Statistics and Probability Commons^™

Identifying Key Factors Associated With High Risk Asthma Patients To Reduce The Cost Of Health Resources Utilization, Amani Ahmad

LSU Master's Theses

Asthma is associated with frequent use of primary health services and places a burden on the United States economy. Identifying key factors associated with increased cost of asthma is an essential step to improve practices of asthma management.

The aim of this study was to identify factors associated with over utilization of primary health services and increased cost via claims data and to explore the effectiveness of case management program in reducing overall asthma related cost.

Claims data analysis for Medicaid insured asthma patients in Louisiana was conducted. Asthma patients were identified using their ICD-9 and ICD-10 codes, forward variable …

Season-Ahead Forecasting Of Water Storage And Irrigation Requirements – An Application To The Southwest Monsoon In India, Arun Ravindranath, Naresh Devineni, Upmanu Lall, Paulina Concha Larrauri

Publications and Research

Water risk management is a ubiquitous challenge faced by stakeholders in the water or agricultural sector. We present a methodological framework for forecasting water storage requirements and present an application of this methodology to risk assessment in India. The application focused on forecasting crop water stress for potatoes grown during the monsoon season in the Satara district of Maharashtra. Pre-season large-scale climate predictors used to forecast water stress were selected based on an exhaustive search method that evaluates for highest ranked probability skill score and lowest root-mean-squared error in a leave-one-out cross-validation mode. Adaptive forecasts were made in the years …

Demonstrating The Efficacy Of The Health Sciences And Technology Academy: Using Archival Standardized Test Scores To Analyze An Ost College-Preparatory Program For Underserved Youth, Feon Smith, Sherron Mckendall, Ann Chester, Bethany Hornbeck, Alan Mckendall

Faculty & Staff Scholarship

To combat educational and health disparities, out-of-school-time (OST) STEM enrichment programs provide services to underserved youth to encourage them to pursue college and health careers. This article describes a study conducted to determine if the Health Sciences and Technology Academy (HSTA) program participants who receive year-round educational interventions to prepare them for STEM and health sciences majors performed better on the West Virginia Educational Standards Test (WESTEST2) than non-participants. This study provides descriptive and inferential statistics, specifically one-way ANOVAs with one-to-one matching based on grade level, gender, race, and GPA at the end of the 8th grade year for 336 …

Minimizing The Perceived Financial Burden Due To Cancer, Hassan Azhar, Zoheb Allam, Gino Varghese, Daniel W. Engels, Sajiny John

SMU Data Science Review

In this paper, we present a regression model that predicts perceived financial burden that a cancer patient experiences in the treatment and management of the disease. Cancer patients do not fully understand the burden associated with the cost of cancer, and their lack of understanding can increase the difficulties associated with living with the disease, in particular coping with the cost. The relationship between demographic characteristics and financial burden were examined in order to better understand the characteristics of a cancer patient and their burden, while all subsets regression was used to determine the best predictors of financial burden. Age, …

Yelp’S Review Filtering Algorithm, Yao Yao, Ivelin Angelov, Jack Rasmus-Vorrath, Mooyoung Lee, Daniel W. Engels

SMU Data Science Review

In this paper, we present an analysis of features influencing Yelp's proprietary review filtering algorithm. Classifying or misclassifying reviews as recommended or non-recommended affects average ratings, consumer decisions, and ultimately, business revenue. Our analysis involves systematically sampling and scraping Yelp restaurant reviews. Features are extracted from review metadata and engineered from metrics and scores generated using text classifiers and sentiment analysis. The coefficients of a multivariate logistic regression model were interpreted as quantifications of the relative importance of features in classifying reviews as recommended or non-recommended. The model classified review recommendations with an accuracy of 78%. We found that reviews …

Robust Inference For The Stepped Wedge Design, James P. Hughes, Patrick J. Heagerty, Fan Xia, Yuqi Ren

