Human and Clinical Nutrition Commons^™

Successful Aging: A Psychosocial Resources Model For Very Old Adults, G. Kevin Randall, Peter Martin, Mary Ann Johnson, Leonard W. Poon

Department of Nutrition and Health Sciences: Faculty Publications

Objectives.Using data from the first two phases of the Georgia Centenarian Study, we proposed a latent factor structure for the Duke OARS domains: Economic Resources, Mental Health, Activities of Daily Living, Physical Health, and Social Resources. Methods. Exploratory and confirmatory factor analyses were conducted on two waves of the Georgia Centenarian Study to test a latent variable measurement model of the five resources; nested model testing was employed to assess the final measurement model for equivalency of factor structure over time. Results. The specified measurement model fit the data well at Time 1. However, at Time 2, …

Regulation Of P53 Stability And Apoptosis By A Ror Agonist, Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anticancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORa. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

Regulation Of Expression Of Citrate Synthase By The Retinoic Acid Receptor-Related Orphan Receptor A (Rorα), Christine Crumbley, Yongjun Wang, Subhashis Banerjee, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

The retinoic acid receptor-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily of transcription factors that plays an important role in regulation of the circadian rhythm and metabolism. Mice lacking a functional RORα display a range of metabolic abnormalities including decreased serum cholesterol and plasma triglycerides. Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, CS plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis. Here, we identified a functional RORα response element (RORE) in the promoter of the CS gene. ChIP …

Supportive Weight Loss Program, Jenny Koscho Rd, Ldn, Cde

Clinical Nutrition Service

No abstract provided.

Parenteral Nutrition Order Entry Privileges For Registered Dietitians: Unique Approach To Improve Patient Outcomes (Poster), Judy Holaska Rd, Ms, Cnsc , Ldn

Clinical Nutrition Service

No abstract provided.

Parenteral Nutrition Web-Based Order Writing: Educating Prescribers And Registered Dietitians, Judy Holaska Rd, Ms, Cnsc , Ldn

Clinical Nutrition Service

No abstract provided.

Can Antioxidant-Rich Berries Improve Risk Factors Associated With Cardiovascular Disease In Postmenopausal Smokers?, Jordan Alaine Teeple

Graduate Theses and Dissertations

The purpose of this study was to examine the effects of smoking on risk factors associated with cardiovascular disease (CVD) and determine the efficacy of antioxidant-rich berries in ameliorating these risk factors in postmenopausal smokers. Menopause and cigarette smoking have been identified as major risk factors for CVD due to a decrease in antioxidant protection, increase in inflammation and oxidative stress, and adverse changes in serum lipids. Antioxidants, specifically flavonoid compounds found in blackberries and blueberries, have been shown to prevent low-density lipoprotein cholesterol oxidation and thus prevent downstream inflammation and oxidative stress. Healthy, postmenopausal nonsmokers (n=14) and smokers (n=31) …

Perceived Importance And Actual Intake Of Calcium And Vitamin D In Young Female Athletes, Miriam E. Zambrano

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Calcium needs increase as a child grows. Actual intake often decreases as a child gets older, leaving his/her developing bones at risk for injury during childhood and increasing the risk of developing osteoporosis later in life. The purpose of this study was to investigate relationships between psychosocial factors influencing consumption of calcium and vitamin D-rich foods and actual intakes of these nutrients. We examined the dietary calcium and vitamin D intakes, determined serum vitamin D levels, and assessed nutrition knowledge and perception of a sample of 20 young girls participating in competitive cheerleading in Omaha, Nebraska. From this information we …

Intervention To Increase Knowledge And Consumption Of Folate-Rich Foods Based On The Health Belief Model, Lindsay M. Labrosse

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Folate is important in the prevention of birth defects and in the maintenance of general health. Even after mandatory fortification, many people are still not consuming the RDA of 400 mcg/day. Consuming a diet rich in naturally high-folate foods, as opposed to supplementation, may offer additional health benefits and promote an overall healthy diet.

