion Load Factors Considering Climate Change Effect, Qian Tang Dec 2020

Reliability-Based Calibration Of Design Wind Load, Snow Load And Companion Load Factors Considering Climate Change Effect, Qian Tang

Electronic Thesis and Dissertation Repository

Wind load and snow load are two of the environmental loads that need to be considered for structural design. This study compared the statistical characteristics of the annual maximum thunderstorm and non-thunderstorm winds based on the updated wind speed dataset and carried out the extreme value analysis for wind load by treating the synoptic and thunderstorm winds separately. The results indicated that for southern Ontario and the southern part of the Prairies, the extreme winds could be dominated by thunderstorm winds. The consideration of both thunderstorm winds and synoptic winds separately to recommend the reference wind velocity pressure for the …


Cortical Thickness Estimation In Individuals With Cerebral Small Vessel Disease, Focal Atrophy, And Chronic Stroke Lesions, Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F. Holmes, Kirstin Walker, Christopher J.M. Scott, Fuqiang Gao, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Gustavo Saposnik, Ayman Hassan, Jane Lawrence-Dewar, Dariush Dowlatshahi, Stephen C. Strother, Sean Symons, Robert Bartha, Richard H. Swartz, Sandra E. Black Dec 2020

Cortical Thickness Estimation In Individuals With Cerebral Small Vessel Disease, Focal Atrophy, And Chronic Stroke Lesions, Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F. Holmes, Kirstin Walker, Christopher J.M. Scott, Fuqiang Gao, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Gustavo Saposnik, Ayman Hassan, Jane Lawrence-Dewar, Dariush Dowlatshahi, Stephen C. Strother, Sean Symons, Robert Bartha, Richard H. Swartz, Sandra E. Black

Medical Biophysics Publications

Background: Regional changes to cortical thickness in individuals with neurodegenerative and cerebrovascular diseases (CVD) can be estimated using specialized neuroimaging software. However, the presence of cerebral small vessel disease, focal atrophy, and cortico-subcortical stroke lesions, pose significant challenges that increase the likelihood of misclassification errors and segmentation failures. Purpose: The main goal of this study was to examine a correction procedure developed for enhancing FreeSurfer’s (FS’s) cortical thickness estimation tool, particularly when applied to the most challenging MRI obtained from participants with chronic stroke and CVD, with varying degrees of neurovascular lesions and brain atrophy. Methods: In 155 CVD participants …


Experimental Investigation Of Inverse Liquid-Solid Fluidized Bed Hydrodynamics, Saleh A. Srabet Dec 2020

Experimental Investigation Of Inverse Liquid-Solid Fluidized Bed Hydrodynamics, Saleh A. Srabet

Electronic Thesis and Dissertation Repository

Abstract

Inverse liquid-solid fluidized beds have recently received increased attention, particularly for use with wastewater treatment bioreactors (i.e., particle-supported biofilms). The flow behaviour of free-rising light particles is especially interesting because their drag coefficients deviate from the standard drag curve. For this reason, the work presented in this thesis was focussed on investigating the minimum fluidization velocity () and the steady-state bed voidage associated with four particles, with densities of 28, 122, 300, and 678 kg/m3, in a conventional inverse fluidization regime. All experimental measurements were completed using a large-scale system comprising a downer column with a diameter …


Finite Element Analyses And Random Field Modeling Of Naturally Corroded Underground Energy Pipelines, Ji Bao Dec 2020

Finite Element Analyses And Random Field Modeling Of Naturally Corroded Underground Energy Pipelines, Ji Bao

Electronic Thesis and Dissertation Repository

Metal-loss corrosion is one of the major threats to the integrity of oil and natural gas pipelines. The Fitness-For-Service (FFS) assessment is commonly carried out to demonstrate the integrity of the corroded pipelines. The naturally occurring corrosions on the external surfaces are irregularly shaped three-dimensional features. Due to the geometric complexity of the natural corrosion features, the research of FFS assessment in the previous studies always employed the pipe segments containing artificially induced corrosion features. However, since artificial features are in general regular-shaped, e.g. cubic or semi-ellipsoidal, they do not capture geometric characteristics of naturally occurring corrosions. The thesis develops …


