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Increasing Maternal Or Post-Weaning Folic Acid Alters Gene Expression And Moderately Changes Behavior In The Offspring, Subit Barua, Kathryn K. Chadman, Salomon Kuizon, Diego Buenaventura, Nathan W. Stapley, Felicia Ruocco, Umme Begum, Sara R. Guariglia, W. Ted Brown, Mohamad Junaid 2014 New York State Institute for Basic Research in Developmental Disabilities

Increasing Maternal Or Post-Weaning Folic Acid Alters Gene Expression And Moderately Changes Behavior In The Offspring, Subit Barua, Kathryn K. Chadman, Salomon Kuizon, Diego Buenaventura, Nathan W. Stapley, Felicia Ruocco, Umme Begum, Sara R. Guariglia, W. Ted Brown, Mohamad Junaid

Publications and Research

Background: Studies have indicated that altered maternal micronutrients and vitamins influence the development of newborns and altered nutrient exposure throughout the lifetime may have potential health effects and increased susceptibility to chronic diseases. In recent years, folic acid (FA) exposure has significantly increased as a result of mandatory FA fortification and supplementation during pregnancy. Since FA modulates DNA methylation and affects gene expression, we investigated whether the amount of FA ingested during gestation alters gene expression in the newborn cerebral hemisphere, and if the increased exposure to FA during gestation and throughout the lifetime alters behavior in C57BL/6J mice.

Methods …


Modifying Essentialist Beliefs Toward Mental Illness: An Alternative Focus For Anti-Stigma Interventions, Frederick T. Chin 2014 Morehead State University

Modifying Essentialist Beliefs Toward Mental Illness: An Alternative Focus For Anti-Stigma Interventions, Frederick T. Chin

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Science and Technology Morehead State University in Partial Fulfillment of the Requirements for the Degree Master of Science by Fredrick T. Chin on July 8, 2014.


The Role Of Online Communication In Buffering Negative Effects Of Ostracism, Victoria Skye Wingate 2014 Morehead State University

The Role Of Online Communication In Buffering Negative Effects Of Ostracism, Victoria Skye Wingate

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Science and Technology Morehead State University in Partial Fulfillment of the Requirements for the Degree Master of Science by Victoria Skye Wingate on July 7, 2014.


Trends And Determinants Of Up-To-Date Status With Colorectal Cancer Screening In Tennessee, 2002-2008, Sreenivas P. Veeranki, Shimin Zheng 2014 Vanderbilt University

Trends And Determinants Of Up-To-Date Status With Colorectal Cancer Screening In Tennessee, 2002-2008, Sreenivas P. Veeranki, Shimin Zheng

ETSU Faculty Works

BACKGROUND:

Screening rates for colorectal cancer (CRC) are increasing nationwide including Tennessee (TN); however, their up-to-date status is unknown. The objective of this study is to determine the trends and characteristics of TN adults who are up-to-date status with CRC screening during 2002-2008.

METHODS:

We examined data from the TN Behavioral Risk Factor Surveillance System for 2002, 2004, 2006 and 2008 to estimate the proportion of respondents aged 50 years and above who were up-to-date status with CRC screening, defined as an annual home fecal occult blood test and/or sigmoidoscopy or colonoscopy in the past 5 years. We identified trends …


The Interplay Of Trait Anger, Childhood Physical Abuse, And Alcohol Consumption In Predicting Intimate Partner Aggression, Rosalita C. Maldonado, Laura E. Watkins, David DiLillo 2014 University of Nebraska-Lincoln

The Interplay Of Trait Anger, Childhood Physical Abuse, And Alcohol Consumption In Predicting Intimate Partner Aggression, Rosalita C. Maldonado, Laura E. Watkins, David Dilillo

Department of Psychology: Faculty Publications

The current study examined three well-established risk factors for intimate partner aggression (IPA) within Finkel and Eckhardt’s I3 model, including two impellance factors—trait anger and childhood physical abuse history—and the disinhibiting factor of alcohol consumption. Participants were 236 male and female college students in a committed heterosexual dating relationship who completed a battery of self-report measures assessing childhood physical abuse, trait anger, alcohol consumption, and IPA perpetration. Results revealed a significant three-way interaction showing that as the disinhibition factor alcohol consumption increased, the interaction of the two impelling factors, trait anger and childhood physical abuse, became increasingly more positive. …


A Coordinated School Health Approach To Obesity Prevention Among Appalachian Youth: Middle School Student Outcomes From The Winning With Wellness Project, William T. Dalton III, Karen Schetzina, Elizabeth Conway-Williams 2014 Department of Psychology, College of Arts and Sciences, East Tennessee State University

