Biological Psychology Commons^™

Anxiety Symptoms As A Predictor Of Head And Neck Cancer Survival And Potential For Mediation By Cancer Treatment Response., Tyler D. Pollitt

College of Arts & Sciences Senior Honors Theses

BACKGROUND:

Head and neck cancers (HNC) are associated with high rates of depression, which seems to affect overall survival. However, little attention has been paid to the effects of anxiety on overall survival, though anxiety has been shown to activate inflammatory pathways implicated in cancer symptom development and progression. Here it was hypothesized that higher pre-treatment anxiety levels in HNC patients would predict poorer overall two-year survival and a higher likelihood of subsequent HNC treatment failure. Additionally, we expected that the relationship between higher pre-treatment anxiety and poorer two-year overall survival would be mediated by treatment failure.

METHODS:

Patients (n …

The Influence Of Neural Reward Processing On Memory In Depression, Nathan M. Hager

Psychology Theses & Dissertations

Theories and research suggest that depression involves impaired reward sensitivity and a deficit in memory for rewarding stimuli. Some researchers propose that this memory deficit may result from reduced neural reward sensitivity, which impairs the encoding of reward-related memories, but few studies have directly probed this connection. Such research may benefit from examining the reward positivity (RewP), an event-related potential (ERP) previously linked to reduced reward sensitivity in depression. Undergraduates with high or low self-reported depression completed a task in which they chose one of three doors, revealing a neutral word written in a color which indicated an outcome of …

In Search Of Psychiatric Kinds: Natural Kinds And Natural Classification In Psychiatry, Nicholas Slothouber

Electronic Thesis and Dissertation Repository

In recent years both philosophers and scientists have asked whether or not our current kinds of mental disorder—e.g., schizophrenia, depression, bipolar disorder—are natural kinds; and, moreover, whether or not the search for natural kinds of mental disorder is a realistic desideratum for psychiatry. In this dissertation I clarify the sense in which a kind can be said to be “natural” or “real” and argue that, despite a few notable exceptions, kinds of mental disorder cannot be considered natural kinds. Furthermore, I contend that psychopathological phenomena do not cluster together into kinds in the way that paradigmatic natural kinds (e.g., chemical …

The Effects Of Historical Alcohol Use On Neuropsychological Functioning In Older Adults Following A Traumatic Brain Injury, Ryan Sever

Dissertations

The present study aimed to determine the effects of alcohol abuse and dependence in long term functioning of older adults who have experienced a moderate to severe traumatic brain injury. The research question being answered in the current study was if a history of alcohol abuse or dependence would worsen neuropsychological functioning in older adults who experienced at least one moderate to severe traumatic brain injury. Participants of the study were selected from the more extensive database provided by the Brain Aging in Vietnam War Veterans (DOD-ADNI) database. All participants were Vietnam War veterans between the ages of 61 and …

Electroencephalographic Asymmetry, Emotion Regulation, And Their Relationships With Depression Risk, Aliza Jacob

Dissertations, Theses, and Capstone Projects

Background: Research investigating patterns of electroencephalographic (EEG) brain asymmetry aids our understanding of neural systems involved in the processing of emotion, motivation, and psychopathology. Withdrawal-motivated negative emotions characteristic of depression are associated with relative right prefrontal cortex (PFC) activity, whereas approach- motivated positive emotions are associated with relative left PFC activity. Styles of emotion regulation (ER), or modulation of the intensity and duration of emotional responses, are also associated with presence (e.g., suppression, or maladaptive ER) versus absence (e.g., cognitive reappraisal, or adaptive ER) of depression vulnerability. Most PFC asymmetry studies of emotion, depression, and/or ER rely upon EEG recorded …

Emotion Processing Deficits In Psychopathy: Does Cueing To Relevant Facial Features Increase Cognitive And Emotional Empathy?, Shawn E. Fagan

Dissertations, Theses, and Capstone Projects

Psychopathy is a multifaceted disorder characterized by a lack of cognitive and emotional empathy. The traditional model of psychopathy divides the disorder into two factors: Factor 1 consists of the interpersonal and affective traits of psychopathy while Factor 2 measures antisocial behaviors and lifestyle choices. The attention-to-the-eyes hypothesis argues that psychopathic individuals have impaired emotion recognition (specifically for fear) due to deficits in orienting attention to salient facial features like the eyes. Psychopathic individuals also display blunted autonomic responding to emotional stimuli, though whether this is due to attention-orienting deficits remains to be clarified. The present project investigated whether empathy-related …

