Digital Commons Network^™

Cd46 Isoforms And Viral Receptor For Adenovirus Type 64d, Corina Stasiak

Honors Theses

Adenovirus Type 64 (Ad.64) belongs to the adenovirus subgroup D, which causes epidemic keratoconjunctivitis (EKC), otherwise known as viral pink eye. There is currently no known effective treatment for EKC. Membrane Cofactor Protein (CD46) is an integral membrane glycoprotein that, in previous studies, has been identified as a protein receptor for the closely related Ad.37. It has been determined that Ad.64 uses CD46 as a receptor on the cell surface in HeLa cells. CD46 is alternatively spliced when expressed to have different isoforms of interest, including the BC and C isoforms. Certain cell types, like A549 lung carcinoma cells, express …

Cd46 Is A Protein Receptor For Human Adenovirus Type 64, Alexander Michael Robertson

Honors Theses

Adenoviruses are important gene delivery vectors and causative agents for a variety of human diseases such as the common cold and gastrointestinal infections. Human adenovirus type 64 (Ad64; formerly 19c) and type 37 are associated with epidemic keratoconjunctivitis. Based upon its high homology and similar disease tropism to Ad37, we hypothesized that Ad64 would have the same protein receptor, CD46 (membrane cofactor protein), as Ad37. We show that a recombinant Ad64 containing an enhanced Green Fluorescent Protein transgene (Ad64.eGFP) enters Chinese hamster ovary cells expressing human CD46 (CHO-CD46) on the surface. Entry into human cervical carcinoma (HeLa) cells is increased …

Exploring The Impact Of Public Health Messaging On Maternal Health Engagement In The Us: A Focus On Racial Disparities And Persuasive Evidence; By Shelby Mokricky; April 29, 2024, Shelby A. Mokricky

Honors Theses

With the current rise of maternal mortality rates in the United States, particularly among Black women, this project aimed to understand more about how the content of maternal health campaigns affects participants' desire to create action and change. We examined two factors, the type of persuasive evidence presented, anecdotal stories or statistical information, and whether the message discussed the racial disparities in maternal mortality or not. Using Cloud Research’s Connect Platform 500 survey participants were randomly assigned to read one of four public health campaigns, then asked to complete a series of questions relating to their support of combating maternal …

Development Of A Diaryl Oxazole-Based Cleavable Linker For Peptides, Evan Wolff

Honors Theses

The development of new cleavable linkers increases the diversity of compatible conditions for peptide discovery platforms. Potential applications for these linkers include high-throughput pharmaceutical candidate screening when utilized in Peptide Encoded Libraries (PELs). This thesis describes the development of a bifunctional diaryl oxazole-based cleavable linker that may be incorporated into compounds through Solid-Phase Peptide Synthesis (SPPS). This oxazole-based linker may be rapidly cleaved by cerium ammonium nitrate in aqueous conditions and is compatible with most natural amino acids and a variety of unnatural amino acids. This linker represents the first single-electron oxidant labile linker described to our knowledge and it …

#Booktok: Social Media’S Influence On Literature, Madison Hyatt

Honors Theses

Exploring the social media phenomenon, TikTok, and its influence on the community, #Booktok is the newest way readers stay up to date on new books, and what to read. Is this a good thing? A bad thing? And how has this new way of consuming books influenced reading and literature?

The Impacts Of Identity On Perceptions Of Safety On A Predominately White Campus, Rebecca Delrosso

Honors Theses

This quantitative study examines the relationship between students’ marginalized identities of race, gender, and sexuality and their perceptions of safety at a predominantly white institution (PWI). Survey data collected from undergraduates at a small liberal arts university reveal associations between minority identities and feelings of discomfort, insecurity, discrimination, and vulnerability on campus. The findings highlight the need for PWIs to prioritize secure and inclusive environments through policies, practices, and support systems.

Exploration Of Sulfonamides And Benzothiazoles As Peptide-Based Cleavable Linkers, Abigail Dalton

Honors Theses

Cleavable linkers have demonstrated great potential in various applications of medicinal organic chemistry, such as in modern therapeutic development. Linkers are stable compounds that cleave in specific conditions to release molecular cargo. We have developed cleavable linkers based on nucleophilic aromatic substitution reactions on sulfonamide and benzothiazole substrates in small molecule and in peptide studies. Sulfonamides, commonly with an electron-withdrawing group, reacted in high conversion of starting material to the sulfide product in small molecule studies, but was unable to successfully cleave the sulfonamide linker on peptide in mild conditions. Next, a benzothiazole sulfone substrate was analyzed and optimized in …

