Digital Commons Network^™

Vitamin D In The Prevention Of Exacerbations Of Asthma In Preschoolers (Diva): Protocol For A Multicentre Randomised Placebo-Controlled Triple-Blind Trial, Megan E. Jensen, Francine M. Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H. White, Mohsen Sadatsafavi, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E. Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

Paediatrics Publications

Introduction Preschoolers have the highest rate of emergency visits and hospitalisations for asthma exacerbations of all age groups, with most triggered by upper respiratory tract infections (URTIs) and occurring in the fall or winter. Vitamin D insufficiency is highly prevalent in Canadian preschoolers with recurrent asthma exacerbations, particularly in winter. It is associated with more URTIs and, in patients with asthma, more oral corticosteroid (OCS) use. Although evidence suggests that vitamin D supplements significantly decrease URTIs and asthma exacerbations requiring OCS, there is insufficient data in preschoolers. This study aims to determine the impact of vitamin D 3 supplementation on …

Generating Energy Data For Machine Learning With Recurrent Generative Adversarial Networks, Mohammad Navid Fekri, Ananda M. Ghosh, Katarina Grolinger

Electrical and Computer Engineering Publications

The smart grid employs computing and communication technologies to embed intelligence into the power grid and, consequently, make the grid more efficient. Machine learning (ML) has been applied for tasks that are important for smart grid operation including energy consumption and generation forecasting, anomaly detection, and state estimation. These ML solutions commonly require sufficient historical data; however, this data is often not readily available because of reasons such as data collection costs and concerns regarding security and privacy. This paper introduces a recurrent generative adversarial network (R-GAN) for generating realistic energy consumption data by learning from real data. Generativea adversarial …

Chili Pepper Consumption And Cardiovascular Mortality, J. David Spence

Department of Medicine Publications

No abstract provided.

Self-Healing Of Concrete Under Diverse Environmental Exposure, Ahmed Ramadan Suleiman

Electronic Thesis and Dissertation Repository

Self-healing efficiency of cement-based materials has so far been evaluated mostly through the healing of surface cracks, without adequately capturing the dominant effects of environmental exposure or accurately quantifying the volume of cracks healed. In addition, the effects of diverse additions such as silica-based materials, swelling agents, superabsorbent polymers, and carbonating minerals on self-healing performance under different environmental exposure, remain largely unexplored.

In this dissertation, multiple test methods were used to investigate self-healing of cracks in cement mortar incorporating metakaolin, bentonite, fly ash, superabsorbent polymers, and calcium carbonate microfiller under different environmental exposure (i.e. cold and hot temperatures, high and …

Role Of Groundwater-Lake Interactions On The Behavior Of Chemicals In A Nearshore Aquifer, Sabina Rakhimbekova

Electronic Thesis and Dissertation Repository

It is well recognized that groundwater-surface water interactions play an important role in controlling the flux of groundwater-derived inorganic chemicals to surface waters. While these interactions have been well-studied in marine, and river and stream settings, the influence of these interactions on chemical fluxes to large lakes is poorly understood. Nearshore aquifers adjacent to inland coastal waters, such as the Great Lakes, are characterized by dynamic flow patterns and the mixing of groundwater and lake water, which have distinct chemical compositions. This sets up an important reaction zone in the nearshore aquifer that may modify the fate of groundwater-derived chemicals …

Partial Nitritation Anammox Process For Sidestream Wastewater Treatment In Mabr Technology, Panagiota Stamatopoulou

Electronic Thesis and Dissertation Repository

There has been an increased interest in alternative wastewater treatment systems to improve nutrients removal and energy consumptions while achieving acceptable discharge limits. Wastewater treatment plants (WWTP) have shifted their interest in treating the sidestream wastewater; a reject liquid post anaerobic digestion, rich in ammonium-nitrogen. A dedicated sidestream wastewater treatment unit has become an attractive option with the finding of a relatively new species of bacteria, anaerobic ammonium oxidizers (anammox), able to convert ammonium and nitrite into nitrogen gas. However, anammox bacteria are sensitive in environmental changes, and in combination with their low growth rate, it is challenging to establish …

Algorithms For Mappings And Symmetries Of Differential Equations, Zahra Mohammadi

