Digital Commons Network^™

Departure From Magical Realism: Female Agency In Latin American Post-Boom Literature, Nicole Darian Llacza Morazzani

Honors Theses

his thesis explores depictions of female agency in post-colonial Latin American literature. I highlight three primary texts: Gabriel García Márquez's (1927-2014) 1967 One Hundred Years of Solitude, a canonical magical realist novel; Isabel Allende's (1942-present) 1982 The House of Spirits, her debut novel and a multi-generational story similar to Márquez's, and Isabel Allende's 2022 Violeta, a historical novel offering an autodiegetic narrative of a woman's 100 years of life in an unnamed South American country, to analyze how female characters evolve in response to changing sociopolitical landscapes and literary movements in Latin America. My central focus is Allende's most recent …

Exploration Of Sulfonamides And Benzothiazoles As Peptide-Based Cleavable Linkers, Abigail Dalton

Honors Theses

Cleavable linkers have demonstrated great potential in various applications of medicinal organic chemistry, such as in modern therapeutic development. Linkers are stable compounds that cleave in specific conditions to release molecular cargo. We have developed cleavable linkers based on nucleophilic aromatic substitution reactions on sulfonamide and benzothiazole substrates in small molecule and in peptide studies. Sulfonamides, commonly with an electron-withdrawing group, reacted in high conversion of starting material to the sulfide product in small molecule studies, but was unable to successfully cleave the sulfonamide linker on peptide in mild conditions. Next, a benzothiazole sulfone substrate was analyzed and optimized in …

(Re)Constructing Race: How Essentialist Beliefs Shape Social Justice Support, Abbey Alvarado

Honors Theses

The political climate and social discourse around social justice has grown increasingly tense and hostile in recent years. The current study investigated potential predictors of the opposition to support for racial equity and social justice reforms. Research illustrates that a biological conceptualization of race (“essentialism”) has powerful implications on information processing and social-psychological outcomes regarding issues of race and racism. In the current study, we conducted a survey of 164 University of Richmond undergraduate students. The survey examined the interplay of essentialism and beliefs about systemic racism and white privilege on social justice support. The results showed that essentialist beliefs …

Examining Variability In And Contextual Predictors Of College Student Belonging, Yangyue Li

Honors Theses

The purpose of the study is to examine disparities in belonging and whether contextual factors predict a higher sense of belonging among fourth-year undergraduate students at UR. My findings suggest that 1) underrepresented students (with racial/ethnic minority, low-income, and first-generation identities) reported lower belonging compared to their majority peers, 2) inclusive campus climate and contact with peers from different backgrounds predicted greater belonging, and 3) first-generation status moderated the association between contact with diverse peers and sense of belonging.

Exploring The Impact Of Public Health Messaging On Maternal Health Engagement In The Us: A Focus On Racial Disparities And Persuasive Evidence; By Shelby Mokricky; April 29, 2024, Shelby A. Mokricky

Honors Theses

With the current rise of maternal mortality rates in the United States, particularly among Black women, this project aimed to understand more about how the content of maternal health campaigns affects participants' desire to create action and change. We examined two factors, the type of persuasive evidence presented, anecdotal stories or statistical information, and whether the message discussed the racial disparities in maternal mortality or not. Using Cloud Research’s Connect Platform 500 survey participants were randomly assigned to read one of four public health campaigns, then asked to complete a series of questions relating to their support of combating maternal …

Cd46 Isoforms And Viral Receptor For Adenovirus Type 64d, Corina Stasiak

Honors Theses

Adenovirus Type 64 (Ad.64) belongs to the adenovirus subgroup D, which causes epidemic keratoconjunctivitis (EKC), otherwise known as viral pink eye. There is currently no known effective treatment for EKC. Membrane Cofactor Protein (CD46) is an integral membrane glycoprotein that, in previous studies, has been identified as a protein receptor for the closely related Ad.37. It has been determined that Ad.64 uses CD46 as a receptor on the cell surface in HeLa cells. CD46 is alternatively spliced when expressed to have different isoforms of interest, including the BC and C isoforms. Certain cell types, like A549 lung carcinoma cells, express …

Cd46 Is A Protein Receptor For Human Adenovirus Type 64, Alexander Michael Robertson

Honors Theses

Adenoviruses are important gene delivery vectors and causative agents for a variety of human diseases such as the common cold and gastrointestinal infections. Human adenovirus type 64 (Ad64; formerly 19c) and type 37 are associated with epidemic keratoconjunctivitis. Based upon its high homology and similar disease tropism to Ad37, we hypothesized that Ad64 would have the same protein receptor, CD46 (membrane cofactor protein), as Ad37. We show that a recombinant Ad64 containing an enhanced Green Fluorescent Protein transgene (Ad64.eGFP) enters Chinese hamster ovary cells expressing human CD46 (CHO-CD46) on the surface. Entry into human cervical carcinoma (HeLa) cells is increased …

