Social and Behavioral Sciences Commons^™

Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh

Electronic Thesis and Dissertation Repository

Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …

The Development Of Sleep-Wake Rhythms And The Search For Elemental Circuits In The Infant Brain, Mark S. Blumberg, Andrew J. Gall, William D. Todd

Faculty Publications

Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, …

Evolutionary Pressures On Primate Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

From finding food to choosing mates, animals must make intertemporal choices that involve fitness benefits available at different times. Species vary dramatically in their willingness to wait for delayed rewards. Why does this variation across species exist? An adaptive approach to intertemporal choice suggests that time preferences should reflect the temporal problems faced in a species' environment. Here, I use phylogenetic regression to test whether allometric factors (relating to body size), relative brain size, and social group size predict how long 13 primate species will wait in laboratory intertemporal choice tasks. Controlling for phylogeny, a composite allometric factor that includes …

The Effect Of Early Life Stress On Methamphetamine Damage In The Striatum, Emily Hensleigh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methamphetamine (METH) abuse impacts the global economy through costs associated with drug enforcement, emergency room visits, and treatment. Hyperthermia is a leading cause of METH induced emergency room visits and may lead to neural damage. Previous research has demonstrated early life stress, such as childhood abuse, increases the likelihood of developing a substance abuse disorder. However, the effects of early life stress on neuronal damage induced by chronic METH administration are unknown. We aimed to elucidate the effects of early life stress on METH induced dopamine damage in the striatum. Animals were separated three hours per day during the first …

Impact Of Faah Genotype And Marijuana Use On Brain Structure And Neuropsychological Performance In Emerging Adults, Skyler Gabriel Shollenbarger

Theses and Dissertations

Introduction: Chronic MJ use may be associated with higher cognitive ability impairments (see Lisdahl et al., 2013). Regions undergoing later maturation (Gogtay 2004), may be at increased risk for MJ-induced alterations. Endogenous cannabinoid signaling (ECS) is modulated by the function the enzyme Fatty Acid Amide Hydrolase (see Ho & Hilard, 2005), thus the gene encoding for this enzyme (FAAH) impacts ECS (Sipe et al., 2002). Here, we examine the impact of MJ use and FAAH genotype on PFC complexity and underlying frontal white matter (WM) integrity in young adults. Methods: Participants included 37 MJ users and 37 non-using young adults …

Role Of The Ventral Tegmental Area And Ventral Tegmental Area Nicotinic Acetylcholine Receptors In The Incentive Amplifying Effect Of Nicotine, Ashley B. Sheppard

Electronic Theses and Dissertations

Nicotine has multiple behavioral effects as a result of its action in the central nervous system. Nicotine strengthens the behaviors that lead to nicotine administration (primary reinforcement), and this effect of nicotine depends on mesotelencephalic systems of the brain that are critical to goal directed behavior, reward, and reinforcement. Nicotine also serves as a ‘reinforcement enhancer’ – drug administration enhances behaviors that lead to other drug and nondrug reinforcers. Although the reinforcement enhancing effects of nicotine may promote tobacco use in the face of associated negative health outcomes, the neuroanatomical systems that mediate this effect of nicotine have never been …

An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins

Honors Scholar Theses

Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …

Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage, Timothy P. Diperi

Undergraduate Honors Theses

Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we have determined that myocardial …

Electrophysiological Cross-Modality Comparisons Of Infant Individual Differences In Holistic Processing And Selective Inhibition, Matthew Singh

Chancellor’s Honors Program Projects

No abstract provided.

