Social and Behavioral Sciences Commons^™

Pancreatitis Pain Quality Changes At Year 1 Follow-Up, But Gp130 Remains A Biomarker For Pain, Jami L Saloman, Kristofer Jennings, Kimberly Stello, Shuang Li, Anna Evans Phillips, Kristen Hall, Evan L Fogel, Santhi Swaroop Vege, Dana K Andersen, William E Fisher, Christopher E Forsmark, Phil A Hart, Stephen J Pandol, Walter G Park, Mark D Topazian, Stephen K Van Den Eeden, Jose Serrano, Darwin L Conwell, Liang Li, Dhiraj Yadav

Center for Medical Ethics and Health Policy Staff Publications

Background/objectives: Debilitating abdominal pain is a common symptom affecting patients with chronic pancreatitis (CP). CP pain is dynamic due to multiple underlying mechanisms. The objective of this study was to 1) evaluate changes in pain phenotype at one year follow-up and 2) validate putative pain biomarkers in a prospective cohort study.

Methods: The Neuropathic and Nociceptive PROMIS-PQ questionnaires were used to classify pain for participants with in the PROCEED study. Putative serum biomarkers were measured via immunoassay.

Results: At enrollment, 17.6 % (120/681) subjects with CP reported no pain in the previous year. Of those, 29 % experienced pain during …

First Interim Results From Fine-Real: A Prospective, Non-Interventional, Phase 4 Study Providing Insights Into The Use And Safety Of Finerenone In A Routine Clinical Settingfirst Interim Results From Fine-Real: A Prospective, Non-Interventional, Phase 4 Study Providing Insights Into The Use And Safety Of Finerenone In A Routine Clinical Setting, Susanne B Nicholas, Ricardo Correa-Rotter, Nihar R Desai, Lixin Guo, Sankar D Navaneethan, Kevin M Pantalone, Christoph Wanner, Stefanie Hamacher, Samuel T Fatoba, Andrea Horvat-Broecker, Antonio Garreta-Rufas, Alain Gay, Martin Merz, David C Wheeler

Center for Medical Ethics and Health Policy Staff Publications

Background: Finerenone, a selective non-steroidal mineralocorticoid receptor antagonist, improves kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D). The FINE-REAL study (NCT05348733) aims to evaluate the characteristics and treatment patterns of participants treated with finerenone in clinical practice.

Methods: FINE-REAL is a prospective, single-arm, non-interventional study of patients initiated on finerenone as part of their routine care in accordance with country-approved labels. The study, initiated in June 2022, is expected to be completed by January 2028. The cutoff for this pre-specified interim analysis was June 13, 2023.

Results: Participants were …

Measuring Perceived Utility Of Genomic Sequencing: Development And Validation Of The Genetic Utility (Gene-U) Scale For Adult Screening, Hadley Stevens Smith, Caryn Kseniya Rubanovich, Jill Oliver Robinson, Ariel N Levchenko, Sarah A Classen, Janet Malek, Adam H Buchanan, Barbara Biesecker, Kyle B Brothers, Benjamin S Wilfond, Christine Rini, Cinnamon S Bloss, Amy L Mcguire, Sara J Knight

Center for Medical Ethics and Health Policy Staff Publications

Purpose: As population-based screening programs to identify genetic conditions in adults using genomic sequencing (GS) are increasingly available, validated patient-centered outcome measures are needed to understand participants' experience. We aimed to develop and validate an instrument to assess the perceived utility of GS in the context of adult screening.

Methods: Informed by a 5-domain conceptual model, we used a 5-step approach to instrument development and validation: (1) item writing, (2) cognitive testing, (3) pilot testing and item reduction, (4) psychometric testing, and (5) evaluation of construct validity. Adults undergoing risk-based or population-based GS who had received GS results as part …

Neighborhood-Level Deprivation Mediates Racial And Ethnic Disparities In Hcc Diagnosis In Texas, Itunu O Sokale, Aaron P Thrift, Hashem B El-Serag, Abiodun O Oluyomi

Faculty, Staff and Students Publications

BACKGROUND: Texas has the highest HCC rates in the United States, and the greatest burden is among Hispanics. Racial and ethnic disparities in HCC incidence have multiple underpinning factors. We conducted a mediation analysis to examine the role of neighborhood disadvantage (Area Deprivation Index) as a potential mediator of the association between neighborhood race and ethnicity distribution and neighborhood HCC case counts in Texas.

