Psychiatry and Psychology Commons^™

Clinical Applications Of Cyp Genotyping In Psychiatry, Edoardo Spina, Jose De Leon

Psychiatry Faculty Publications

A critical review of the limited available evidence and the authors’ experience and judgment are used to summarize the role of cytochrome P450 (CYP) genetic variants in the pharmacokinetics of and clinical response to psychotropic medications. CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 genetic polymorphisms and their contributions to the metabolism of psychotropic drugs are reviewed. CYP1A2, CYP2B6 and CYP3A4 genotyping have limited current clinical utility. CYP2C9 genotyping has no utility in psychiatry. Psychiatrists should master tricyclic antidepressant (TCA) prescription, and if they use TCAs, they should have expertise in CYP2D6 and CYP2C19 genotyping and in TCA therapeutic drug monitoring …

Chronic Behavioral And Cognitive Deficits In A Rat Survival Model Of Organophosphate Toxicity, Beverly Huang

Theses and Dissertations

Organophosphates (OPs) are a major class of pesticides and nerve agents that elicit acute toxicity by inhibiting acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine in the central and peripheral nervous systems. Acetylcholine accumulation following extensive AChE inhibition leads to an acute cholinergic syndrome characterized by autonomic dysfunction, involuntary movements, muscle fasciculations, respiratory distress, and seizures. Despite their classification as moderate to highly toxic, OP pesticides are the most widely used class of insecticides in the U.S., and are even more commonly used worldwide. Additionally, there is a growing concern that OP nerve agents could be …

Asthma-Related Anxiety And Quick-Relief Medication Use In Urban Children With Asthma, Sarah E. Astrab, Robin Everhart

UROP Posters

Among children, asthma is the most common chronic illness. Although not curable, asthma is manageable with the use of both daily controller medication and quick relief or rescue medication. Anxiety has been found to increase asthma symptoms in children. Caregivers who are anxious about their child’s asthma symptoms may perceive their child’s asthma as more severe or doubt their ability to manage their child’s asthma, which can result in the misuse of asthma medication. This study focused on the association between asthma-related anxiety and the use of quick-relief asthma medications in a low-income, urban sample in Richmond, Virginia. Child participants …

Smoking Patterns Among Vcu Students, Jasmine Saini

UROP Posters

For some individuals, college can be a high risk time for the development of problems associated with alcohol use and other substances. The purpose of this study is to examine these initiation and use patterns as they relate to nicotine use among college students 18 years of age and older enrolled in Spit for Science: The VCU Student Survey. The Spit for Science research project evaluates how genetic and environmental factors contribute to substance use and emotional health among college students at VCU. This study uses data from the Spit for Science 2011 cohort (n=2007) to investigate smoking patterns among …

Frequency Of Metabolic Syndrome In Psychiatric Patients, Is This The Time To Develop A Standardized Protocol To Reduce The Morbidity From An Acute Care Psychiatry Unit., Tariq Munshi, Archana Patel, Mir Nadeem Mazhar, Emaduddin Siddiqui

Department of Emergency Medicine

OBJECTIVE:

To determine the frequency of Metabolic Syndrome among psychiatric patients and to look for the correlation between the two medical conditions.

METHODS:

The cross-sectional study was conducted from February to April 2013 at the acute care psychiatry in-patient unit at Kingston General Hospital, Ontario, Canada, and comprised adult patients of both genders diagnosed under the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. For Metabolic Syndrome, definitions outlined by the International Diabetes Federation were used. The patients were divided into two groups on the basis of presence or absence of the Syndrome and were compared for clinical and …

The Rewarding Nature Of Anger Rumination In Borderline Personality Disorder: An Fmri Investigation, Jessica R. Peters

Theses and Dissertations--Psychology

Anger rumination, or persistently dwelling on feelings of anger, is associated with borderline personality disorder (BPD) and related features, such as aggressive behavior and cognitive distortions. To develop more effective treatments, it is crucial to understand why individuals with BPD engage in anger rumination despite its negative outcomes. The activation of energy associated with anger, as well as feelings of justification and validation, may be experienced in the short-term as rewarding. This may prevent individuals with BPD from attempting to reduce their rumination.

