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Anxiety In Children And Adolescents With Autism Spectrum Disorder: Behavioural Phenotypes And Environmental Factors, Caitlin E. Leachman Miss

Electronic Thesis and Dissertation Repository

Anxiety is the most prevalent comorbidity among children and adolescents with autism spectrum disorder (ASD). The phenotypical presentation of anxiety among children and adolescents with ASD is lacking within the literature. This study sought to differentiate behavioral phenotypes associated with anxiety in children with ASD from anxiety in typically-developing children. Participants completed a series of child and parent reports measuring anxiety, depressive symptoms, ASD symptom severity, emotional problems, parental stress, and socioeconomic factors. Three distinct anxiety profiles, including moderate, high, and low, were identified. Results demonstrated that depression is the strongest predictor of high anxiety among children and adolescents with …

Cognitive Decline In Thrombotic Thrombocytopenic Purpura Survivors: The Role Of White Matter Health As Assessed By Mri., F Hannan, J Hamilton, C J Patriquin, K Pavenski, M T Jurkiewicz, L Tristao, A M Owen, P K Kosalka, S C L Deoni, J Théberge, J Mandzia, S H S Huang, J D Thiessen

Department of Medicine Publications

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare condition caused by severe ADAMTS13 deficiency, leading to platelet aggregation and thrombosis. Despite treatment, patients are prone to cognitive impairment and depression. We investigated brain changes in iTTP patients during remission using advanced magnetic resonance imaging (MRI) techniques, correlating these changes with mood and neurocognitive tests. Twenty iTTP patients in remission (30 days post-haematological remission) were compared with six healthy controls. MRI scans, including standard and specialized sequences, were conducted to assess white matter health. Increased T1 relaxation times were found in the cingulate cortex (p < 0.05), and elevated T2 relaxation times were observed in the cingulate cortex, frontal, parietal and temporal lobes (p < 0.05). Pathological changes in these areas are correlated with impaired cognitive and depressive scores in concentration, short-term memory and verbal memory. This study highlights persistent white matter damage in iTTP patients, potentially contributing to depression and cognitive impairment. Key regions affected include the frontal lobe and cingulate cortex. These findings have significant implications for the acute and long-term management of iTTP, suggesting a need for re-evaluation of treatment approaches during both active phases and remission. Further research is warranted to enhance our understanding of these complexities.

Achy Awfulness, Rylee J. Rumble

Electronic Thesis and Dissertation Repository

This written thesis is an accompaniment to a Master of Fine Arts Degree and Exhibition, at Western University, in London, Ontario. The following thesis dossier looks at how I use colour in my painting practice to archive my raw and vulnerable experiences with depression, anxiety, and ADHD. Having colour be the signifier for memories, feelings, emotions, and objects that pertain to my mental health, while painting, has allowed me to project my experiences onto the canvas essentially creating a physical archive; one that allows for me to shed the weight I am carrying and working through. The dossier is split …

A Multi-Method Assessment Of The Impact Of Stress On Families’ Mental Health During The Covid-19 Pandemic, Andrew R. Daoust

Electronic Thesis and Dissertation Repository

The COVID-19 pandemic was a pervasive disaster, creating stress for people across the globe. As such, understanding how pandemic-related stress has impacted individuals’ mental health is vital for guiding intervention programs and limiting the impact of future similar crises. This is especially true for youth, who are at heightened risk for mental disorder and may experience pandemic-related social stress as particularly aversive, given the developmental challenges unique to this period. Although substantial efforts have been made to measure the impact of the pandemic-related stress on individuals’ mental health, the pandemic’s relatively sudden onset has limited researchers’ abilities to conduct fulsome …

The Multidimensional Symptom Index: User Manual And Questionnaire, David Walton

Physical Therapy Publications

The user manual for the MultiDimensional Symptom Index, including hard copy versions in both English and Canadian French translations.