Black Lives Matter: Is It Political?, Caroline O. Glaser

Honors Theses

The present research focused on foster ing greater support for the Black Lives Matter (BLM) movement by examining factors that predict support for the movement, and possible mechanisms implicated in this relationship. The BLM movement was founded in 2013 following the death of teenager Trayvon Martin, and reached a remarkable height of media attention in the summer of 2020, following the murder of George Floyd. Since then, support for BLM has fluctuated, becoming a highly politicized movem ent that has faced much public debate.

Our study focused on factors that predict support for BLM in the current politic al climate. …

Development Of A Diaryl Oxazole-Based Cleavable Linker For Peptides, Evan Wolff

Honors Theses

The development of new cleavable linkers increases the diversity of compatible conditions for peptide discovery platforms. Potential applications for these linkers include high-throughput pharmaceutical candidate screening when utilized in Peptide Encoded Libraries (PELs). This thesis describes the development of a bifunctional diaryl oxazole-based cleavable linker that may be incorporated into compounds through Solid-Phase Peptide Synthesis (SPPS). This oxazole-based linker may be rapidly cleaved by cerium ammonium nitrate in aqueous conditions and is compatible with most natural amino acids and a variety of unnatural amino acids. This linker represents the first single-electron oxidant labile linker described to our knowledge and it …

Immigration Level And Its Impact On The United States Labor Market Tightness, Khai Quay La

Honors Theses

This research investigates the complex interplay between immigration labor and market equilibrium in the United States, focusing on the period from 2000 to 2019. By examining the correlation between the rate of net international migration and the unemployment-to-vacancy ratio (U/V) across 51 states, the study uncovers significant relationships that shed light on immigration dynamics in response to labor market conditions. The findings support the hypothesis that a decrease in the U/V ratio leads to an increase in immigration in the following period as immigrants seek improved job employment prospects.

Structural Phylogenetics Of A Family Dna Polymerases, Yagmur Bingul

Honors Theses

The transition from the RNA to the DNA world stands as an important event, demanding the emergence of enzymatic activities for DNA precursor synthesis, retro-transcription of RNA templates, and replication of single and double-stranded DNA molecules. The distribution of protein families associated with these activities across the three domains of life—Archaea, Eukarya, and Bacteria—adds layers of complexity to the narrative. While Archaea and Eukarya often share similar protein structures, structural biology shows homologous, but distinct, structures in Bacteria. On the other hand, viral polymerases emerge as a crucial part of genome replication and transcription. Their versatility, including RNA-dependent RNA polymerase, …

#Booktok: Social Media’S Influence On Literature, Madison Hyatt

Honors Theses

Exploring the social media phenomenon, TikTok, and its influence on the community, #Booktok is the newest way readers stay up to date on new books, and what to read. Is this a good thing? A bad thing? And how has this new way of consuming books influenced reading and literature?

Opioid Policy Solutions: Administrative Law, Legislation, And Constitutional Reform, Trevin Stevens

Honors Theses

I have written three separate policy briefs addressing issues in the pharmaceutical industry that allowed for the opioid epidemic to reach the magnitude that it has in the last three decades. I examined public policy regarding labeling, drug diversion, and misuse, as well as marketing. By studying existing policies, I was able to provide insight into possible reforms, while accounting for potential obstacles to systematic reform, such as constitutional concerns regarding free speech.

Functionalized Gold Nanoparticles And Halogen Bond Interactions With Neonicotinoid Pesticides, Molly Mccuen “Mackey” Sherard

Honors Theses

Neonicotinoid (NN) pesticides have emerged globally as one of the most widely used agricultural tools for protecting crops from pest damage and boosting food production. Unfortunately, some NN compounds, such as extensively employed imidacloprid-based pesticides, have also been identified as likely endangering critical pollinating insects like honey bees. To this end, NN pesticides pose a potential threat to world food supplies. As more countries restrict or prohibit the use of NN pesticides, tools are needed to effectively and quickly identify the presence of NN compounds like imidacloprid on site (e.g., in storage areas on farms or pesticide distribution warehouses). This …

Taylor, Genealogy, History, Peter Hawes

Honors Theses

In this paper I compare two different genealogies of the idea of the ‘self’: Charles Taylor’s and Michel Foucault’s. I begin by arguing that Taylor’s focus on combating what he calls “subtraction stories” places him in the genealogical tradition with Foucault. I then engage with Foucault's genealogy of the self, which illuminates how the notion of the ‘self’ was constructed as a means of control, which leads him to say we should do away with trying to understand it outside of relations of power. This call for the rejection of the self, I suggest, presents a problem for us, who …

