Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li
Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li
Department of Psychology: Faculty Publications
Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test.We also examined howthese two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump(HAL-0.25 CONT; 0.25mgkg−1 day−1, …
Impact Of Faah Genotype And Marijuana Use On Brain Structure And Neuropsychological Performance In Emerging Adults, Skyler Gabriel Shollenbarger
Impact Of Faah Genotype And Marijuana Use On Brain Structure And Neuropsychological Performance In Emerging Adults, Skyler Gabriel Shollenbarger
Theses and Dissertations
Introduction: Chronic MJ use may be associated with higher cognitive ability impairments (see Lisdahl et al., 2013). Regions undergoing later maturation (Gogtay 2004), may be at increased risk for MJ-induced alterations. Endogenous cannabinoid signaling (ECS) is modulated by the function the enzyme Fatty Acid Amide Hydrolase (see Ho & Hilard, 2005), thus the gene encoding for this enzyme (FAAH) impacts ECS (Sipe et al., 2002). Here, we examine the impact of MJ use and FAAH genotype on PFC complexity and underlying frontal white matter (WM) integrity in young adults. Methods: Participants included 37 MJ users and 37 non-using young adults …
Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li
Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li
Department of Psychology: Faculty Publications
Rationale Risperidone use in children and adolescents for the treatment of various neuropsychiatric disorders (e.g., schizophrenia, autism, disruptive behavior, etc.) has increased substantially in recent decades. However, its long-term effect on the brain and behavioral functions is not well understood. Objective The present study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response in adulthood in the conditioned avoidance response and phencyclidine (PCP)-induced hyperlocomotion tests. Methods Male adolescent Sprague-Dawley rats (postnatal days [P] 40–44 or 43–48) were first treated with risperidone (0.3, 0.5, or 1.0 mg/kg, subcutaneously (sc)) and tested in the conditioned avoidance or PCP (3.2 mg/kg, …
Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li
Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li
Department of Psychology: Faculty Publications
This preclinical study investigated howa short-termrisperidone treatment in adolescence impacts antipsychotic response to olanzapine and clozapine in adulthood. Antipsychotic effect was indexed by a drug's suppressive effect on avoidance responding in a rat conditioned avoidance response (CAR) model. Male adolescent Sprague–Dawley rats were first treated with risperidone (1.0mg/kg, sc) or sterile water and tested in the CAR model for 5 consecutive days from postnatal days P 40 to 44. After they became adults (~P 80–84), they were switched to olanzapine (0.5mg/kg, sc), clozapine (5.0mg/kg, sc) or vehicle treatment and tested for avoidance for 5 days. During the adolescent period, repeated …