Click here for a direct link to an online interactive version of the MSI: dwalton5.pythonanywhere.com

Depression As A Prognostic Factor For Lumbar Spinal Stenosis Outcomes, Ariel M. Morales

Electronic Thesis and Dissertation Repository

Lumbar spinal stenosis (LSS) is a degenerative disease common in older adults and is associated with significantly reduced health-related quality of life and increased disability. Depression has been found to be associated with poorer health-related outcomes in patients with spinal conditions. A systematic review was conducted to examine the literature regarding the prognostic value of depression for LSS outcomes. Findings suggest small to moderate prognostic value of depressive symptoms for postoperative outcomes in patients with LSS, with strong evidence for disability. Next, a secondary analysis of a cohort study was conducted to investigate two objectives. The first objective was to …

Relationship Between Humor Styles And Individual Difference Variables, Mira Ismail

Undergraduate Student Research Internships Conference

Humor styles provide a better understanding of one’s personality and may vary based on individual difference variables. This study explores humor by looking at how different humor styles may correlate with other variables such as, loneliness, depression, the Big Five traits, self-esteem, age and sex. The following poster outlines the methodology used, as well as the proposed means of data analysis that will be conducted.

Exceptional Canadian Contributions To Research On Cognitive Vulnerability To Depression., David J. A. Dozois, Elizabeth P. Hayden

Psychology Publications

For more than four decades, Canadian psychologists have made significant contributions to the understanding of cognitive vulnerability to depression. This article highlights some of these exceptional contributions and the important roles Canadian scientists have played in enhancing our understanding of the cognitive products (e.g., dysfunctional attitudes), cognitive operations/processes (e.g., attention, encoding, and memory biases), and cognitive structures (i.e., cognitive organization) involved in depression. Following this review, we discuss research that has integrated cognitive vulnerability with other risk factors for depression, address some important measurement issues in cognitive vulnerability research, and highlight directions for future research. (PsycInfo Database Record (c) 2022 …

Neuroimaging Depression Risk In A Sample Of Never-Depressed Children, Matthew R. J. Vandermeer

Electronic Thesis and Dissertation Repository

Children of mothers with a history of depression are at significantly higher risk for developing depression themselves. Although numerous mechanisms explaining this relationship have been proposed (Goodman & Gotlib, 1999), relatively little is known about the neural substrates of never-depressed children’s depression risk. Of the few studies that have used neuroimaging techniques to characterize risk-based differences in children’s neural structure, function, and functional connectivity, most have used samples that include participants with a personal history of depression or older samples (i.e., past the typical age of onset for depressive disorders). These approaches limit what can be determined regarding whether findings …

Chronic Pain Following Musculoskeletal Injuries: Where Do Familial Factors, Depression, And Distress Fit In?, Shirin Modarresi

Electronic Thesis and Dissertation Repository

Background: Currently, there is a paucity of effective therapeutic options for chronic pain. A better understanding of the factors that can contribute to chronic pain development and maintenance can lead to more informed prevention and management strategies.

Purpose: The driving force for this thesis comes from the biopsychosocial model of pain. The main purpose was to investigate the contribution of various psychosocial factors to chronic pain with the following objectives: 1) to systematically review the literature on the existence of a familial sub-type of complex regional pain syndrome (fCRPS); 2) CRPS can follow injuries such as distal radius fractures (DRFs), …

Sensory Function And Psychological Factors In Children With Complex Regional Pain Syndrome Type 1, Emma E. Truffyn, Massieh Moayedi, Stephen C. Brown, Danielle Ruskin, Emma G. Duerden

Brain and Mind Institute Researchers' Publications

Objective: To assess thermal-sensory thresholds and psychosocial factors in children with Complex Regional Pain Syndrome Type 1 (CRPS-I) compared to healthy children. Methods: We conducted quantitative sensory testing on 34 children with CRPS-I and 56 pain-free children. Warm, cool, heat, and cold stimuli were applied to the forearm. Children with CRPS-I had the protocol administered to the pain site and the contralateral-pain site. Participants completed the self-report Behavior Assessment System for Children. Results: Longer pain durations (>5.1 months) were associated with decreased sensitivity to cold pain on the pain site (P =.04). Higher pain-intensity ratings were associated with elevated …