UW Biostatistics Working Paper Series

Based on a permutation argument, we derive a closed form expression for an estimate of the treatment effect, along with its standard error, in a stepped wedge design. We show that these estimates are robust to misspecification of both the mean and covariance structure of the underlying data-generating mechanism, thereby providing a robust approach to inference for the treatment effect in stepped wedge designs. We use simulations to evaluate the type I error and power of the proposed estimate and to compare the performance of the proposed estimate to the optimal estimate when the correct model specification is known. The …

Generalizing Multistage Partition Procedures For Two-Parameter Exponential Populations, Rui Wang

LSU New Orleans Theses and Dissertations

ANOVA analysis is a classic tool for multiple comparisons and has been widely used in numerous disciplines due to its simplicity and convenience. The ANOVA procedure is designed to test if a number of different populations are all different. This is followed by usual multiple comparison tests to rank the populations. However, the probability of selecting the best population via ANOVA procedure does not guarantee the probability to be larger than some desired prespecified level. This lack of desirability of the ANOVA procedure was overcome by researchers in early 1950's by designing experiments with the goal of selecting the best …

A Comparison Of R, Sas, And Python Implementations Of Random Forests, Breckell Soifua

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The Random Forest method is a useful machine learning tool developed by Leo Breiman. There are many existing implementations across different programming languages; the most popular of which exist in R, SAS, and Python. In this paper, we conduct a comprehensive comparison of these implementations with regards to the accuracy, variable importance measurements, and timing. This comparison was done on a variety of real and simulated data with different classification difficulty levels, number of predictors, and sample sizes. The comparison shows unexpectedly different results between the three implementations.

Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor

Electronic Theses and Dissertations

Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …

Generalized Spatiotemporal Modeling And Causal Inference For Assessing Treatment Effects For Multiple Groups For Ordinal Outcome., Soutik Ghosal

Electronic Theses and Dissertations

This dissertation consists of three projects and can be categorized in two broad research areas: generalized spatiotemporal modeling and causal inference based on observational data. In the first project, I introduce a Bayesian hierarchical mixed effect hurdle model with a nested random effect structure to model the count for primary care providers and understand their spatial and temporal variation. This study further enables us to identify the health professional shortage areas and the possible impacting factors. In the second project, I have unified popular parametric and nonparametric propensity score-based methods to assess the treatment effect of multiple groups for ordinal …

Predictions Generated From A Simulation Engine For Gene Expression Micro-Arrays For Use In Research Laboratories, Gopinath R. Mavankal, John Blevins, Dominique Edwards, Monnie Mcgee, Andrew Hardin

SMU Data Science Review

In this paper we introduce the technical components, the biology and data science involved in the use of microarray technology in biological and clinical research. We discuss how laborious experimental protocols involved in obtaining this data used in laboratories could benefit from using simulations of the data. We discuss the approach used in the simulation engine from [7]. We use this simulation engine to generate a prediction tool in Power BI, a Microsoft, business intelligence tool for analytics and data visualization [22]. This tool could be used in any laboratory using micro-arrays to improve experimental design by comparing how predicted …

Data Scientist’S Analysis Toolbox: Comparison Of Python, R, And Sas Performance, Jim Brittain, Mariana Cendon, Jennifer Nizzi, John Pleis

SMU Data Science Review

A quantitative analysis will be performed on experiments utilizing three different tools used for Data Science. The analysis will include replication of analysis along with comparisons of code length, output, and results. Qualitative data will supplement the quantitative findings. The conclusion will provide data support guidance on the correct tool to use for common situations in the field of Data Science.