METHODS: The primary outcome measure was counts of new HCC diagnoses per census tract based on Texas Department of State Health Services Texas Cancer Registry data. The primary exposure of interest was the race and ethnicity-based …

Update On Pediatric Cancer Surveillance Recommendations For Patients With Neurofibromatosis Type 1, Noonan Syndrome, Cbl Syndrome, Costello Syndrome, And Related Rasopathies, Melissa R Perrino, Anirban Das, Sarah R Scollon, Sarah G Mitchell, Mary-Louise C Greer, Marielle E Yohe, Jordan R Hansford, Jennifer M Kalish, Kris Ann P Schultz, Suzanne P Macfarland, Wendy K Kohlmann, Philip J Lupo, Kara N Maxwell, Stefan M Pfister, Rosanna Weksberg, Orli Michaeli, Marjolijn C J Jongmans, Gail E Tomlinson, Jack Brzezinski, Uri Tabori, Gina M Ney, Karen W Gripp, Andrea M Gross, Brigitte C Widemann, Douglas R Stewart, Emma R Woodward, Christian P Kratz

Center for Medical Ethics and Health Policy Staff Publications

Neurofibromatosis type 1 (NF1), Noonan syndrome, and related syndromes, grouped as RASopathies, result from dysregulation of the RAS-MAPK pathway and demonstrate varied multisystemic clinical phenotypes. Together, RASopathies are among the more prevalent genetic cancer predisposition syndromes and require nuanced clinical management. When compared with the general population, children with RASopathies are at significantly increased risk of benign and malignant neoplasms. In the past decade, clinical trials have shown that targeted therapies can improve outcomes for low-grade and benign neoplastic lesions but have their own challenges, highlighting the multidisciplinary care needed for such individuals, specifically those with NF1. This perspective, which …

Automated Electronic Health Record Data Extraction And Curation Using Extractehr, Tamara P Miller, Kelly D Getz, Edward Krause, Yun Gun Jo, Sandhya Charapala, M Monica Gramatages, Karen Rabin, Michael E Scheurer, Jennifer J Wilkes, Brian T Fisher, Richard Aplenc

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Although the potential transformative effect of electronic health record (EHR) data on clinical research in adult patient populations has been very extensively discussed, the effect on pediatric oncology research has been limited. Multiple factors contribute to this more limited effect, including the paucity of pediatric cancer cases in commercial EHR-derived cancer data sets and phenotypic case identification challenges in pediatric federated EHR data.

Methods: The ExtractEHR software package was initially developed as a tool to improve clinical trial adverse event reporting but has expanded its use cases to include the development of multisite EHR data sets and the support …

Exploring Latent Clusters In Pediatric Ocd Based On Symptoms, Severity, Age, Gender, And Comorbidity, Orri Smárason, Robert R Selles, Davíð R M A Højgaard, John R Best, Karin Melin, Tord Ivarsson, Per Hove Thomsen, Bernhard Weidle, Nicole Michelle Mcbride, Eric A Storch, Daniel Geller, Sabine Wilhelm, Lara J Farrell, Allison M Waters, Sharna Mathieu, Noam Soreni, S Evelyn Stewart, Gudmundur Skarphedinsson

Center for Medical Ethics and Health Policy Staff Publications

Given diverse symptom expression and high rates of comorbid conditions, the present study explored underlying commonalities among OCD-affected children and adolescents to better conceptualize disorder presentation and associated features. Data from 830 OCD-affected participants presenting to OCD specialty centers was aggregated. Dependent mixture modeling was used to examine latent clusters based on their age- and gender adjusted symptom severity (as measured by the Children's Yale-Brown Obsessive-Compulsive Scale; CY-BOCS), symptom type (as measured by factor scores calculated from the CY-BOCS symptom checklist), and comorbid diagnoses (as assessed via diagnostic interviews). Fit statistics favored a four-cluster model with groups distinguished primarily by …