Functional magnetic resonance imaging (fMRI) and behavioral methods were utilized to examine this theory in a sample …

Development Of An Avian Model For Identifying Individual Differences In Drug Vulnerability, Beth A. Rice

Theses and Dissertations--Psychology

The attribution of incentive salience to cues that become associated with drugs of abuse is a critical characteristic of individuals who may be vulnerable to drug addiction. Rodents with the propensity to sign track are thought to be vulnerable to drug abuse. The goal of the current work was to investigate whether sign trackers (STs) would acquire cocaine conditioned place preference (CPP) to a discrete cue using an avian species. In Experiment 1, sign and goal trackers (GTs) were first identified using a one third rank order split. Following identification, cocaine-CPP was conducted with a discrete cue in each end …

Interpersonal Rejection Sensitivity Predicts Burnout: A Prospective Study, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

We examined whether interpersonal rejection sensitivity (IRS)—the hallmark of atypical depression – prospectively predicted burnout, controlling for baseline symptoms, history of depressive disorders, antidepressant intake, gender, age, and length of employment (mean between-assessment duration: 21 months; n = 578; 74% female). IRS was related to a 119% increased risk of burnout at follow-up. Three of four burned out participants reported to be affected by IRS, or 2.5 times the rate observed in participants with no (or subthreshold) burnout symptoms. Our study highlights a dispositional factor in burnout’s etiology also known to be a key component of atypical depression’s etiology. The …

Burnout Does Not Help Predict Depression In French Schoolteachers, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Objectives: Burnout has been viewed as a phase in the development of depression. However, supportive research is scarce. We examined whether burnout predicted depression among French school teachers.

Methods: We conducted a 2-wave, 21-month study involving 627 teachers (73% female) working in French primary and secondary schools. Burnout was assessed with the Maslach Burnout Inventory and depression with the 9-item depression module of the Patient Health Questionnaire (PHQ-9). The PHQ-9 grades depressive symptom severity and provides a provisional diagnosis of major depression. Depression was treated both as a continuous and categorical variable using linear and logistic regression analyses. We controlled …

Can You Work It? Or Flip It And Reverse It?: Protecting Lgbt Youth From Sexual Orientation Change Efforts, Sanam Assil

Cardozo Journal of Equal Rights & Social Justice

The note advocates for raising the minimum age for Sexual Orientation Change Efforts (SOCE) from eighteen to twenty-one, arguing that individuals under twenty-one lack the emotional maturity to consent to such therapies. It emphasizes the harmful effects of SOCE, supported by findings from psychological organizations, and proposes incremental legislative changes to eventually achieve a nationwide ban on conversion therapy.

A Narrative Study Of Emotions Associated With Negative Childhood Experiences Reported In The Adult Attachment Interview, Lynne Hartman

Antioch University Dissertations & Theses

Attachment patterns, which tend to be stable over time, are passed from one generation to the next. Secure attachment has been linked to adaptive social functioning and has been identified as a protective factor against mental illness. The parents’ state of mind with regard to attachment—as measured with the Adult Attachment Interview (AAI) (Main, Goldwyn, & Hesse, 2002)—predicts the attachment classification for the infant in Ainsworth’s Strange Situation Procedure (Ainsworth, Blehar, Waters, & Wall, 1978). Earned-secure individuals have overcome negative childhood experiences to achieve a secure state of mind in adulthood. Earned security, like continuous security, strongly predicts infant security …

Theoretically Guided Examination Of Caregiver Strain And Its Relationship With School-Based Mental Health Services Utilization And Parent Engagement In Services, Amy Lynn Green

USF Tampa Graduate Theses and Dissertations

Broadly, the purpose of this study was to address the gaps in the knowledge base of caregiver strain through an examination of this and other theoretically related constructs in a sample of parents of high-risk youth. In the last two decades, a growing body of research has pointed to the significance of strain that can result from this caregiving experience, particularly as it relates to patterns of mental health services utilization. Despite the fact that the majority of children who receive mental health receive them from the school, few studies have examined caregiver strain in the context of school-based mental …

Behavioral Adjustment In Children With Life Threatening Illness A Qualitative Study, E. Joseph Becher Jr.

Antioch University Dissertations & Theses

This study investigated factors that affect adjustment in children with life-threatening illness from the viewpoint of the parents/caregivers. The data were collected from parents/caregivers whose children have a life threatening diagnosis. Parents/caregivers were interviewed and asked to complete the Parent Request Questionnaire (PRQ) which was given to them after the in-person interview. This newly developed PRQ was utilized into prior research to predict the levels of adjustment in children. It includes age, whether the child has been informed of the diagnosis, whether the child engages in age-appropriate activities, the child's prior experience with death, the child's family's involvement in treatment, …

Predicting Depression Symptoms Among College Students: The Influence Of Parenting Style, Sarah Whitmire Clark

Theses and Dissertations

This study examined parenting style variables in predicting college students’ depression symptoms. Participants were 989 college students who participated in the first wave of the Spit for Science project (Dick et al., 2011). This study described the prevalence of depression symptoms, including the percentage of the sample endorsing various depression symptoms, and the frequency depression scores were elevated at multiple time points. A hierarchical multiple regression was conducted to examine whether two dimensions of parenting style, Autonomy Granting and Parental Involvement, would interact in predicting depression symptoms in the Junior year. The present study demonstrates that parenting style predicts a …