Reflecting On My Adventures In Experiential Learning, Will Sharpe Dec 2020

Reflecting On My Adventures In Experiential Learning, Will Sharpe

SASAH 4th Year Capstone and Other Projects: Publications

This report analyzes and reflects on my experiential learning experiences with the Forest City Film Festival and Western Libraries. I look back at my initial feelings of bewilderment and imposter syndrome and then track my progress as I’m pushed out of my comfort zone and learn the skills I need to excel. My time with the Forest City Film Festival and Western Libraries, as well as my peers’ testimonies, taught me that at SASAH, we all have the skills needed to succeed in our fields — and the experiential learning program is an excellent place to nurture them.


A Novel Spatio-Temporal Examination Of Children's Accessibility, Exposure, And Engagement To Parks And Recreation Spaces In Middlesex-London, Ontario, Malcolm K. Little Dec 2020

A Novel Spatio-Temporal Examination Of Children's Accessibility, Exposure, And Engagement To Parks And Recreation Spaces In Middlesex-London, Ontario, Malcolm K. Little

Electronic Thesis and Dissertation Repository

Children are spending more free time engaged in activities indoors, rather than in outdoor environments such as parks and recreation spaces. Parks and recreation spaces provide amenities that promote physical, cognitive, and social health among children. As it relates to the complexities of children’s living situations, properly measuring children’s levels of interactions with these spaces is poorly understood in geography research.

By examining various attributes of children, this thesis improves on the measurement of children’s levels of interactions with parks and recreation spaces. Research herein utilized household survey data, a high-resolution GIS dataset of environmental factors, and GPS logs from …


Efficient Hardware Architectures For Public-Key Cryptosystems, Mohammadamin Saburruhmonfared Dec 2020

Efficient Hardware Architectures For Public-Key Cryptosystems, Mohammadamin Saburruhmonfared

Electronic Thesis and Dissertation Repository

Finite field arithmetic plays an essential role in public-key cryptography as all the underlying operations are performed in these fields. The finite fields are either prime fields or binary fields. Binary field elements can mainly be represented on a polynomial basis or a normal basis (NB). NB representation offers a simple squaring operation, especially in hardware. However, multiplication is typically complex, and a particular subset of NB called Gaussian Normal Basis (GNB) features an efficient multiplication operation used in this work. The first part of this thesis has focused on improving finite field arithmetic architectures over GNB. Among different arithmetic …


Towards Efficient And Secure Iiot: Solutions For The Sensing Domain, Elena Uchiteleva Dec 2020

Towards Efficient And Secure Iiot: Solutions For The Sensing Domain, Elena Uchiteleva

Electronic Thesis and Dissertation Repository

This work explores reduced complexity solutions for the increased efficiency and safety of the industrial Internet of Things (IIoT) sensing domain. Resource virtualization, security, and predictive modeling are the main subjects of these studies.

The first solution is a joint throughput and time-resource allocation scheme for virtualization of IEEE 802.15.4-based wireless sensor networks. Virtualization is realized through the utilization of the guaranteed time slot mechanism for scheduling on the medium access control (MAC) layer. The solution abstracts resources into logical units that are allocated to segregated applications with different service requirements. The problem is formulated in a linear optimization framework …


Population-Based Studies On Medications And Fall-Related Injury In Older Adults, Yu Ming Dec 2020

Population-Based Studies On Medications And Fall-Related Injury In Older Adults, Yu Ming

Electronic Thesis and Dissertation Repository

Background: Fall-related injuries in older adults result in serious consequences to individuals and health care system, especially with the increasing aging population. The purpose of this study was to (1) describe medication prescription patterns within one year prior to fall-related injuries; (2) identify medication classes prescribed within 30 days prior to the injury that were associated to fall-related injury; and (3) examine the association between fall-related injuries and continuous use or new initiation of most commonly prescribed medications.