Hierarchical Bayesian Data Fusion Using Autoencoders, Yevgeniy Vladimirovich Reznichenko

Master's Theses (2009 -)

In this thesis, a novel method for tracker fusion is proposed and evaluated for vision-based tracking. This work combines three distinct popular techniques into a recursive Bayesian estimation algorithm. First, semi supervised learning approaches are used to partition data and to train a deep neural network that is capable of capturing normal visual tracking operation and is able to detect anomalous data. We compare various methods by examining their respective receiver operating conditions (ROC) curves, which represent the trade off between specificity and sensitivity for various detection threshold levels. Next, we incorporate the trained neural networks into an existing data …

Improving Shewhart Control Chart Performance In The Presence Of Measurement Error Using Multiple Measurements And Two-Stage Sampling, Kenneth W. Linna

Journal of International & Interdisciplinary Business Research (2014-2019)

The usual Shewhart control chart efficiently detects large shifts in the mean of a quality characteristic and has been extensively studied in the literature. Most proposed alternatives to the Shewhart chart aim to improve either the signal performance for smaller mean shifts or reduce the sampling effort required to detect a larger shift. Measurement error has been shown in the literature to result in reduced power to detect process shifts. The combination of multiple measurements and two-stage sampling is considered here as a strategy for both regaining power lost due to measurement error and specifically tuning the charts for shifts …

Integrating Statistical Methods In Engineering Technology Courses, Sanjeevi Chitikeshi, Jake Hildebrant, Otilia Popescu, Orlando M. Ayala, Vukica M. Jovanovic

Engineering Technology Faculty Publications

Statistical methods and procedures are very important in engineering applications. In most of the engineering fields electronic devices are used as sensing and controlling components. Lack of proper calibration of these devices and of performance analysis using different statistical methods may lead to erroneous measurements and results. In medical or manufacturing areas such errors in the experimental results could be catastrophic. Applying different statistical tests and procedures enhance the quality of engineering work. Traditionally, most engineering curricula have at least one required course in applied statistics in engineering, but that is not generally the case in engineering technology programs. Most …

A 3d Characteristics Database Of Land Engraved Areas With Known Subclass, Entni Lin

Student Theses

Subclass characteristics on bullets may mislead firearm examiners when they rely on traditional 2D images. In order to provide indelible examples for training and help avoid identification errors, 3D topography surface maps and statistical methods of pattern recognition are applied to toolmarks on bullets containing known subclass characteristics. This research was conducted by collecting 3D topography surface map data from land engraved areas of bullets fired through known barrels. This data was processed and used to train the statistical algorithms to predict their origin. The results from the algorithm are compared with the “right answers” (i.e. correct IDs) of the …

Discrete Ranked Set Sampling, Heng Cui

Statistical Science Theses and Dissertations

Ranked set sampling (RSS) is an efficient data collection framework compared to simple random sampling (SRS). It is widely used in various application areas such as agriculture, environment, sociology, and medicine, especially in situations where measurement is expensive but ranking is less costly. Most past research in RSS focused on situations where the underlying distribution is continuous. However, it is not unusual to have a discrete data generation mechanism. Estimating statistical functionals are challenging as ties may truly exist in discrete RSS. In this thesis, we started with estimating the cumulative distribution function (CDF) in discrete RSS. We proposed two …

Evaluation Of Using The Bootstrap Procedure To Estimate The Population Variance, Nghia Trong Nguyen

Electronic Theses and Dissertations

The bootstrap procedure is widely used in nonparametric statistics to generate an empirical sampling distribution from a given sample data set for a statistic of interest. Generally, the results are good for location parameters such as population mean, median, and even for estimating a population correlation. However, the results for a population variance, which is a spread parameter, are not as good due to the resampling nature of the bootstrap method. Bootstrap samples are constructed using sampling with replacement; consequently, groups of observations with zero variance manifest in these samples. As a result, a bootstrap variance estimator will carry a …

Assessing The Ordinality Of Response Bias With Item Response Models: A Case Study Using The Phq-9, Venessa N. Singhroy

Dissertations, Theses, and Capstone Projects

Improper scale usage in psychological and clinical assessment is an important problem. If respondents do not use the scales in a consistent manner, the reliability of a composite is likely to be attenuated. This is particularly problematic when particular items are singled out for special treatment or when subscales are of interest, not just a total score. This study used both non-parametric and parametric item response theory (IRT) methods to gain further insight into the validity of the PHQ-9, a dual purpose instrument that assesses the severity of depressive symptoms using nine Likert-scale items and allows the investigator to establish …