Structural Phylogenetics Of A Family Dna Polymerases, Yagmur Bingul

Honors Theses

The transition from the RNA to the DNA world stands as an important event, demanding the emergence of enzymatic activities for DNA precursor synthesis, retro-transcription of RNA templates, and replication of single and double-stranded DNA molecules. The distribution of protein families associated with these activities across the three domains of life—Archaea, Eukarya, and Bacteria—adds layers of complexity to the narrative. While Archaea and Eukarya often share similar protein structures, structural biology shows homologous, but distinct, structures in Bacteria. On the other hand, viral polymerases emerge as a crucial part of genome replication and transcription. Their versatility, including RNA-dependent RNA polymerase, …

(Re)Constructing Race: How Essentialist Beliefs Shape Social Justice Support, Abbey Alvarado

Honors Theses

The political climate and social discourse around social justice has grown increasingly tense and hostile in recent years. The current study investigated potential predictors of the opposition to support for racial equity and social justice reforms. Research illustrates that a biological conceptualization of race (“essentialism”) has powerful implications on information processing and social-psychological outcomes regarding issues of race and racism. In the current study, we conducted a survey of 164 University of Richmond undergraduate students. The survey examined the interplay of essentialism and beliefs about systemic racism and white privilege on social justice support. The results showed that essentialist beliefs …

Defending The Role Of A Principle Of Proportionality In Just Punishment, Emma Mecklenburg

Honors Theses

What makes a punishment just or unjust is a familiar topic that the public and scholars alike recognize as an important question. Many factors are involved in conversations surrounding the just length of sentences, but this paper will specifically investigate two central questions: First, what makes a punishment just, and second, what role does a principle of proportionality play in thinking about just punishment.

Modeling The Opioid Crisis In Virginia: A Differential Equations Model Assessing The Impact Of Medication-Assisted Treatment On The Addicted Population, Maniha Zehra Akram

Honors Theses

The opioid epidemic is prevalent in countless communities throughout the United States and has yet to be mitigated. Treatments for OUD (opioid use disorder) include Medication-Assisted Treatment (MAT) and treatment without medication (non-MAT), with the former being judged as more effective in terms of lower relapse rates, death rates, and criminal activity (U.S. Food & Drug Administration, 2023; SAMHSA, 2024). Motivated by the promising research on MAT, this paper models the relationship

between the treatment and addicted populations using a system of ordinary differential equations. In addition to producing closed-form equilibrium solutions, the model leads to the conclusion that expanding …

Departure From Magical Realism: Female Agency In Latin American Post-Boom Literature, Nicole Darian Llacza Morazzani

Honors Theses

his thesis explores depictions of female agency in post-colonial Latin American literature. I highlight three primary texts: Gabriel García Márquez's (1927-2014) 1967 One Hundred Years of Solitude, a canonical magical realist novel; Isabel Allende's (1942-present) 1982 The House of Spirits, her debut novel and a multi-generational story similar to Márquez's, and Isabel Allende's 2022 Violeta, a historical novel offering an autodiegetic narrative of a woman's 100 years of life in an unnamed South American country, to analyze how female characters evolve in response to changing sociopolitical landscapes and literary movements in Latin America. My central focus is Allende's most recent …

Immigration Level And Its Impact On The United States Labor Market Tightness, Khai Quay La

Honors Theses

This research investigates the complex interplay between immigration labor and market equilibrium in the United States, focusing on the period from 2000 to 2019. By examining the correlation between the rate of net international migration and the unemployment-to-vacancy ratio (U/V) across 51 states, the study uncovers significant relationships that shed light on immigration dynamics in response to labor market conditions. The findings support the hypothesis that a decrease in the U/V ratio leads to an increase in immigration in the following period as immigrants seek improved job employment prospects.

Taylor, Genealogy, History, Peter Hawes

Honors Theses

In this paper I compare two different genealogies of the idea of the ‘self’: Charles Taylor’s and Michel Foucault’s. I begin by arguing that Taylor’s focus on combating what he calls “subtraction stories” places him in the genealogical tradition with Foucault. I then engage with Foucault's genealogy of the self, which illuminates how the notion of the ‘self’ was constructed as a means of control, which leads him to say we should do away with trying to understand it outside of relations of power. This call for the rejection of the self, I suggest, presents a problem for us, who …

Examining Variability In And Contextual Predictors Of College Student Belonging, Yangyue Li

Honors Theses

The purpose of the study is to examine disparities in belonging and whether contextual factors predict a higher sense of belonging among fourth-year undergraduate students at UR. My findings suggest that 1) underrepresented students (with racial/ethnic minority, low-income, and first-generation identities) reported lower belonging compared to their majority peers, 2) inclusive campus climate and contact with peers from different backgrounds predicted greater belonging, and 3) first-generation status moderated the association between contact with diverse peers and sense of belonging.