Methods: Studies used administrative health care data in Ontario. Study 1 described the frequency of medications prescribed to older adults within one …


Pathway‐Extended Gene Expression Signatures Integrate Novel Biomarkers That Improve Predictions Of Patient Responses To Kinase Inhibitors, Ashis Bagchee‐Clark, Eliseos J. Mucaki, Tyson Whitehead, Peter Rogan Dec 2020

Pathway‐Extended Gene Expression Signatures Integrate Novel Biomarkers That Improve Predictions Of Patient Responses To Kinase Inhibitors, Ashis Bagchee‐Clark, Eliseos J. Mucaki, Tyson Whitehead, Peter Rogan

Biochemistry Publications

Cancer chemotherapy responses have been related to multiple pharmacogenetic biomarkers, often for the same drug. This study utilizes machine learning to derive multi‐gene expression signatures that predict individual patient responses to specific tyrosine kinase inhibitors, including erlotinib, gefitinib, sorafenib, sunitinib, lapatinib and imatinib. Support vector machine (SVM) learning was used to train mathematical models that distinguished sensitivity from resistance to these drugs using a novel systems biology‐based approach. This began with expression of genes previously implicated in specific drug responses, then expanded to evaluate genes whose products were related through biochemical pathways and interactions. Optimal pathway‐extended SVMs predicted responses in …


Adaptive Randomised Controlled Non-Inferiority Multicentre Trial (The Ketodex Trial) On Intranasal Dexmedetomidine Plus Ketamine For Procedural Sedation In Children: Study Protocol, Naveen Poonai, Kamary Coriolano, Terry Klassen, Anna Heath, Maryna Yaskina, Darcy Beer, Scott Sawyer, Maala Bhatt, April Kam, Quynh Doan, Vikram Sabhaney, Martin Offringa, Petros Pechlivanoglou, Serena Hickes, Samina Ali Dec 2020

Adaptive Randomised Controlled Non-Inferiority Multicentre Trial (The Ketodex Trial) On Intranasal Dexmedetomidine Plus Ketamine For Procedural Sedation In Children: Study Protocol, Naveen Poonai, Kamary Coriolano, Terry Klassen, Anna Heath, Maryna Yaskina, Darcy Beer, Scott Sawyer, Maala Bhatt, April Kam, Quynh Doan, Vikram Sabhaney, Martin Offringa, Petros Pechlivanoglou, Serena Hickes, Samina Ali

Paediatrics Publications

Introduction Up to 40% of orthopaedic injuries in children require a closed reduction, almost always necessitating procedural sedation. Intravenous ketamine is the most commonly used sedative agent. However, intravenous insertion is painful and can be technically difficult in children. We hypothesise that a combination of intranasal dexmedetomidine plus intranasal ketamine (Ketodex) will be non-inferior to intravenous ketamine for effective sedation in children undergoing a closed reduction. Methods and analysis This is a six-centre, four-arm, adaptive, randomised, blinded, controlled, non-inferiority trial. We will include children 4-17 years with a simple upper limb fracture or dislocation that requires sedation for a closed …


Adaptive Randomised Controlled Non-Inferiority Multicentre Trial (The Ketodex Trial) On Intranasal Dexmedetomidine Plus Ketamine For Procedural Sedation In Children: Study Protocol, Naveen Poonai, Kamary Coriolano, Terry Klassen, Anna Heath, Maryna Yaskina, Darcy Beer, Scott Sawyer, Maala Bhatt, April Kam, Quynh Doan, Vikram Sabhaney, Martin Offringa, Petros Pechlivanoglou, Serena Hickes, Samina Ali Dec 2020

Adaptive Randomised Controlled Non-Inferiority Multicentre Trial (The Ketodex Trial) On Intranasal Dexmedetomidine Plus Ketamine For Procedural Sedation In Children: Study Protocol, Naveen Poonai, Kamary Coriolano, Terry Klassen, Anna Heath, Maryna Yaskina, Darcy Beer, Scott Sawyer, Maala Bhatt, April Kam, Quynh Doan, Vikram Sabhaney, Martin Offringa, Petros Pechlivanoglou, Serena Hickes, Samina Ali

Paediatrics Publications

Introduction Up to 40% of orthopaedic injuries in children require a closed reduction, almost always necessitating procedural sedation. Intravenous ketamine is the most commonly used sedative agent. However, intravenous insertion is painful and can be technically difficult in children. We hypothesise that a combination of intranasal dexmedetomidine plus intranasal ketamine (Ketodex) will be non-inferior to intravenous ketamine for effective sedation in children undergoing a closed reduction. Methods and analysis This is a six-centre, four-arm, adaptive, randomised, blinded, controlled, non-inferiority trial. We will include children 4-17 years with a simple upper limb fracture or dislocation that requires sedation for a closed …