Functional Characterization Of Rai1 In Zebrafish, Joshua S. Beach

Theses and Dissertations

Smith-Magenis Syndrome (SMS; OMIM #182290) is a multiple congenital abnormality and intellectual disability (ID) disorder caused by either an interstitial deletion of the 17p11.2 region containing the retinoic acid induced-1 (RAI1) gene or a mutation of the RAI1 gene. Individuals diagnosed with SMS typically present characteristics such as ID, self-injurious behavior, sleep disturbance, ocular and otolaryngological abnormalities, craniofacial and skeletal abnormalities, neurological and behavioral abnormalities, as well as other systemic defects and manifestations. Previous work by Vyas in 2009 showed temporal expression of rai1 in zebrafish embryos as early as 9 hpf. We hypothesize that there is maternal …

Examination Of Corporal Punishment From Three Perspectives: A Recommended Corporal Punishment Counseling Model And Its Application, Ayla Akbash

Khazar Journal of Humanities and Social Sciences

The corporal punishment has been examined through three different of perspectives, and a new psychological counseling model has been suggested for corporal punishment. The suggested model (CPC) has been applied in a psychological counseling group therapy. Consequently, new psycho-social developments such as behaviors, attitudes, emotions, opinions and experiences thoughts related to corporal punishment have been observed. Counseling sessions and evaluations have been presented in the study as well.

First Generation Azerbaijani Immigrants In The United States: Socio-Cultural Characteristics And Identity Issues., Ahmad Guliyev

Khazar Journal of Humanities and Social Sciences

The community of Azerbaijani immigrants in the United States, which is the subject of our proposed study, is a pretty recent phenomenon. Most Azerbaijani-Americans have immigrated to the United States mainly from Iran, Azerbaijan, Russia or Turkey. Azerbaijani immigration and integration in the United States have not been documented and studied thoroughly. There is no population survey that provides information of any kind on the attitudes and opinions of Azerbaijani Americans. Based on the survey conducted among sample of 103 Azerbaijani immigrants, this paper aims to provide the profile of the Azerbaijani community, socio-cultural characteristics, assess the immigrant’s identification with …

Domestic Violence Against Women In Bangladesh: A Review Of The Literature And The Gaps To Fill-In By Future Interventions, Anisur Rahman Khan

Khazar Journal of Humanities and Social Sciences

Although Bangladesh maintains inadequate records of the various forms of violence against women, it is clear that domestic violence against women is the most insidious problem for women in Bangladesh. For many Bangladeshi women, home is a place of pain and humiliation and violence is an integral part of everyday life. Domestic violence against women, perpetrated by their husbands, is a multi-faceted problem in Bangladesh. The efforts of the scholars to empirically investigate the problem are inadequate and a lot of issues are yet to be explored. This review is an attempt to present the findings of the major empirical …

Contributions Of The Cognitive, Affective And Linguistic Domains To Strategy Use And Degree Of Strategy Use To Effective Reading Performance, Seyed Hassan Talebi, Behnaz Seifallahpur

Khazar Journal of Humanities and Social Sciences

According to Oxford (1990), different learner variables affect the choice of learning strategy. It was also found that effective L2 readers know how to use strategies to foster reading comprehension and ineffective readers have little awareness of strategies to read effectively (Yang, 2002). This study investigates the contribution of three relatively important variables and their components (namely, the cognitive domain or awareness and use of strategies, the linguistic domain or general English proficiency level, and the affective domain or attitude toward reading in L2), to reading strategy use in English. The second purpose of the study is to find out …

The Nonreligious – Nonspiritual Scale (Nrnss): Measuring Everything From Atheists To Zionists, Ryan T. Cragun, Joseph H. Hammer, Michael Nielsen

Psychology: Faculty Publications

Although hundreds of measures of personal religiousness and spirituality exist, none are capable of reliably and validly assessing individuals who identify as nonreligious and nonspiritual. There is a need to develop a valid and reliable measure of (non)religiousness and (non)spirituality. This article discusses these problems, and presents the development and initial validation of a 17-item Nonreligious-Nonspiritual Scale (NRNSS) across three studies. The NRNSS exhibited high internal consistency (α > .94) and high test-retest reliability (r = .92). Two exploratory and one confirmatory factor analysis of the NRNSS supported the hypothesized two-factor solution: (a) institutional religiousness and (b) individualistic spirituality. The NRNSS …