The purpose of this pilot study was to test the hypothesis that a learner-centered educational intervention based on the Health Belief Model (HBM) will successfully increase knowledge and consumption of folate-rich foods, while increasing positive beliefs about folate and health. A two group parallel control trial …

Effects Of Diet Type And Supplementation Of Glucosamine, Chondroitin, And Msm On Body Composition, Functional Status, And Markers Of Health In Women With Knee Osteoarthritis Initiating A Resistance-Based Exercise And Weight Loss Program, Teresa Magrans-Courtney, Colin Wilborn, Christopher Rasmussen, Maria Pontes Ferreira, Lori Greenwood, Bill Campbell, Chad M. Kerksick, Erica Nassar, Rui Li, Mike Iosia, Matt Cooke, Kristin Dugan, Darryn Willoughby, Luann Soliah, Richard B. Kreider

Nutrition and Food Science Faculty Research Publications

Background: The purpose of this study was to determine whether sedentary obese women with knee OA initiating an exercise and weight loss program may experience more beneficial changes in body composition, functional capacity, and/or markers of health following a higher protein diet compared to a higher carbohydrate diet with or without GCM supplementation.

Methods: Thirty sedentary women (54 ± 9 yrs, 163 ± 6 cm, 88.6 ± 13 kg, 46.1 ± 3% fat, 33.3 ± 5 kg/m²) with clinically diagnosed knee OA participated in a 14-week exercise and weight loss program. Participants followed an isoenergenic low fat higher …

High-Density Lipoprotein Metabolism In Human Apolipoprotein B100 Transgenic/Brown Adipose Tissue Deficient Mice: A Model Of Obesity-Induced Hyperinsulinemia, Sarah J. Ehlers, Stephanie M. Larson, Heather E. Rasmussen, Young-Ki Park, Ji-Young Lee

Department of Nutrition and Health Sciences: Faculty Publications

Obese and diabetic humans display decreased plasma high-density lipoprotein cholesterol (HDL-C) concentrations and an increased risk for coronary heart disease. However, investigation on HDL metabolism in obesity with a particular emphasis on hepatic ATP-binding cassette transporter A1 (ABCA1), the primary factor for HDL formation, has not been well studied. Human apolipoprotein B₁₀₀ transgenic (hApoB^tg) and brown adipose tissue deficient (BATless) mice were crossed to generate hApoB^tg/BATless mice. Male and female hApoB^tg and hApoB^tg/BATless mice were maintained on either a regular rodent chow diet or a diet high …

A High Fiber Diet Versus A Low-Carbohydrate Diet For Weight Loss In Obese Individuals With Or Without Type 2 Diabetes, Neal G. Malik

Loma Linda University Electronic Theses, Dissertations & Projects

In the United States, obesity rates have climbed steadily over the years. Many different diets for weight loss have been proposed and studied, yet no one diet seems to clearly be more beneficial. Among diets that have been promoted are those high in fiber and low in carbohydrates, yet thus far, results of these studies have been mixed.

Using a 2x2 complete factorial design, 173 obese men and women with or without type 2 diabetes were randomized to one of two conditions: (a) a high fiber diet (> 40 grams of fiber per day for women, >50 grams of fiber …

Contribution Of Dietary Supplements To The Nutritional Status Of College Students, Caroline Yu

Honors Scholar Theses

Little is known about the prevalence of dietary supplement usage among college students. Though taking dietary supplements can cover nutrient shortages not achieved through diet alone, it is often recommended to improve the quality of one's diet rather than rely on supplements. The main objective of this research study was to determine the prevalence of dietary supplement use among college students in relation to a variety of demographic and lifestyle variables, and to find out what portion of total nutrient intake is supplied by supplements. Subjects were all recruited from the University of Connecticut, and each participant completed a health …

The Importance Of Metrics And Communication In Cafeteria School Policy, Andre Sanchez, Atreya Chakraborty

Interdisciplinary Perspectives: a Graduate Student Research Showcase

Obesity has become an epidemic amongst American youth in the 21st century, and is spreading not only into other developed nations such as the UK and Australia, but is also beginning to effect developing nations such as India (Bhardwaj, 2008). It is estimated that nationwide, childhood obesity affects around 17% of American children (Center For Disease Control, 2011). Obesity has been linked to many health disorders, including but not limited to, heart disease and diabetes. Subsequently, this rise in childhood obesity is having a severe impact on the healthcare services sector in America, with some studies suggesting childhood obesity in …

Unsaturated Fatty Acids Repress The Expression Of Atp-Binding Cassette Transporter A1 In Hepg2 And Fhs 74 Int Cells, Chai Siah Ku, Heather E. Rasmussen, Young-Ki Park, Elliot D. Jesch, Ji-Young Lee

