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Articles 1 - 30 of 138
Full-Text Articles in Biological Psychology
Neuropsychological Profiles To Aid In Determining The Necessity For Neuroimaging Reviews: Providing Evidence For A Screener For Cerebrovascular Abnormalities, Kayla Blaire Miller
Neuropsychological Profiles To Aid In Determining The Necessity For Neuroimaging Reviews: Providing Evidence For A Screener For Cerebrovascular Abnormalities, Kayla Blaire Miller
Theses and Dissertations
This study aimed to provide evidence for a white matter abnormality (WMA) screener by investigating whether commonly used neuropsychological measures of executive functioning and processing speed have predictive power for identifying high WMA burden.
Participants were administered a brief neuropsychological evaluation by a doctoral student under the direct supervision of a board-certified clinical neuropsychologist and underwent an MRI scan. A neurologist rated each participant’s MRI results using the Fazekas scale. A total of 178 participants were included, divided into two groups based on their Fazekas rating: low WMA burden (46%) and high WMA burden (54%).
A confirmatory factor analysis indicated …
The Hypnagogic State And Hypnagogic Constraint Modulation In Ocd, Ari Rad
The Hypnagogic State And Hypnagogic Constraint Modulation In Ocd, Ari Rad
Academic Leadership Journal in Student Research
The past few decades of scholarly inquiries on the topic of the hypnagogic state and N1 sleep onset have introduced a new understanding of human general mentation. The underlying phenomenological, psychological, and neurological aspects of the hypnagogic state have been explored in depth by researchers. Hypnagogia and N1 sleep onset have been associated with creativity, spontaneous access to insights, symbolic representation of cognitive processes, and visual and auditory perceptions. The default mode network (DMN) has been largely associated with creativity and spontaneous thinking during N1 sleep onset. This paper reviews the basics of the neurology and phenomenology of N1 and …
Evaluation Of Neuroplastic Changes In Psychological Intervention And Contemporary Treatments Of Depression, Taylor Severance
Evaluation Of Neuroplastic Changes In Psychological Intervention And Contemporary Treatments Of Depression, Taylor Severance
Dissertations
Major depressive disorder is one of the most prevalent mental health disorders worldwide. There is a vast range of treatment options for depression, with varying levels of effectiveness. Recent treatments for depression have expanded, increasing alternative treatments, and it is unknown which treatments have the largest impact on depression. This research was designed to examine the treatments of depression, with a focus on psychotherapy and contemporary treatments such as ketamine, psilocybin, and transcranial magnetic stimulation. A literature review was conducted to assess treatment outcomes and neuroplastic changes in these interventions, as well as combinations of the interventions. Data were evaluated …
Exercise Therapy For Mood Disorders In Retiring/Former Athletes, Christian Antos
Exercise Therapy For Mood Disorders In Retiring/Former Athletes, Christian Antos
Dissertations
This dissertation examined the potential integration of exercise therapy and psychotherapy as a treatment approach for mood-related difficulties experienced by former elite athletes during the transition out of competitive sport. Retirement from athletics is often associated with significant biopsychosocial challenges, including disruptions in identity, healthy routines, social support, and emotional well-being. Existing literature suggests that exercise may serve as an effective adjunctive intervention for improving mood and overall psychological functioning, though limited research has explored its application among retiring athletes within psychotherapeutic contexts. This literature review synthesized current research related to athletic retirement, neurobiological mechanisms associated with physical activity, and …
Clinician Perspectives On Fistula Mental Health, Victoria K. Leonard
Clinician Perspectives On Fistula Mental Health, Victoria K. Leonard
Doctoral Dissertations
Background – Obstetric fistula is a childbirth injury caused by prolonged labor that leads to stillbirth and incontinence, spurring social exclusion and isolation. These layers of trauma put women with fistula at great risk for psychological suffering, which has profound negative socioeconomic impacts on them, their families, and communities. This study captured treatment as usual at Comprehensive Community Based Rehabilitation in Tanzania (CCBRT), the country’s largest provider of fistula care.
