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Articles 751 - 780 of 1633

Full-Text Articles in Statistical Theory

Estimation Of A Non-Parametric Variable Importance Measure Of A Continuous Exposure, Chambaz Antoine, Pierre Neuvial, Mark J. Van Der Laan Oct 2011

Estimation Of A Non-Parametric Variable Importance Measure Of A Continuous Exposure, Chambaz Antoine, Pierre Neuvial, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

We define a new measure of variable importance of an exposure on a continuous outcome, accounting for potential confounders. The exposure features a reference level x0 with positive mass and a continuum of other levels. For the purpose of estimating it, we fully develop the semi-parametric estimation methodology called targeted minimum loss estimation methodology (TMLE) [van der Laan & Rubin, 2006; van der Laan & Rose, 2011]. We cover the whole spectrum of its theoretical study (convergence of the iterative procedure which is at the core of the TMLE methodology; consistency and asymptotic normality of the estimator), practical implementation, simulation …


A Regularization Corrected Score Method For Nonlinear Regression Models With Covariate Error, David M. Zucker, Malka Gorfine, Yi Li, Donna Spiegelman Sep 2011

A Regularization Corrected Score Method For Nonlinear Regression Models With Covariate Error, David M. Zucker, Malka Gorfine, Yi Li, Donna Spiegelman

Harvard University Biostatistics Working Paper Series

No abstract provided.


A Proof Of Bell's Inequality In Quantum Mechanics Using Causal Interactions, James M. Robins, Tyler J. Vanderweele, Richard D. Gill Sep 2011

A Proof Of Bell's Inequality In Quantum Mechanics Using Causal Interactions, James M. Robins, Tyler J. Vanderweele, Richard D. Gill

COBRA Preprint Series

We give a simple proof of Bell's inequality in quantum mechanics which, in conjunction with experiments, demonstrates that the local hidden variables assumption is false. The proof sheds light on relationships between the notion of causal interaction and interference between particles.


Effectively Selecting A Target Population For A Future Comparative Study, Lihui Zhao, Lu Tian, Tianxi Cai, Brian Claggett, L. J. Wei Aug 2011

Effectively Selecting A Target Population For A Future Comparative Study, Lihui Zhao, Lu Tian, Tianxi Cai, Brian Claggett, L. J. Wei

Harvard University Biostatistics Working Paper Series

When comparing a new treatment with a control in a randomized clinical study, the treatment effect is generally assessed by evaluating a summary measure over a specific study population. The success of the trial heavily depends on the choice of such a population. In this paper, we show a systematic, effective way to identify a promising population, for which the new treatment is expected to have a desired benefit, using the data from a current study involving similar comparator treatments. Specifically, with the existing data we first create a parametric scoring system using multiple covariates to estimate subject-specific treatment differences. …


Multiple Testing Of Local Maxima For Detection Of Peaks In Chip-Seq Data, Armin Schwartzman, Andrew Jaffe, Yulia Gavrilov, Clifford A. Meyer Aug 2011

Multiple Testing Of Local Maxima For Detection Of Peaks In Chip-Seq Data, Armin Schwartzman, Andrew Jaffe, Yulia Gavrilov, Clifford A. Meyer

Harvard University Biostatistics Working Paper Series

No abstract provided.


On The Covariate-Adjusted Estimation For An Overall Treatment Difference With Data From A Randomized Comparative Clinical Trial, Lu Tian, Tianxi Cai, Lihui Zhao, L. J. Wei Jul 2011

On The Covariate-Adjusted Estimation For An Overall Treatment Difference With Data From A Randomized Comparative Clinical Trial, Lu Tian, Tianxi Cai, Lihui Zhao, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.