Electronic Thesis and Dissertation Repository

Differential Equations are used to mathematically express the laws of physics and models in biology, finance, and many other fields. Examining the solutions of related differential equation systems helps to gain insights into the phenomena described by the differential equations. However, finding exact solutions of differential equations can be extremely difficult and is often impossible. A common approach to addressing this problem is to analyze solutions of differential equations by using their symmetries. In this thesis, we develop algorithms based on analyzing infinitesimal symmetry features of differential equations to determine the existence of invertible mappings of less tractable systems of …

Current State Of Precision Medicine In Primary Systemic Vasculitides, Erkan Demirkaya, Zehra Serap Arici, Micol Romano, Roberta Audrey Berard, Ivona Aksentijevich

Paediatrics Publications

Precision medicine (PM) is an emerging data-driven health care approach that integrates phenotypic, genomic, epigenetic, and environmental factors unique to an individual. The goal of PM is to facilitate diagnosis, predict effective therapy, and avoid adverse reactions specific for each patient. The forefront of PM is in oncology; nonetheless, it is developing in other fields of medicine, including rheumatology. Recent studies on elucidating the genetic architecture of polygenic and monogenic rheumatological diseases have made PM possible by enabling physicians to customize medical treatment through the incorporation of clinical features and genetic data. For complex inflammatory disorders, the prevailing paradigm is …

Miniature Cone Penetration Tests With Shear Wave Velocity And Electrical Resistivity Measurements In Characterization Of Silica Sand, Ronit Ganguly

Electronic Thesis and Dissertation Repository

Geotechnical engineering design and analysis require sound identification and characterization of in-situ soil. To characterize is to gather information about the engineering properties of a particular soil which will affect the performance of any structure built on it. As a result of complications associated with the retrieving of undisturbed samples of cohesionless soils, calibration chamber-based experiments under controlled laboratory settings are used for the determination of several geotechnical engineering parameters. The capability of a reduced-scale calibration chamber-based cone penetration testing system along with shear wave velocity and electrical resistivity measurements, to better characterize in-situ soil is examined in this study. …

Biomechanical Analysis Of Open-Skull High-Rate Traumatic Brain Injury Using Finite Element Mouse Brain Model, Lihong Lu

Electronic Thesis and Dissertation Repository

To better understand traumatic brain injury (TBI), it is necessary to correlate with injuries, which are observed from in vivo laboratory experiments, to brain mechanical responses, which can so far be best predicted by finite element (FE) models. Firstly, a previously validated FE model was improved to investigate the effect of repeated impacts and lateral movements on brain responses to ensure the accuracy and reproducibility of controlled cortical impact (CCI) across different labs. Then, a new FE mouse brain model with the detailed three-dimensional (3D), non-linear vasculature was developed to study how the vasculature affected brain response in CCI and …

Public Interest In Razón Pública: A Data-Driven Network Analysis, Emilio Calderon Reyes

Electronic Thesis and Dissertation Repository

This thesis is a case study based on a network analysis of the magazine Razón Pública. This project took an inductive, data-driven approach to public interest in the context of a specific digital network. The main objectives were to characterize the magazine’s authors and subscribers, identify its prevalent news topics, and validate to what extent subscribers agree that the resulting topics are of public interest or not. In order to achieve these objectives, a mixed methodology was used; it consisted of combining Natural Language Processing (NLP) techniques -keyword network, n-grams analysis, and Latent Dirichlet Allocation (LDA) topic modeling-, qualitative …

Prediction-Based Learning And Processing Of Event Knowledge., Ken Mcrae, Kevin S Brown, Jeffrey L Elman

Psychology Publications

Knowledge of common events is central to many aspects of cognition. Intuitively, it seems as though events are linear chains of the activities of which they are comprised. In line with this intuition, a number of theories of the temporal structure of event knowledge have posited mental representations (data structures) consisting of linear chains of activities. Competing theories focus on the hierarchical nature of event knowledge, with representations comprising ordered scenes, and chains of activities within those scenes. We present evidence that the temporal structure of events typically is not well-defined, but it is much richer and more variable both …

Energy Modelling To Evaluate The Thermal Regulation Of Aquaculture Raceways Using Geothermal Heat Exchange, Mitchell H. Kuska

