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Full-Text Articles in Biological Psychology
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Electronic Theses, Projects, and Dissertations
Parkinson's Disease (PD) is a neurodegenerative disease characterized by motor (e.g. tremors) and non-motor symptoms (e.g. cognitive impairment). PD patients' change in cognitive functioning can be observed using the following classifications: cognitively intact, mild cognitive impairment (MCI), or dementia (PDD). MCI has many subtypes, one of which is MCI reversion which is defined as those with MCI at one time point reverting to cognitively intact later. While there is limited research into the utility of MCI reversion and its relationship with cerebrospinal fluid (CSF) biomarkers in PD, this study will begin to elucidate this relationship. To this end, data from …
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Electronic Theses, Projects, and Dissertations
Adolescence is a vulnerable developmental period in regards to drug initiation and use. The gateway hypothesis suggests that adolescent cigarette smoking may result in a heightened risk for methamphetamine use. However, little is understood about the role of nicotine on adolescent methamphetamine addiction. The aim of the present study was to determine whether early, late, or continuous adolescent nicotine exposure would alter oral methamphetamine self-administration, extinction, or reinstatement. A total of 164 male and female Sprague-Dawley rats were pretreated with saline or nicotine (0.16, or 0.64 mg/kg, sc) beginning on postnatal day (PD) 25 for 10 consecutive days. On PD …
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Electronic Theses, Projects, and Dissertations
A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to …