Mitigating Operational Greenhouse Gas Emissions In Ageing Residential Buildings Using An Urban Digital Twin Dashboard, Pradeep Alva, Martín Mosteiro-Romero, Clayton Miller, Rudi Stouffs

Research Collection College of Integrative Studies

With the increasing stock of ageing infrastructure and resource constraints in Singapore, related risks and carbon emissions can be mitigated through long-term resilience planning, automated building inspection, and effective maintenance. Sustainable actions are needed to maintain Singapore's ageing infrastructure. Hence, a state-of-the-art control and management system is required in the form of smart city digital tools. We introduce an Urban Digital Twin (UDT)—GHG App for decision-makers in Singapore's operational building greenhouse gas (GHG) emission mitigation and decarbonisation initiatives. Based on multiple-criteria decision analysis (MCDA), a Potential for Intervention (PFI) map was created to rejuvenate the building system. Decision-makers can use …

Media Use, Interpersonal Communication, And Personal Relevance As External And Internal Representations Of Climate Change, Sonny Rosenthal, Pengya Ai

Research Collection College of Integrative Studies

Personal relevance is a key driver of individual climate action. It is also related to media use and interpersonal communication, which the current study examines from two perspectives. First, individuals may find climate change personally relevant because they experience it vicariously through the media and other information sources. Second, they may engage with climate change information because the issue is personally relevant. This study tested these models using structural equation modeling of online survey data from representative samples in Singapore (n = 1,997) and the United States (n = 2,009). Findings supported both models, albeit the first one more strongly. …

Chinatown, Part Five? ‘Capitalism With Asian Values’ In Vancouver: Commentary On Elvin Wyly’S ‘Regarding The Pain Of (Indigenous) Others, Justin Kh Tse

Research Collection College of Integrative Studies

In this commentary on Elvin Wyly’s ‘Regarding the Pain of (Indigenous) Others’, I comment on the absent ontology of Asian subjectivities in urban studies of neoliberal global cities. Wyly’s account of neoliberal Vancouver hellscapes frames racial formations and narratives of dispossession as formed by capital. Asian subjectivities, I argue in this commentary, are also flattened by narratives of capital into purely economic subjects, but what Wyly’s reading of Vancouver opens up, I also hope to show, is the possibility of tracing the complex life stories of Asian capitalist characters in Vancouver’s neoliberal hellscape. In this way, Wyly avoids the trap …

A Dynamic Urban Digital Twin Integrating Longitudinal Thermal Imagery For Microclimate Studies, Vasantha Ramani, Marcel Ignatius, Joie Lim, Filip Biljecki, Clayton Miller

Research Collection College of Integrative Studies

Recently, the concept of a digital twin for the built environment has received significant attention due to its potential benefits to urban planners, engineers, and designers. The development of tools that aid in integrating real-world physical systems with digital capabilities is essential for advancing digital twin technology. In this work, we present one such digital twin tool that integrates the longitudinal thermal envelope data of buildings on the campus of the National University of Singapore with a virtual 3D model. Thermal images of the buildings were captured using a neighborhood-scale infrared observatory for a few months. The temperature profile of …

A Qualitative Study Of The Career Experiences Of Asian And Asian American Female Administrators In U.S. Higher Education, Yunru Shen

Electronic Theses and Dissertations

This qualitative phenomenological study explored the experiences of Asian and Asian American women administrators’ career paths in U.S. higher education. The research fills a gap in the literature regarding the careers of Asian and Asian American women administrators. The recruitment process was completed between May 13 and July 9, 2024. Recruitment emails were sent to 25 potentially qualified participants, including a network of 17 people made up of mentors, professors, and colleagues, as well as eight professional associations and LinkedIn. The participants were six Asian and Asian American biologically female administrators at U.S. colleges and universities. These participants currently hold …

The Erosion Of Identity: A Study Of The Influence Of Racial Microaggressions On K-12 African American School Leaders, Rayfield J. Lavan Iii