Structure And Function Of Dopamine In The Inner Ear And Auditory Efferent System Of A Vocal Fish, Jonathan T. Perelmuter

Dissertations, Theses, and Capstone Projects

The neuromodulator dopamine is considered essential for coordinating the internal motivational state of an organism with appropriate behavioral responses to stimuli in the external environment. This could be accomplished by modifying the function of neural circuits involved in sensory processing such that they are “tuned in” and optimally sensitive to important stimuli during critical time windows. While dopamine modulation of auditory processing has been studied in the central nervous system, neuromodulation can also occur outside the brain, in the inner ear. The majority of investigations of dopamine in the ear are conducted using rodents and focus on its role in …

Neural Correlates Of Automatic Emotional Processing And Emotion Regulation In Empathy And Psychopathy-Related Coldheartedness, Danielle Difilipo

Dissertations, Theses, and Capstone Projects

Psychopathy is a personality disorder that is defined, in part, by a lack of empathy. Psychopathy-related empathic deficits have been associated with atypical behavioral and neural responses to emotional facial expressions. Although the mirror neuron system (MNS) has been implicated in empathy, very few studies have examined the role of MNS functioning as it pertains to empathy impairments in psychopathy. Moreover, there is very little empirical research regarding emotion regulation in psychopathy, and specifically whether emotional responses can be intentionally upregulated. The present study sought to clarify whether the MNS is functionally intact in adults with subclinical psychopathic traits, particularly …

Voluntary Oral Methamphetamine Reveals Susceptibilities To Spatial Memory Deficits, Decreased Dopamine Marker Expression And Increased Neuroinflammation In The Hippocampus Of Male And Female Mice, Jorge A. Avila

Dissertations, Theses, and Capstone Projects

Methamphetamine is an addictive illicit psychostimulant that produces lasting neurochemical and behavioral changes. The mechanisms underlying these deficits have been characterized in animal models using extremely high doses. Currently, better translational models are needed to understand the onset and progression of these deficits that more accurately reflect the gradual and voluntary dosing parameters as chosen by an abuser. To that end, a new model of methamphetamine administration, labeled Voluntary Oral Methamphetamine Administration (VOMA), offers a means to examine the progression of neurotoxicity, behavioral deficits, and the addiction process through a voluntary consumption framework.

Female populations show consistent vulnerabilities to methamphetamine, …

Clinical Characteristics And Neuroanatomical Predictors Of Acute Antidepressant Outcome For Patients With Comorbid Depression And Mild Cognitive Impairment, Jeffrey N. Motter

Dissertations, Theses, and Capstone Projects

Background: Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. The classification of cognitive impairment severity continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Previous studies have found associations between treatment outcome and both cortical thickness and white matter hyperintensities (WMH), though report inconsistent directionality and affected regions. In this study, we examined baseline clinical characteristics and neuroanatomical features as prognostic indicators for older adults with comorbid DEP and CI participating in an open antidepressant trial. EMCI is hypothesized to have greater …

The Role Of The Direct And Indirect Basal Ganglia Pathways In The Learning, Performance, And Goal-Directed Control Of Action Sequences, Eric Garr

Dissertations, Theses, and Capstone Projects

Animals engage in intricately woven action sequences that are constructed from trial-and-error learning, but the mechanisms by which the brain links together individual actions which are later recalled as fluid chains of behavior are not fully understood. The aim of this dissertation is to investigate the learning and goal-directed control of action sequences in rats. Experiment 1 addresses a question that comes out of a reinforcement learning model of action sequencing: how does the extent of training change how the performance of an action sequence is impacted by reward devaluation. The data show that action sequences remain goal-directed overall regardless …

Dermatoglyphic Measures In Relation To Depressive Symptoms Among Non-Clinical Adolescents And Young Adults, Yosefa A. Modiano

Dissertations, Theses, and Capstone Projects

Depressive disorders are highly prevalent and can be devastating. Increasingly, depressive symptomatology is understood from a dimensional perspective such that non- or sub-clinical presentations may share a similar etiology. Depression etiology is believed to include genetic and environmental factors that may contribute to underlying vulnerability (diathesis) by way of neurodevelopment. Birth cohort studies have provided empirical evidence of the relationship between prenatal insult and later experience of adverse outcomes, including increased risk for depressive disorders. Retrospective investigation of the possible influence of prenatal disturbance on later experience of depressive symptoms has methodological limitations. Dermatoglyphic measurements offer a more methodologically viable …