Heterocycles As Peptide-Based Cleavable Linkers, John Blobe

Honors Theses

As cancer cases continue to rise, the need for advancing the treatment options for cancer is ever increasing. Current cancer therapeutics, while effective at treating localized cancers and a fraction of advanced cancers, generally lack the specificity needed to target more advanced cancers. Recent advancements in cancer treatments have leveraged antibodies to target certain cancers. A class of drugs that utilize antibodies to deliver anti-cancer therapy preferentially to cancer cells, termed antibody-drug conjugates (ADCs), have been quite effective in treating certain advanced forms of certain cancers. These ADCs could be more effective if they could allow for the facile release …

Modeling The Opioid Crisis In Virginia: A Differential Equations Model Assessing The Impact Of Medication-Assisted Treatment On The Addicted Population, Maniha Zehra Akram

Honors Theses

The opioid epidemic is prevalent in countless communities throughout the United States and has yet to be mitigated. Treatments for OUD (opioid use disorder) include Medication-Assisted Treatment (MAT) and treatment without medication (non-MAT), with the former being judged as more effective in terms of lower relapse rates, death rates, and criminal activity (U.S. Food & Drug Administration, 2023; SAMHSA, 2024). Motivated by the promising research on MAT, this paper models the relationship

between the treatment and addicted populations using a system of ordinary differential equations. In addition to producing closed-form equilibrium solutions, the model leads to the conclusion that expanding …

Defending The Role Of A Principle Of Proportionality In Just Punishment, Emma Mechlenburg

Honors Theses

What makes a punishment just or unjust is a familiar topic that the public and scholars alike recognize as an important question. Many factors are involved in conversations surrounding the just length of sentences, but this paper will specifically investigate two central questions: First, what makes a punishment just, and second, what role does a principle of proportionality play in thinking about just punishment.

Sigma Hole Trends Across D-Block Metal Halides, Nam Huy Pham

Honors Theses

he effects of d-block metals on halogen bonding and other sigma hole interactions is currently understudied. We identify and document the trend of MFnI compounds serving as halogen bond donors across the d-block for M = groups 3 to 12 metals. Compounds were investigated using density functional theory and electrostatic potential (ESP) values at the I center have been examined to compare sigma hole strengths. d-block metal halides are found to be relatively weak compared to their p-block counterparts in inducing sigma holes, with only few exceptions. An interesting phenomenon involving the MXI compounds (X = F, Cl, Br, I) …

La Perception Et La Représentation Du Corps Des Femmes Africaines Par Rapport À La Colonisation Française, Mofiyinfoluwa Tunji-Ekundayo

Honors Theses

The thesis proposes an analysis of the perception that the French colonizers had towards the bodies of black women in France, women from northern Africa, and women from western Africa. Then, the work evaluates how this perception manifests in current French and francophone media. Furthermore, it traces how much influence these perceptions have on the depiction and representation of African female bodies. This influence could manifest as a reinforcement or an opposition to colonial perceptions.

The Impact Of U.S. News And World Report College Rankings On Prospective Students’ Decisions And Enrollment Outcomes, Camilla Schneider

Honors Theses

The following paper further expands on previous research using more recent data which is important given changes in the last decade. This paper will answer the question: How do U.S. News and World Report college rankings impact college application and enrollment decisions for prospective students within American public and private colleges and universities? Application decisions refer to the choice to apply to a school while enrollment decisions refer to the choice to attend a school after being accepted. This paper analyzes Integrated Postsecondary Education Data System (IPEDs) admissions/applicant, fall enrollment, and financial data alongside historical USNWR rankings lists to investigate …

The Value Of Prison Education: Evaluating The Impact Of Education Through Desistance, Cheryl Chan

Honors Theses

The United States faces an epidemic of incarceration, draining resources, disrupting families, and hindering societal participation. Prison education emerges as a method to address this cycle, with vocational and academic programs being pivotal. While vocational programs are more common, their long-term efficacy remains uncertain. Academic education, exemplified by programs like the Bard Prison Initiative, provides incarcerated individuals with an opportunity to change. Typically, the success of these programs are measured using recidivism. However, recidivism has become too narrow of a measure to properly capture the nuances of an education. There has been an emerging body of scholarship studying desistance and …