Electronic Theses and Dissertations

This qualitative study explored the experiences of African American educational leaders in navigating racial microaggressions in the workplace, specifically within K-12 educational settings. Using Taxonomy of Racial Microaggressions and emotion regulation theory as frameworks, this research examines how these leaders manage, respond to, and cope with various forms of racial bias while maintaining their professional identities. Data were collected through in-depth interviews with African American leaders, and thematic analysis was used to identify recurring patterns of microaggressions and corresponding emotion regulation strategies. Key findings reveal that participants frequently encounter microaggressions such as assumption of inferiority, criminality, and second-class citizenship, with …

Understanding The Barriers Of General Education Teachers Implementing Inclusive Practices, Sonya Garrette Woodfork

Electronic Theses and Dissertations

The inclusion of students with disabilities has become more prevalent in general education classrooms advocating for children to be educated in the least restrictive environment. This participatory action research aimed to investigate the effects of general education teachers’ lack of sufficient preservice training and attitudes on learning outcomes for children with special needs placed in inclusive learning environments. The participatory action research took place on one elementary and one early childhood campus. Data collection methods took place via triangulation using data from interviews, journals, and surveys. There are many barriers to successfully implementing inclusion in general education classrooms. This study …

Estimating Models For Engineering Costs On The State Highway Operation And Protection Program (Shopp) Portfolio Of Projects, Elhami Nasr, Tariq Shehab, Nigel Blampied, Vinit Kanani

Mineta Transportation Institute

The State Highway Operation and Protection Program (SHOPP) is crucial for maintaining California’s 15,000-mile state highway system, which includes projects like pavement rehabilitation, bridge repair, safety enhancements, and traffic management systems. Administered by Caltrans, SHOPP aims to preserve highway efficiency and safety, supporting economic growth and public safety. This research aimed to develop robust cost-estimating models to improve budgeting and financial planning, aiding Caltrans, the California Transportation Commission (CTC), and the Legislature. The research team collected and refined comprehensive data from Caltrans project expenditures from 1983 to 2021, ensuring a high-quality dataset. Subject matter experts validated the data, enhancing its …

A Phenomenological Study Of The Lived Experiences Of Black Entrepreneur Women’S Personal Development And Its Effect On Their Self-Identity, Mayrion Ann Washington

Electronic Theses and Dissertations

The purpose of this qualitative study was to explore Black entrepreneur women’s personal development and its effect on their self-identity. The study specifically aimed to explore personal development, entrepreneurship, and self-identity as they related to and affected Black entrepreneur women, in the United States, and their experiences with oppression, challenges, barriers, intersectionality, and systemic subordination. Historically, Black entrepreneur women have experienced systematic oppression and faced increased challenges that have and continue to negatively affect their entrepreneurial progress and their self-identity. Preliminary findings from the literature found that when Black entrepreneurial women engage in personal development, the results are reflected in …

تأثير الرضا الوظيفي على استمرار الموظفين الإماراتيين في العمل في القطاع الخاص, وضحه سعيد القايدي

Theses

The Impact of Job Satisfaction on the Continuation of Emirati Employees to Work in the Private Sector

Despite the significant attention given by the government of the United Arab Emirates to the localization n of national talent in the private sector through its support for various government programs and initiatives aimed at enhancing the participation of Emiratis in the labor market across different economic sectors, and the notable success of these programs and initiatives, which have contributed to an increase in the number of Emiratis joining the private sector to nearly 100,000, the most prominent challenge that may affect the …

Governance Of Religious Affairs In The United Arab Emirates, Ayesha Helal Al Qubaisi

Theses

This study seeks to investigate policies, measures and efforts on religious affairs governance in the UAE, through enacting laws and establishing local religious institutions by uncovering the necessity of the procedures that are in place, the goals of religious governance, how religious affairs are regulated, and the challenges that the government faces in the process. The main objective of this thesis is to provide one possible adoption model for religious regulation. Further, since there are few studies on the topic of religious governance in general, and in the UAE particularly, the researchers synthesized and integrated existing knowledge from diverse sources …

An Empirical Analysis Of The Mmpi-3 Suicidal/Death Ideation Scale, Brittany Barnes Rhodes

Theses and Dissertations

Suicide is a significant concern in society and is one of the leading causes of death in the United States and around the world. Suicidality is particularly prevalent in outpatient psychological treatment centers, with some studies estimating a tenfold increase in prevalence in this setting compared to the population at large. Several measures have been developed to assess suicide risk potential based on symptom frequency and combinations of risk factors, and broadband personality measures have also incorporated suicidality scales into their tests. The current study was focused on assessing the effectiveness of the Suicidal/Death Ideation (SUI) scale on the third …

