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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett
A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett
Department of Psychology: Dissertations, Theses, and Student Research
Smoking and tobacco dependence are serious health concerns in the United States and globally. Reward via the pharmacological effects of nicotine are believed to be the principal motivating factor that drive tobacco dependence. Research reveals differences in sensitivity between males and females to the motivational effects of nicotine in tobacco use. Enhancement of reinforcement value of non-nicotine rewards contributes to overall nicotine reward. Similar value-enhancing effects have been observed by the two most commonly prescribed smoking cessation aids, bupropion and varenicline. The present dissertation investigated the value-enhancing effects of nicotine, bupropion and varenicline in both male and female rats using …
Role Of The Ventral Tegmental Area And Ventral Tegmental Area Nicotinic Acetylcholine Receptors In The Incentive Amplifying Effect Of Nicotine, Ashley B. Sheppard
Role Of The Ventral Tegmental Area And Ventral Tegmental Area Nicotinic Acetylcholine Receptors In The Incentive Amplifying Effect Of Nicotine, Ashley B. Sheppard
Electronic Theses and Dissertations
Nicotine has multiple behavioral effects as a result of its action in the central nervous system. Nicotine strengthens the behaviors that lead to nicotine administration (primary reinforcement), and this effect of nicotine depends on mesotelencephalic systems of the brain that are critical to goal directed behavior, reward, and reinforcement. Nicotine also serves as a ‘reinforcement enhancer’ – drug administration enhances behaviors that lead to other drug and nondrug reinforcers. Although the reinforcement enhancing effects of nicotine may promote tobacco use in the face of associated negative health outcomes, the neuroanatomical systems that mediate this effect of nicotine have never been …