La Perception Et La Représentation Du Corps Des Femmes Africaines Par Rapport À La Colonisation Française, Mofiyinfoluwa Tunji-Ekundayo

Honors Theses

The thesis proposes an analysis of the perception that the French colonizers had towards the bodies of black women in France, women from northern Africa, and women from western Africa. Then, the work evaluates how this perception manifests in current French and francophone media. Furthermore, it traces how much influence these perceptions have on the depiction and representation of African female bodies. This influence could manifest as a reinforcement or an opposition to colonial perceptions.

Black Lives Matter: Is It Political?, Caroline O. Glaser

Honors Theses

The present research focused on foster ing greater support for the Black Lives Matter (BLM) movement by examining factors that predict support for the movement, and possible mechanisms implicated in this relationship. The BLM movement was founded in 2013 following the death of teenager Trayvon Martin, and reached a remarkable height of media attention in the summer of 2020, following the murder of George Floyd. Since then, support for BLM has fluctuated, becoming a highly politicized movem ent that has faced much public debate.

Our study focused on factors that predict support for BLM in the current politic al climate. …

Opioid Policy Solutions: Administrative Law, Legislation, And Constitutional Reform, Trevin Stevens

Honors Theses

I have written three separate policy briefs addressing issues in the pharmaceutical industry that allowed for the opioid epidemic to reach the magnitude that it has in the last three decades. I examined public policy regarding labeling, drug diversion, and misuse, as well as marketing. By studying existing policies, I was able to provide insight into possible reforms, while accounting for potential obstacles to systematic reform, such as constitutional concerns regarding free speech.

Shifting Grounds: Movement And Continuity In Mustang, Nepal, Lauren Carter

Honors Theses

This thesis explores the socio-cultural and economic transformations in the Mustang region of Nepal. Drawing from fieldwork conducted over a month, this study examines how traditional economic activities, particularly yak herding, are being replaced by tourism and agriculture due to shifting socio-economic conditions and global influences. The concept of 'adaptive traditionality' is introduced to describe how the community in Mustang actively engages with both internal pressures and external changes to reshape their socio-cultural landscape. This adaptability is evident in the transition from nomadic pastoralism to more sedentary agricultural practices and tourism, which not only reflects a survival tactic but also …

Heterocycles As Peptide-Based Cleavable Linkers, John Blobe

Honors Theses

As cancer cases continue to rise, the need for advancing the treatment options for cancer is ever increasing. Current cancer therapeutics, while effective at treating localized cancers and a fraction of advanced cancers, generally lack the specificity needed to target more advanced cancers. Recent advancements in cancer treatments have leveraged antibodies to target certain cancers. A class of drugs that utilize antibodies to deliver anti-cancer therapy preferentially to cancer cells, termed antibody-drug conjugates (ADCs), have been quite effective in treating certain advanced forms of certain cancers. These ADCs could be more effective if they could allow for the facile release …

The Value Of Prison Education: Evaluating The Impact Of Education Through Desistance, Cheryl Chan

Honors Theses

The United States faces an epidemic of incarceration, draining resources, disrupting families, and hindering societal participation. Prison education emerges as a method to address this cycle, with vocational and academic programs being pivotal. While vocational programs are more common, their long-term efficacy remains uncertain. Academic education, exemplified by programs like the Bard Prison Initiative, provides incarcerated individuals with an opportunity to change. Typically, the success of these programs are measured using recidivism. However, recidivism has become too narrow of a measure to properly capture the nuances of an education. There has been an emerging body of scholarship studying desistance and …

Black And Blue All Over: Whose Lives Matter?, Bella Purvis

Honors Theses

This study investigated the influence of beliefs about race on support for the Black Lives Matter (BLM) and Blue Lives Matter (BluLM) movements, mediated by attitudes towards police and beliefs about white privilege. Utilizing a sample of undergraduate university students, data were obtained through a survey measuring beliefs in the biological and social constructs of race, support for police, belief in white privilege, and attitudes toward BLM and BluLM. Results indicated that individuals who perceive race as a biological construct are less likely to support BLM and more likely to support BluLM, while beliefs in white privilege and attitudes towards …

Examining The Link Between Autistic Personality Traits And Processing Of Metonymy, Miranda Moe