Method – Improving holistic fistula treatment requires engaging the clinicians who care for women with fistula. This study aimed to investigate the training, beliefs, and treatment approaches of nurses and …
The Effects Of Cannabidiol (Cbd) On The Social, Cognitive, And Physical Facets Of Anxiety Sensitivity, Ezri Rathbun
The Effects Of Cannabidiol (Cbd) On The Social, Cognitive, And Physical Facets Of Anxiety Sensitivity, Ezri Rathbun
Psychological Science Undergraduate Honors Theses
The current study investigated how repeated administration of 300mg of cannabidiol (CBD), when compared to a placebo, affects the social, cognitive, and physical facets of anxiety sensitivity (AS), a characteristic that reflects fear of the consequences of anxious arousal. Prior work suggests CBD may have anxiolytic effects that may be specific to the social aspects of anxiety. Thus, it was hypothesized that, that, relative to placebo, CBD would reduce self-reported AS-social concerns, but not AS-cognitive or AS-physical concerns, compared to baseline. Participants (N= 79; 52 women; Mage = 22.06) with elevated perceived stress were randomly assigned to 14 …
The Relationship Between Symptom Catastrophizing And Sociocultural Factors Among Adults With Persistent Sympathetic Activation Syndromes, Whitney M. Redemer
The Relationship Between Symptom Catastrophizing And Sociocultural Factors Among Adults With Persistent Sympathetic Activation Syndromes, Whitney M. Redemer
Theses and Dissertations
Persistent Sympathetic Activation (PSA) has emerged as a potential unifying mechanism underlying a range of complex chronic health conditions yet remains poorly characterized within biomedical and psychosocial research. Limited research has delineated how PSA manifests across diverse populations or how diagnostic and sociocultural factors shape lived experiences of this phenomenon; thus, the objective of the present study was to examine whether diagnostic certainty – operationalized as provider-confirmed versus self-suspected PSA-related diagnoses – is associated with symptom catastrophizing, and whether this relationship varies as a function of sociocultural factors. Drawing on data from a larger study aimed at characterizing the lived …
The Relationship Between Estradiol And Progesterone Concentration Levels, Alcohol Consumption, And Inhibitory Control, Layne Elizabeth Robinson B.S.
The Relationship Between Estradiol And Progesterone Concentration Levels, Alcohol Consumption, And Inhibitory Control, Layne Elizabeth Robinson B.S.
Theses and Dissertations--Psychology
Alcohol use is increasing among women, with estimates for binge drinking having risen to levels similar to those seen in men. Despite this trend, sex differences regarding mechanisms of alcohol consumption have seldom been investigated. Our group and others have found evidence to suggest that ovarian sex hormones are associated with alcohol consumption and mechanisms that might be related to alcohol consumption, such as executive function deficits. The current study sought to extend this prior research in a larger sample with higher drinking rates and more rigorous methods, and to explore inhibitory control associations with drinking. Across the two samples …
Dispositional Mindfulness And Autonomic Reactivity, Thomas Dylan Boyer
Dispositional Mindfulness And Autonomic Reactivity, Thomas Dylan Boyer
Graduate Theses, Dissertations, and Problem Reports (ETD)
To explain how different facets of mindfulness were associated with task performance in distinctive ways, Lindsay and Creswell (2017) proposed the Monitor and Acceptance Theory (MAT). According to this model, the mindfulness facet of monitoring present state awareness was thought to influence task performance differently than the nonjudgmental acceptance facet of mindfulness, but no studies to date have examined this model with respect to an individual's physiological response to stressful tasks. Because dispositional mindfulness has been associated with both increased and decreased physiological and affective reactions to stress in previous studies, the present study tested whether the Monitoring facet of …
Heat Waves And Heart Rates: Exploring The Correlation Between Temperature And Anxiety, Denise Lori Loewinger, Laci Joy Walmer
Heat Waves And Heart Rates: Exploring The Correlation Between Temperature And Anxiety, Denise Lori Loewinger, Laci Joy Walmer
Student Scholar Symposium