Variable Importance Analysis With The Multipim R Package, Stephan J. Ritter, Nicholas P. Jewell, Alan E. Hubbard Jul 2011

Variable Importance Analysis With The Multipim R Package, Stephan J. Ritter, Nicholas P. Jewell, Alan E. Hubbard

U.C. Berkeley Division of Biostatistics Working Paper Series

We describe the R package multiPIM, including statistical background, functionality and user options. The package is for variable importance analysis, and is meant primarily for analyzing data from exploratory epidemiological studies, though it could certainly be applied in other areas as well. The approach taken to variable importance comes from the causal inference field, and is different from approaches taken in other R packages. By default, multiPIM uses a double robust targeted maximum likelihood estimator (TMLE) of a parameter akin to the attributable risk. Several regression methods/machine learning algorithms are available for estimating the nuisance parameters of the models, including …


A Unified Approach To Non-Negative Matrix Factorization And Probabilistic Latent Semantic Indexing, Karthik Devarajan, Guoli Wang, Nader Ebrahimi Jul 2011

A Unified Approach To Non-Negative Matrix Factorization And Probabilistic Latent Semantic Indexing, Karthik Devarajan, Guoli Wang, Nader Ebrahimi

COBRA Preprint Series

Non-negative matrix factorization (NMF) by the multiplicative updates algorithm is a powerful machine learning method for decomposing a high-dimensional nonnegative matrix V into two matrices, W and H, each with nonnegative entries, V ~ WH. NMF has been shown to have a unique parts-based, sparse representation of the data. The nonnegativity constraints in NMF allow only additive combinations of the data which enables it to learn parts that have distinct physical representations in reality. In the last few years, NMF has been successfully applied in a variety of areas such as natural language processing, information retrieval, image processing, speech recognition …


Multiple Testing Of Local Maxima For Detection Of Unimodal Peaks In 1d, Armin Schwartzman, Yulia Gavrilov, Robert J. Adler Jul 2011

Multiple Testing Of Local Maxima For Detection Of Unimodal Peaks In 1d, Armin Schwartzman, Yulia Gavrilov, Robert J. Adler

Harvard University Biostatistics Working Paper Series

No abstract provided.


Component Extraction Of Complex Biomedical Signal And Performance Analysis Based On Different Algorithm, Hemant Pasusangai Kasturiwale Jun 2011

Component Extraction Of Complex Biomedical Signal And Performance Analysis Based On Different Algorithm, Hemant Pasusangai Kasturiwale

Johns Hopkins University, Dept. of Biostatistics Working Papers

Biomedical signals can arise from one or many sources including heart ,brains and endocrine systems. Multiple sources poses challenge to researchers which may have contaminated with artifacts and noise. The Biomedical time series signal are like electroencephalogram(EEG),electrocardiogram(ECG),etc The morphology of the cardiac signal is very important in most of diagnostics based on the ECG. The diagnosis of patient is based on visual observation of recorded ECG,EEG,etc, may not be accurate. To achieve better understanding , PCA (Principal Component Analysis) and ICA algorithms helps in analyzing ECG signals . The immense scope in the field of biomedical-signal processing Independent Component Analysis( …


Propensity Score Analysis With Matching Weights, Liang Li May 2011

Propensity Score Analysis With Matching Weights, Liang Li

COBRA Preprint Series

The propensity score analysis is one of the most widely used methods for studying the causal treatment effect in observational studies. This paper studies treatment effect estimation with the method of matching weights. This method resembles propensity score matching but offers a number of new features including efficient estimation, rigorous variance calculation, simple asymptotics, statistical tests of balance, clearly identified target population with optimal sampling property, and no need for choosing matching algorithm and caliper size. In addition, we propose the mirror histogram as a useful tool for graphically displaying balance. The method also shares some features of the inverse …


Model Diagnostics For Proportional And Partial Proportional Odds Models, Ann A. O'Connell, Xing Liu May 2011

Model Diagnostics For Proportional And Partial Proportional Odds Models, Ann A. O'Connell, Xing Liu

Journal of Modern Applied Statistical Methods

Although widely used to assist in evaluating the prediction quality of linear and logistic regression models, residual diagnostic techniques are not well developed for regression analyses where the outcome is treated as ordinal. The purpose of this article is to review methods of model diagnosis that may be useful in investigating model assumptions and in identifying unusual cases for PO and PPO models, and provide a corresponding application of these diagnostic methods to the prediction of proficiency in early literacy for children drawn from the kindergarten cohort of the Early Childhood Longitudinal Study (ECLS-K; NCES, 2000).