Electronic Thesis and Dissertation Repository

Raceways are used in the aquaculture industry to farm fish species that swim against an upstream current. Raceways often draw water from a large waterbody and hence, their temperature changes due to seasonal variation, which directly affect the production yield. This study investigates a novel approach to regulate the raceway water temperature in a sustainable way by utilizing geothermal energy exchange. Energy models were developed to simulate heat transfer in a geothermal borehole heat exchange system and in the raceway system. The two models were then coupled to simulate the thermal regulation of the raceway water via borehole heat exchangers. …

Numerical And Semi-Analytical Estimation Of Convective Heat Transfer Coefficient For Buildings In An Urban-Like Setting, Anwar Demsis Awol

Electronic Thesis and Dissertation Repository

Urban building arrangements such as packing density, orientation and size are known to influence the microclimate surrounding each building. Studies on the impact of urban microclimatic changes on convective heat transfer coefficient (CHTC) from a stock of buildings, however, have been rare in surveyed literature. The present study focuses on numerical and analytical investigation of CHTC from building-like models with homogeneous set of equal and unequal planar and frontal densities. Consequently, the study discusses the CHTC response in relation to broader changes in the urban surface form. Part of the process involves the development of a simplified one-dimensional semi-analytical CHTC …

Leveraging Cloud-Based Nfv And Sdn Platform Towards Quality-Driven Next-Generation Mobile Networks, Hassan Hawilo

Electronic Thesis and Dissertation Repository

Network virtualization has become a key approach for Network Service Providers (NSPs) to mitigate the challenge of the continually increasing demands for network services. Tightly coupled with their software components, legacy network devices are difficult to upgrade or modify to meet the dynamically changing end-user needs. To virtualize their infrastructure and mitigate those challenges, NSPs have started to adopt Software Defined Networking (SDN) and Network Function Virtualization (NFV). To this end, this thesis addresses the challenges faced on the road of transforming the legacy networking infrastructure to a more dynamic and agile virtualized environment to meet the rapidly increasing demand …

Spatial And Temporal Characteristics Of Temperature-Precipitation Covariability Across Canada In A Changing Climate, Harsimrenjit Singh

Electronic Thesis and Dissertation Repository

Changes in the regional characteristics of temperature and precipitation can intensify the occurrence and severity of extreme events such as rain-on-snow induced flooding, droughts and wildfires. Analyzing these climate variables in isolation without considering their interdependencies might result in severe underestimation of their combined effects. In this study, copula functions are used to describe the joint behaviour of temperature and precipitation across Canada over a historical period of 1910-present using observations and further till the end of the 21st century using three large ensembles of regional climate models. Moreover, given the lack of observation data over Canada, gridded datasets are …

X-Ray Absorption Spectroscopy, X-Ray Diffraction And Optical Luminescence Studies Of Phase Transition Of Titania Nanotubes, Lu Yao

Electronic Thesis and Dissertation Repository

The one-dimensional (1D) TiO₂ nanotubes (NTs) and their derivatives have been extensively studied due to their wide applications, such as photocatalysts, solar cell, paints and so on. Since TiO₂ has a wide band gap (~3.0 eV), its photo-absorption as the photocatalyst only occurs in the UV region that wastes mostly solar energy. Therefore, the solution to higher photocatalytic efficiency has been sought for some time. This thesis presents a study of the size-dependent phase transitions of TiO₂ NTs using synchrotron-based X-ray techniques. The chemical environment including local symmetry and the luminescence origin of the TiO₂ NTs …

Integrated Science 3002a: Proposal For Plumbing Initiative For Water Conservation In London, Rebecca Oeyangen, Jennifer Evans, Ali Coyle, John Chepesiuk, Nadia Aiaseh, Trystan Lee

Community Engaged Learning Final Projects

No abstract provided.

No Space To Sing: A Narrative Inquiry Into The Experiences Of Classical Singers With Primary Muscle Tension Dysphonia, Elizabeth Lepock

Electronic Thesis and Dissertation Repository

This study was designed as a qualitative narrative inquiry study into the experiences of classical singers with Primary Muscle Tension Dysphonia (PMTD). PMTD is defined as Muscle Tension Dysphonia (MTD) without organic or neurological factors. In the population of professional voice users, PMTD is typically associated with occupational/behavioural causes.