“Will an individual be more prone to anxiety or panic attacks with an increase in body temperature?” Anxiety is defined as a feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome. Commonly known is the idea that situational factors, such as the death of a family member or financial stress may increase a person’s anxiety levels. Yet, according to research, factors such as physical location or high temperatures may also determine the prominence of anxiety. Using temperature- controlled environments in conjunction with medical instruments, we measured the anxiety levels of participants through …
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Journal of Humanities and Social Sciences
The current study investigates the relationship between noun classes and plant folk taxonomy in Chasu (G 22). The study focuses on two objectives: the first objective is to describe the plant folk taxonomy in Chasu and the second objective is to determine the relationship between noun classes and plant folk taxonomy in Chasu. Data were collected from rural villages in Same and Mwanga districts by using free listing, field interviews (jungle-walk-and-identify), and written texts containing Chasu plant names. The findings reveal that Chasu folk taxonomy reflects different ethnobotanical categories; including a unique beginner which is mmea/mimea ‘plant(s)’, and three life …
Dermatoglyphic Fluctuating Asymmetry In Schizotypy, Marcus R. Thomas
Dermatoglyphic Fluctuating Asymmetry In Schizotypy, Marcus R. Thomas
All-Inclusive List of Electronic Theses and Dissertations
Schizotypy has been linked with many of the proposed endophenotypes of schizophrenia, but research is limited on the relationship between schizotypy and dermatoglyphic fluctuating asymmetry. The present study sought to examine relationships between schizotypy, dermatoglyphic fluctuating asymmetry, handedness, and season of birth. 146 undergraduate students were identified as schizotypes (n = 52) or controls (n = 94) based on the Multidimensional Schizotypy Scale and had their finger and palm prints collected along with completing additional measures of schizotypy and handedness. Schizotypes did not exhibit a greater degree of dermatoglyphic fluctuating asymmetry, negative schizotypy was associated with increased absolute finger ridge …
Hormonal Modulation Of Sexual Approach And Avoidance Among Women With A History Of Sexual Trauma, Anneliis Susan Sartin-Tarm
Hormonal Modulation Of Sexual Approach And Avoidance Among Women With A History Of Sexual Trauma, Anneliis Susan Sartin-Tarm
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
A history of sexual trauma places women at a high risk for sexual dysfunction and other health sequelae, yet the influence of ovarian hormones in this population is poorly understood. This dissertation tested the theory that the effects of ovarian hormones are mediated by cognitive approach-avoidance systems to shape sexual well-being, and that this process is moderated by sexual trauma history. This was investigated across three studies examining the menstrual cycle, hormonal contraceptive use, and menopause. Across each chapter, I present complementary evidence demonstrating that hormones interact with the interpretation of ambiguous internal and external cues with respect to sexual …
Fear Of Pain In Migraine: Psychological Factors In Perceptions Of Headache Triggers, Sarah Basha, Todd Smitherman
Fear Of Pain In Migraine: Psychological Factors In Perceptions Of Headache Triggers, Sarah Basha, Todd Smitherman
Honors Theses
Migraine is a debilitating neurological disorder affecting millions worldwide, with substantial societal and personal burdens. Psychological factors, particularly fear of pain, may influence migraine experience by impacting perceptions of headache triggers. This study investigates the relationship between fear of pain and perceived triggers in individuals with migraine. A sample of 2,959 young adults meeting diagnostic criteria for migraine completed a structured diagnostic interview and self-report measures of fear of pain, headache-related disability, and beliefs about headache triggers (which stimuli triggered headache, most important triggers, and likelihood of developing a headache upon exposure to the most important trigger [trigger potency]). Linear …
Stress As A Means Of Success: Investigating The Effect Of Stress Appraisals On Willpower, Ego Depletion, And Physiological Responses In College Students, Anna Minor
Honors College Theses