Sample Size Considerations For Multiple Comparison Procedures In Anova, Gordon P. Brooks, George A. Johanson May 2011

Sample Size Considerations For Multiple Comparison Procedures In Anova, Gordon P. Brooks, George A. Johanson

Journal of Modern Applied Statistical Methods

Adequate sample sizes for omnibus ANOVA tests do not necessarily provide sufficient statistical power for post hoc multiple comparisons typically performed following a significant omnibus F test. Results reported support a comparison-of-most-interest approach for sample size determination in ANOVA based on effect sizes for multiple comparisons.


Type I Error Inflation Of The Separate-Variances Welch T Test With Very Small Sample Sizes When Assumptions Are Met, Albert K. Adusah, Gordon P. Brooks May 2011

Type I Error Inflation Of The Separate-Variances Welch T Test With Very Small Sample Sizes When Assumptions Are Met, Albert K. Adusah, Gordon P. Brooks

Journal of Modern Applied Statistical Methods

This Monte Carlo study shows that the separate-variances Welch t test has inflated Type I error rates at very small sample sizes, especially when sample sizes are very small in one group and larger in the second group – even when all assumptions for the statistical test are met.


One Is Not Enough: The Need For Multiple Respondents In Survey Research Of Organizations, Joseph L. Balloun, Hilton Barrett, Art Weinstein May 2011

One Is Not Enough: The Need For Multiple Respondents In Survey Research Of Organizations, Joseph L. Balloun, Hilton Barrett, Art Weinstein

Journal of Modern Applied Statistical Methods

The need for multiple respondents per organization in organizational survey research is supported. Leadership teams’ ratings of their implementations of market orientation are examined, along with learning orientation, entrepreneurial management, and organizational flexibility. Sixty diverse organizations, including not-for-profit organizations in education and healthcare as well as manufacturing and service businesses, were included. The major finding was the large rating variance within the leadership teams of each organization. The results are enlightening and have definite implications for improved design of survey research on organizations.


Is Next Twelve Months Period Tumor Recurrence Free Under Restricted Rate Due To Medication? A Probabilistic Warning, Ramalingam Shanmugam May 2011

Is Next Twelve Months Period Tumor Recurrence Free Under Restricted Rate Due To Medication? A Probabilistic Warning, Ramalingam Shanmugam

Journal of Modern Applied Statistical Methods

A methodology is formulated to analyze tumor recurrence data when its incidence rate is restricted due to medication. Analytic results are derived to make a probabilistic early warning of tumor recurrence free period of length τ; that is, the chance for a safe period of lengthτ is estimated. The captured data are length biased. Expressions are developed to extract and relate to counterparts of the non-length biased data. Three data sets are considered as illustrations: (1) patients who are given a placebo, (2) patients who are given the medicine pyridoxine and (3) patients who are given the medicine thiotepa.


The Likelihood Of Choosing The Borda-Winner With Partial Preference Rankings Of The Electorate, Ömer Eğecioğlu, Ayça Ebru Giritligil May 2011

The Likelihood Of Choosing The Borda-Winner With Partial Preference Rankings Of The Electorate, Ömer Eğecioğlu, Ayça Ebru Giritligil

Journal of Modern Applied Statistical Methods

Given that n voters report only the first r (1 ≤ r < m) ranks of their linear preference rankings over m alternatives, the likelihood of implementing Borda outcome is investigated. The information contained in the first r ranks is aggregated through a Borda-like method, namely the r-Borda rule. Monte-Carlo simulations are run to detect changes in the likelihood of r-Borda winner(s) to coincide with the original Borda winner(s) as a function of m, n and r. The voters’ preferences are generated through the Impartial Anonymous and Neutral Culture Model, where both the names of the …


An Exact Test For The Equality Of Intraclass Correlation Coefficients Under Unequal Family Sizes, Madhusudan Bhandary, Koji Fujiwara May 2011

An Exact Test For The Equality Of Intraclass Correlation Coefficients Under Unequal Family Sizes, Madhusudan Bhandary, Koji Fujiwara