Shifting Grounds: Movement And Continuity In Mustang, Nepal, Lauren Carter

Honors Theses

This thesis explores the socio-cultural and economic transformations in the Mustang region of Nepal. Drawing from fieldwork conducted over a month, this study examines how traditional economic activities, particularly yak herding, are being replaced by tourism and agriculture due to shifting socio-economic conditions and global influences. The concept of 'adaptive traditionality' is introduced to describe how the community in Mustang actively engages with both internal pressures and external changes to reshape their socio-cultural landscape. This adaptability is evident in the transition from nomadic pastoralism to more sedentary agricultural practices and tourism, which not only reflects a survival tactic but also …

Black And Blue All Over: Whose Lives Matter?, Bella Purvis

Honors Theses

This study investigated the influence of beliefs about race on support for the Black Lives Matter

(BLM) and Blue Lives Matter (BluLM) movements, mediated by attitudes towards police and beliefs

about white privilege. Utilizing a sample of undergraduate university students, data were obtained

through a survey measuring beliefs in the biological and social constructs of race, support for police,

belief in white privilege, and attitudes toward BLM and BluLM. Results indicated that individuals who

perceive race as a biological construct are less likely to support BLM and more likely to support BluLM,

while beliefs in white privilege and attitudes towards …

Examining The Link Between Autistic Personality Traits And Processing Of Metonymy, Miranda Moe

Honors Theses

Previous research has investigated the real-time processing and offline interpretation of metonyms. This work has generally shown that readers experience longer processing times for metonyms versus control nouns because of the extra time needed to access the figurative sense of a metonym. Recent research has also demonstrated different processing patterns on nonliteral language for individuals with autism spectrum disorder compared to typically developing participants. The current study was designed to explore whether previous findings on the processing of metonymy are modulated by individual differences in autistic personality traits. Through an eye-tracking during reading experiment, participants read sentences in which factors …

The Effect Of Solvent Identity And Hydride-Donor On The Reduction Of Co2 Into Useful Fuels, Abigail Mcentire

Honors Theses

One possible strategy for decreasing CO2 emissions is through electrocatalytic reduction reactions to convert the CO2 back into combustible fuels , such as methane or methanol. However, it can be challenging to control the reaction to select one of these useful fuels as opposed to carbon monoxide or formate. Our strategy is to investigate a specific hydride donor and solvent combinations for which the reaction favors conversion to methanol. It was found that in acetonitrile , several hydride donors were capable of selective reduction of CO2 to the methanol oxidation state.

The Effect Of The Expanded Child And Dependent Care Tax Credit On Maternal Labor Supply, Abby Letocha

Honors Theses

Policies that subsidize childcare have many potential economic benefits such as mitigating the high cost of childcare, incentivizing families to have more children, increasing paid childcare participation, and increasing parental labor supply. In this paper, I focus on the effect of childcare subsidies on maternal labor supply through a tax policy expansion. The Child and Dependent Care Tax Credit (CDCTC) is the primary federal childcare subsidy in the United States, and it was temporarily expanded in 2021 under the American Rescue Plan Act. This expansion increased the generosity of the credit and made it fully refundable for the 2021 tax …

Trading Perspectives: The Impact Of Gender In Shaping National Trade Policies, Katherine Kwiatkowski

Honors Theses

Economic and political factors have been shown to influence the trade policy decisions of national leaders. The impact of a national leader’s gender on their trade policy preferences remains an underexplored area of research. The increasing share of female national leaders raises the question of whether their policy preferences vary from those of male leaders because of their gender. In this study, I utilize the gender of a nation’s leader to implement a two-way fixed effects regression that analyzes the impact of gender on a leader’s trade policy preferences. Controlling for factors that could also impact a leader’s trade policy …

Diaryl Oxazoles As Cleavable Linkers For Drug Discovery Platforms, Elizabeth Taggart

Honors Theses

Within the field of medicine and pharmacology, discovering small molecule or biologic based molecules with therapeutic potential is a difficult task. Current methods involve individually screening hundreds of compounds on a potential target biomolecule, and recent technologies have explored peptide encoded libraries (PELs) as a means of making this screening process more high-throughput. These libraries produce a large number of small molecule drug candidates each conjugated to a unique peptide fragment, functioning as a barcode. Analysis of PELs requires the capture of hit small molecules and the subsequent release of their peptide tags; however, current approaches are limited in their …

Exploring The Structure Of Partial Difference Sets With Denniston Parameters, Nicolas Ferree

Honors Theses

In this work, we investigate the structure of particular partial difference sets (PDS) of size 70 with Denniston parameters in an elementary abelian group and in a nonelementary abelian group. We will make extensive use of character theory in our investigation and ultimately seek to understand the nature of difference sets with these parameters. To begin, we will cover some basic definitions and examples of difference sets and partial difference sets. We will then move on to some basic theorems about partial difference sets before introducing a group ring formalism and using it to explore several important constructions of partial …