A review of the literature shows that occupational disorders are associated with stigma in the classical music community, that research on PMTD in the demographic of singers is sparse and often broadly defined, and that PMTD is not well-represented in the vocal pedagogy literature. Additionally, PMTD may present differently in classical …

Exploring Cognitive Maps Through Sketching, Melissa M. Nantais

Electronic Thesis and Dissertation Repository

Abstract

Periodic testing has been found to improve the accuracy of participants’ cognitive maps when an onscreen map is provided, however, it is unclear whether the same results would occur without the onscreen map. The current study investigated whether drawing a map periodically while exploring the virtual environment Silcton would improve cognitive map accuracy. Participants explored Silcton and were stopped every 4 minutes to either sketch a map of Silcton, identify items seen in Silcton, or colour an unrelated picture, and a baseline group was not stopped. All groups drew a final sketch map and completed a direction estimation task. …

Investigating The Effects Of Tissue-Specific Extracellular Matrix On The Adipogenic And Osteogenic Differentiation Of Human Adipose-Derived Stromal Cells Within Composite Hydrogel Scaffolds, Arthi Shridhar, Brian G. Amsden, Elizabeth R. Gillies, Lauren E. Flynn

Bone and Joint Institute

© Copyright © 2019 Shridhar, Amsden, Gillies and Flynn. While it has been postulated that tissue-specific bioscaffolds derived from the extracellular matrix (ECM) can direct stem cell differentiation, systematic comparisons of multiple ECM sources are needed to more fully assess the benefits of incorporating tissue-specific ECM in stem cell culture and delivery platforms. To probe the effects of ECM sourced from decellularized adipose tissue (DAT) or decellularized trabecular bone (DTB) on the adipogenic and osteogenic differentiation of human adipose-derived stem/stromal cells (ASCs), a novel detergent-free decellularization protocol was developed for bovine trabecular bone that complemented our established detergent-free decellularization protocol …

High Strain Dynamic Test On Helical Piles: Analytical And Numerical Investigations, Mohammed Fahad Alwalan

Electronic Thesis and Dissertation Repository

Helical piles are currently considered a preferred foundation option in a wide range of engineering projects to provide high compressive and uplift resistance to static and dynamic loads. In view of the large capacity of large diameter helical piles, there is a need to determine their capacity using accurate and economically feasible testing techniques. The capacity of piles is usually determined by conducting a Static Load Test (SLT). However, the SLT can be costly and time consuming, especially for large capacity piles. The High Strain Dynamic Load Test (HSDT) evaluates the pile capacity using dynamic measurements generated through subjecting the …

Teaching Video Neuroimages: Atypical Childhood Epilepsy With Centrotemporal Spikes: Seizures Often Discussed, Rarely Seen, Egidio Spinelli, Khrystyna Moskalyk, Sunita N. Misra

Paediatrics Publications

A 7-year-old right-handed boy with poorly controlled epilepsy presented to the epilepsy monitoring unit for further clarification of his diagnosis. Seizure onset was at 3 years with focal motor seizures of left face and arm followed by confusion and aphasia. Prominent behavioral and school difficulties were also reported. Valproic acid monotherapy (23 mg/kg/d) was weaned by day 2 and a habitual event captured on day 5 (figure, video 1). Brain MRI and an epilepsy gene panel (including GRIN2A) were nonrevealing. The diagnosis was therefore consistent with atypical childhood epilepsy with centrotemporal spikes. This differs from benign rolandic epilepsy because of …

Perceptions Of Institutional Teaching Culture By Tenured, Tenure-Track, And Sessional Faculty, Debra Dawson, Ken Meadows, Erika Kustra, Kathryn Hanson

Centre for Teaching and Learning Publications

The Institutional Teaching Culture Perception Survey (ITCPS) was used to investigate beliefs of tenured, tenure-track, and sessional faculty members (N=576) about the teaching culture within three large research-intensive universities in Canada. As predicted, we found significant differences between these three groups of faculty members’ perceptions of their institutions’ teaching cultures. Sessional faculty perceived that their universities rewarded effective teaching less than their tenured or tenure-track colleagues. Tenured faculty were less likely than the tenure-track and sessional faculty to believe it was important to encourage, recognize, or assess effective teaching. These results have important implications for the quality of teaching and, …