Journal of Modern Applied Statistical Methods

An exact test for the equality of two intraclass correlation coefficients under unequal family sizes based on two independent multi-normal samples is proposed. This exact test consistently and reliably produced results superior to those of the Likelihood Ratio Test (LRT) and the large sample Z-test proposed by Young and Bhandary (1998). The test generally performed better in terms of power (for higher intraclass correlation values) for various combinations of intraclass correlation coefficient values and the exact test remained closer to the significance level under the null hypothesis compared to the other two tests. For small sample situations, sizes of the …


Extension Of Grizzle’S Classic Crossover Design, James F. Reed Iii May 2011

Extension Of Grizzle’S Classic Crossover Design, James F. Reed Iii

Journal of Modern Applied Statistical Methods

The crossover design compares treatments A and B over two periods using sequences AB and BA (the AB|BA design) and is the classic design most often illustrated and critiqued in textbooks. Other crossover designs have been used but their use is relatively rare and not always well understood. This article introduces alternatives to a randomized two-treatment, two-period crossover study design. One strategy, which is to extend the classic AB|BA by adding a third period to repeat one of the two treatments, has several attractive advantages; an added treatment period may not imply a large additional cost but will allow carryover …


Double Acceptance Sampling Plans Based On Truncated Life Tests For Marshall-Olkin Extended Lomax Distribution, G. Srinivasa Rao May 2011

Double Acceptance Sampling Plans Based On Truncated Life Tests For Marshall-Olkin Extended Lomax Distribution, G. Srinivasa Rao

Journal of Modern Applied Statistical Methods

Double Acceptance Sampling Plans (DASP) is developed for a truncated life test when the lifetime of an item follows the Marshall-Olkin extended Lomax distribution. Probability of Acceptance (PA) is calculated for different consumer’s confidence levels fixing the producer’s risk at 0.05. Probability of acceptance and producer’s risk are illustrated with examples.


Estimation Of Population Mean In Successive Sampling By Sub-Sampling Non-Respondents, Housila P. Singh, Sunil Kumar, Sandeep Bhougal May 2011

Estimation Of Population Mean In Successive Sampling By Sub-Sampling Non-Respondents, Housila P. Singh, Sunil Kumar, Sandeep Bhougal

Journal of Modern Applied Statistical Methods

The estimation of the population mean in mail surveys is investigated in the context of sampling on two occasions where the population mean of the auxiliary variable is available in the presence of non-response only for the current occasion in two occasion successive sampling. The behavior of the proposed estimator is compared with the estimator for the same situation but in the absence of non-response. An empirical illustration demonstrates the performance of the proposed estimator.


Fisher’S Exact Test For Misclassified Data, Tze-San Lee May 2011

Fisher’S Exact Test For Misclassified Data, Tze-San Lee

Journal of Modern Applied Statistical Methods

Ecole Supérieure de Commerce de Tunis. Fisher’s exact test is adapted to handle the misclassified data arising from comparing two binomial populations. The bias-adjusted odds ratio is proposed to account for misclassification errors. Its expected power depends in a nonlinear way on the true sensitivity and specificity of the classification method. The data taken from the no conviction rate of criminality for two types of twin populations was used to illustrate how to calculate true sensitivity and specificity and the expected power of the adjusted odds ratio.


Improved Estimation Of The Population Mean Using Known Parameters Of An Auxiliary Variable, Rajesh Tailor, Balkishan Sharma May 2011

Improved Estimation Of The Population Mean Using Known Parameters Of An Auxiliary Variable, Rajesh Tailor, Balkishan Sharma

Journal of Modern Applied Statistical Methods

An improved ratio-cum-product type estimator of the finite population mean is proposed using known information on the coefficient of variation of an auxiliary variate and correlation coefficient between a study variate and an auxiliary variate. Realistic conditions are obtained under which the proposed estimator is more efficient than the simple mean estimator, usual ratio and product estimators and estimators proposed by Singh and Diwivedi (1981), Pandey and Dubey (1988), Upadhaya and Singh (1999), and Singh, et al., (2004). An empirical study supports theoretical findings.