Department of Nutrition and Health Sciences: Faculty Publications

Adenosine triphosphate–binding cassette transporter A1 (ABCA1) plays a critical role in the formation and metabolism of high-density lipoproteins (HDLs). Adenosine triphosphate–binding cassette transporter A1 in the liver and small intestine, in particular, accounts for approximately 90% of plasma HDL cholesterol. Therefore, any alterations in the hepatic and intestinal expression of ABCA1 could have a large impact on HDL biogenesis. We tested the hypothesis that ABCA1 expression is regulated differentially by different types of fatty acids in the liver and small intestine. Human hepatoma HepG2 and human small intestine epithelial FHs 74 Int cells were used as an in vitro model. …

Preschool Children’S Willingness To Try And Preference For Docosahexaenoic Acid Omega-3 Foods, Bethany Joann Bettenhausen

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

During the preschool years, obesigenic eating habits are formed which are strongly associated with risk of developing chronic diseases later in life particularly cardiovascular disease. Docosahexaenoic acid (DHA) omega-3 fatty acid is a polyunsaturated fat with known benefits for heart health, brain cell structure, and retinal development. Current intakes of DHA are below recommended levels. United States (US) Midwestern children may be particularly at risk for suboptimal intakes of DHA. However, foods fortified with life’sDHA^TM, a product of Martek Biosciences and omega-3 eggs may provide culturally acceptable sources of DHA to Midwestern children.

Very little is known about …

Assessment, Referral, And Self Perception In Binge Eating And Obesity Among Adults, Mary Solberg

Walden Dissertations and Doctoral Studies

In the past 30 years, binge eating and obesity has increased among all age groups due to lifestyle, environment, social, and biological reasons. To change eating habits, individuals may have to collaborate with others beyond the medical professional. Societal impacts of binge eating and obesity include increases in insurance rates, medical costs, and increased early-age mortality. The purposes of this study were to assess how individuals are referred to other professionals if they self-identify as binge eaters or obese and to understand personal awareness individuals had of binge eating and obesity. Cognitive behavioral theory was used as the theoretical foundation. …

The Healthy Monday Campaign: Health Awareness In Elementary Schools, Sheena Pravin Patel

Theses and Dissertations--Nutrition and Food Systems

Childhood obesity is a major public health concern for Americans. Many school-based health interventions and campaigns have been in place in the elementary school setting to help lower the rates of childhood obesity and to make students aware of their health. This study focuses on the implementation of the Healthy Monday campaign to fourth and fifth grade students in two Kentucky elementary schools. Particularly the focal points of the campaign consist of nutrition and physical activity. The campaign highlights two spin-off campaigns from the Healthy Monday campaign titled the Monday Mile and Meatless Monday. This study looks at the effectiveness …

The Impact Of Nutrition-Teaching Self-Efficacy On Daily Fruit And Vegetable Intake, Leslie E. Rawls Hoglund

Walden Dissertations and Doctoral Studies

Lack of fruit and vegetable (FV) consumption is directly linked to the prevalence of obesity and chronic disease in the United States. The USDA Fresh Fruit and Vegetable Program (FFVP) offers elementary school teachers access to healthy foods as part of the public school classroom experience. The purpose of this study---which was based on self-efficacy theory and the socio-ecological model---was to examine if an association exists between selected factors: (a) daily fruit and vegetable consumption, training status in the USDA Fresh Fruit and Vegetable Program (FFVP), and an established school nutrition policy and (b) nutrition-teaching self-efficacy (NTSE) among elementary school …

Adipose Tissue Abca1 Contributes To Hdl Biogenesis In Vivo, Soonkyu Chung, Janet K. Sawyer, Abraham K. Gebre, Nobuyo Maeba, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

Background—Adipose tissue (AT) is the body’s largest free cholesterol (FC) reservoir and abundantly expresses ATP binding cassette transporter A1 (ABCA1), a key cholesterol transporter for HDL biogenesis. However, the extent to which AT ABCA1 expression contributes to HDL biogenesis in vivo is unknown.

Methods and Results—Adipocyte-specific ABCA1 knockout mice (ABCA1^−A/−A) were

generated by crossing ABCA1floxed mice with aP2 cre transgenic mice. AT from ABCA1^−A/−A mice had −^A/−A mice had a twofold increase in FC content, compared to WT mice, and failed to efflux cholesterol to apoA-I. …