Stress impacts our emotions, cognition, behavior, and health. Although stress is abundant and unavoidable, recent research suggests our perception of stress can strongly influence its outcomes. The Biopsychosocial Model of Challenge and Threat (BPS) states that we appraise a stressful scenario in one of two ways: challenge or threat. A challenge appraisal involves a positive perception of stress and is associated with lower physiological output while a threat appraisal involves a negative perception of stress and increased physiological arousal. The current research seeks to apply the BPS to a cognitive task and consider its relation to willpower, ego depletion, and …
Racial Health Disparities Among Pregnant Women Of Color In New York City: Biological And Systemic Impacts, Kaylin Peña
Racial Health Disparities Among Pregnant Women Of Color In New York City: Biological And Systemic Impacts, Kaylin Peña
Pitzer Senior Theses
Racial Health Disparities Among Pregnant Women of Color in New York City: Biological and Systemic Impacts
Abstract
This thesis aims to explore how racial health disparities, underrepresentation in gynecology, and socioeconomic barriers contribute to adverse pregnancy outcomes among women of color in New York City. Through an interdisciplinary approach that combines resources from medical anthropology and human biology, this research will examine the biological implications of chronic stress, specifically HPA axis dysregulation, and its role in maternal health outcomes. With the idea of intersectionality, as conceptualized by Kimberlé Crenshaw, the study analyzes the various effects of systemic inequities and social …
Navigating Online Dating: Exploring The Intersection Of Attachment Styles, Parental Attachments, And Sociosexuality In Online Dating Among College Students, Jensley Velez-Lozada
Navigating Online Dating: Exploring The Intersection Of Attachment Styles, Parental Attachments, And Sociosexuality In Online Dating Among College Students, Jensley Velez-Lozada
Honors Undergraduate Theses
The aim of this thesis is to explore the connection between attachment styles, parental attachment, and sociosexuality as predictors of online dating attitudes among college students. As society navigates this new digital era of online dating, how does it continue to transform young adults as they form romantic and sexual connections? It becomes increasingly important to understand the psychological mechanisms that influence these behaviors. This study examined how anxious and avoidant attachment styles, parental attachment, and sociosexuality may have contributed to online hookup attempts and outcomes behaviors. It also examined how these variables interacted and influenced both the likelihood of …
Weighted Family History Density Of Substance Use: Influence On Participant Substance Use Onset, Escalation, And Duration, Carleigh A. Litteral
Weighted Family History Density Of Substance Use: Influence On Participant Substance Use Onset, Escalation, And Duration, Carleigh A. Litteral
Theses and Dissertations--Psychology
Substance use disorders impose a staggering toll on the United States (U.S.), straining healthcare systems, destabilizing communities, and profoundly impacting both individuals and families. Approximately one in six Americans aged 12 and older had a past-year substance use disorder in 2022 (Key Substance Use, 2022), and nearly one-third of adults experience a substance use disorder in their lifetime (Wu, 2010), contributing to an economic burden exceeding $400 billion annually (National Drug Threat Assessment, 2011). Family history of substance use disorders is a key predictor of vulnerability, with individuals who have affected relatives being 2–8 times more …
Exploring The Effects Of Transcranial Direct Current Stimulation Of The Right Inferior Frontal Gyrus On Inhibitory Control In Posttraumatic Stress Disorder, Colton Rippey
Theses and Dissertations--Psychology
Background: The right inferior frontal gyrus (rIFG) is implicated in stop signal reaction time (SSRT) performance – a common measure of inhibitory control – and emotional expression and control. Individuals with posttraumatic stress disorder (PTSD) exhibit poorer stop SSRT performance, which is associated with rIFG hypoactivity. Neuromodulation of the rIFG with transcranial direct current stimulation (tDCS) can significantly improve inhibitory control and reduce fearful responding to threatening stimuli. Research has yet to test the effects of multifocal tDCS targeting the rIFG on inhibitory control or emotional reactivity in individuals with PTSD.