The Simultaneous Book: Women's Writing In Contemporary Art, Maryse Lariviere

Electronic Thesis and Dissertation Repository

Novels written by women authors who don’t adhere to the classification “visual artist” are nonetheless gaining momentum in today's contemporary art world. Yet works by authors such as Chris Kraus or Catherine Millet are often not recognized as artist’s novels because their authors are not or/and do not consider themselves to be visual artists. I contend that we can usefully situate their work within the genre of the artist’s novel by addressing how they invent artistic postures and artistic alter-egos within the autofictional worlds of their texts. My dissertation The Simultaneous Book proposes to open up the definition of the …

Application Of Bayesian Networks To Integrity Management Of Energy Pipelines, Wei Xiang

Electronic Thesis and Dissertation Repository

Metal-loss corrosion and third-party damage (TPD) are the leading threats to the integrity of buried oil and natural gas pipelines. This thesis employs Bayesian networks (BNs) and non-parametric Bayesian networks (NPBNs) to deal with four issues with regard to the reliability-based management program of corrosion and TPD. The first study integrates the quantification of measurement errors of the ILI tools, corrosion growth modeling and reliability analysis in a single dynamic Bayesian network (DBN) model, and employs the parameter learning technique to learn the parameters of the DBN model from the ILI-reported and filed-measured corrosion depths. The second study develops the …

Exploring Stretto: An Investigation Into The Use Of Stretto In J. S. Bach's Well-Tempered Clavier, Kathryn Mcdonald

Electronic Thesis and Dissertation Repository

Stretto—the technique of using a fugue subject in counterpoint with itself, beginning at different time points—occurs prevalently in fugues by J. S. Bach and other baroque composers. This study investigates the formal function of stretto using a corpus analysis of Bach’s use of stretto in the forty-eight fugues of the Well-Tempered Clavier. It documents details regarding each instance of stretto within the corpus and explores connections between these data using graphs and statistical tests, generally as well as in investigation of three specific hypotheses. The conclusion, density, and quantity hypotheses predict that there will be more stretto passages, time-intervals between …

Evaluating The Utility Of Protein Biomarker, S100a7, And Diagnostic Test, Straticyte, In Predicting The Progression Of Oral Dysplasia, Lachlan Mclean

Electronic Thesis and Dissertation Repository

Five-year survival of oral cancer has remained relatively unchanged despite advancements in treatment, mostly because diagnosis is often made at an advanced stage of disease. The progression of dysplasia to oral cancer often follows a stepwise progression. Histopathology is considered the ‘gold standard’ for diagnosing dysplasia and lesions at a high risk of progression to oral cancer, but lends itself to subjectivity. The protein biomarker, S100A7, in oral dysplasia and squamous cell carcinoma has shown some predictive value for the transformation of dysplasia to cancer. Straticyte, a diagnostic test utilizing S100A7 to predict the probability of progression of oral dysplasia …

Arthropod Diversity In Contrasting Ontario Peatlands, Grace Carscallen

Electronic Thesis and Dissertation Repository

Peatlands are important wetland systems, but dominant macroarthropod groups endemic to peatlands and the environmental factors that affect them are poorly represented in the literature. I examined the richness, abundance, and community composition of soil and surface dwelling macroarthropods using emergence traps, peat sorting, and pitfall traps in two Ontario fens differing in water table, nutrient level, and vegetation. I found 218 arthropod morphospecies, with each site having a similar richness of emergent arthropods, but patterns of community composition differed between the two sites. The Carex (sedge) dominated site had twice as many emergent individuals, and total abundances declined dramatically …

A Wearable Mechatronic Device For Hand Tremor Monitoring And Suppression: Development And Evaluation, Yue Zhou

Electronic Thesis and Dissertation Repository

Tremor, one of the most disabling symptoms of Parkinson's disease (PD), significantly affects the quality of life of the individuals who suffer from it. These people live with difficulties with fine motor tasks, such as eating and writing, and suffer from social embarrassment. Traditional medicines are often ineffective, and surgery is highly invasive and risky. The emergence of wearable technology facilitates an externally worn mechatronic tremor suppression device as a potential alternative approach for tremor management. However, no device has been developed for the suppression of finger tremor that has been validated on a human.

It has been reported in …