Murine Genetic Variance In Sugar And Fat-Conditioned Flavor Preferences: Roles Of Dopamine, Opioid And Nmda Receptors And Nutritive Sensing, Tamar T. Kraft

Dissertations, Theses, and Capstone Projects

As obesity and diabetes have emerged as a severe public health crisis, understanding the mechanisms underlying the consumption of sugars and fats has become a topic of vigorous study. From a biological standpoint, genetic dispositions, neurochemical and hormonal influences, and predetermined orosensory and postingestive signals that modulate the hunger and satiety process may govern physiological aspects of the obesity puzzle. In addition to an innate appetite and attraction for simple carbohydrates and fats, learning plays an important role in modulating preferences for sugar- and fat-rich foods in rodents, including inbred mouse strains. Marked genetic variance has been observed among murine …

The Effect Of Dopamine Blockade On Sensorimotor Gating In Social Phenotypes Of The African Cichlid Fish Astatotilapia Burtoni, Raymond A. Turco

Theses and Dissertations

We asked if blocking dopamine could improve implicit sensory gating deficits in a socially-defeated fish of a naturally-agonistic species. This study investigated the effects of dopamine D2R receptor antagonist metoclopramide on sensorimotor gating using a prepulse inhibition (PPI) paradigm in social phenotypes of male A. burtoni African cichlid fish.

Adult And Juvenile Rats Differentially Express Mpfc Glua2 Following Traumatic Memory Retrieval, Edgar Rodriguez

Theses and Dissertations

To advance our understanding of how traumatic memories are modulated between adults and juveniles, we characterize the AMPAr subunits, GluA1, GluA2, GluA3 in the mPFC of rodents following traumatic memory retrieval.

GluA2 was differentially expressed in adults but not juveniles rats. There were no changes in GluA1 or GluA3 expression

Do Psychopathic Traits Influence Distractibility By Empathy-Eliciting Pictures?, Priya M. Reji

Student Theses

Empathy is a crucial component in forming interpersonal connections, and reflects the ability to share and understand the feelings of others. Psychopathy is often associated with a reduced ability to feel and display empathetic concern towards other people. The Response Modulation Hypothesis argues that such individuals have an attentional deficit, which makes it difficult for them to shift focus between stimuli, thus individuals who have high scores on the interpersonal-affective factor of psychopathy have an increased ability to ignore emotional stimuli that are goal-irrelevant. The current study investigated whether psychopathic traits would influence distractibility on an emotional Stroop (eStroop) task. …

Emotion Identification And Beliefs About Emotions As Mediators Of Ptsd And Parenting Meta-Emotion Philosophies, Maegan Calvert

Graduate Theses and Dissertations

Approximately 20% of women are sexually victimized and incarcerated women’s rates of victimization are much higher. In addition, women have a higher rate of PTSD and trauma-related sequelae than men. Interpersonal trauma experiences can have a negative impact on emotional processes such as alexithymia, recognizing others’ emotions, and healthy beliefs about emotional experiences. These difficulties are associated with problematic parenting. However, the mediational processes by which PTSD and disruptive emotional processes affect parenting is unclear. The current study examines the associations among PTSD, alexithymia, negative beliefs about emotions, emotion recognition in children, and parenting meta-emotion philosophies in incarcerated women presenting …

Validating Empathy As Captured By The Meanness In Psychopathy-Self Report, Stephanie Marie Molina

UNLV Theses, Dissertations, Professional Papers, and Capstones

Psychopathy is a distinctive personality disorder with an array of interpersonal and affective deficits. In particular, deficits in affective and cognitive empathy skills are noted to be a central feature of psychopathy. Specifically, the construct of psychopathic meanness, which is conceptualized as a tendency to act aggressively without regard for others, is preferentially related to deficient empathy. To elucidate the relationship between psychopathic meanness and empathy, three studies were conducted utilizing the Meanness in Psychopathy-Self Report (MiP- SR). The MiP-SR is a new measure that parses apart the construct of psychopathic meanness into three factors: Malice, Coldness, and Imperviousness. MiP-SR …