Methods: The current study aims to examine the impact …
What Is It Like To Be A Diplomat? Reflections On Donald Griffin And Emotion, Oliver H. Turnbull
What Is It Like To Be A Diplomat? Reflections On Donald Griffin And Emotion, Oliver H. Turnbull
Animal Sentience
This commentary addresses three aspects of Donald Griffin’s work: (1) his thoughts beyond cognition, on emotion; (2) his views on the earliest origins of mind, including primitive forms of consciousness; and (3) his diplomatic use of memorable phrases to facilitate change.
Does Emotion Regulation Capacity Moderate Social Anxiety Risk Given Experiences Of Racial Microaggressions In Black/African American Undergraduate Students?, Alisha M. Sylvester
Does Emotion Regulation Capacity Moderate Social Anxiety Risk Given Experiences Of Racial Microaggressions In Black/African American Undergraduate Students?, Alisha M. Sylvester
Honors College Theses
Racial microaggressions are intentional or unintentional slights toward members of a marginalized community that may come in the form of verbal, behavioral, or environmental insults. Black/African Americans experience racial microaggressions frequently, and these experiences threaten mental health. Specifically, experiencing more racial microaggressions is linked with a risk for social anxiety. However, not all individuals within the community go on to experience social anxiety. Therefore, the present study sought to identify which individuals are more vulnerable to social anxiety given experiences of racism. Poorer emotion regulation (i.e., the ability to manage emotions) is a known risk factor for anxiety. Thus, I …
Fear, Distress, And Dissociation: Correlates Of Physiological Hyporeactivity After Interpersonal Victimization, Natalia Kecala
Fear, Distress, And Dissociation: Correlates Of Physiological Hyporeactivity After Interpersonal Victimization, Natalia Kecala
Dissertations
Background and Objective: Despite consistent findings of high reactivity to trauma cues in PTSD, there exists a consistent subset of physiological nonresponders who exhibit more complex and severe posttraumatic symptomatology. Research has identified different patterns of defensive reactivity representing Fear (core) and Distress (complex) PTSD symptoms. However, no studies have directly compared responders and nonresponders on physiological and clinical symptoms posttrauma.
Method: 66 adult women who had experienced first-degree sexual or physical assault within the last month were categorized using heart rate reactivity (HRR) to two personalized trauma scripts. Participants exhibiting negative HRR to both scripts were classified as nonresponders …
Resting-State Eeg Microstate Features For Major Depressive Disorder Classification, George M. V. Quinn
Resting-State Eeg Microstate Features For Major Depressive Disorder Classification, George M. V. Quinn
Dissertations, Theses, and Capstone Projects
Neuroimaging studies have revealed consistent abnormalities in functional connectivity within specific neural networks that may serve as biomarkers for major depressive disorder (MDD). It is important to find inexpensive, non-invasive techniques that target these biomarkers to make diagnosis easier and more objective. EEG microstates are quasi-stable potential topographies that are thought to reflect the quasi-stable network activity of the underlying neural generators. MDD has been shown to alter features of the four canonical EEG microstates (A, B, C, D) with some conflicting results. The most consistent network abnormalities in MDD are found in the anterior default mode network, and this …
High Beta Brainwaves And Emotion Dysregulation In A Sample Of Children With Attention Deficit/Hyperactivity Disorder, Rebecca Carr
High Beta Brainwaves And Emotion Dysregulation In A Sample Of Children With Attention Deficit/Hyperactivity Disorder, Rebecca Carr
Theses and Graduate Projects
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity. The current study investigated the relationship between high beta brain wave activity, anxiety, emotion dysregulation, and comorbid mental health diagnoses in children with ADHD. Utilizing archival data from the Clinic for Attention, Learning, and Memory (CALM) in Minneapolis, MN, the study included 184 participants aged 6-14 years who underwent quantitative electroencephalogram (qEEG) assessments. The study utilized linear and logistic regressions to test three hypotheses: whether high beta activity predicted (1) increased anxiety symptoms, (2) emotion dysregulation, and (3) the likelihood of comorbid mental health …