From Sustainable Agriculture To Sustainable Agrifood Systems: A Comparative Review Of Alternative Models, Qian Forrest Zhang

Research Collection School of Social Sciences

This paper reviews, compares, and critically evaluates two broad groups of sustainable agriculture models: “sustainable agriculture” and “sustainable agrifood systems”. The “sustainable agriculture” models—comprising organic farming, regenerative agriculture, climate-smart agriculture, carbon-capture agriculture, and nature-based solutions—focus primarily on improving ecological sustainability through farm-level practices. These models emphasize reducing external, industrial inputs, enhancing biodiversity, and promoting climate resilience, relying on technological and market-based solutions to address environmental concerns. On the other hand, the “sustainable agrifood systems” models—agroecology, alternative food networks, and permaculture—offer more ambitious visions of systemic transformation. These approaches not only seek to implement environmentally sound practices but also aim to …

Cultural Contexts Differentially Shape Parents’ Loneliness And Wellbeing During The Empty Nest Period, Andree Hartanto, Lester Wei Xiang Sim, Davelle Jing Yi Lee, Naydanna M. Majeed, Jose C. Yong

Research Collection School of Social Sciences

The coming decades will see a substantial increase in the population of older adults, accompanied by significant demographic and family structure changes worldwide. As a result, the empty nest period—the postparental phase in parents’ lives when their children have left home and they are no longer engaged in childrearing—is becoming an increasingly common experience in Western and Asian cultures. The current theoretical review examines the psychological consequences of the empty nest period on loneliness and well-being across cultures, emphasizing the impact of cultural factors on these experiences. By synthesizing research from Western and Asian contexts, we explore two primary theoretical …

What Have Corporations Got To Do With It? A Political Economy Approach To Organizations And Climate Change, Annika Rieger

Research Collection School of Social Sciences

Ecological issues are often seen as only one of the many “problems” societies face today, even though they go deep and affect everything – from physical disruption and displacement to perhaps more subtle long-term changes in temperature, flora, and fauna that alter the face of the planet and the norms of everyday life. As a result of this view, the study of the environment has been siloed into the realm of “environmental sciences” with a few “environmental fill-in-the-social-science-blank” subfields scattered about. This is not to say that only “environmental” problems are important, but that across all disciplines and subfields, greater …

Ai And Data Science For Public Policy, Kenneth Benoit

Research Collection School of Social Sciences

Artificial intelligence (AI) and data science are reshaping public policy by enabling more data-driven, predictive, and responsive governance, while at the same time producing profound changes in knowledge production and education in the social and policy sciences. These advancements come with ethical and epistemological challenges surrounding issues of bias, transparency, privacy, and accountability. This special issue explores the opportunities and risks of integrating AI into public policy, offering theoretical frameworks and empirical analyses to help policymakers navigate these complexities. The contributions explore how AI can enhance decision-making in areas such as healthcare, justice, and public services, while emphasising the need …

The Impact Of Race-Related Stress On The Minnesota Multiphasic Personality Inventory (Mmpi-3) Of An African American Community Sample, Cassandra Clayton

Theses and Dissertations

Black Americans have endured profound racial discrimination and systemic injustices rooted in the historical legacy of slavery in the United States. These injustices persist today, permeating various facets of life, such as social interactions, education, politics, legal systems, and employment opportunities. Previous research has explored the cultural ramifications of these experiences, which often lead to race-related stressors and negative impacts on the psychological well-being of Black Americans. However, the exploration of how discrimination and racial stressors impact personality test scores of African Americans, such as on the Minnesota Multiphasic Personality Inventory, 3^rd edition (MMPI-3), is limited. This study investigated …

Towards Social And Environmental Sustainability At Food Tourism Festivals: Perspectives From The Local Community And Festival Organizers, Timo Thelen, Sangkyun Kim