Yoga To Decrease The Stress Response: Gentle Yoga Encourages Faster Decline In Salivary Cortisol Concentrations Following Participation In Tsst, Tabetha Gaile Hopke

MSU Graduate Theses

Short-term, activation of the human stress response system is beneficial as it prepares the body to deal with stressors at hand (McEwen & Stellar, 1993). If this system is overactive or chronically active however, it can negatively impact health and longevity (Cohen, Janicki-Deverts, & Miller, 2007). According to a review conducted by Ross & Thomas (2010) implementation of a yoga practice has been shown to down-regulate the stress response system. The present study aimed to expand on current research involving yoga for stress reduction by exploring whether participation in gentle yoga could decrease the stress response more quickly than naturally …

The Impact Of Traumatic Brain Injury On Neuropsychological Functioning And Tau Accumulation Later In Life In Military Veterans, Lindsay Eatman

Dissertations

Abstract The following study examines aging veterans that experience a TBI while in service and

compares to older veteran without a history of TBI. The objective is to look at cognitive profile later in life for military veterans with moderate to severe TBI different and compared to older veterans with no history of TBI. Is there a difference in tau accumulations on neuroimaging in military veterans with moderate to severe TBI compared to older veterans without a history of TBI? What is the relationship between the cognitive profile and tau imaging correlates for military veterans with moderate to severe TBI …

Investigating How Neural Entrainment Relates To Beat Perception By Disentangling The Stimulus-Driven Response, Aaron Wc Gibbings

Electronic Thesis and Dissertation Repository

Beat perception – the ability to perceive a steady pulse in music – is nearly ubiquitous in humans, but the neural mechanisms underlying this ability are unknown. A growing number of electroencephalography (EEG) studies suggest that beat perception is related to neural entrainment, a phenomenon in which cyclic changes in the excitability of populations of neurons synchronize with a rhythmic stimulus. However, the relationship between acoustically-driven and entrainment-driven neural activity is unclear. This thesis presents EEG research that extends our understanding neural entrainment is related to beat perception by characterizing, equating, and finally removing the stimulus-driven response in the neural …

Age-Dependent Effects Of Eedq On Cocaine-Induced Locomotor Activity And D2 Receptor Supersensitivity, Angie Teran

Electronic Theses, Projects, and Dissertations

The neurochemical changes occurring between the preweanling period and adolescence could be crucial for understanding the role development plays in the manifestation of psychotic behaviors. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) fully attenuates the DA agonist-induced behaviors of adult rats, while potentiating the DA agonist-induced locomotor activity of preweanling rats. My specific hypotheses were as follows: (1) Systemically administered EEDQ would block the cocaine-induced locomotor activity of adult rats. (2) Systemically administered EEDQ would potentiate the cocaine-induced locomotion of preweanling rats. (3) EEDQ would increase the E_max values (a measure of D2 receptor sensitivity) of preweanling rats, but not adolescent or adult rats. …

Evaluating Changes In Error-Monitoring Electrocortcial Responses As An Outcome Of Attention Bias Modification Training, Jeremy Andrzejewski

All NMU Master's Theses

Anxiety disorders are among one of the most debilitating and prevalent mental disorders. Maladaptive anxiety has been associated with enhanced attention bias to threat as well as heightened error-monitoring following an erroneous response. In an effort to reduce an anxious individual’s attention bias to threat, an attention training paradigm known as attention bias modification (ABM) was developed. While ABM training has demonstrated the ability to reduce attention bias and anxiety symptoms, there are inconsistencies in the magnitude of symptom reduction and there is a lack of neuroimaging support in regards to ABM outcome. Therefore, this study evaluated the outcome of …

Laboratory Induced Cortisol Reactivity Predicts Greater Rates Of Treatment Success In Affective Disorders., Andres David Roque

Psychology Theses and Dissertations

Response rates to first line treatments for affective disorders remain unsatisfactory (Loerinc et al., 2015). Identification of moderators and mediators that can facilitate treatment success is of great scientific and clinical interest. One such candidate could be stress-induced cortisol reactivity. For instance, higher cortisol reactivity to a pretreatment presentation of combat-related stimuli related to significantly worse outcome at post-treatment following 6-sessions of virtual reality exposure therapy in individuals with PTSD (Norrholm et al., 2016). By contrast, greater cortisol reactivity to an acute stressor predicted greater treatment response in not only depressive symptoms (Dieleman et al., 2016) but also anxiety symptoms …