Inference In Simple Regression For The Intercept Utilizing Prior Information On The Slope, Ayman Baklizi, Adil E. Yousif May 2011

Inference In Simple Regression For The Intercept Utilizing Prior Information On The Slope, Ayman Baklizi, Adil E. Yousif

Journal of Modern Applied Statistical Methods

Shrinkage type estimators are developed for the intercept parameter of a simple linear regression model and the case when it is suspected a priori that the slope parameter is equal to some specific value is considered. Three different estimators of the intercept parameters are examined. The relative performances of the estimators are investigated based on a simulation study of the biases and mean squared errors. The associated bootstrap confidence intervals are also studied and their performance is evaluated.


Factors Influencing The Mixture Index Of Model Fit In Contingency Tables Showing Independence, Xuemei Pan, C. Mitchell Dayton May 2011

Factors Influencing The Mixture Index Of Model Fit In Contingency Tables Showing Independence, Xuemei Pan, C. Mitchell Dayton

Journal of Modern Applied Statistical Methods

Several competing computational techniques for dealing with sampling zeros were evaluated when estimating the two-point mixture model index, π* , in contingency tables under an independence assumption. Also, the performance of the estimate and associated standard errors were studied under various combinations of conditions.


Bayesian Regression Analysis With Examples In S-Plus And R, Sheikh P. Ahmad, A. A. Khan, A. Ahmed May 2011

Bayesian Regression Analysis With Examples In S-Plus And R, Sheikh P. Ahmad, A. A. Khan, A. Ahmed

Journal of Modern Applied Statistical Methods

An extended version of normal theory Bayesian regression models, including extreme-value, logistic and normal regression models is examined. Methods proposed are illustrated numerically; the regression coefficient of pH on electrical conductivity (EC) of soil data is analyzed using both S-PLUS and R software.


Bayesian Threshold Moving Average Models, Mahmoud M. Smadi, M. T. Alodat May 2011

Bayesian Threshold Moving Average Models, Mahmoud M. Smadi, M. T. Alodat

Journal of Modern Applied Statistical Methods

A Bayesian approach in threshold moving average model for time series with two regimes is provided. The posterior distribution of the delay and threshold parameters are used to examine and investigate the intrinsic characteristics of this nonlinear time series model. The proposed approach is applied to both simulated data and a real data set obtained from a chemical system. Key words: Threshold time series, moving average model, Bayesian


A Robust One-Sided Variability Control Chart, P. Borysov, Ping Sa May 2011

A Robust One-Sided Variability Control Chart, P. Borysov, Ping Sa

Journal of Modern Applied Statistical Methods

A new control charting technique to monitor the variability of any distribution is proposed. The simulation study shows that the new method outperforms all the existing methods in controlling the Type I error rates and it also has good power performance for all distributions considered in the study.


A Test That Combines Frequency And Quantitative Information, Norman Cliff May 2011

A Test That Combines Frequency And Quantitative Information, Norman Cliff

Journal of Modern Applied Statistical Methods

In many simple designs, observed frequencies in subclasses defined by a qualitative variable are compared to the frequencies expected on the basis of population proportions, design parameters or models. Often there is a quantitative variable which may be affected in the same way as the frequencies. Its differences among the groups may also be analyzed. A simple test is described that combines the effects on the frequencies and on the quantitative variable based on comparing the sums of the values for the quantitative value within each group to the random expectation. The sampling variance of the difference is derived and …


Comparing The Strength Of Association Of Two Predictors Via Smoothers Or Robust Regression Estimators, Rand R. Wilcox May 2011

Comparing The Strength Of Association Of Two Predictors Via Smoothers Or Robust Regression Estimators, Rand R. Wilcox

Journal of Modern Applied Statistical Methods

Consider three random variables, Y , X1 and X2, having some unknown trivariate distribution and let n2j (j = 1, 2) be some measure of the strength of association between Y and Xj. When n2j is taken to be Pearson’s correlation numerous methods for testing Ho : n21 = n22 have been proposed. However, Pearson’s correlation is not robust and the methods for testing H0 are not level robust in general. This article examines methods for testing H0 based on a robust fit. The …