A Coordinated School Health Approach To Obesity Prevention Among Appalachian Youth: Middle School Student Outcomes From The Winning With Wellness Project, William T. Dalton Iii, Karen Schetzina, Elizabeth Conway-Williams

International Journal of Health Sciences Education

The Winning With Wellness (WWW) project was a school-based obesity prevention program that was developed to promote healthy eating and physical activity in youth residing in rural Appalachia. The project was based on the Coordinated School Health model (Centers for Disease Control and Prevention (CDC), 2013a) and used a community-based participatory research approach with an emphasis on feasibility and sustainability. The purpose of this study was to examine self-reported health outcomes for middle school students across the course of the intervention. Sixth grade middle school students (N = 149; 52% girls) from four schools in Northeast Tennessee completed a …


Family Criticism And Depressive Symptoms In Older Adult Primary Care Patients: Optimism And Pessimism As Moderators, Jameson K. Hirsch, Kristin L. Walker, Ross B. Wilkinson, Jeffrey M. Lyness 2014 East Tennessee State University

Family Criticism And Depressive Symptoms In Older Adult Primary Care Patients: Optimism And Pessimism As Moderators, Jameson K. Hirsch, Kristin L. Walker, Ross B. Wilkinson, Jeffrey M. Lyness

ETSU Faculty Works

Objective: Depression is a significant global public health burden, and older adults may be particularly vulnerable to its effects. Among other risk factors, interpersonal conflicts, such as perceived criticism from family members, can increase risk for depressive symptoms in this population. We examined family criticism as a predictor of depressive symptoms and the potential moderating effect of optimism and pessimism.

Methods: One hundred five older adult, primary care patients completed self-report measures of family criticism, optimism and pessimism, and symptoms of depression. We hypothesized that optimism and pessimism would moderate the relationship between family criticism and depressive symptoms.

Results: In …


Learning From Las Vegas: Gambling, Technology, Capitalism, And Addiction, David T. Courtwright 2014 University of North Florida

Learning From Las Vegas: Gambling, Technology, Capitalism, And Addiction, David T. Courtwright

Occasional Papers

Gambling has always led to addictive behavior in some individuals. However, the number and types of addicted gamblers have changed over time and in response to specific gambling environments. Recent work by historians, journalists, and anthropologists, reviewed in this paper, suggests that the situation worsened during the modern era, and that it has become worse still during the last half century. Technological, organizational, and marketing innovations have “weaponized” gambling, increasing both the likelihood that people will gamble and that they will gamble compulsively—a phenomenon with parallels to several other consumer products, including processed food, digitized games, and psychoactive drugs.


Theta And Learning: Dorsal And Ventral Hippocampal Theta Oscillation Respond Differently To Learning, Gregory N. Newman 2014 University of Connecticut - Storrs

Theta And Learning: Dorsal And Ventral Hippocampal Theta Oscillation Respond Differently To Learning, Gregory N. Newman

Honors Scholar Theses

Rhythmic oscillations within the hippocampus are thought to synchronize various subregions during learning, maximizing efficiency of the neural circuits. In rats, the most prominent oscillation is hippocampal theta. Theta is known to be modulated by an animal’s velocity, but it has also been shown to change in response to cognitive demands. To determine if theta is important for learning and memory, EEG recordings were examined for changes in theta related to the decision point of a spatial or non-spatial T-maze task. Additionally, a straight runway served as a control to verify the consistent relationship between velocity and theta during a …


The Effect Of Patient Education On Anxiety Levels In Patients Receiving Chemotherapy For The First Time, Sarah Garcia 2014 Valparaiso University

The Effect Of Patient Education On Anxiety Levels In Patients Receiving Chemotherapy For The First Time, Sarah Garcia

Evidence-Based Practice Project Reports

Cancer affects approximately 1.5 million people every year throughout the United States.Comprehensive care that includes psychosocial aspects is important to help patients effectively adapt to their diagnosis and treatment plan. Improper prevention and management of anxiety can lead to poor psychosocial outcomes, dissatisfaction with care, and decreased adherence to treatment. Current evidence suggests that education is effective at helping reduce anxiety in patients receiving chemotherapy for the first time. The purpose of this evidenced based practice project was to determine if nurse-led patient education regarding chemotherapy side effects, side-effect management, and orientation to the infusion center was effective at decreasing …


Do Culture And Biological Sex Influence People Who Engage In Non-Suicidal Self-Injury?, Rachel Berger 2014 University of Texas Permian Basin

Do Culture And Biological Sex Influence People Who Engage In Non-Suicidal Self-Injury?, Rachel Berger