Attenuating The Attentional Blink And Its Consequences: Support For The Wyble-Bowman-Nieuwenstien Model, Samantha Riane Debes

Honors Capstone Projects - All

When participants are asked to detect two targets (T1 and T2) in a stream of rapidly presented visual stimuli, T2 accuracy decreases when it follows T1 by 200 ms to 500 ms, a phenomenon known as the attentional blink (AB). Researchers have been attempting to attenuate the AB through experimental manipulations in order to understand temporal processing in the visual domain. Studies that have successfully attenuated the blink have often (but not always) done so using a concurrent task. One current model of visual temporal attention, the Wyble-Bowman-Nieuwenstien model (2009) suggests that a byproduct of the attenuation of the attentional …

Long Term Effects Of Chemotherapy On Cognition, Preventative Potential Of Antidepressants, Ryan Hall

Honors College

Each year, over 1.6 million people in the U.S. alone will be diagnosed with some form of cancer. With advances in treatment, survival rates have risen to nearly 65%. While remission and survival are the ultimate goals of treatment, it has become clear that many cancer survivors (estimates range from 15% to 70%) treated with chemotherapy experience significant, long-lasting cognitive impairment. This chemotherapy associated cognitive impairment is often called "Chemo Fog" or "Chemo Brain." For some, the effects are mild, such as having difficulty with focusing, concentrating, and speed of processing. For others, the cognitive impairments can be significant and …

Bayes, Brains & Babies: Electrophysiology And Mathematics Of Infant Holistic Processing And Selective Inhibition, Matthew Singh

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

No abstract provided.

Behavioral Sensitization Following Concurrent Exposure To Mephedrone And D-Amphetamine In Female Mice, Michael D. Berquist Ii, M. Melissa Peet, Lisa Baker

Research and Creative Activities Poster Day

Introduction

• Mephedrone (4-methylmethcathinone) is an active constituent of the illicit designer drugs commonly known as “bath salts”. In recent years, the recreational use and abuse of mephedrone and related synthetic methcathinones have dramatically increased in popularity in the U.S. and U. K. (e.g., Dybdal-Hargreaves et al., 2013; Winstock et al., 2010).

• Mephedrone consumption is associated with a number of adverse side effects such as palpitations, bruxism, agitation (Winstock et al., 2011; Wood et al., 2010; Dargan et al., 2010), paranoia, hallucinations, aggressive/violent behavior, excited delirium, and psychosis (Ross et al., 2012).

• Mephedrone may facilitate deleterious effects of other drugs of …

Facial Discrimination And Recognition Behavior In Capuchin Monkeys, Kegan Isaack

Georgia State Undergraduate Research Conference

No abstract provided.

Biological Psychiatry: A Practice In Search Of A Science, W. Joseph Wyatt, Donna M. Midkiff

W. Joseph Wyatt

The rise of the biological causation model in the past thirty years is traced to psychiatry’s efforts to regain lost status and to protect itself from intrusions by non-medical practitioners, as well as to the pharmaceutical industry’s drive for profits. Evidence in support of the model, including studies of identical twins and of brain structure and function, are less revealing than was earlier thought, due to problems in methodology and interpretation. Organized psychiatry, when challenged in 2003, was unable to provide compelling evidence for biological causation of most mental and behavioral disorders. A paradigm shift away from biological causation and …

Six-To-One Gets The Job Done: Comments On The Reviews, W. Joseph Wyatt, Donna M. Midkiff

W. Joseph Wyatt

We are pleased to note that six of the seven responses to our article were marked by approval, and/or thoughtful contemplation, regarding our central theses—that the research said to support biological causation of mental disorders is relatively weak, and that the claims of drug effectiveness are often overstated.

The Interaction Between Spatial Working And Reference Memory In Rats On A Radial Maze, Nicole Ann Guitar

Undergraduate Honors Theses

The present study investigated the interaction between working and reference spatial memory in an effort to develop an animal model of this interaction. Twelve male Long-Evans rats were tested on an eight-arm radial maze in a two-phase procedure. In the study phase, a rat was allowed to enter four randomly selected arms for a food reward placed at the end of each arm. The test phase allowed the rat access to all eight arms, but only the previously unentered arms contained food. Two of the correct test arms were defined as reference memory arms because they were always correct. The …

Independent Component Analysis Of Self-Referential Processing In Women With Posttraumatic Stress Disorder, Elizabeth Thornley

