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Full-Text Articles in Biological Psychology
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Theses Digitization Project
The purpose of this thesis was to: a) investigate the effects of intrastriatally administered N-ethoxycarbonyl-2ethoxy-1, 2-dihydroquinoline (EEDQ) on nonselective dopamine agonists (NPA) -induced locomotor activity in preweanling and adult rats; b) determine which dopamine receptor subtype (D1- or D2-like) is responsible for modulating EEDQ's paradoxical behavioral effects in preweanling rats; and c) examine the magnitude of EEDQ-induced D1- and D2-like receptor inactivation in both adult and preweanling rats. Subjects were 252 male and female rat pups of Sprague-Dawley descent (Charles River Laboratories, Hollister, CA, USA), born and raised at California State University, San Bernardino (CSUSB).
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Theses Digitization Project
Infusions of the nonselective dopamine agonist R( - ) propylnorapomorphine (NPA) into the dorsal striatum of preweanling rats atteuates kappa opioid-mediated locomotor activity. The purpose of this thesis was to ascertain which dopamine receptor subtype (D1 or D2) is responsible for this effect. It was hypothsized that a) D1, but not D2, receptors in the dorsal striatum underlie NPA's ability to attenuate the kappa opioid-mediated locomotor activity of preweanling rats, and b) microinjectng SKF38393 (a D1 agonist), and not quinpirole (a D2 agonist), would attenuate kappa opioid-mediated locomotion.
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
Theses Digitization Project
No abstract provided.