Honors Theses

Previous research has investigated the real-time processing and offline interpretation of metonyms. This work has generally shown that readers experience longer processing times for metonyms versus control nouns because of the extra time needed to access the figurative sense of a metonym. Recent research has also demonstrated different processing patterns on nonliteral language for individuals with autism spectrum disorder compared to typically developing participants. The current study was designed to explore whether previous findings on the processing of metonymy are modulated by individual differences in autistic personality traits. Through an eye-tracking during reading experiment, participants read sentences in which factors …

Functionalized Gold Nanoparticles And Halogen Bond Interactions With Neonicotinoid Pesticides, Molly Mccuen “Mackey” Sherard

Honors Theses

Neonicotinoid (NN) pesticides have emerged globally as one of the most widely used agricultural tools for protecting crops from pest damage and boosting food production. Unfortunately, some NN compounds, such as extensively employed imidacloprid-based pesticides, have also been identified as likely endangering critical pollinating insects like honey bees. To this end, NN pesticides pose a potential threat to world food supplies. As more countries restrict or prohibit the use of NN pesticides, tools are needed to effectively and quickly identify the presence of NN compounds like imidacloprid on site (e.g., in storage areas on farms or pesticide distribution warehouses). This …

The Effect Of Solvent Identity And Hydride-Donor On The Reduction Of Co2 Into Useful Fuels, Abigail Mcentire

Honors Theses

One possible strategy for decreasing CO2 emissions is through electrocatalytic reduction reactions to convert the CO2 back into combustible fuels , such as methane or methanol. However, it can be challenging to control the reaction to select one of these useful fuels as opposed to carbon monoxide or formate. Our strategy is to investigate a specific hydride donor and solvent combinations for which the reaction favors conversion to methanol. It was found that in acetonitrile , several hydride donors were capable of selective reduction of CO2 to the methanol oxidation state.

The Effect Of The Expanded Child And Dependent Care Tax Credit On Maternal Labor Supply, Abby Letocha

Honors Theses

Policies that subsidize childcare have many potential economic benefits such as mitigating the high cost of childcare, incentivizing families to have more children, increasing paid childcare participation, and increasing parental labor supply. In this paper, I focus on the effect of childcare subsidies on maternal labor supply through a tax policy expansion. The Child and Dependent Care Tax Credit (CDCTC) is the primary federal childcare subsidy in the United States, and it was temporarily expanded in 2021 under the American Rescue Plan Act. This expansion increased the generosity of the credit and made it fully refundable for the 2021 tax …

Trading Perspectives: The Impact Of Gender In Shaping National Trade Policies, Katherine Kwiatkowski

Honors Theses

Economic and political factors have been shown to influence the trade policy decisions of national leaders. The impact of a national leader’s gender on their trade policy preferences remains an underexplored area of research. The increasing share of female national leaders raises the question of whether their policy preferences vary from those of male leaders because of their gender. In this study, I utilize the gender of a nation’s leader to implement a two-way fixed effects regression that analyzes the impact of gender on a leader’s trade policy preferences. Controlling for factors that could also impact a leader’s trade policy …

Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu

Honors Theses

Human adenovirus type 64 (Ad64) is a causative agent of contagious viral pink eye. We do not understand why Ad64 causes eye infections. One likely reason is the presence of a receptor molecule on the exposed surface of eye cells, but not other cells. Ad64 binds to a protein called CD46 on the cell surface. We aim to visualize how CD46 binds to the surface of Ad64. I mixed the extracellular portion of CD46 with purified Ad64 virus, then visualized it using negative stain transmission electron microscopy. In order to gain insight into how the virus binds CD46, we used …

Divided Discourse: Analyzing Abortion Rhetoric In The 2016 Presidential Debates, Ella Hayes

Honors Theses

How did the party affiliation of the speaker affect the rhetoric used to talk about abortion in the 2016 American presidential election? Using computer-assisted qualitative analysis and coding for instances of framing, metaphors, and bridging rhetoric, I look at debate transcripts during the election cycle from the American Presidency Project, tracing both Democratic and Republican primaries into the general election. I argue that across all debates and speeches, Democrats invoke the“morality as empathy metaphor and the Nurturant Parent model in their arguments more than Republicans. In contrast, I argue that Republicans invoke the“morality as strength" metaphor and the Strict Father …

Longitudinal Associations Between Peer Victimization And School Belonging In Elementary-Aged Children, Bridget E. Mcguiness

Honors Theses

Belonging is crucial for children’s social adjustment, and peer victimization has the potential to threaten belonging. Alternatively, it is possible that low levels of belonging can elicit higher victimization. My study determined the directionality of the relationship between peer victimization and belonging and whether gender moderated the relationship. There was no evidence that peer victimization was associated with decreases in classroom belonging, but low belonging was associated with higher levels of peer victimization. Gender did not moderate the relationship.