Treatment-Resistant Major Depressive Disorder: Canadian Expert Consensus On Definition And Assessment, Yuri E. Rybak, Ka S.P. Lai, Rajamannar Ramasubbu, Fidel Vila-Rodriguez, Daniel M. Blumberger, Peter Chan, Nicholas Delva, Peter Giacobbe, Caroline Gosselin, Sidney H. Kennedy, Hani Iskandar, Shane Mcinerney, Paula Ravitz, Verinder Sharma, Ari Zaretsky, Amer M. Burhan

Paediatrics Publications

Background: Treatment-resistant depression (TRD) is a debilitating chronic mental illness that confers increased morbidity and mortality, decreases the quality of life, impairs occupational, social, and offspring development, and translates into increased costs on the healthcare system. The goal of this study is to reach an agreement on the concept, definition, staging model, and assessment of TRD. Methods: This study involved a review of the literature and a modified Delphi process for consensus agreement. The Appraisal of Guidelines for Research & Evaluation II guidelines were followed for the literature appraisal. Literature was assessed for quality and strength of evidence using the …

Depressive Cognition On Twitter., David J A Dozois

Psychology Publications

No abstract provided.

Is Postpartum Depression A Clinically Useful Concept?, Verinder Sharma

Paediatrics Publications

No abstract provided.

Social Media As A Predictor Of Depression Rates Among Male Versus Female Adolescents During The Covid-19 Pandemic, Kaylee A. Fishback

Undergraduate Honours Theses

Technology use has drastically and progressively increased as the COVID-19 pandemic has continued to unfold. Adolescents are now reliant on technology for their education, in addition to communication with friends and family (Pfefferbaum & North, 2020). With the recency of the pandemic, research on the effects of increased internet and social media use for adolescent mental health is decidedly underdeveloped. This study aimed to fill the research gap by examining how the frequency of male and female adolescents’ social media use is associated with depression rates during the pandemic by using a longitudinal design. Participants for this study included 351 …

Anxiety And Depression In Canada During The Covid-19 Pandemic: A National Survey., David J. A. Dozois, Mental Health Research Canada

Psychology Publications

Depression and anxiety are the most prevalent mental health problems in Canada. The COVID-19 pandemic will likely result in a large increase in the incidence and prevalence of anxiety and depression and experts are already warning of an “echo pandemic” of mental health problems. The objective is this research was to explore how Canadians are managing with the COVID-19 outbreak and determine the impact of the pandemic on levels of anxiety and depression. A nationally representative sample of 1,803 participants completed an online survey that was offered in both official languages. The percentage of respondents who indicated that their anxiety …

The Importance Of Social Connectedness: From Interpersonal Schemas In Depression To Relationship Functioning And Well-Being, David J. A. Dozois

Psychology Publications

In this article, a program of research is described, which began with a focus on depression. A number of studies have demonstrated that negative self-schemas, particularly for interpersonal content, are well organized and appear to represent stable vulnerability factors for depression. Fortunately, this negative interpersonal structure is also modifiable through effective treatments (both psychological and pharmacological). An important extension of this research has involved investigating the impact of schemas on interpersonal phenomena (e.g., excessive reassurance seeking) and the formation of schemas about others (e.g., romantic partners). The dyadic partner-schema model, which articulates how self- and partner-schemas impact relationship functioning, is …

Diffusion Dispersion Imaging: Mapping Oscillating Gradient Spin-Echo Frequency Dependence In The Human Brain., Aidin Arbabi, Jason Kai, Ali R Khan, Corey A Baron

Brain and Mind Institute Researchers' Publications

PURPOSE: Oscillating gradient spin-echo (OGSE) diffusion MRI provides information about the microstructure of biological tissues by means of the frequency dependence of the apparent diffusion coefficient (ADC). ADC dependence on OGSE frequency has been explored in numerous rodent studies, but applications in the human brain have been limited and have suffered from low contrast between different frequencies, long scan times, and a limited exploration of the nature of the ADC dependence on frequency.

THEORY AND METHODS: Multiple frequency OGSE acquisitions were acquired in healthy subjects at 7T to explore the power-law frequency dependence of ADC, the "diffusion dispersion." Furthermore, a …

Concordance Between Health Administrative Data And Survey-Derived Diagnoses For Mood And Anxiety Disorders, J. Edwards, A. Thind, S. Stranges, M. Chiu, Kelly K. Anderson

Epidemiology and Biostatistics Publications

Objective: To assess whether estimates of survey structured interview diagnoses of mood and anxiety disorders were concordant with diagnoses of these disorders obtained from health administrative data.