Initial Evidence Of Construct Validity Of Data From A Self-Assessment Instrument Of Technological Pedagogical Content Knowledge (Tpack) In 2-Year Public College Faculty In Texas, Kristin C. Scott

Human Resource Development Theses and Dissertations

Technological pedagogical content knowledge (TPACK) has been studied in K-12 faculty in the U.S. and around the world using survey methodology. Very few studies of TPACK in post-secondary faculty have been conducted and no peer-reviewed studies in U.S. post-secondary faculty have been published to date. The present study is the first reliability and validity of data from a TPACK survey to be conducted with a large sample of U.S. post-secondary faculty. The professorate of 2-year public college faculty in Texas will help their institutions meet the goals of the state’s higher education strategic plan, 60x30TX. In order to do …

Using Random Forests To Describe Equity In Higher Education: A Critical Quantitative Analysis Of Utah’S Postsecondary Pipelines, Tyler Mcdaniel

Butler Journal of Undergraduate Research

The following work examines the Random Forest (RF) algorithm as a tool for predicting student outcomes and interrogating the equity of postsecondary education pipelines. The RF model, created using longitudinal data of 41,303 students from Utah's 2008 high school graduation cohort, is compared to logistic and linear models, which are commonly used to predict college access and success. Substantially, this work finds High School GPA to be the best predictor of postsecondary GPA, whereas commonly used ACT and AP test scores are not nearly as important. Each model identified several demographic disparities in higher education access, most significantly the effects …

The Influence Of A Proposed Margin Criterion On The Accuracy Of Parallel Analysis In Conditions Engendering Underextraction, Justin M. Jones

Masters Theses & Specialist Projects

One of the most important decisions to make when performing an exploratory factor or principal component analysis regards the number of factors to retain. Parallel analysis is considered to be the best course of action in these circumstances as it consistently outperforms other factor extraction methods (Zwick & Velicer, 1986). Even so, parallel analysis could benefit from further research and refinement to improve its accuracy. Characteristics such as factor loadings, correlations between factors, and number of variables per factor all have been shown to adversely impact the effectiveness of parallel analysis as a means of identifying the number of factors …

Developing Statistical Methods For Data From Platforms Measuring Gene Expression, Gaoxiang Jia

Statistical Science Theses and Dissertations

This research contains two topics: (1) PBNPA: a permutation-based non-parametric analysis of CRISPR screen data; (2) RCRnorm: an integrated system of random-coefficient hierarchical regression models for normalizing NanoString nCounter data from FFPE samples.

Clustered regularly-interspaced short palindromic repeats (CRISPR) screens are usually implemented in cultured cells to identify genes with critical functions. Although several methods have been developed or adapted to analyze CRISPR screening data, no single spe- cific algorithm has gained popularity. Thus, rigorous procedures are needed to overcome the shortcomings of existing algorithms. We developed a Permutation-Based Non-Parametric Analysis (PBNPA) algorithm, which computes p-values at the gene level …

Robust Estimation Of The Average Treatment Effect In Alzheimer's Disease Clinical Trials, Michael Rosenblum, Aidan Mcdermont, Elizabeth Colantuoni

Johns Hopkins University, Dept. of Biostatistics Working Papers

The primary analysis of Alzheimer's disease clinical trials often involves a mixed-model repeated measure (MMRM) approach. We consider another estimator of the average treatment effect, called targeted minimum loss based estimation (TMLE). This estimator is more robust to violations of assumptions about missing data than MMRM.

We compare TMLE versus MMRM by analyzing data from a completed Alzheimer's disease trial data set and by simulation studies. The simulations involved different missing data distributions, where loss to followup at a given visit could depend on baseline variables, treatment assignment, and the outcome measured at previous visits. The TMLE generally has improved …

Satellite Communications In The V And W Band: Tropospheric Effects, Bertus A. Shelters

Theses and Dissertations

An investigation into the use of Weather Cubes compiled by the atmospheric characterization package, Laser Environmental Effects Definition and Reference (LEEDR), to develop accurate, long-term attenuation statistics for link-budget analysis is presented. A Weather Cube is a three-dimensional mesh of numerical weather prediction (NWP) data plus LEEDR calculations that allows for the quantification of rain, cloud, aerosol, and molecular effects at any UV to RF wavelength on any path contained within the cube. The development of this methodology is motivated by the potential use of V (40-75 GHz) and W (75-110 GHz) band frequencies for the satellite communication application, as …

Tinnitus And Dysfunctional Interactions Between Distributed Resting State Networks, Sivayini Kandeepan

Western Research Forum

It is known that peripheral lesions in the cochlea or the auditory nerve produce dysfunctional input to central auditory structures and induce changes in the auditory system causing tinnitus. Recently, it has been proposed that the unified percept of tinnitus could be considered as an emergent property of multiple overlapping dynamic brain networks, each encoding a specific tinnitus characteristic.

The aim of our study was to investigate the neuronal activation patterns associated with specific clinical tinnitus characteristics using fMRI. We hypothesize that tinnitus clinical characteristics could be associated with specific resting-state activity and connectivity patterns and that this could be …

Incorporating Historical Models With Adaptive Bayesian Updates, Philip S. Boonstra, Ryan P. Barbaro

The University of Michigan Department of Biostatistics Working Paper Series

This paper considers Bayesian approaches for incorporating information from a historical model into a current analysis when the historical model includes only a subset of covariates currently of interest. The statistical challenge is two-fold. First, the parameters in the nested historical model are not generally equal to their counterparts in the larger current model, neither in value nor interpretation. Second, because the historical information will not be equally informative for all parameters in the current analysis, additional regularization may be required beyond that provided by the historical information. We propose several novel extensions of the so-called power prior that adaptively …

Building A Better Risk Prevention Model, Steven Hornyak

National Youth Advocacy & Resilience Conference

This presentation chronicles the work of Houston County Schools in developing a risk prevention model built on more than ten years of longitudinal student data. In its second year of implementation, Houston At-Risk Profiles (HARP), has proven effective in identifying those students most in need of support and linking them to interventions and supports that lead to improved outcomes and significantly reduces the risk of failure.

Optimized Adaptive Enrichment Designs For Multi-Arm Trials: Learning Which Subpopulations Benefit From Different Treatments, Jon Arni Steingrimsson, Joshua Betz, Tiachen Qian, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

We consider the problem of designing a randomized trial for comparing two treatments versus a common control in two disjoint subpopulations. The subpopulations could be defined in terms of a biomarker or disease severity measured at baseline. The goal is to determine which treatments benefit which subpopulations. We develop a new class of adaptive enrichment designs tailored to solving this problem. Adaptive enrichment designs involve a preplanned rule for modifying enrollment based on accruing data in an ongoing trial. The proposed designs have preplanned rules for stopping accrual of treatment by subpopulation combinations, either for efficacy or futility. The motivation …

Phase Ii Adaptive Enrichment Design To Determine The Population To Enroll In Phase Iii Trials, By Selecting Thresholds For Baseline Disease Severity, Yu Du, Gary L. Rosner, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

We propose and evaluate a two-stage, phase 2, adaptive clinical trial design. Its goal is to determine whether future phase 3 (confirmatory) trials should be conducted, and if so, which population should be enrolled. The population selected for phase 3 enrollment is defined in terms of a disease severity score measured at baseline. We optimize the phase 2 trial design and analysis in a decision theory framework. Our utility function represents a combination of the cost of conducting phase 3 trials and, if the phase 3 trials are successful, the improved health of the future population minus the cost of …