Quantitative Reasoning: Individual Differences In Heart Rate And Response Latency, Abigail L. Van Nuland

MSU Graduate Theses

Math is something that all students are required to use at some point during their academic careers. Then they must use it again in the real world. Unfortunately, many students struggle with quantitative processing. In the current study, participants answered first grade level math problems in order to assess cognitive effort when solving math problem. Participants were then assigned randomly to one of two conditions; Answer or Equation. In the Answer Condition participants were asked to solve a series of math problems, whereby they were given a math equation and then they were asked to choose an answer. In the …

An Erp Investigation Of Reward Signals For Differing Classes Of Reinforcing Stimuli, Darin R. Brown

Psychology ETDs

In order to successfully traverse an actively complex environment, an agent is required to learn from the consequences of their actions. For over a century, models of behavior have been developed demonstrating these consequence-based learning systems. More recently, underlying biological systems have been found to adhere to these constructs of learning. The electroencephalographic signal known as the Reward Positivity (RewP) is thought to reflect a dopamine-dependent cortical signal specific to reward receipt. Importantly, this signal has been shown to adhere to an axiomatic (rule-like) positive reward prediction error, whereby it is evoked following outcomes that are better than expected. These …

Characterization Of Ethanol-Related Phenotypic Differences Between C57bl/6j And C57bl/6nj Substrains: Role Of Cyfip2?, Matthew C. Hartmann

Electronic Theses and Dissertations

The C57BL/6 (B6) mouse is the most commonly used inbred strain in biomedical research, and has served as the basis for various large-scale genetic and genomic projects. Although the parental substrain, C57BL/6J (B6J), originated at The Jackson Laboratory, isolated breeding colonies are now maintained at numerous sites. This separation has resulted in genetic drift that has led to the emergence of phenotypic differences among these colonies. For instance, B6J mice display higher levels of voluntary ethanol consumption and increased locomotor responses to psychostimulants, relative to C57BL/6N mice (B6N). Initial progress has been made in elucidating the genetic bases of these …

Developing Sensory Behavioral Assays For Zebrafish Autism Model, Shannon Wagner

Honors College Theses

Individuals of all ages can suffer from a wide variety of symptoms and disabilities that could be diagnosed as Autism Spectrum Disorder (ASD). Due to new methods and technology, individuals are now being diagnosed in the first two years of their life, which is when the signs of ASD are initially exhibited. Individuals diagnosed with ASD share many similar disabilities and symptoms such as hyperactivity to social, visual, and auditory stimuli, as well as hyposensitivity to olfactory stimuli. Neural circuit-based alterations are widely considered as a cause for these behavioral aberrations. We have created behavioral assays using zebrafish larvae to …

The Effects Of Adenosine Antagonists On Vigilant Attention In Sleep Restricted Rats, Morgan Crewe

Masters Theses, 2010-2019

The relation between chronic sleep restriction and performance on the Psychomotor Vigilance Task (PVT) have been well documented in the human literature, with chronic sleep restriction as little as 7 hours per night resulting in significant impairment in sustained attention performance measured via the PVT. Recently, an analogous version of the human PVT has been developed for use with rodent models (rPVT). Recent studies have measured the effects of sleep restriction on rPVT performance, citing similar results found in the human literature. However, few studies to date have directly examined the role of adenosine accumulation during sleep deprivation in producing …

The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia, Heath W. Shelton

Electronic Theses and Dissertations

Recent studies have shown elevated neuroinflammation in a large subset of individuals diagnosed with schizophrenia. A pro-inflammatory cytokine, tumor necrosis factor-alpha (TNFα), has been directly linked to this neuroinflammation. This study examined the effects of two TNFα modulators (PD2024 and PD340) produced by our collaborators at P2D Bioscience, Inc., to alleviate auditory sensorimotor gating deficits and reduce microglial cell activation present in the polyinosinic:polycytidylic (Poly I:C) rodent model of schizophrenia. Auditory sensorimotor gating was assessed using prepulse inhibition and microglial activation was examined and quantified using immunohistochemistry and confocal microscopy, respectively. Both PD2024 and PD340 alleviated auditory sensorimotor gating deficits …