Graduate Theses

Non-Suicidal Self-Injury (NSSI) refers to behaviors in which a person intentionally harms and causes tissue damage to oneself, without the desire to end his or her life. There have been contradictory findings with regard to differences in NSSI by biological sex and culture. In this study, I sought to examine if adults with independent cultural self- construals would report more occurrences of NSSI in comparison to those with interdependent cultural self-construals. Furthermore, I was interested in whether females would report more instances of NSSI in comparison to males in independent based cultures, and I examined whether the methods and reasons …


Depression And Risk Perceptions In Older African Americans With Diabetes, Barry W. Rovner, MD, Julia A. Haller, MD, Robin J. Casten, PhD, Ann P. Murchison, MD, MPH, Lisa A. Hark, PhD, RD 2014 Thomas Jefferson University

Depression And Risk Perceptions In Older African Americans With Diabetes, Barry W. Rovner, Md, Julia A. Haller, Md, Robin J. Casten, Phd, Ann P. Murchison, Md, Mph, Lisa A. Hark, Phd, Rd

Department of Psychiatry and Human Behavior Faculty Papers

Introduction: The purpose of this study is to describe the impact of depression on perceptions of risks to health, diabetes self-management practices, and glycemic control in older African Americans with type 2 diabetes.

Methods: The authors analyzed data on depression, risk perceptions, diabetes self-management, and hemoglobin A1C in African Americans with type 2 diabetes.T tests, chi square, and multivariate regression were used to analyze the data.

Results: The sample included 177 African Americans (68% women) whose average age was 72.8 years. Thirty four (19.2%) participants met criteria for depression. Compared to non-depressed participants, depressed participants scored significantly higher on Personal …


The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn 2014 University of Connecticut - Storrs

The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn

Honors Scholar Theses

Substantial evidence has shown that dopamine (DA), particularly in the nucleus accumbens (NAc), is involved in behavioral activation and effort-related processes, such as overcoming work related response costs. Interference with accumbens DA transmission through administration of the vesicular monoamine transportor-2 (VMAT-2) inhibitor tetrabenazine (TBZ) produces an alteration of response allocation in the concurrent FR5/chow choice procedure, biasing animals toward the lower effort alternative. It has been suggested that these drug-induced shifts in effort-related choice behavior seen in rodents are analogous to symptoms such as psychomotor retardation, anergia, and fatigue, which can be observed in people with depression and other related …


Eye-Tracking Measures Of Attentional Bias In Cocaine Dependent Subjects, Nadeeka Dias 2014 The University of Texas Graduate School of Biomedical Sciences at Houston

Eye-Tracking Measures Of Attentional Bias In Cocaine Dependent Subjects, Nadeeka Dias

Dissertations and Theses (Open Access)

Cocaine-dependent (CD) subjects show evidence of attentional bias toward cocaine-related cues, and this measure of cue-reactivity is predictive of craving and relapse. In previous work, cue-reactivity and attentional bias have been assessed by models that present drug-relevant stimuli (e.g., cocaine-specific Stroop task) and measure physiological and behavioral reactivity (e.g., heart rate, reaction times). Studies have indicated competition between the higher-order cortical processes (frontal eye-fields, DLPFC) in voluntary eye control (i.e., anti-saccades) and more reflexive saccades driven by involuntary midbrain (superior colliculus) perceptual input (i.e., pro-saccades). In addition, neuroimaging studies in patients with cocaine dependence have shown activation in frontal regions …


Possible Psychosocial Benefits Of Having A Sibling With A Disability, Jenna M. Talbott 2014 Liberty University

Possible Psychosocial Benefits Of Having A Sibling With A Disability, Jenna M. Talbott

Senior Honors Theses

Possible psychosocial benefits resulting from exposure to siblings with disabilities are investigated in the current study. Previous literature has generally overlooked the possibility of psychosocial benefits by exclusively focusing on the negative effects of having a sibling with disabilities. Contact theory suggests that the increased exposure to individuals with disabilities should increase positive attitude toward those who are struggling with disadvantages. This investigation hypothesized that this tendency would be manifested as elevated empathy and compassion in individuals who have siblings with disabilities, and that these traits would be influenced by certain demographic variables. A survey was distributed, and the responses …


Changes In Sleep Time And Sleep Quality Across The Ovulatory Cycle As A Function Of Fertility And Partner Attractiveness, Brooke N. Jenkins, Elizabeth G. Pillsworth, Aaron T. Goetz 2014 Chapman University

Changes In Sleep Time And Sleep Quality Across The Ovulatory Cycle As A Function Of Fertility And Partner Attractiveness, Brooke N. Jenkins, Elizabeth G. Pillsworth, Aaron T. Goetz

