Biological Psychology Commons^™

The Effects Of Historical Alcohol Use On Neuropsychological Functioning In Older Adults Following A Traumatic Brain Injury, Ryan Sever

Dissertations

The present study aimed to determine the effects of alcohol abuse and dependence in long term functioning of older adults who have experienced a moderate to severe traumatic brain injury. The research question being answered in the current study was if a history of alcohol abuse or dependence would worsen neuropsychological functioning in older adults who experienced at least one moderate to severe traumatic brain injury. Participants of the study were selected from the more extensive database provided by the Brain Aging in Vietnam War Veterans (DOD-ADNI) database. All participants were Vietnam War veterans between the ages of 61 and …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …