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Full-Text Articles in Biostatistics
An Extension Of The Cochran Q Test, Soo-Young Cho
An Extension Of The Cochran Q Test, Soo-Young Cho
Loma Linda University Electronic Theses, Dissertations & Projects
The familiar x 2 test is ordinarily used to compare percentage distributions of categorical data for two or more independent samples. A more accurate com parison of the percentages is sometimes obtained if the samples consist of matched individuals. The NcNemar test is generally used when comparing only two related samples. Where there are three or more samples the Cochran Q test is used. Both of these tests apply only to the case of dichotomized responses. This thesis extends the Cochran Q test to the case where the responses are multinomial. A generalized statistic corresponding to Cochran's result is obtained. …
Relationship Of Ventilation Ability And Positioning In Left-Sided Congestive Heart Failure Patients, Nancy E. Carson
Relationship Of Ventilation Ability And Positioning In Left-Sided Congestive Heart Failure Patients, Nancy E. Carson
Loma Linda University Electronic Theses, Dissertations & Projects
Proper positioning is used to relieve dyspnea, edema, and fatigue in congestive heart failure patients. According to the review of literature, improved ventilation as measured by specific lung volumes and lung mechanics occurred with upright positioning in normal persons. The effects of specific changes in lung volumes related to position change in congestive heart failure patients has not been documented in literature, although various recommendations related to positioning are made. This exploratory study was undertaken with nine congestive heart failure patients to see if a relationship existed between degree of head elevation and lung ventilation ability as measured by water-bell …
Group Sequential Methods For Clinical Trials Applied To The Logistic Regression Model, Joy Duci Mele
Group Sequential Methods For Clinical Trials Applied To The Logistic Regression Model, Joy Duci Mele
Theses and Dissertations
The objectives of this thesis are
1. to provide a comprehensive guide to using Pocock's group sequential method for clinical trials and
2. to show by computer simulations that the group sequential method is appropriate when using the logistic regression model.
In section 1.2, clinical trials are defined with an emphasis on Phase III clinical trials. The primary intent of sections 1.2 and 1.3 is to describe clinical trial characteristics which suggest that interim analyses are desirable. In section 1.4, it is shown that interim analyses should not consist of performing the usual significance tests. Chapter 1, then, describes the …