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Full-Text Articles in Biological Psychology
The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg
The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg
Electronic Theses, Projects, and Dissertations
Addiction is a complex process in which behavioral sensitization may be an important component. While the behavioral effects of sensitization are well established, the intricate neurobiology of the phenomenon is still largely unknown. Dopamine systems mediate the induction of behavioral sensitization in adult rats, but there is a large amount of evidence showing that other neurotransmitter systems also modulate the induction process. For example, the α1b-adrenergic and 5-HT2A receptor systems are known to modulate the sensitized responding of adult rats, but the roles that these receptor systems play in the induction and expression of behavioral sensitization during the preweanling …
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Electronic Theses, Projects, and Dissertations
A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to …
Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof
Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof
Electronic Theses, Projects, and Dissertations
The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the selective dopamine D2-like receptor antagonist raclopride 15 min prior to treatment with the indirect dopamine agonists cocaine or methamphetamine. Acute control groups received two injections of saline. The pretreatment regimens occurred on either PND 16 or PND 20 (one-trial behavioral …