Methods: All Ontario respondents to the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH) were linked to health administrative databases at ICES (formerly known as the Institute for Clinical Evaluative Sciences). Survey structured interview diagnoses were compared with health administrative data diagnoses obtained using a standardized algorithm. We used modified Poisson regression analyses to assess whether socio-demographic factors were associated with concordance between the two measures.

Results: Of the 4157 Ontarians included in our …

Neural Activity During Self-Referential Processing In Children At Risk For Depression., Pan Liu, Matthew R J Vandermeer, Marc F Joanisse, Deanna M Barch, David J A Dozois, Elizabeth P Hayden

Psychology Publications

BACKGROUND: According to cognitive theories of depression, more negative and less positive self-schemas are thought to play a causal role in the disorder. Existing evidence speaks to the neural substrates of self-referential processes in both healthy and depressed individuals, but little is known about how the brain relates to self-referential processing in the context of depression risk in children. We therefore studied the neural substrates of self-referential processing in never-depressed preadolescent children at high and low risk for depression based on maternal depression history.

METHODS: A total of 87 never-depressed 10-12-year-old children (29 with maternal depression) completed a self-referential encoding …

A Study Of Multiple Predictors Of Cognitive Fatigue In Individuals With Multiple Sclerosis, Leila M. Mackay

Electronic Thesis and Dissertation Repository

Persons with multiple sclerosis (PwMS) commonly experience cognitive fatigue (CF), defined as a decrease in cognitive performance over a sustained activity and measured objectively or subjectively. In the present research, we evaluated the extent to which depression, anxiety, information processing speed, sleep quality, and disease severity predict subjective and objective CF, in a sample of 55 PwMS (37 females, M = 44.23). Although no statistically significant predictors of objective CF were demonstrated, all variables predicted subjective CF, R2adj = .384 [F (6, 40) = 5.783, p = .0002]. In particular, depression and information processing speed were found to be significant …

Women's Freedom Of Movement And Participation In Psychosocial Support Groups: Qualitative Study In Northern India, Nicola Gailits, Kaaren Mathias, Elysée Nouvet, Pooja Pillai, Lisa Schwartz

Health Studies Publications

© 2019 The Author(s). Background: Depression, the world's leading cause of disability, disproportionately affects women. Women in India, one of the most gender unequal countries worldwide, face systemic gender disadvantage that significantly increases the risk of common mental disorders. This study's objective was to examine the factors influencing women's participation in psychosocial support groups, within an approach where community members work together to collectively strengthen their community's mental health. Methods: This community-based qualitative study was conducted from May to July 2016, across three peri-urban sites in Dehradun district, Uttarakhand, Northern India. Set within an NGO-run mental health project, data were …

A Randomized Controlled Trial Of Internet-Delivered Cbt And Attention Bias Modification For Early Intervention Of Depression, R. Mcdermott, David J. A. Dozois

Psychology Publications

Abstract

The conceptualization and empirical knowledge base related to major depression has increased dramatically in recent years. We now have well-developed and validated models of depression from a range of theoretical perspectives. These models have significantly enhanced the development of effective treatments and preventative interventions. Although various prevention programs are available, Web-based protocols can enhance accessibility to evidence-based prevention programs. The current study involved a randomized controlled trial focused on the prevention and treatment of depression in high-risk first- and second-year undergraduate students. Three Internet-delivered preventative programs were compared: cognitive behavioral therapy (CBT; MoodGym), attentional bias modification, and an active …

Pathways Over The Life Course: Patterns Of Depressive Symptoms In Adolescence And Their Potential Impact On Educational Attainment, Stephen Carneiro Fernandes

MA Research Paper

This analysis draws on life course sociology to investigate the association between depression in adolescence and postsecondary completion in young adulthood. Three gaps in the mental health and education literature are addressed: lack of attention to the duration and timing of depressive symptoms, the overuse of high school degree receipt and college entry as outcome variables, and the exclusion of theoretically important confounders, such as self-rated health. Using panel data from the National Longitudinal Study of Adolescent to Adult Health, distinct mental health pathways that are based on a 12-item revision of the Center for Epidemiologic Studies Depression Scale are …