Correlates Of Preventable Emergency Department Visits In Canada: Evidence From The Literature And The Canadian Community Health Survey, Tammy Lau Dec 2020

Correlates Of Preventable Emergency Department Visits In Canada: Evidence From The Literature And The Canadian Community Health Survey, Tammy Lau

Electronic Thesis and Dissertation Repository

Emergency department (ED) visits for primary healthcare-treatable conditions are preventable and indicate barriers to primary healthcare. The goal of this thesis was to explore the prevalence and key correlates of preventable ED visits among adults in Canada. Our systematic review found that the prevalence of these visits ranged from 4.3% to 59.1% and were associated with younger age, low education, low income, rural residence, and worse self-rated health. Our analysis of data from the 2015-2016 Canadian Community Health Survey found that 39.9% of adults with a regular healthcare provider considered their last ED visit to be preventable. In addition to …


Higher-Dose Sitagliptin And The Risk Of Congestive Heart Failure In Older Adults With Ckd, Flory T. Muanda, Matthew A. Weir, Lavanya Bathini, Kristin K. Clemens, Vlado Perkovic, Manish M. Sood, Eric Mcarthur, Jessica M. Sontrop, Richard B. Borobia, Hoi Y. Tong, Cristina Dávila-Fajardo, Mariana Rodrigues Botton, Stephane Bourgeois, Panos Deloukas, Michael D. Caldwell, Jim K. Burmester, Richard L. Berg, Larisa H. Cavallari, Katarzyna Drozda, Min Huang, Li Zi Zhao, Han Jing Cen, Rocio Gonzalez-Conejero, Vanessa Roldan, Yusuke Nakamura, Taisei Mushiroda Dec 2020

Higher-Dose Sitagliptin And The Risk Of Congestive Heart Failure In Older Adults With Ckd, Flory T. Muanda, Matthew A. Weir, Lavanya Bathini, Kristin K. Clemens, Vlado Perkovic, Manish M. Sood, Eric Mcarthur, Jessica M. Sontrop, Richard B. Borobia, Hoi Y. Tong, Cristina Dávila-Fajardo, Mariana Rodrigues Botton, Stephane Bourgeois, Panos Deloukas, Michael D. Caldwell, Jim K. Burmester, Richard L. Berg, Larisa H. Cavallari, Katarzyna Drozda, Min Huang, Li Zi Zhao, Han Jing Cen, Rocio Gonzalez-Conejero, Vanessa Roldan, Yusuke Nakamura, Taisei Mushiroda

Paediatrics Publications

Background and objectives Sitagliptin, a dipeptidylpeptidase-4 inhibitor, is commonlyprescribed to patientswith type 2 diabetes. As this drug is primarily eliminated by the kidney, a reduced dose is recommended for patients with CKD. Some evidence suggests that sitagliptin is associated with a higher risk of congestive heart failure, particularly at higher doses.Wecompare the 1-year risk of death or hospitalizationwith congestive heart failure in patients with CKD newly prescribed sitagliptin at <50 versus ≤50 mg/d. Design, setting, participants, & measurements This population-based cohort study included older adults (>66 years) with type 2 diabetes and an eGFR<45 ml/min per 1.73 m2 (but not receiving dialysis) who were newly prescribed sitagliptin between 2010 and 2017 in Ontario, Canada. We used inverse probability of treatment weighting on the basis of propensity scores to balance baseline characteristics. The primary composite outcome was death or hospitalization with congestive heart failure. Secondary outcomes included hospitalization with pancreatitis or hypoglycemia, all-cause hospitalization, and glycemic control. Weighted hazard ratios were obtained using Cox proportional hazards regression, and 95%confidence intervalswere obtained using bootstrap variance estimators. Results Of 9215 patients, 6518 started sitagliptin at >50 mg/d, and 2697 started sitagliptin at ≤50 mg/d. The 1-year risk of death or hospitalization with congestive heart failure did not …


Comparing Neuromuscular System Function In Healthy And Mobility-Impaired Older Females, Neal B. Mckinnon Dec 2020

Comparing Neuromuscular System Function In Healthy And Mobility-Impaired Older Females, Neal B. Mckinnon

Electronic Thesis and Dissertation Repository

Objectives: The objective of this thesis was to evaluate and compare neuromuscular system function in a group of young, healthy old and mobility-impaired older females (gait speed less than 1m/s) in an attempt to identify which neuromuscular factors contribute most to the loss of mobility and functional performance with age.