Alcohol And The Resulting Consequences Of Delirium Tremens, Nicasio L. Santos
Alcohol And The Resulting Consequences Of Delirium Tremens, Nicasio L. Santos
2024 Symposium
Alcohol is a depressant drug, inhibiting the function of the central nervous system (CNS) and neurons in the mind (Greenberg, 1953). This results in physiological effects that are typical of an inhibited CNS; slowing of the heartbeat and breathing, and decreasing blood pressure (Scorzelli & Chaudhry, 2009). However, this inhibition of both the CNS and the neural chemistry develops a tolerance, and in turn withdrawal symptoms (Polli et al., 2023). These withdrawal symptoms are the inverse of the inhibition caused by the depressant effects of alcohol (i.e., an overactive CNS, increased activity of neurons; Smith-Alnimer & Watford, 2004). In extreme …
Grief Like Mine: A Literature Review Exploring Culturally Informed Grief Work For Black Youth Using Dance/Movement Therapy, Darrell Hyche
Grief Like Mine: A Literature Review Exploring Culturally Informed Grief Work For Black Youth Using Dance/Movement Therapy, Darrell Hyche
Expressive Therapies Capstone Theses
Black American youth are exposed to more death related circumstances than their peers yet are severely underrepresented in literature focused on the broader scope of children’s bereavement. More research and analysis are required to develop and implement culturally relevant interventions as they embark on their grief journey. Dance/movement therapy has the capacity for providing support that is culturally specific and able to meet the developmental levels of children, yet its grief focus work is limited. This literature review aims to bridge the gap between Black grief and dance/movement therapy as a culturally informed practice. An analysis of various forms of …
The Relationship Between Amygdala And Orbitofrontal Cortex Volume In The Context Of Oppositional Defiant Disorder, Rahul Alla
Honors Scholar Theses
Disobedient and rebellious attitude in children is on the rise and this type of behavior is categorized as Oppositional Defiant Disorder (ODD). ODD in children can be identified as a persistent pattern of angry or irritable mood, argumentative or defiant behavior or vindictiveness toward others according to the Diagnostic and Statistical Manual (DSM-5, Fifth Edition) of Mental Disorders.1 Children with ODD typically have difficulty regulating and processing their emotions. Issues with regulating emotions is defined as the process by which individuals “influence which emotions they have, when they have them, and how they experience and express them”.2 Dysregulation of emotions …
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Psychological Science Undergraduate Honors Theses
Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …
The Relationship Between Cognitive Impairment In Psychiatric Patients And Readmission Rate To An Inpatient Facility, Cherilyn Isis Schuff
The Relationship Between Cognitive Impairment In Psychiatric Patients And Readmission Rate To An Inpatient Facility, Cherilyn Isis Schuff
Theses and Dissertations
The primary intention of this study was to further understand the impact of assessing cognitive impairment in psychiatric patients, as a mediating factor on readmission rates. Mild cognitive dysfunction impacts a patient’s functional outcomes (Bowie & Harvey, 2006; Davis et al., 2012; Marcantonio, et al., 2001). Little information exists to guide best practices in the treatment of adults with cognitive impairment who are hospitalized for acute conditions (Davis et al., 2012). A cognitive impairment may impact patient prognosis and ability to function outside of a setting focused on stabilization. Neuropsychological testing is a valuable tool in predicting a patient’s cognitive …
Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg
Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg
Psychology Division Scholarship
Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. …