Psychology Faculty Articles and Research

Research suggests that near ovulation women tend to consume fewer calories and engage in more physical activity; they are judged to be more attractive, express greater preferences for masculine and symmetrical men, and experience increases in sexual desire for men other than their primary partners. Some of these cycle phase shifts are moderated by partner attractiveness and interpreted as strategic responses to women’s current reproductive context. The present study investigated changes in sleep across the ovulatory cycle, based on the hypothesis that changes in sleep may reflect ancestral strategic shifts of time and energy toward reproductive activities. Participants completed a …


Comparison Of Functional Network Connectivity For Passive-Listening And Active-Response Narrative Comprehension In Adolescents, Yingying Wang, Scott K. Holland 2014 Cincinnati Children's Hospital & University of Cincinnati

Comparison Of Functional Network Connectivity For Passive-Listening And Active-Response Narrative Comprehension In Adolescents, Yingying Wang, Scott K. Holland

Center for Brain, Biology, and Behavior: Faculty Publications

Comprehension of narrative stories plays an important role in the development of language skills. In this study, we compared brain activity elicited by a passive-listening version and an active-response (AR) version of a narrative comprehension task by using independent component (IC) analysis on functional magnetic resonance imaging data from 21 adolescents (ages 14–18 years). Furthermore, we explored differences in functional network connectivity engaged by two versions of the task and investigated the relationship between the online response time and the strength of connectivity between each pair of ICs. Despite similar brain region involvements in auditory, temporoparietal, and frontoparietal language networks …


Impulsive Choice In Unmedicated And Medicated Children Diagnosed With Adhd: Examining The Variables Of Reward Type And Adhd Subtype, Nicole Henriksen 2014 Western Michigan University

Impulsive Choice In Unmedicated And Medicated Children Diagnosed With Adhd: Examining The Variables Of Reward Type And Adhd Subtype, Nicole Henriksen

Dissertations

Developmentally inappropriate and impairing impulsive behaviors are often seen in attention-deficit/hyperactivity disorder (ADHD). One method for objectively assessing impulsivity is the Choice-Delay Task (C-DT) which presents repeated opportunities to choose between a smaller, sooner (SS) or larger, later (LL) reward. A preference for the SS reward that results in less total reward is considered impulsive. Many studies have found that participants diagnosed with ADHD choose the SS reward more than typical controls. However, less is known about the effects of different types of rewards, or the comparative performance of certain subgroups, such as children diagnosed with ADHD Predominantly Inattentive Type …


Linking Brain Electrical Signals Elicited By Current Outcomes With Future Risk Decision-Making, Dandan Zhang, Ruolei Gu, Lucas S. Broster, Yang Jiang, Wenbo Luo, Jian Zhang, Yue-Jia Luo 2014 Shenzhen University, China

Linking Brain Electrical Signals Elicited By Current Outcomes With Future Risk Decision-Making, Dandan Zhang, Ruolei Gu, Lucas S. Broster, Yang Jiang, Wenbo Luo, Jian Zhang, Yue-Jia Luo

Behavioral Science Faculty Publications

The experience of current outcomes influences future decisions in various ways. The neural mechanism of this phenomenon may help to clarify the determinants of decision-making. In this study, thirty-nine young adults finished a risky gambling task by choosing between a high- and a low-risk option in each trial during electroencephalographic data collection. We found that risk-taking strategies significantly modulated mean amplitudes of the event-related potential (ERP) component P3, particularly at the central scalp. The event-related spectral perturbation and the inter-trial coherence measurements of the independent component analysis (ICA) data indicated that the “stay” vs. “switch” electrophysiological difference associated with subsequent …


Patient Attitudes Towards Physician Nonverbal Behaviors During Consultancy: Result From A Developing Country, Fahad Hanif Khan, Raheela Hanif, Rumina Tabassum, Waris Qidwai Dr, Kashmira Nanji 2014 Civil Hospital

Patient Attitudes Towards Physician Nonverbal Behaviors During Consultancy: Result From A Developing Country, Fahad Hanif Khan, Raheela Hanif, Rumina Tabassum, Waris Qidwai Dr, Kashmira Nanji

Department of Family Medicine

Background. Nonverbal behaviors have a significant impact on patients during consultations. This study was undertaken to find out the attitudes and preferences of the patients regarding nonverbal communication during consultations with physicians, in a tertiary care hospital.
Methods. A questionnaire based cross-sectional study was carried out at the Aga Khan University Hospital, Karachi, Pakistan, during the months of January to March 2012. All patients (>18 years of age) coming for consultancy in the family medicine clinics were approached; out of 133, 120 agreed to participate. The subjects were asked questions regarding physician’s comforting touch and eye contact and …


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