Methods: The ankle dorsiflexor and knee extensor muscles were used as a model in these studies. First, in Chapter 2 quantitative electromyography (EMG) was used to evaluate motor unit (MU) numbers, properties and the fidelity of the neuromuscular junction. Next, Chapter 3 conducted magnetic resonance imaging (MRI) to examine contractile …


Community Of Entrepreneurs In Coworking Space, Nam Kyoon Kim Dec 2020

Community Of Entrepreneurs In Coworking Space, Nam Kyoon Kim

Electronic Thesis and Dissertation Repository

This dissertation studies the novel phenomenon related to the social context of entrepreneurship—coworking space. Coworking spaces are known for creating a social community of entrepreneurial workforce—entrepreneurs, freelancers, contractors, remote workers, and others. The three essays that form this dissertation collectively highlight the entrepreneurial community in coworking spaces by proposing a novel typology of coworking space based on community, discovering the community building process, and analyzing user reviews of coworking spaces.

The first essay contributes to the literature on coworking space by creating novel ideal types of coworking spaces. Based on interviews conducted and archival data from 16 coworking spaces, this …


Improving Hydrid Pet/Mri Cardiovascular Imaging With Improved Hardware Design And Attenuation Correction Coefficient, Adam Helmy Farag Dec 2020

Improving Hydrid Pet/Mri Cardiovascular Imaging With Improved Hardware Design And Attenuation Correction Coefficient, Adam Helmy Farag

Electronic Thesis and Dissertation Repository

According to the World Health Organization (WHO) report in 2019, cardiovascular diseases (CVD) cause 52% of all illness-related deaths globally and are considered to be the second most common cause of death in Canada. CVD is also estimated to cost the Canadian economy about $21.2 billion in direct and indirect costs. With these figures, it is vital to develop the most effective and accurate methods and tools to diagnose accurately CVD and their causes. One of the promising tools for accurate diagnostic and therapeutic of CVD is the integrated Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) PET/MRI technology, …


“It's All Window Dressing:” Canadian Police Officers' Perceptions Of Mental Health Stigma In Their Workplace, Lesley J. Bikos Dec 2020

“It's All Window Dressing:” Canadian Police Officers' Perceptions Of Mental Health Stigma In Their Workplace, Lesley J. Bikos

Sociology Publications

Purpose: This study will provide a preliminary, general overview of Canadian police officers’ perception of stigma toward mental illness in their workplace culture and its impacts.

Design/methodology/approach: This study uses a mixed methods approach with two nationwide datasets: a self-report survey (N=727) and 116 semi-structured interviews with police officers from 31 police services. Results are grounded in theories of stigma, masculinities, and organizational culture.

Findings: Results indicate that most officers believe stigma toward mental illness in their workplace remains, despite senior management messaging and program implementation. Reporting mental illness was often seen as high risk, both personally and professionally. Policewomen, …


Targeting Cd5 To Enhance Immune T Cell Activation And Function In Treatment Of Solid Tumours, Faizah Alotaibi Dec 2020

Targeting Cd5 To Enhance Immune T Cell Activation And Function In Treatment Of Solid Tumours, Faizah Alotaibi

Electronic Thesis and Dissertation Repository

CD5 is a member of scavenger receptor cysteine-rich superfamily that is expressed primarily on T cells. It can attenuate T-cell receptor signaling and impair cytotoxic T lymphocyte (CTL) activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against tumours (including solid tumours) has not been explored. CD5- solid tumours in CD5 knockout mice display increased in anti-tumour immunity. Hence, blocking CD5 function may have a potential therapeutic effect by enhancing CTL function. Here, I assessed CD5 levels in …