Changes In Depression And Positive Mental Health Among Youth In A Healthy Relationships Program, Natalia Lapshina, Claire Crooks, Amanda Kerry

Journal Articles

Mental health promotion programming in schools and community settings is an important part of a comprehensive mental health strategy. The goal of this study was to identify and explore meaningful classes of youth based on their pre- and post-intervention depression symptoms scores with 722 youth involved in a 15-week healthy relationships and mental health promotion program. We utilized latent class growth analysis to identify depression class trajectories, controlling for group clustering effects. A three-class solution identified high decreasing, moderate stable, and low stable trajectories. Gender, age, and reported experience of bullying victimization predicted trajectory class membership. The low stable class …

Who Is At Risk For Problematic Video Gaming? Risk Factors In Problematic Video Gaming In Clinically Referred Canadian Children And Adolescents, Chloe Lau, Shannon L. Stewart, Catalina Sarmiento, Donald H. Saklofske, Paul F. Tremblay

Paediatrics Publications

Both Internet and offline video gaming have become a normal aspect of child development, with estimates of children playing video games ranging from 90% to 97%. Research on problematic video gaming (PVG) has grown substantially in the last decade. Much of that research has focused on community samples, while research on clinically referred children and youth is lacking. The present study includes 5820 clinically referred children and youth across 44 mental health agencies, assessed using the interRAI Child and Youth Mental Health Assessment. Logistic regression analyses revealed that older age, male sex, extreme shyness, internalizing symptoms, externalizing symptoms, and poor …

An Analysis Of The Relationship Between Humor Styles And Depression, Marisa L. Kfrerer

Electronic Thesis and Dissertation Repository

The present study examined the relationship between humor styles and depression using two methods of examination: (1) the mean humor style differences between individuals who reported that they had been diagnosed with depression versus those who did not report being depressed; and (2) a short scale assessing depressed affect. Participants were 878 adult Australians. With respect to mean differences, depressed individuals were found to use self-defeating humor more, and self-enhancing humor less than non-depressed adults. When the depressed affect scale score was analyzed, negative correlations were found between depressed affect and both positive styles of humor, affiliative and self-enhancing. Additionally, …

Beneficial Pleiotropic Antidepressive Effects Of Cardiovascular Disease Risk Factor Interventions In The Metabolic Syndrome, Stephanie J. Frisbee, Sarah S. Singh, Dwayne N. Jackson, Kent A. Lemaster, Samantha A. Milde, J. Kevin Shoemaker, Jefferson C. Frisbee

Bone and Joint Institute

© 2018 The Authors. Background--Although the increased prevalence and severity of clinical depression and elevated cardiovascular disease risk represent 2 vexing public health issues, the growing awareness of their combined presentation compounds the challenge. The obese Zucker rat, a model of the metabolic syndrome, spontaneously develops significant depressive symptoms in parallel with the progression of the metabolic syndrome and, thus, represents a compelling model for study. The primary objective was to assess the impact on both cardiovascular outcomes, specifically vascular structure and function, and depressive symptoms in obese Zucker rats after aggressive treatment for cardiovascular disease risk factors with long-term …

The Contribution Of Health And Psychological Factors In Patients With Chronic Neck Pain And Disability: A Cross-Sectional Study, Pavlos Bobos, Goris Nazari, Stephania Palimeris, Evdokia Billis, Joy C. Macdermid

Bone and Joint Institute

© 2018, Journal of Clinical and Diagnostic Research. All rights reserved. Introduction: One approach to reduce the burden of neck pain is the management of the prognostic factors that are associated with greater disability. Studies which quantify these predictors can support interventions that attempt to modify these trajectories. Aim: The aim of the present study to determine the contribution of psychological and health factors that are commonly associated with neck pain and disability levels. Materials and Methods: Patients between 18-65 years old were recruited to participate in the present study if they had neck pain for more than three months, …

Are "Stress Busters" The Solution? Teaching Wellness At The Academic Library, Emily Carlisle

FIMS Publications

No abstract provided.