Research outputs 2022 to 2026

This study aims to examine the underlying barriers that hinder social and environmental sustainability at food tourism festivals from the perspectives of the local community and festival organizers. In the context of an abalone festival in Japan, a qualitative analysis of in-depth interviews with key stakeholders was conducted. The findings suggest that the local community's skepticism and mediocre (un)involvement, ambiguous representation of local tradition/culture, and limited social interactions between hosts and tourists were hindering social sustainability. Challenges in food resource management and the effects of climate change impacted the food festival's environmental sustainability. The study confirms that social and environmental …

Place Attachment And Lived Values In Western Australian Communities, A. Kelly, P. Tschakert, C. Lawrence, P. Horwitz, C. Bourgault, N. Ellis

Research outputs 2022 to 2026

Substantial research exists on attachments people have to places and the phenomena and objects they value. However, insights on how values vary between different locations and across demographics and how place attachment differs between rural and urban areas are more limited. These understandings are needed to design meaningful adaptation strategies for people and communities at risk from climate change. This study examines attachment to place and things people value in eight communities in Western Australia, using a survey with 403 participants. Results showed that residents across the rural communities shared similar values, but that the values of urban communities were …

Experimental Evidence Of Instagram Influencers’ Impact On Well-Being, Kimberly Yiting T'Ng, Kai Qin Chan, Andree Hartanto

Research Collection School of Social Sciences

With Instagram influencers holding significant sway over public perception, their presumed psychological impact on young adults has gathered public attention. It has been claimed that influencers, known for showcasing enviable lifestyles, have the potential to affect their followers’ well-being. However, these claims have been based on correlational data that focuses on diffused indicators of social media consumption rather than specific features of Instagram. This limits our insight into the direct effects of Instagram on well-being. We experimentally investigated the effects of a brief exposure to Instagram influencers on the well-being. Our results showed that viewing profiles of demographically similar social …

Dispositional Optimism, Sleep, And Trait Affective Mediators: A Latent Variable Approach, Nicole Ruiying Chen, Nadyanna Binte Mohamed Majeed, Adalia Yin Hui Goh, Paye Shin Koh, Jonathan Louis Jie Sheng Chia, Andree Hartanto

Research Collection School of Social Sciences

Dispositional optimism has been shown to be associated with better sleep. However, most existing studies rely on subjective assessments of sleep, which may not align with objective assessments of sleep. Additionally, research investigating the mechanisms underlying the association between optimism and sleep is lacking. Moreover, the confounding role of possible content overlap in measures relevant to the constructs of interest has been neglected. To address these gaps, we utilised latent variable analysis and investigated the mediating role of depression and trait anxiety across two large-scale studies (total N = 2312), with objective sleep measures included in Study 2. In Study …

Uncovering Merchants’ Willingness To Wait In On-Demand Food Delivery Markets, Jian Liang, Ya Zhao, Hai Wang, Zuopeng Xiao, Jintao Ke

Research Collection School Of Computing and Information Systems

While traditional on-demand food delivery services help restaurants reach more customers and enable doorstep deliveries, they also come with drawbacks, such as high commission fees and limited control over the delivery process. White-label food delivery services have emerged as an alternative, ready-to-use platform for restaurants to arrange delivery for customer orders received through their applications or websites, without the constraints imposed by traditional on-demand food delivery platforms or the need to develop an in-house delivery operation. Although several studies have investigated consumer behavior when using traditional on-demand food delivery services, there is limited research on merchants’ behavior when adopting white-label …

From Data To Application: Harnessing Big Spatial Data And Spatially Explicit Machine Learning Model For Landslide Susceptibility Prediction And Mapping, Min Naing Khant, Mei Yi Victoria Grace Ann, Tin Seong Kam

Research Collection School Of Computing and Information Systems

Recent advancements in information and communication technology have significantly enhanced access to extensive geospatial data, presenting a valuable opportunity to leverage big spatial data for improved modeling and predictive capabilities in natural disaster risk assessment. This paper explores the integration of a comprehensive dataset comprising historical landslide events and various geo-environmental variables within a spatially explicit machine learning framework. The study empirically demonstrates that incorporating big spatial data allows a more nuanced understanding of local variations and spatial dependencies. Ultimately, this empirical assessment produces more accurate landslide risk predictions than traditional baseline models. Using Italy’s expansive Valtellina Valley as a …