Undergraduate Honors Theses

Posttraumatic stress disorder (PTSD) is a condition than can develop after exposure, or repeated exposure, to a traumatic event. Recent changes to the diagnostic criteria for PTSD reflect a new emphasis on the dysregulation of emotions related to self-appraisal and self-referential processing (SRP). SRP concerns stimuli that are experienced as strongly related to one’s own person and can be measured using valenced stimuli that relate to the participant’s concept of self. These paradigms are referred to as self- referential processing tasks. The current study used data from functional magnetic resonance imaging (fMRI) to investigate the activation of brain areas related …

Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Rationale Risperidone use in children and adolescents for the treatment of various neuropsychiatric disorders (e.g., schizophrenia, autism, disruptive behavior, etc.) has increased substantially in recent decades. However, its long-term effect on the brain and behavioral functions is not well understood. Objective The present study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response in adulthood in the conditioned avoidance response and phencyclidine (PCP)-induced hyperlocomotion tests. Methods Male adolescent Sprague-Dawley rats (postnatal days [P] 40–44 or 43–48) were first treated with risperidone (0.3, 0.5, or 1.0 mg/kg, subcutaneously (sc)) and tested in the conditioned avoidance or PCP (3.2 mg/kg, …

No Two Can Be Alike, Harry Whitaker, Leah Piggott, Nicoletta Fraire, Emily Depetro, Casey Pernaski

Poster Sessions

No abstract provided.

Visual Search And Attention In Blue Jays (Cyanocitta Cristata): Associative Cuing And Sequential Priming, Kazuhiro Goto, Alan B. Bond, Marianna Burks, Alan C. Kamil

Alan Bond Publications

Visual search for complex natural targets requires focal attention, either cued by predictive stimulus associations or primed by a representation of the most recently detected target. Because both processes can focus visual attention, cuing and priming were compared in an operant search task to evaluate their relative impacts on performance and to determine the nature of their interaction in combined treatments. Blue jays were trained to search for pairs of alternative targets among distractors. Informative or ambiguous color cues were provided before each trial, and targets were presented either in homogeneous blocked sequences or in constrained random order. Initial task …

Depression, Emotional Eating And Food Choice, Jhen-Da Prince

Honors College

The prevalence of depression has been steadily growing throughout the years, especially among college students. Depression has been rated third amongst the presenting problems in college counseling centers (Drum & Baron, 1998) and studies have indicated that as much as 80% of college students say they have experienced some form of depression throughout college (Westefeld & Furr, 1987). Not only does depression affect college students, but positive affect does as well. Evidence that suggests that those with a history of depression may get the most benefit from having positive affect, given a negative relationship between positive affect and depressive symptoms …

Fiber Pathways For Language In The Developing Brain: A Diffusion Tensor Imaging (Dti) Study, Iris J. Broce

FIU Electronic Theses and Dissertations

The present study characterized two fiber pathways important for language, the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and the frontal aslant tract (FAT), and related these tracts to speech, language, and literacy skill in children five to eight years old. We used Diffusion Tensor Imaging (DTI) to characterize the fiber pathways and administered several language assessments. The FAT was identified for the first time in children. Results showed no age-related change in integrity of the FAT, but did show age-related change in the left (but not right) SLF/AF. Moreover, only the integrity of the right FAT was related to phonology but …

Effects Of Increased Levels Of Prenatal Mesotocin On Postnatal Individual Recognition And Stress Responsiveness In Northern Bobwhite Quail (Colinus Virginianus), Brittany Yusko

FIU Electronic Theses and Dissertations

Oxytocin (OT) plays a key role in the mediation of social and stress behaviors across many species; however, the mechanism is still unclear. The present study investigated the influence of prenatal levels of mesotocin (MT; avian homologue of OT) on postnatal social and stress behavior in Northern bobwhite quail. Experiment one determined endogenous levels of MT during prenatal development using an enzyme-linked immunoassay kit. Experiment two examined the influence of increased MT during prenatal development on chicks' individual recognition ability and stress response to a novel environment. Experiment one showed MT levels increased significantly throughout embryonic development. Experiment two showed …

Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression – and its known interaction with dopamine – it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study,we examined the effects of 5-HT_2C receptor agonism and 5-HT_2A receptor antagonism on maternal behavior in postpartum female rats.We hypothesized that activation of 5-HT_2C receptors and blockade of 5-HT …

Direct And Relational Representation During Transitive List Linking In Pinyon Jays (Gymnorhinus Cyanocephalus), Cynthia Wei, Alan Kamil, Alan B. Bond

Alan Bond Publications

The authors used the list-linking procedure (Treichler & Van Tilburg, 1996) to explore the processes by which animals assemble cognitive structures from fragmentary and often contradictory data. Pinyon jays (Gymnorhinus cyanocephalus) were trained to a high level of accuracy on two implicit transitive lists. They were then given linkage training on the single pair that linked the two lists into a composite, 10-item hierarchy. Following linkage training, the birds were tested on nonadjacent probe pairs drawn both from within (B-D and 2–4) and between (D-1, E-2, B-2, C-3) each original list. Linkage training resulted in a significant transitory disruption in …

Using Otoacoustic Emissions To Evaluate Efferent Auditory Function In Humans, Simon Henin

Dissertations, Theses, and Capstone Projects

The auditory system continually adapts to changes in the acoustic environment over short periods of time. This fine-tuning of its dynamics is mediated in part by the medial olivocochlear (MOC) bundle, a neural feedback loop which aids in the regulation of cochlear micro-mechanics. The ability to measure the response of the MOC system in humans may provide significant insight into unique cochlear functions, such as its sharp frequency selectivity and wide dynamic range. In humans the efferent system can be investigated non-invasively using otoacoustic emissions (OAEs). However, how OAEs can best be used to evaluate efferent function, the pitfalls associated …

Mediating Factors Of Perceived Discrimination: Physiological And Affective Markers., Kymberlee O'Brien, Edward Tronick, Celia Moore

Kymberlee M. O'Brien

Early life adversity influences later health and may be mediated by psychosocial, affective, and physiological stress and immune factors. We report evidence from MIDUS biomarker project (N = 845, age 34-84, M = 55.09, SD = 11.70) confirming the predicted relationship between early adversity and frequency of diagnosed chronic illnesses (M = 2.8, SD =1.2). Specific psychosocial and physiological variables were tested as mediators. Lifetime (M = .95, SD = 1.5) and daily (M = 12.8, SD = 1.2) discrimination, urinary cortisol (M = 1.1, SD = 1.2 ug/dL), IL-6 (M =2.8, SD = 2.8 pg/mL) (all ps<.001), and …

Changes In Cerebral White Matter, Vascular Risk And Cognition Across The Adult Lifespan, Andrew Robert Bender

Wayne State University Dissertations

Numerous studies over the past decade have used diffusion tensor imaging (DTI) to examine associations between age, diffusion and anisotropy measures of cerebral white matter (WM), and cognitive performance. However, few have examined relationships between intra-individual change in DTI measures of WM and cognitive function. It is possible that the extant cross-sectional findings are a poor representation of age-related change in WM and cognition. The present study used latent difference-score modeling (LDM) to assess change over two years in DTI indices fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). In addition, we examined the effects …

Self-Construal Moderates Testosterone Reactivity To Competitive Outcomes, Keith Welker

Wayne State University Dissertations

Previous research shows that testosterone reactivity to competitive outcomes predicts aggressive behavior in men. However, some studies have failed to find these effects, and it has been suggested that individual differences moderate the relationships between competitive outcomes, testosterone fluctuations, and aggressive behavior. The current research examined whether one individual difference--self-construal--would moderate these effects. In Study 1, participants were assigned to win or lose a competitive video game and engaged in a reactive aggression task. Results indicated that increases in testosterone in response to winning and decreases in response to losing occurred in men with independent, not interdependent, self-construals. These changes …